• YAKHAK HOEJI
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• v.26 no.1
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• pp.1-8
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• 1982

Derivation of triterpenoids and then the screening for corticomimetics among them is our primary interest. $C_{11}$-oxo-triterprenoids except glycyrrhetinic acid are rarely found in the plant kingdom. Based on the facts that $C_{3}$ and $C_{11}$-Oxo-group are essential for the corticoid-like-activity through its competitive inhibition on the corticoid-5.betha.-reductase, it was attempted to produce artificial inhibitor on the enzyme by introducing $C_{11}$-oxo group to the triterpenoids of oleanene series such as oleanolic acid and hederagenin. We could obtain the $C_{11}$-oxo-oleanolic acid m.p. $264-6^{\circ}$, uv ${\lambda}max$ 249 and $C_{11}$-oxo-hederagenin amorp. uv ${\lambda}max$ 251 by acetylation, $CrO_{3}$-oxid., and deacetylation. Glycyrrhetinic acid, a natural 11-oxo-compound and the other 11-oxo-derivatives of oleanolic acid and hederagenin were compared in their inhibitory activity on the corticoid-5.betha.-reductase. The inhibitory activity of those compound were decreased in the order of $C_{11}$-oxo-oleanolic acid, $C_{11}$-oxo- hederagenin, glycyrrhetinic acid. This suggests more strong corticomimetic activity of those artificially derived $C_{11}$-oxo-oleanolic acid and $C_{11}$-oxa-hederagenin. Their Ki value were $4.6{\times}10^{-4}M$ and $5.8{\times}10^{-4}M$ respectively.

• Journal of Fisheries and Marine Sciences Education
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• v.19 no.1
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• pp.1-7
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• 2007

The purpose of this study was to investigate geochemical characteristics of surface sediments in the Keum river estuary adjacent to coastal area. For this study we collected the 21 surface sediments samples. Mean size of surface samples was $3.24{\sim}6.65{\phi}$ on inner estuary and was $2.15{\sim}3.42{\phi}$ on outside estuary. Surface samples were composed of silt on inner estuary and were composed of sand which was more larger than $4{\phi}$ on outside estuary. Most major elements except CaO, $Na_2O$ showed good relationships between variation of contents and grain size. Contents of $Al_2O_3$, $Fe_2O_3$, MgO, $K_2O$, $TiO_2$, $P_2O_5$ and $M_nO$ were increased predominately owing to the variation of mean size of surface samples. Contents of Co, Cr, Cu, Li, Sr, Zn, La, Ce, Pb, Rb, Nd have a good relationships with grain size but Ba, Th, Sm have not. All of major and minor elements contents except $K_2O$ and Ba were less than world mean contents of shallow surface sediments but apprehend a high pollution possibility on silt sediments in the estuaries.

• Korean Journal of Clinical Pharmacy
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• v.8 no.1
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• pp.23-28
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• 1998

The pharmacokinetics of atenolol (25 mg/kg, i.v.) in the folate-induced renal failure rabbits was studied. Renal failure was induced by the i.v. injection of folate (50, 100, and 200 mg/kg). At folate dose of 100 and 200 mg/kg, the serum creatinine concentration (Scr) and blood urea nitrogen (BUN) increased significantly compared with control rabbits. Plasma concentrations and AUC of atenolol increased significantly at folate dose of 100 and 200 mg/kg. The elimination rate constant $(K_{el})$ and total body clearance $(CL_t)$ of atenolol decreased significantly, and half-life ($t_{1/2}$) and mean residence time (MRT) of atenolol increased significantly at folate dose of 100 and 200 mg/kg. The serum creatinine concentration $(S_{cr})$ correlated well (p<0.05) with half-life $(t_{1/2})$ and elimination rate constant $(K_{el})$ of atenolol, as well as BUN with AUC and total body clearance $(CL_t)$ of atenolol.

• Economic and Environmental Geology
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• v.25 no.4
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• pp.435-446
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• 1992

REE, major and trace elements analyses of the Jurassic Daebo granite and Cretaceous Bulguksa granite were carried out to interpet their petrogenesis and relationships between petrogenesis and tectonics. Analytical results are summarized as follows. (1) $SiO_2$ content of the Bulguksa granite (aver. 74.6%) are significantly higher than those of the Daebo granite (aver. 68.1%). Major elements of $TiO_2$, $Al_2O_3$, $P_2O_5$, CaO, MgO, Total FeO, and trace elements of Co, V and Sr are negatively correlated with $SiO_2$. Incompatible elements such as Ba, Sr, Y, Zr and HREE are contained differently in the Bulguksa granites distributed in between Okchon folded belt and Kyongsang sedimentary basin. (2) Trace element abundances show a good discrimination between two goups of granitic rocks. Ba, Sr and V are enriched in Daebo granites, while Zn and Cr are depleted in them. (3) Jurassic granites have quite different Eu anomalies and REE patterns from those of Cretaceous granites: Large negative Eu anomaly in the former and mild or absent Eu anomaly in the latter. The large Eu negative of Cretaceous granitic rocks are interpreted as a differentiated product of fractional crystallization of granitic magma from the upper mantle. Meanwhile, the Daebo plutonic rocks was resulted from the partial melting of subcrustal material or crustal contamination during ascending granitic magma from the mantle. Senario of igneous activities of Mesozoic age in South Korea was proposed based on Kula-Pacific ridge subduction model.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.115-115
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• 2010

광 결정 발광 다이오드를 제작하는데 있어서 문제가 되는, 표면 비 발광 재결합을 줄이기 위해서 $(NH_4)_2S_x$ 패시베이션 효과를 연구하였고, 실제 소자를 공정하였다. $(NH_4)_2S_x$ 패시베이션의 영향을 알아보기 위해서, GaAs 기판위에 10쌍 다중 양자 우물 구조를 가진, 에피탁시를 이용하여 광 결정 다이오드를 제작하였고, 그 후 패시베이션 처리를 하였다. 광 결정 격자 상수는 600 nm 였고, 전자 빔 노광기법을 이용하여 패턴을 만들었다. 패시베이션효과는 시분해 발광 측정을 이용하여 캐리어 라이프 타임의 변화를 통해 확인 할 수 있었다. 광 결정 구조가 없는 발광 다이오드에서의 라이프 타임은 2206 ps였고, 광 결정 구조를 가진 발광다이오드에서의 라이프타임은 831ps였다. 이는 식각된 구멍의 표면에서 비 발광 재결합이 증가했다는 것을 의미한다. 패시베이션 처리된 광 결정 발광다이오드의 라이프 타임은 1560 ps 으로 광 결정 구조의 표면에서 발생된 비 발광 표면 재결합이 상당히 줄었음을 알 수 있다. 상용 에피탁시에 실제 소자에 적용 가능한 광 결정 발광 다이오드를 제작하였다. 상용 에피탁시는 20쌍의 다중 양자우물과, 16쌍의 Distributed Bragg Reflector를 가진 구조이다. 이 상용 에피탁시에 광 결정 구조를 만들기 위해서 니켈 크롬 (NiCr) 마스크를 사용하였고, 기존 식각 시간보다 세배 길어진 식각 시간을 달성하였다.

• Applied Science and Convergence Technology
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• v.26 no.6
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• pp.208-213
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• 2017

Flexible opto-electronic devices are developed on the insulating layer deposited stainless steel (STS) substrates. The silicon dioxide ($SiO_2$) material as the diffusion barrier of Fe and Cr atoms in addition to the electrical insulation between the electronic device and STS is processed using the plasma enhanced chemical vapor deposition method. Noble silver (Ag) films of approximately 100 nm thickness have been formed on $SiO_2$ deposited STS substrates by E-beam evaporation technique. The films then were annealed at $650^{\circ}C$ for 20 min using the rapid thermal annealing (RTA) technique. It was investigated the variation of the surface morphology due to the interaction between Ag films and $SiO_2$ layers after the RTA treatment. The results showed the movement of Si atoms in silver film from $SiO_2$. In addition, the structural investigation of Ag annealed at $650^{\circ}C$ indicated that the Ag film has the material property of p-type semiconductor and the bandgap of approximately 1 eV. Also, the films annealed at $650^{\circ}C$ showed reflection with sinusoidal oscillations due to optical interference of multiple reflections originated from films and substrate surfaces. Such changes can be attributed to both formation of $SiO_2$ on Ag film surface and agglomeration of silver film between particles due to annealing.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.105-112
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• 2006

Liquefaction-induced lateral spreading has been the most extensive damage to pile foundations during earthquakes. However, a case of pile failure was reported despite the fact that a large margin of safety factor was employed in their design. This means that the current seismic design method of pile is not agreeable with the actual failure mechanism of pile. Newly proposed failure mechanism of pile is a pile failure based on buckling instability. In this study, failure behavior of pile embedded in liquefied soil deposits was analyzed considering lateral spreading and buckling instability performing 1g shaking table test. As a result, it can be concluded that the pile subjected to excessive axial loads ($near\;P_{cr}$) can fail by buckling instability during liquefaction. When lateral spreading took place in sloping grounds, lateral spreading increased lateral deflection of pile and reduced the buckling load, promoting more rapid collapse. In addition, buckling shape of pile was observed. In the ease of pile buckling, hinge formed at the middle of the pile, not at the bottom. And in sloping grounds, location of hinge got loiter compared with level ground because of the effects of lateral spreading.

• Bulletin of the Korean Chemical Society
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• v.21 no.10
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• pp.951-952
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• 2000

Acylation of an intermediate tetrahydroxoplatinum(IV) complex, $[Pt(OH)_4(dach)]$ (dach = $trans-(\pm)-12-di-aminocyclohexane)$, with one or two kinds of carboxylic anhydrides in stepwise manner afforded various car-boxylatoplatinum(IV) complexes, $[Pt(O_2CR)\chi(OR’)4-\chi(dach)]$ (R = $(CH_2)_3CH_3$ or $C(CH_3)_3$, R’ = H or $OCCH_3$, and $\chi$ = 1-4) with a wide range of lipophilicity. The title complexes were subjected to bioassay using the murine leukemia L1210 cell line, and in particular, their in vivo oral antitumor activity was attempted to correlate with their lipophilicity and water solubility. The most orally active complex exhibited intermediate lipophilicity and water solubility, but it has been found that an exact relationship between the lipophilicity and oral anticancer activity could not be established, since the lipophilicity of the complexes is not the sole parameter to determine the oral activity. One of the important intermediate complexes partially substituted was subjected to X-ray anal-ysis for positit of the substituted group: $[Pt(OPiv)_3(OH)(dach)]$ crystallizes in the tetragonal sys-tem, space group $P42_1c$ with a = 21.161(3) $\AA$, b = 21.161(6) $\AA$, c = 12.816(3) $\AA$, $\alpha=\beta=$ r $=90^{\circ}$, V = 5739(2) $\AA^3$ and Z = 8.

• Journal of Environmental Science International
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• v.30 no.8
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• pp.673-684
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• 2021

Raw leachates from three landfills and treated leachates from two landfills on Jeju Isalnd were analyzed for ten perfluorinated compounds (PFCs) detected in aquaruc environments. The leachates were collected six times in 2014 and 2015. Among the ten PFCs, three were not detected, namely perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and perfluorodecane sulfonate (PFDS). The total concentrations of PFCs ranged as 724-3313 ng/L (mean 1999 ng/L) in raw leachates and from less than the limit of quantification (LOQ) to 394 ng/L (mean 133.2 ng/L) in treated leachates. The domonant compounds measured were perfluorooctanoic acid (PFOA) (mean contribution 37.7%) and perfluorobutane sulfonate (PFBS) (mean contribution 38.2%) in raw leachates, and PFOA (mean contribution 40.7%), perfluorohexanoic acid (PFHxA) (mean contribution 27.3%) and PFBS (mean contribution 26.5%) in treated leachates. No significant correlations were observed between total/several individual PFCs and leachate pH and COD_Cr, which may be due to complex chemical nature of landfill leachates and characteristics of waste and landfills.

• Steel and Composite Structures
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• v.46 no.4
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• pp.565-575
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• 2023

This study represents a numerical research in vibration and buckling of functionally graded material (FGM) beam comprising edge crack by using finite element method (FEM) and multilayer perceptron (MLP). It is assumed that the material properties change only according to the exponential distributions along the beam thickness. FEM and MLP solutions of the natural frequencies and critical buckling load are obtained of the cracked FGM beam for clamped-free (C-F), hinged-hinged (H-H), and clamped-clamped (C-C) boundary conditions. Numerical results are obtained to show the effects of crack location (c/L), material properties (E₂/E₁), slenderness ratio (L/h) and end supports on the bending vibration and buckling properties of cracked FGM beam. The FEM analysis used in this paper was verified with the literature, and the fundamental frequency ratio ($\overline{P_{cr}}$) and critical buckling load ratio ($\overline{{\omega}}$) results obtained were compared with FEM and MLP. The results obtained are quite compatible with each other.