• 대한간호학회지
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• 제28권1호
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• pp.70-80
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• 1998

This study is designed to contribute to the nursing intervention of adolescent domestic violence victims by describing specifically what they go through and on this basis work out a grounded theory on the adolescent's experience in domestic violence. The data were analyzed in the framework of grounded theory as mapped out by Strauss & Corbin(1990). The major findings of this research are as follows : The core category was found to be the the adaptation of "Joyudeum" or “Straight jacketing”. The sub-categories identified in the process of grounded data analysis were 'menacing', 'being harassed', 'being pressed', 'being attacked', 'being strapped', 'being filled with anger'. 'getting angry', 'being oppressed', 'being strained', 'becoming hard', 'endurance', 'regulation', 'seriousness'. 'repitition'. 'being helpful', 'dependence', 'thinking oriented', 'blowing off', 'going astray', 'self-deprecating', 'shaking off', 'covering up', 'governing', 'being devoted', 'performing', 'being transformed'. 'bolting', 'being shaken', 'withdrawing', 'disliking', 'bitterness'. These categories were again grouped into 13 categories including 'threatening'. 'straight jacketing', 'tolerance', 'violence', 'supporter', 'supporting type', 'thinking oriented'. 'impulsive response', 'self-controlled', 'response', 'self-reliance', 'wandering', 'withdrawal' and pain'. Of these the five sub-categories 'being filled with anger'. 'getting angry', 'being oppressed', 'being strained', 'becoming hard' were grouped into a core category "straight jacketing". Those adolescents brought up in a violent family go through three stages of the adaptation of "straight Jacketing". that is, generation, response and adaptation. The following four theses were confirmed on the basis of repetitive relations : 1) If a subject's tolerance is strong, the episodes of the violence are frequent and serious, with the resulting straight jacketing being stronger but the subject's supporter is highly mature, the supporting type is concrete and the thinking oriented is wishful, the responses to the straight jacketing result in a self-control whose consequence is self-reliance with part of it resulted in withdrawal and pain. 2) If a subject's tolerance is weak, the episodes of the violence are frequent but not serious, with the resulting straight jacketing being weaker but the subject's supporter is immature, the supporting type is superficial and the thinking oriented is extemporary, the responses to the straight jacketing result in an impulsion whose consequence is wandering with part of it resulted in withdrawal and pain. 3) If a subject's tolerance is weak, the episodes of the violence are frequent and serious, the straight jacketing is strong, the subject's supporter is immature and the supporting type is superficial but the thinking oriented is wishful, the responses to the straight jacketing result in an impulsion whose consequence is withdrawal and pain with part of it resulted in wandering. 4) If a subject's tolerance is strong and the episodes of the violence are infrequent and not serious, the straight jacketing is weak, the subject's supporter is immature and the supporting type is superficial but the thinking oriented is wishful, the responses to the straight jacketing result in a self-control whose consequence is withdrawal and pain with part of it resulted in self-reliance.

• 정신신체의학
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• 제10권1호
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• pp.18-26
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• 2002

연구목적: 본 연구의 목적은 만성요통 환자에서 스트레스지각 및 통증지각과 대응전략 간의 관계를 알아보고자 하는데 있다. 본 연구에는 만성요통 환자 80명과 정상대조군 100명이 참여하였다. 방법: 스트레스인자 및 스트레스반응에 대한 지각은 각각 스트레스인자 지각척도 (Global Assessment of Recent Stress Scale) 및 스트레스반응 척도(Stress Response Inventory)를, 대응전략 및 통증지각은 각각 대응척도(The Way of Coping-revised) 및 통증지각척도(Pain Discomfort Scale)를 이용하여 평가하였다. 결과: 만성요통환자들이 정상대조군보다 일 및 직장, 대인관계, 대인관계의 변화, 질병 및 상해에 관련된 스트레스인자 지각점수, 전체 스트레스인자지각 정수가 각각 유의하게 더 높았다. 스트레스반응점수에서는 피로점수가 정상대조군보다 환자군에서 유의하게 더 높았으나, 통증지각에서는 양군 간에 유의한 차이를 보이지 않았다. 대응전략에서는 환자군이 정상대조군에 비해 계획적 문제해결 및 긍정적 재평가를 더 많이 사용하였다. 환자군에서 통증지각은 전체 스트레스반응 점수, 질병 및 상해에 관련한 스트레스인자지각 점수와 각각 유의한 양상관성을 보였다. 도피 회피 점수는 연령과 유의한 음상관성을, 거리감두기 및 도피-회피 점수는 유의한 양상관성을 보였다. 한편 책임수용은 여자가 남자보다 더 유의하게 많이 사용하였다. 그러나 대응전략과 스트레스인자지각 및 스트레스반응 통증지각 간에는 각각 유의한 상관성을 보이지 않았다. 결론: 이상의 결과들은 만성요통환자들이 정상인에 비해 스트레스인자에 대한 지각이 더 높으나, 더 적극적인 대응을 하고 있음을 시사한다. 또한 환자군에서 사용하는 대응전략은 스트레스인자지각, 스트레스반응, 통증지각과 연관성을 보이지 않는 반면 사회인구학적 특정들과 연광성이 높음을 시사한다.

• The Korean Journal of Pain
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• 제14권1호
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• pp.19-25
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• 2001

Background: Transcutaneous electrical nerve stimulation (TENS) has been used widely, but its effects are controversial. This is probably due to the varying intensity and type of pain. We designed a study to assess the effects of the TENS on the RIII nociceptive flexion reflex as the resting pain level and the temporal summation as a repeated, movement related pain in 7 normal volunteer subjects. Methods: High frequency (80 Hz), non-noxious TENS was applied over the left popliteal fossa for 20 minutes. Ipsilateral RIII reflexes induced by single electrical stimulus and temporal summation of pain responses to repeated stimuli (five stimuli at 2 Hz) were recorded before, during (just before stopping), and subsequently at 20 minutes after TENS. Results: R (III) nociceptive flexion reflex activity during and after TENS was more significantly decreased than before treatment. However, the temporal summation threshold was not changed. Conclusions: We conclude that high frequency, non-noxious TENS could be effective on resting pain relief in the same segment but not on the movement related pain.

• The Korean Journal of Pain
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• 제14권2호
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• pp.142-149
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• 2001

Background: The expression of the proto-oncogene c-fos in spinal cord neurons following various noxious stimuli has been demonstrated in numerous studies. However, the pattern of expression of c-fos after incisional stimulus has not been evaluated. This study was designed to examine c-fos expression in an incisional pain model of rats. Methods: A 1 cm longitudinal incision was made through the skin, fascia and muscle of the plantar aspect of the hindpaw in enflurane-anesthetized rats. Withdrawal responses were measured using von Frey filaments at areas around the wound before surgery and for the next 48 hours. The expression of c-fos protein in the lumbar spinal cord was examined by immunohistochemistry. Results: After incision, c-fos was strongly expressed within laminae I, II, III, IV, V and VI ipsilateral to the incision. C-fos positive neurons were detected in the controlateral site, as well. Conclusions: These studies suggest that spinal c-fos protein may not be used as a specific marker for spinal nociceptive processing in an incisional pain model.

• The Korean Journal of Pain
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• 제28권4호
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• pp.236-243
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• 2015

Background: Chemotherapy-induced peripheral neuropathy is a major side effect of anti-cancer drugs, and our knowledge of its mechanisms is lacking. Several models for chemotherapy-induced neuropathy have been introduced. However, the outcomes of these models differ significantly among laboratories. Our object was to create a model of chemotherapy-induced neuropathy in rats with cancer. Methods: Female Sprague-Dawley rats were used. Mammary rat metastasis tumor (MRMT-1) cells were implanted subcutaneously in rats. Chemotherapy-induced peripheral neuropathy was induced by injection of cisplatin once a day for four days. The responses to mechanical and thermal stimuli were examined using von Frey filaments, acetone, and radiant heat. Results: Cisplatin (2 mg/kg/day) produced mechanical allodynia, while it did not induce cold allodynia or thermal hyperalgesia. This dose of cisplatin could work successfully against cancer. Body weight loss was not observed in cisplatin-treated rats, nor were other abnormal behaviors noted in the same rats. Conclusions: Repeated injection of intraperitoneal cisplatin induced peripheral neuropathic pain in rats. Thus, this type of rat model has broad applicability in studies related to searching for the mechanism of cisplatin-induced mechanical allodynia and agents for the treatment of neuropathic pain.

• 가정∙방문간호학회지
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• 제17권1호
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• pp.55-62
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• 2010

Purpose: This study investigated the sought to identify the pain management knowledge and attitude of nurses in internal medicine and surgery stream wards and intensive care units to obtain basic information needed for improved pain control. Method: Data was collected through self-reported questionnaires and analyzed by descriptive statistics, t-test and ANOVA using SPSS Win 12.0. Results: Pain management knowledge score averaged 51.1 out of 100, with significant differences evident depending on age, marital status, educational level, position, total work career, working department and cancer care-giving experience. Pain management attitude score averaged 2.9 out of 4, and significant differences were evident depending on age, marital status, educational level, position, total work career, working department, cancer care-giving experience, education experience and number of patients treated. Conclusion: Further studies are necessary to develop effective nursing knowledge and attitude education programs and evaluation such as discussion by cases, workshops, system of expert help for uncontrollable pain or a multi-disciplinary pain management task force. In addition, patient satisfaction level with pain management should be assessed and the responses reflected practically.

• The Korean Journal of Pain
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• 제29권3호
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• pp.164-171
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• 2016

Background: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action. Here we investigated the role of the spinal dopaminergic neurotransmission in the antinociceptive effect of nefopam administered intravenously or intrathecally. Methods: The effects of intravenously and intrathecally administered nefopam were examined using the rat formalin test. Then we performed a microdialysis study to confirm the change of extracellular dopamine concentration in the spinal dorsal horn by nefopam. To determine whether the changes of dopamine level are associated with the nefopam analgesia, its mechanism was investigated pharmacologically via pretreatment with sulpiride, a dopaminergic D2 receptor antagonist. Results: When nefopam was administered intravenously the flinching responses in phase I of the formalin test were decreased, but not those in phase II of the formalin test were decreased. Intrathecally injected nefopam reduced the flinching responses in both phases of the formalin test in a dose dependent manner. Microdialysis study revealed a significant increase of the level of dopamine in the spinal cord by intrathecally administered nefopam (about 3.8 fold the baseline value) but not by that administered intravenously. The analgesic effects of intrathecally injected nefopam were not affected by pretreatment with sulpiride, and neither were those of the intravenous nefopam. Conclusions: Both the intravenously and intrathecally administered nefopam effectively relieved inflammatory pain in rats. Nefopam may act as an inhibitor of dopamine reuptake when delivered into the spinal cord. However, the analgesic mechanism of nefopam may not involve the dopaminergic transmission at the spinal level.

• Child Health Nursing Research
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• 제5권3호
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• pp.262-280
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• 1999

This study was Performed to understand Pediatric Pain management status and nurses' knowledge and attitudes toward it. In addition. it aimed to provide basic data in order to establish effective nursing intervention strategies by confirming the barriers of effective pain management in practice. The subjects were 195 nurses working in pediatric units(general pediatric unit. oncology unit, neonatal unit. neonatal ICU, Pediatric ICU) of 8 university hospitals and one general hospital. Data was collected by the questionnaire from the 3rd of August to the 20th of September in 1999. The instrument developed by Sanna(1999) to measure nurses' knowledge and their attitudes and the other tool by Cleeland(1984) to evaluate barriers in effective Pain management was used. Results of this study are summarized as follows 1. Most nurses learn about the pain management knowledges from through regular curriculum of nursing school(62.0%) And almost nurses(90.8%) don't used to utilize pain assessment tool, but the 'Faces Rating Scale' is the most frequently used by nurses. 2. The use of pain medication(65.6%) is most frequently taken by nurses as pain management and is followed by massage (55.9%) , distraction(27.7%). 3. Nurses' knowledge level is moderate (Mn=3.07). Nurses don't seem to understand pediatric Physical development (Mn = 2.86), psychological development(Mn=2.94) well, meanwhile they seem relatively Quite knowledgeable about the way pain emerges. 4. Nurses' attitudes toward pain is based on behavioral and physiological responses to Pain. They believe 'changes in behavior are a way of assessing pain in child' and 'acute pain increases the number of respiration' Nurses are ready to accept pediatric pain, but are not positive in adopting pain intervention in practice. 5. The barriers of effective pain management are inadequate assessment of pain and pain relief(81.5%), ineffective incorporation among health professionals(80%), and lack of equipment or skills(80.0%).

• Journal of Yeungnam Medical Science
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• 제40권2호
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• pp.115-122
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• 2023

Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

• Natural Product Sciences
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• 제20권4호
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• pp.301-305
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• 2014

The aim of our study is to investigate the anti-nociceptive and anti-inflammatory properties of an ethanol extract of the leaf and stem of Aralia cordata. Writhing responses induced by acetic acid, tail immersion test, and formalin-induced paw pain response for nociception and formalin-induced paw edema for inflammation were evaluated in mice. A. cordata (50 - 200 mg/kg, p.o.) and ibuprofen (100 mg/kg, p.o.), a positive non-steroidal anti-inflammatory drugs (NSAIDs), inhibited the acetic acid-induced writhing response, but they did not protect the thermal nociception in tail immersion test. However, morphine (5 mg/kg, s.c.) used as positive opioid control alleviated both the acetic acid-induced writhing response and thermal nociception in tail immersion test. In the formalin test, A. cordata (50 - 200mg/kg) and ibuprofen (200mg/kg) inhibited the second phase response (peripheral inflammatory response), but not the first phase response (central response), whereas morphine inhibited both phase pain responses. Both A. cordata (100 mg/kg) and ibuprofen (200 mg/kg) significantly alleviated the formalin-induced increase of paw thickness, the index of inflammation. These results show for the first time that the leaf and stem of A. cordata has a significant anti-nociceptive effect that seems to be peripheral, but not central. A. cordata also displays an anti-inflammatory activity in an acute inflammation model. The present study supports a possible use of the leaf and stem of A. cordata to treat pain and inflammation.