• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권4호
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• pp.388-396
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• 2020

Purpose: Impaired intestinal mucosal integrity may affect the gastrointestinal function, especially in relation to nutrition, absorption, and barrier function. The purpose of this study was to measure the prevalence of impaired intestinal mucosal integrity in presumed healthy children aged 1-3 years and assess the effects of zinc, glutamine, fiber, and prebiotic supplementation in them. Methods: A cross-sectional study was conducted in 200 children aged 1-3 years in Pasar Minggu, South Jakarta, Indonesia. A randomized double-blind parallel group method clinical trial was then performed to assess the effects of zinc, glutamine, fiber, and prebiotic supplementation. Results: Elevated calprotectin was found in 91/200 subjects (45.5%) at the onset of the study. After 10 months, 144 subjects completed the study: 72 subjects received the trial formula, whereas the other 72 received the standard formula. A transitory decrease in fecal calprotectin (FC) was observed after 6 months in the subgroup with normal FC levels, who were fed the test formula (p=0.012). Conclusion: The prevalence of impaired intestinal mucosal integrity in this group of Indonesian children aged 1-3 years was high. Supplementation with zinc, glutamine, fiber, and prebiotics during 6 months reduced FC only in those who had low levels at baseline but not in those with impaired integrity.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2005년도 전력전자학술대회 논문집
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• pp.774-777
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• 2005

In this paper, a constant frequency phase shifting PWM controlled voltage source full bridge-type series load resonant high-frequency inverter using the IGBT power modules is presented for innovative consumer electromagnetic induction heating applications such as a hot water producer, steamer and super heated steamer. The full bridge arm side link passive quasi-resonant capacitor snubbers in parallel with the each power semiconductor device and high frequency AC load side linked active edge inductive snubber-assisted series load resonant tank soft switching inverter with a constant frequency phase shifted PWM control scheme is discussed and evaluated on the basis of the simulation and experimental results. It is proved from a practical point of view that the series load resonant and edge resonant hybrid high-frequency soft switching PWM inverter topology, what is called class DE type. including the variable-power variable-frequency(VPVF) regulation function can expand zero voltage soft switching commutation range even under low output power setting ranges, which is more suitable and acceptable for induction heated dual packs fluid heater developed newly for consumer power utilizations. Furthermore, even in the lower output power regulation mode of this high-frequency load resonant tank high frequency inverter circuit it is verified that this inverter can achieve ZVS with the aid of the single auxiliary inductor snubber.

• Structural Monitoring and Maintenance
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• 제6권4호
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• pp.317-346
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• 2019

Performance assessment of pavements proves useful, in terms of handling the ride quality, controlling the travel time of vehicles and adequate maintenance of pavements. Roughness profiles provide a good measure of the deteriorating condition of the pavement. For the accurate estimates of pavement roughness from dynamic vehicle responses, vehicle parameters should be known accurately. Information on vehicle parameters is uncertain, due to the wear and tear over time. Hence, condition monitoring of pavement requires the identification of pavement roughness along with vehicle parameters. The present study proposes a scheme which estimates the roughness profile of the pavement with the use of accurate estimates of vehicle parameters computed in parallel. Pavement model used in this study is a two-layer Euler-Bernoulli beam resting on a nonlinear Pasternak foundation. The asphalt topping of the pavement in the top layer is modeled as viscoelastic, and the base course bottom layer is modeled as elastic. The viscoelastic response of the top layer is modeled with the help of the Burgers model. The vehicle model considered in this study is a half car model, fitted with accelerometers at specified points. The identification of the coupled system of vehicle-pavement interaction employs a coupled scheme of an unbiased minimum variance estimator and an optimization scheme. The partitioning of observed noisy quantities to be used in the two schemes is investigated in detail before the analysis. The unbiased minimum variance estimator (MVE) make use of a linear state-space formulation including roughness, to overcome the linearization difficulties as in conventional nonlinear filters. MVE gives estimates for the unknown input and fed into the optimization scheme to yield estimates of vehicle parameters. The issue of ill-posedness of the problem is dealt with by introducing a regularization equivalent term in the objective function, specifically where a large number of parameters are to be estimated. Effect of different objective functions is also studied. The outcome of this research is an overall measure of pavement condition.

• Journal of Electrical Engineering and Technology
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• 제2권1호
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• pp.89-97
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• 2007

This paper presents a new circuit topology of active edge resonant snubbers assisted half-bridge soft switching PWM inverter type DC-DC high power converter for DC bus feeding power plants. The proposed DC-DC power converter is composed of a typical voltage source-fed half-bridge high frequency PWM inverter with a high frequency planar transformer link in addition to input DC busline side power semiconductor switching devices for PWM control scheme and parallel capacitive lossless snubbers. The operating principle of the new DC-DC converter treated here is described by using switching mode equivalent circuits, together with its unique features. All the active power switches in the half-bridge arms and input DC buslines can achieve ZCS turn-on and ZVS turn-off commutation transitions. The total turn-off switching losses of the power switches can be significantly reduced. As a result, a high switching frequency IGBTs can be actually selected in the frequency range of 60 kHz under the principle of soft switching. The performance evaluations of the experimental setup are illustrated practically. The effectiveness of this new converter topology is proved for such low voltage and large current DC-DC power supplies as DC bus feeding from a practical point of view.

• Journal of Nutrition and Health
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• 제56권1호
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• pp.1-11
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• 2023

Purpose: Obesity is associated with alterations in vitamin D metabolism and elevation of parathyroid hormone (PTH). Increased PTH level in obesity is likely one of the factors contributing to the dysregulation of vitamin D metabolism. We investigated the effects of lowering the PTH level in high-fat diet-induced obese mice on vitamin D metabolism. Methods: Five-week-old male C57BL/6N mice were fed either with control (10% energy as fat) or high-fat (60% energy as fat) diets ad libitum for 12 weeks, and vehicle or cinacalcet HCl (30 ㎍/g body weight) was gavaged daily during the final week of the experiment. The following groups were studied: CON (control diet + vehicle), HFD (high-fat diet + vehicle), and HFD-CIN (high-fat diet + cinacalcet HCl). PTH, 1,25-dihydroxyvitamin D (1,25[OH]₂D), 25-hydroxyvitamin D (25[OH]D), calcium, and phosphate levels in circulation, and the expression of genes related to vitamin D metabolism in the liver and kidneys were determined. Results: Renal 1α-hydroxylase expression in the HFD group was higher than that in the CON group despite the lack of a difference in the PTH levels between the 2 groups. The plasma PTH level in the HFD-CIN group was 60% lower than that in the HFD group (p < 0.05). In parallel, the HFD-CIN group had lower adipose tissue amount (9% lower), renal 1α-hydroxylase expression (48% lower), and plasma 1,25(OH)₂D concentration (38% lower) than the HFD group. Conclusion: Lowering the PTH levels in high-fat diet-induced obese mice recovered the expression of renal 1α-hydroxylase and might be associated with lower amounts of white adipose tissue.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권3호
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• pp.958-979
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• 2023

Due to laws, regulations, privacy, etc., between 70-90 percent of providers do not share medical data, forming a "data island". It is essential to collaborate across multiple institutions without sharing patient data. Most existing methods adopt distributed learning and centralized federal architecture to solve this problem, but there are problems of resource heterogeneity and data heterogeneity in the practical application process. This paper proposes a collaborative deep learning modelling method based on the blockchain network. The training process uses encryption parameters to replace the original remote source data transmission to protect privacy. Hyperledger Fabric blockchain is adopted to realize that the parties are not restricted by the third-party authoritative verification end. To a certain extent, the distrust and single point of failure caused by the centralized system are avoided. The aggregation algorithm uses the FedProx algorithm to solve the problem of device heterogeneity and data heterogeneity. The experiments show that the maximum improvement of segmentation accuracy in the collaborative training mode proposed in this paper is 11.179% compared to local training. In the sequential training mode, the average accuracy improvement is greater than 7%. In the parallel training mode, the average accuracy improvement is greater than 8%. The experimental results show that the model proposed in this paper can solve the current problem of centralized modelling of multicenter data. In particular, it provides ideas to solve privacy protection and break "data silos", and protects all data.

• Journal of Nutrition and Health
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• 제49권2호
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• pp.63-71
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• 2016

본 연구에서는 자외선 조사와 함께 녹차 추출물 식이를 10주간 공급한 무모생쥐 (GTE군)의 표피 pH 관련 인자의 함량과 LDH 효소의 단백질 발현 및 활성 변화를 자외선 비조사군 (UV-군) 및 자외선 조사군 (UV+군)과 비교 분석하였으며 결과는 다음과 같다. UV+군의 피부 pH는 UV-군보다 유의적으로 증가한 반면 GTE군의 피부 pH는 UV+군에 비해 감소하였으며 그 감소 정도는 UV-군과 유사하였다. UV+군의 젖산 함량은 UV-군에 비해 현저히 감소한 반면 GTE군의 젖산 함량은 UV+군에 비해 증가하였다. UV+군과 UV-군의 총 유리아미노산 함량은 군간 유사하였으나 GTE군의 총 유리아미노산 함량은 UV-군에 비해 현저히 증가하였다. UV+군 및 GTE군의 총 유리지방산 함량은 군간 차이 없이 모두 UV-군에 비해 감소하였으며, GTE군에서 주요 유리지방산인 PA, OA 및 LA의 개별 함량은 모두 UV-군과 유사하거나 감소하였다. UV+군의 LDH 단백질 발현 및 활성은 UV-군에 비해 유의적으로 감소한 반면, GTE군의 LDH 단백질 발현 및 활성은 모두 UV+군보다 증가하였으며 특히 LDH 활성의 증가 정도는 UV-군과 유사하였다. 결론적으로 자외선 조사와 병행된 녹차 추출물 식이 공급은 LDH 발현 및 활성 증가와 함께 젖산 과 총 유리아미노산 함량을 증가시켰으며 궁극적으로 자외선 조사에 의해 증가된 피부 pH를 정상화시켰다.

• Journal of Nutrition and Health
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• 제46권2호
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• pp.109-118
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• 2013

본 연구에서는 자외선 조사에 의한 피부 광노화 유도와 함께 산지 별 국내산 및 중국산 로얄제리 식이를 6주간 공급한 무모 생쥐 표피의 필라그린과 유리 아미노산 함량 및 관련 대사 효소의 발현 변화를 정상대조군인 UV - 군 및 자외선 조사군인 UV + 군과 비교 분석하였고 그 결과는 다음과 같다. 1) UV + 군의 필라그린과 중간 생성물 및 profilaggrin을 포함한 총 필라그린 함량은 UV - 군에 비하여 유의적으로 감소하였다. RJ1군의 총 필라그린 함량이 UV + 군에 비하여 유의적으로 높게 나타났고 RJ2, RJ3 및 RJ4군에서는 UV + 군과 유사하거나 낮았다. 2) PAD3 발현은 UV + 군의 발현이 UV - 군에 비하여 유의적으로 감소하였고 로얄제리 공급군의 PAD3 발현은 모두 UV + 군에 비하여 유의적으로 높았다. 다만 각 로얄제리를 섭취시킨 군 사이에서 군간 유의성은 없었다. 3) 총 유리 아미노산 함량은 군간 유의적인 차이는 보이지 않았다. 그러나 개별 유리 아미노산 함량 변화를 분석한 결과, UV + 군에서 glutamate와 serine의 함량이 UV - 군에 비해 낮은 경향을 보였다. 반면 RJ1군의 glutamate와 serine의 함량은 UV + 군에 비해 유의적으로 높았으며 RJ2와 RJ3군은 serine의 함량이 UV + 군에 비해 다소 높았다. 결론적으로 RJ1의 식이는 표피의 필라그린 함량과 관련 대사 효소의 발현을 높이고 그에 따라 표피에서 천연보습인자로서 보습 증진에 크게 기여하는 glutamate와 serine의 함량을 증가시킴으로써 자외선 조사로 인해 저하된 피부 보습 능력을 회복시키는 역할을 하는 것으로 여겨진다.

• Asian-Australasian Journal of Animal Sciences
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• 제33권5호
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• pp.788-801
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• 2020

Objective: This study was conducted to evaluate the effects of diets containing different wet rice distillers' by-product (RDP) levels on growth performance, nutrient digestibility, blood profiles and gut microbiome of weaned piglets. Methods: A total of 48 weaned castrated male crossbred pigs, initial body weight 7.54±0.97 kg, and age about 4 wks, were used in this experiment. The piglets were randomly allocated into three iso-nitrogenous diet groups that were fed either a control diet, a diet with 15% RDP, or a diet with 30% RDP for a total of 35 days. Chromium oxide was used for apparent digestibility measurements. On d 14 and d 35, half of the piglets were randomly selected for hemato-biochemical and gut microbiota evaluations. Results: Increasing inclusion levels of RDP tended to linearly increase (p≤0.07) average daily gain on d 14 and d 35, and decreased (p = 0.08) feed conversion ratio on d 35. Empty stomach weight increased (p = 0.03) on d 35 while digestibility of diet components decreased. Serum globulin concentration decreased on d 14 (p = 0.003) and red blood cell count tended to decrease (p = 0.06) on d 35, parallel to increase RDP levels. Gene amplicon profiling of 16S rRNA revealed that the colonic microbiota composition of weaned pigs changed by inclusion of RDP over the period. On d 14, decreased proportions of Lachnospiraceae_ge, Ruminococcaceae_ge, Ruminococcaceae_UCG-005, and Bacteroidales_ge, and increased proportions of Prevotellaceae_ge, Prevotella_2, and Prevotella_9 were found with inclusion of RDP, whereas opposite effect was found on d 35. Additionally, the proportion of Lachnospiraceae_ge, Ruminococcaceae_ge, Ruminococcaceae_UCG-005, and Bacteroidales_ge in RDP diets decreased over periods in control diet but increased largely in diet with 30% RDP. Conclusion: These results indicate that RDP in a favorable way modulate gastrointestinal microbiota composition and improve piglet performance despite a negative impact on digestibility of lipids and gross energy.

• 대한전자공학회논문지SD
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• 제47권11호
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• pp.6-12
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• 2010

본 논문에서는 시그마-델타 변조기에 기반 한 D급 오디오 증폭기를 제안한다. 16-비트 병렬의 디지털 입력신호는 4-차 디지털 시그마-델타 변조기에 의해 2-비트의 신호로 직렬화되고, 이 신호는 4-차 아날로그 시그마-델타 변조기로 인가된다. 아날로그 시그마 델타 변조기의 출력단의 파워 스위치는 3-레벨로 동작하며, 3-레벨의 펄스 밀도 변조(PDM) 출력 신호는 LC-필터를 통해 저역 통과되어 스피커에 전달된다. 아날로그 시그마-델타 변조기의 첫 단의 적분기는 디지털 시그마-델타 변조기의 출력으로부터 샘플된 이산 시간 영역의 신호를 입력으로 받아들이고, 동시에 파워 스위칭 단의 연속 시간 영역의 출력 신호를 부궤환(feedback) 받기 위해 스위치드-캐패시터 적분기와 연속시간 영역의 적분기를 혼합된 형태로 구현되었다. 제안된 클래스-D 오디오증폭기는 CMOS 0.13-um 공정을 이용해 제작되었으며 100-Hz 부터 20-kHz의 신호 주파수 영역에서 동작한다. 제작된 D급 오디오 증폭기는 4-${\Omega}$ 부하 저항에서 최대 18.3-mW을 내고 0.035-%의 전고조파 왜율(total harmonic distortion pluse noise : THD+N) 성분과 80-dB의 입력신호 대역폭(dynamic range)을 갖는다. 아날로그 및 디지털 변조기는 1.2-V 전원 전압으로 동작하며 총 457-uW의 전력을 소모한다.