• 응용통계연구
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• 제24권3호
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• pp.495-503
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• 2011

When a patent of an innovative (brand-name) small-molecule drug expires, generic copies of the innovative drug may be marketed if their therapeutic equivalence to the innovative drug has been shown. The small-molecule drugs are considered therapeutically equivalent and can be used interchangeably if two drugs are shown to be pharmaceutically equivalent with identical active substance and bioequivalent with comparable pharmacokinetics in a crossover clinical trial. However, the therapeutic equivalence paradigm cannot be applied to biosimilars since the active ingredients of biosimilars are huge molecules with complex and heterogeneous structures, and these molecules are difficult to replicate in every detail. The European Medicine Agency(EMEA) has introduced a regulatory biosimilar pathway which mandates clinical trials to show therapeutic equivalence. In this paper, we discuss statistical considerations in the design and analysis of biosimilar cancer clinical trials.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1994년도 Proceedings of the Korea Automatic Control Conference, 9th (KACC) ; Taejeon, Korea; 17-20 Oct. 1994
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• pp.100-105
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• 1994

In this paper, we discuss a method for design of an ambulance stretcher which call decrease blood pressure fluctuation caused by ambulance acceleration. Recently, a lot of stretchers which can isolate the vertical vibration to reduce body resonances (4-10 Hz) have been used during ambulance transport. However, we have found that blood pressure of a patient laying in the stretcher fluctuates when the ambulance accelerates or decelerates. Since the enforced change of the blood pressure may deteriorate the patent's condition, a stretcher to cancel head-to-foot acceleration and to decrease the blood pressure variation (BPV) is expected for safe transport. We propose a method to design a stretcher which is tilted according to an adequate angle to cancel head-to-foot acceleration by gravity when the ambulance accelerates or decelerates. A control method of the stretcher is constructed by means of simulation analysis using acceleration data measured during ambulance transport. It is confirmed that the active controlled stretcher proposed has good performance for the BPV reduction.

• 한국컴퓨터정보학회논문지
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• 제21권1호
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• pp.125-129
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• 2016

In this paper, we propose an efficient dynamic workload balancing strategy which improves the performance of high-performance computing system. The key idea of this dynamic workload balancing strategy is to minimize execution time of each job and to maximize the system throughput by effectively using system resource such as CPU, memory. Also, this strategy dynamically allocates job by considering demanded memory size of executing job and workload status of each node. If an overload node occurs due to allocated job, the proposed scheme migrates job, executing in overload nodes, to another free nodes and reduces the waiting time and execution time of job by balancing workload of each node. Through simulation, we show that the proposed dynamic workload balancing strategy based on CPU, memory improves the performance of high-performance computing system compared to previous strategies.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2007년도 정기 학술대회 논문집
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• pp.57-61
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• 2007

Changes of construction industry entails needs of new construction technologies. In order to address the needs and new challenges, innovative interdisciplinary research programs are considered to be a good solution. To identify such research programs, technology-push and market needs investigations are conducted. Through analysis of international journals and patent maps, technology fusion-based research program are developed. This paper suggest the strategy for technology fusion-based construction process innovation.

• 한국컴퓨터정보학회논문지
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• 제23권12호
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• pp.179-184
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• 2018

In this paper, we have proposed the development of DC-DC converter for LRT power supply. First of all, we have studied converter technology, main functions and characteristics were determined. In also, the converter design was carried out to meet the system design conditions. Based on this design, converter simulation is performed to enable stable charging and discharging of the vehicle system. We have performed the Light-load test according to charge mode, discharge mode. As a result, the manufactured converter performance was verified through the load test, and it's stability was confirmed.

• 한국경제지리학회지
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• 제19권1호
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• pp.1-17
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• 2016

본 논문은 내국인 특허출원 자료에서 복수 발명자들의 주소지들을 파악하고 가산자료의 특성을 통제할 수 있는 영과잉 음이항 회귀모형을 사용하여 230개 시군구 간 발명자 네트워크의 공간구조와 그것의 결정요인을 분석한다. 발명자 네트워크의 공간적 연계에 영향을 미치는 몇 가지 요인들이 확인된다. 이출지역이 민간 R&D, 고등교육수준, 인구규모, 특허 생산성 등과 같은 R&D 관련 지역 특수적 자산들을 많이 보유하면 동태적인 수요효과를 통해 공간적 연계는 다른 지역으로 확대된다. 그리고 물리적 거리뿐만 아니라 기술적 거리에서도 거리조락현상이 나타난다. 이입지역이 R&D 관련 지역 특수적 자산을 많이 보유하면 유사한 논리로 공간적 연계에서 정(+)의 효과가 발생한다.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2009년도 춘계학술발표논문집
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• pp.319-324
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• 2009

Lately, knowledge-based society comes, it is important for enterprises to creatively utilize knowledge of technology for technological innovation. So, Technological innovation capacity of enterprises is important factor of business success. To improve technological innovation capacity, enterprises should well utilize their internal knowledges and external knowledges which come from technological diffusion. To well utilize external knowledges of enterprises they should well understand external knowledge flow. Especially knowledge flow also occurs frequently between nations, understanding of knowledge flow which occurs between nations is important to improve nation`s technological innovation capacity. So this paper presents comparison of technological innovation capacity and knowledge diffusion flow between nations.

• International Journal of Fluid Machinery and Systems
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• 제3권1호
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• pp.20-28
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• 2010

This paper deals with the Design and Analysis of a Controlled Diffusion Aerofoil (CDA) Blade Section for an Axial Compressor Stator and Effect of incidence angle and Mach No. on Performance of CDA. CD blade section has been designed at Axial Flow Compressor Research Lab, Propulsion Division of National Aerospace Laboratories (NAL), Bangalore, as per geometric procedure specified in the U.S. patent (4). The CFD analysis has been performed by a 2-D Euler code (Denton's code), which gives surface Mach No. distribution on the profiles. Boundary layer computations were performed by a 2-D boundary layer code (NALSOF0801) available in the SOFFTS library of NAL. The effect of variation of Mach no. was performed using fluent. The surface Mach no. distribution on the CD profile clearly indicates lower peak Mach no. than MCA profile. Further, boundary layer parameters on CD aerofoil at respective incidences have lower values than corresponding MCA blade profile. Total pressure loss on CD aerofoil for the same incidence range is lower than MCA blade profile.

• 한국경제지리학회지
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• 제10권4호
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• pp.394-413
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• 2007

본 연구는 여러 유형의 공간적 개념과 상호작용을 함의하는 다양한 공간가중행렬을 사용하는 공간계량모형을 통해 시군구 단위에서 혁신활동의 특정한 공간적 패턴을 야기하는 결정요인들을 분석하였다. 이러한 분석을 통해 혁신활동의 공간적 외부효과의 결정요인이 파악될 수 있으며, 이는 지식 확산효과의 공간적 상호작용과 공간 구조에 대한 이해를 심화시킬 수 있다.

• 한국멀티미디어학회논문지
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• 제11권5호
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• pp.567-578
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• 2008

인터넷에 있는 방대한 양의 웹 페이지들을 분석하기 위해서는 웹 페이지에 내재된 정보를 추출하는 것이 필요하다. 본 논문에서는 웹 페이지로부터 정보를 추출하고 이를 XML 문서로 변환하여 다차원적으로 분석하는 방법을 제안한다. 웹 페이지로부터 정보를 추출하기 위하여 두 종류의 언어를 제안한다. 하나는 객체지향 모델에 의거하여 웹 정보 추출 규칙을 기술하기 위한 것이고, 다른 하나는 추출하고자 하는 정보를 찾기 위한 HTML 태그 패턴을 정규식으로 기술하기 위한 것이다. XML 문서에 대한 다차원 분석을 위하여 관계형 데이터에 대해 하는 것처럼 웨어하우스를 구축하고 이로부터 다양한 큐브를 생성하는 방법을 제안한다. 마지막으로 본 논문에서 제안한 방법을 미국특허 웹 페이지에 적용한 예를 통해 그 타당성을 보인다.