• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.13 no.3
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• pp.56-63
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• 1999

In power system, substation facilities have become too complex and large according to extended power system. Also, some facilities becorre old and often break down unexpectedly. In order to improve the sectrity of transformer out of substation facilities, the development of diagnosis technique to transformer is very needed. In this paper, we developed a method to be analysis the origin and degree of aging by KSOM based on the dissolved gases in power transfonrer. KSOM can do topological mapping for the multi-dimensional pattern based on the dissolved gases to two dimensional plane. And potential possibility and degree of aging for nonna1 transfonrer are presented using the proposed quantitative criterion. Furtherrrore, the aging process of transfonrer is analyzed based on the proposed criterion to special transfonrer. To demonstrate the validity of peoposed method, case study is performed and its results are presented.sented.

• The Journal of Engineering Geology
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• v.2 no.2
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• pp.155-165
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• 1992

The purpose of this study is to evaluate compatability of seismic source characteristics of the Kern County earthquake to those of Korean Peninsula seismotectonics. The compatability could be used to make Korean type response spectrum from the strong ground motions observed from the assingned earthquake. The July 21, 1952, Kern County, California, earthquake is the largest earthquake to occur in the western U.S. since 1906, and the repeat of this event poses a significant seismic hazard. The Kern County event was a complex thrusting event, with a surface rupture pattern that varied from pure leftlateral strike-slip to pure dip-slip. A time dependent moment tensor inversion was applied to ten observed teleseismic long-period body waves to investigate the source complexity. Since a conventional moment tensor inversion(constant geometry through time) returns a non-double-couple source when the seismic source changes(fault orientation and direction of slip) with time, we are required to use the time dependent moment tensor which allows a first-order mapping of the geometric and temporal complexity. From the moment tensor inversion, a two-point seismic source model with significant overlap for the White Wolf fault, which propagates upward(20 km to 5 km) from SW to NE, fits most of the observed seismic waveforms in the least squares sense. Comparison of P, T and B axes of focal mechanisms and focal depths suggests that seismic source characteristics of the Kern County earthquake is consistant with those of Korean Peninsula Seismotectonics.

• Korean Journal of Remote Sensing
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• v.27 no.6
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• pp.637-651
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• 2011

This study presents a rule-based urban image classification method for time series analysis of changes in the vicinity of Asan-si and Cheonan-si in Chungcheongnam-do, using Landsat satellite images (1991-2006). The area has been highly developed through the relocation of industrial facilities, land development, construction of a high-speed railroad, and an extension of the subway. To determine the yearly changing pattern of the urban area, eleven classes were made depending on the trend of development. An algorithm was generalized for the rules to be applied as an unsupervised classification, without the need of training area. The analysis results show that the urban zone of the research area has increased by about 1.53 times, and each correlation graph confirmed the distribution of the Built Up Index (BUI) values for each class. To evaluate the rule-based classification, coverage and accuracy were assessed. When Optimal allowable factor=0.36, the coverage of the rule was 98.4%, and for the test using ground data from 1991 to 2006, overall accuracy was 99.49%. It was confirmed that the method suggested to determine the maximum allowable factor correlates to the accuracy test results using ground data. Among the multiple images, available data was used as best as possible and classification accuracy could be improved since optimal classification to suit objectives was possible. The rule-based urban image classification method is expected to be applied to time series image analyses such as thematic mapping for urban development, urban development, and monitoring of environmental changes.

• Korean Journal of Remote Sensing
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• v.36 no.5_4
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• pp.1221-1229
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• 2020

In urgent situations such as disasters and accidents, rapid data acquisition and processing is required. Therefore, in this study, a rapid geocoding method according to EOP (Exterior Orientation Parameter) correction was proposed through pattern analysis of the initial UAV image information. As a result, in the research area with a total flight length of 1.3 km and a width of 0.102 ㎢, the generation time of geocoding images took about 5 to 10 seconds per image, showing a position error of about 8.51 m. It is believed that the use of the rapid geocoding method proposed in this study will help provide basic data for on-site monitoring and decision-making in emergency situations such as disasters and accidents.

• International Journal of Industrial Entomology and Biomaterials
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• v.18 no.2
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• pp.113-120
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• 2009

Embryonic lethal abnormal visual (elav) is a lethal gene in Drosophila inducing the abnormal development and function of nervous system. We cloned a Bm-elav gene by bioinformatics and biological experiment, based on sequence of ELAV protein and dbEST of Bombyx mori. The full-length of Bm-elav cDNA is 1498 bp, contains a 906 bp open read frame (ORF) encoding a precursor of 301 amino acid residues with a calculated molecular weight of 34 kDa and pI of 8.99. Bm-ELAV protein precursor contains three RNA recognition motifs (RRM) in $24{\sim}91$, $110{\sim}177$ and $222{\sim}295$ bit amino acid residues respectively, and belongs to RNA-binding protein family. Bm-ELAV shared varying positives, ranging from 56% to 60% (Identities from 41% to 45%), with RRM from other species of Xenopus tropicalis, Apis mellifera, Tribolium castaneum, Branchiostoma belcheri and Drosophila. Gene localization indicated that Bm-elav is a single-copy gene, gene mapping within 12-chromosome from 7916.68 knt to 7918.16 knt region of nscaf2993. Spatiotemporal expressions pattern analysis revealed that Bm-elav expressed higher in most tested tissues and developmental stages in whole generation, such as silk gland, fat body, midgut, hemopoietic organ and ovary, but almost no expression in terminated diapause eggs. This suggested that the expression of Bm-elav in early developmental embryonic stages might induce abnormal development like in Drosophila. Cloning of the Bm-elav gene enables us to test its potential role in controlling pests by transferring the gene into field lepidopteran insects in the future.

• Science of Emotion and Sensibility
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• v.15 no.4
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• pp.585-592
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• 2012

Food is crucial for the nutrition and survival of humans. Taste system is one of the fundamental senses. Taste cells detect and respond to five basic taste modalities (sweet, bitter, salty, sour, and umami). However, the cortical processing of taste sensation is much less understood. Recently, there were many efforts to observe the brain activation in response to taste stimulation using functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and optical imaging. These different techniques do not provide directly comparable data each other, but the complementary investigations with those techniques allowed the description and understanding of the sequence of events with the dynamics of the spatiotemporal pattern of activation in the brain in response to taste stimulation. The purpose of this study is the understanding of the brain activities to taste stimuli in sensory and affective aspects and the reviewing of the recent research of the gustotopic map by functional brain mapping.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.9
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• pp.1237-1241
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• 2005

Mannose-P-dolichol utilization defect 1 (MPDU1) gene is required for utilization of the mannose donor MPD in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols (GPI) which are important for functions such as protein folding and membrane anchoring. The full length cDNA of the porcine MPDU1 was determined by in silico cloning and rapid amplification of cDNA ends (RACE). The deduced amino acid showed 91% identity to the corresponding human sequence with five predicted transmembrane regions. RT-PCR was performed to detect its expression pattern in five tissues and results showed that it is expressed ubiquitously among the tissues checked. A single nucleotide substitution resulting in the amino acid change (137 Tyr-137 His) was detected within exon 5. Allele frequencies in six pig breeds showed distinctive differences between those Chinese indigenous pigs breeds and European pigs. Using the pig/rodent somatic cell hybrid panel (SCHP), we mapped the porcine MPDU1 gene to SSC12, which is consistent with the comparative mapping result as conservative syntenic groups presented between human chromosome 17 and pig chromosome 12.

• Journal of Korean Society of Transportation
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• v.26 no.5
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• pp.7-16
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• 2008

There are unique aspects of truck vehicle movements compared with the personal travel in trip chaining. This paper reports an analysis on the truck vehicle trip chaining which intercity/metropolitan/intraregional trips are classified. Data collected from the travel dairy survey is used the truck trip-chaining analysis. The pattern of trip chaining classes is classified by the GIS mapping based on orgin-destination trip information. The physical index and efficiency index for each trip diary is used to the truck vehicle activity. Truck trips lengths and time differs from its truck type, service type and travel patterns. It is shown that the efficiency of the truck trip chaining depends on vehicle types and its delivery patterns. There are many other topics for research on trip chaining modeling such as the classification of trip chain, time use and mode choice by trip chaining.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2003.10a
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• pp.271-277
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• 2003

Recently as the environmental noise getting influential social problem, it is the fact that the demand on noise reduction increases with the advance of the standard of living. Therefore increasing the interest on the noise in common, it is eagerly demanded that the endeavour for reducing the noise of the rotating machinery, especially the machinery related a flowing including the household electric products, which is pointed out the primary noise source in environment. As proceeding study for fan noise, theory of fan noise property is arranged and this control method is shown. Blade passage noise of total noise spectrum. Thus in the aspect of noise reduction, noise source and identification of noise radiation characteristics of axial flow fan are demanded in detail. The sound source is analyzed by using sound pressure and sound intensity. In that time, synchronization of axial flow fan using optical sensor is executed, and to identify the location of exact noise source in the fan profile determination of recording time is proposed. In the rotating of tan, it is explained that the location of noise source exists in and by the directivity, the noise radiation pattern of axial flow fan is determined and the flow of sound is visualized in the figure of contour mapping.