• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.483-489
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• 2004

Fexofenadine HCl is non-sedating histamine H1 receptor antagonist that can be used for the treatment of seasonal allergic rhinitis. The objective of this study was to investigate whether the carriers of deformable liposomes can enhance the transepithelial permeability of fexofenadine HCl across the in vitro ALI human nasal monolayer model. Characterization of this model was achieved by bioelectric measurements and morphological studies. The passage 2 and 3 of cell monolayers exhibited the TEER value of $2852\;{\pm}\;482\;ohm\;{\times}\;cm^2$ on 11 days of seeding and maintained high TEER value for 5 days. The deformable liposome of fexofenadine HCl was prepared with phosphatidylcholine (PC) and cholic acid using extruder method. The mean particle size was about 200 nm and the maximum entrapment efficiency of 33.0% was obtained in the formulation of 1% PC and $100\;{\mu}g/ml$ fexofenadine HCl. The toxicity of the deformable liposome to human nasal monolayers was evaluated by MTT assay and TEER value change. MTT assay showed that it has no toxic effect on the nasal epithelial cells in 2-hour incubation when the PC concentration was below 1%. However, deformable liposome could not enhance the transepithelial permeability $(P_{app})$ and cellular uptake of fexofenadine HCl. In conclusion, the in vitro model could be used in nasal drug transport studies and evaluation of transepithelial permeability of formulations.

• Tunnel and Underground Space
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• v.12 no.4
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• pp.304-311
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• 2002

This study reports the influence of vocid geometry on fracture closure and permeability from numerical experiments. As the aperture distributions of rock fractures are characterized by statistical methods, synthetic fractures have successfully been simulated in this way. Based on the generated fracture models, models for fracture closure and flow calculation have been developed. A fracture closure model has been developed by considering the asperity compression and half-space deformation, and flow calculations have been performed using a finite difference method adopting a local cubic law. The results of numerical experiments have shown that the increase in the aperture spatial correlation leads the fracture closure and the decrease in fracture permeability to increase. Also, it has been indicated that there is an implicit relation between fracture normal stiffness and permeability. The importance of this study is to enhance the understanding the hydro-mechanical behavior of fractured rock massed due to engineering projects.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.6
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• pp.391-396
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• 2016

Wicks play an important role in determining the thermal performance of heat pipes. Foam-type wicks are known to have good potential for enhancing the capillary performance of conventional types of wicks, and this is because of their high porosity and permeability. In this study, we develop an analytic expression for predicting the permeability of a foam-type wick based on extensive numerical work. The proposed correlation is based on the modified Kozeny-Carman's equation, where the Kozeny-Carman coefficient is given as an exponential function of porosity. The proposed correlations are shown to predict the previous experimental results well for an extensive parametric range. The permeability of the foam-type wick is shown to be significantly higher than that of conventional wicks because of their high porosity.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.1C
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• pp.1-10
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• 2011

This paper simulates the piping effect, found levees with large difference in coefficient of permeability within the foundation such as the Gim-po Levee, via centrifuge model test which is a model test. We have also conducted a numerical analysis under the same conditions as the centrifuge model test to compare its results. First, we decided to use the centrifuge model based on the Gim-po Levee, and the tests were executed on a model levee with pore water pressure transducers. We have found that most of the water flows through the permeable layer and causes the piping effect. Via video camera footage, we have found that the piping effect occurred at the toe of the model levee. The characteristic of pressure head distribution, obtained from the pore water pressure transducers, also proves the occurrence of the piping effect. The numerical analysis results also showed the same results as the centrifuge model test. We have simulated the piping effect via centrifuge model test and believe that the centrifuge model test is viable for various tests, predictions and evaluation of the levee problems.

• Journal of the Korean Society of Safety
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• v.14 no.4
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• pp.158-167
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• 1999

In parallel flow condition, to estimate the stability of the extended embankment constructed on a permeable foundation ground, a laboratory model test was performed due to extended materials and water level increasing velocity of a flood period. A laboratory model test was peformed for different permeability coefficients ($K_1=2.0{\times}10^{-5}cm/sec,\;K_2=1.5{\times}10^{-4}cm/sec,\;K_3=2.3{\times}10^{-3}cm/sec$) using seepage. The fluctuation of water level occurring to an extended embankment was analyzed by laboratory model tests as vary the increasing velocity of water level with 0.6cm/min, 1.2cm/min, 2.4cm/min respectively. In analysis results, the increase of water level into embankment occurs rapidly because seepage water moving along with a permeable soil flow into embankment. The larger the permeability coefficient of an extended part is the longer initial seepage distance, and the exit point of downstream slope is gradually increased and then shows unstable seepage behavior as occurring partial collapse. As the increasing velocity of water level increase, the initial seepage line is formed low, and the discharge increases. Therefore, the embankment extended by a lower permeable soil than existing embankment shows stable seepage behavior because an existing embankment plays a role as filter for an extended part.

• Journal of Korea Water Resources Association
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• v.53 no.10
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• pp.861-870
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• 2020

As the flow velocity and Reynolds number increase in rockfill porous media, the flow deviates from Darcy conditions. In this study, the permeability tests of rock column specimen and laboratory gabion weir model were carried out to investigate a head loss behaviour of flow through rockfill deposition in small river artificial recharge. Through column test, the nonlinear relationships between flow velocity and hydraulic gradient and coefficients were determined and the correlation formula of hydraulic mean radius and coefficients was proposed. The flow velocities and discharges in voids estimated by proposed equations were well matched with the measured values of laboratory gabion weir model.

• Transactions of the Korean Society of Automotive Engineers
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• v.15 no.1
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• pp.78-88
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• 2007

In the present study a detailed examination of various porous media models for predicting filtration efficiency and pressure drop of diesel particulate filter (DPF), such as sphere-in-cell and constricted tube models, are attempted. In order for demonstrating their validities of correct estimation on permeability, geometry of property configurations common in commercial cordierite DPFs are correlated to the porous media flow models, and validations of predicted filtration efficiencies due to the use of different unit collectors are made with experiments. The result shows that the porosity, pore size and permeability of cordierite DPF can be successfully correlated by Kuwabara flow field with correction factor of 0.6. The unit collector efficiency predicted by sphere-in-cell model agrees very well with measurements in accumulation mode, whereas that by constricted tube model with significant prediction error.

• Geomechanics and Engineering
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• v.30 no.2
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• pp.153-167
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• 2022

This study proposes a method to analyze the distribution of coal porosity disturbances after the excavation of ultra-large-diameter water jet boreholes using a coal wetting and softening model. The high-pressure jet is regarded as a short-term high-pressure water injection process. The water injection range is the coal softening range. The time when the reference point of the borehole wall is shocked by the high-pressure water column is equivalent to the time of high-pressure water injection of the coal wall. The influence of roadway excavation with support and borehole diameter on the ultra-large-diameter jet drilling excavation is also studied. The coal core around the borehole is used to measure the gas permeability for determining the porosity disturbance distribution of the coal in the sampling plane to verify the correctness of the simulation results. Results show that the excavation borehole is beneficial to the expansion of the roadway excavation disturbance, and the expansion distance of the roadway excavation disturbance has a quadratic relationship with the borehole diameter. Wetting and softening of the coal around the borehole wall will promote the uniform distribution of the overall porosity disturbance and reduce the amplitude of disturbance fluctuations.

• 한국연소학회:학술대회논문집
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• 2006.10a
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• pp.36-41
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• 2006

A simplified model of plastic layer and internal gas pressure In a coke oven is presented. We calculate internal gas pressure using presented model. And results are compared with calculated results using experimental data. Results show the difference of internal gas pressure by coal composition. The model is used to show that the permeability at the resolidification end of the plastic layer is a key determinant of the magnitude of the internal gas pressure.

• Proceedings of the Membrane Society of Korea Conference
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• 1993.10a
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• pp.13-20
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• 1993

The sorption equilibria and permeation rates for carbon dioxide in such glassy polymer membranes with high glass-transition temperature as polyimide, polyetherimide, polysulfone and polyethersulfone membranes, were measured. The sorption isotherms for these systems can be described well by the dual-mode sorption model, whereas the pressure dependences of the mean permeability coefficients are simulated better by a modified dual-mode mobility model than the conventional dual-mode mobility model in which the Henry's law and Langmuir populations execute four kinds of diffusive movement.