• Development and Reproduction
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• v.14 no.4
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• pp.307-316
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• 2010

This thesis attempts to describe the basis and value system respectively selected by opinions pro and against bio engineering technology and to induce discussions on the basis of the concept called 'two culture' issue by C. P. Snow - science culture, human culture, a teleological ethical theory and a deontological ethical theory, traditional eugenics, and liberalism eugenics. In addition, it will discuss about inconvenient truth about science and bio engineering which we have wrongly understood up to now - a myth on objectivity of science, autonomy of science and a scientist, a hunger of world, science expected to be responsible for all men. Lastly, it will describe study ethics and social responsibility, openness, moral imagination, self-examination, character of a bio engineer as professionalism.

• Journal of Nutrition and Health
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• v.33 no.1
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• pp.68-79
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• 2000

This study was developed the nutrition education program for kindergarten children and was evaluated its educational effect by 'Non-equivalent control group design'. Nutrition education program was developed on the basis of the concept which consisted of nutrition, nutrients, food handling, life cycle and social$.$psychological needs. And it was developed on the basis of the theme which consisted of kind of foods, relation between food and body, importance of food, food and sanitation, food and environment, Korean traditional food and good table manners. Subjects consisted of 157 kindergarten children, with 48 in control group and 109 in treatment group. All the subjects completed a pretest and a posttest and the posttest means between control and treatment group were compared. The control group had a adjusted posttest mean score of nutrition knowledge of 50.64 and the treatment group had that of 75.19 and the difference was significant(p<0.001). The control group had a adjusted posttest mean score of food attitude of 65.49 and the treatment group had that of 85.40 and the difference was significant(p<0.001). (Korean J Nutrition 33(1) : 68-79, 2000)

• 제어로봇시스템학회:학술대회논문집
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• 1994.10a
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• pp.731-736
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• 1994

Experiment on a lab-scale pH process is carried out to evaluate the control performance of the neural linearizing control scheme(NLCS) using a radial basis function(RBF) network which was previously proposed by Kim and Park. NLCS was developed to overcome the difficulties of the conventional neural controllers which occur when they are applied to chemical processes. Since NLCS is applicable for the processes which are already controlled by a linear controller and of which the past operating data are enough, we first control the pH process with PI controller. Using the operating data with PI controller, the linear reference model is determined by optimization. Then, a IMC controller replaces the PI controller as a feedback controller. NLCS consists of the IMC controller and a RBF network. After the learning of the neural network is fully achieved, the dynamics of the process combined with the neural network becomes linear and close to that of the linear reference model and the control performance of the linear control improves. During the training, NLCS maintains the stability and the control performance of the closed loop system. Experimental results show that the NLCS performs better than PI controller and IMC for both the servo and the regulator problems.

• Toxicological Research
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• v.20 no.1
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• pp.49-53
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• 2004

The genetic basis of hypertension is complex, and has been considered to be associated with the dopamine D2 receptor gene (DD2R). Because association studies using the candidate gene approach may provide important clues regarding the pathogenesis of hypertension and establish basis for further study, we performed the association study on the relationship between genetic polymorphisms in the DD2R gene and hypertension in Koreans. Eighty nine patients with hypertension and 86 age-matched subjects with normal blood pressure were enrolled. Genomic DNA was extracted from peripheral blood leukocytes. PCR-RFLP analysis was performed to detect the three polymorphic Taq I sites in the DD2R gene. There were no significant differences in genotype, allele and haplotype distributions of any polymorphisms in the DD2R gene between two groups, respectively (P>0.05), although significant linkage disequilibriums among these polymorphic sites were detected by pair-wise analysis (P<0.05). Therefore, our negative result suggest that the three Taq I RFLPs in the DD2R gene were not significantly associated with hypertension in Koreans.

• Journal of Electrical Engineering and Technology
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• v.2 no.2
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• pp.157-164
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• 2007

Diagnosis techniques based on the dissolved gas analysis(DGA) have been developed to detect incipient faults in power transformers. Various methods exist based on DGA such as IEC, Roger, Dornenburg, and etc. However, these methods have been applied to different problems with different standards. Furthermore, it is difficult to achieve an accurate diagnosis by DGA without experienced experts. In order to resolve these drawbacks, this paper proposes a novel diagnosis method using fuzzy clustering and a radial basis neural network(RBFNN). In the neural network, fuzzy clustering is effective for selecting the efficient training data and reducing learning process time. After fuzzy clustering, the RBF neural network is developed to analyze and diagnose the state of the transformer. The proposed method measures the possibility and degree of aging as well as the faults occurred in the transformer. To demonstrate the validity of the proposed method, various experiments are performed and their results are presented.

• Korean Journal of Pharmacognosy
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• v.31 no.4
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• pp.449-454
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• 2000

In search for plant-derived cytotoxic compounds, it was found that the $CHCl_3$ and EtOAC extracts obtained from the flowers of Paulownia coreana Uyeki (Scrophulariaceae) exhibited significant cytotoxic activity against human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15. Activity-guided fractionation on the basis of the inhibitory activity against the growth of human tumor cell lines, in vitro, and repeated column chromatography afforded several cytotoxic compounds from P. coreana. The structures and stereochemistry of these compounds were established, on the basis of analysis of spectra including IR, UV, EI-MS, $^{1}H-NMR,\;^{13}C-NMR$ and some chemical transformations, as Compound PCCl $(2-hydroxy-4(15),11(13)-eudesmadien-8{\beta},12-olide)$, Compound $PCC2(2,3-dihydro-4-hydroxy-1(15),11(13)-xanthadien-8{\beta},12-olide)$, Compound PCE1 (chrysophanol), Compound PCE2 (emodin), Compound PCE3 (physcion). Cytotoxic activity of compounds obtained from P. coreana. on five tumor cells lines was evaluated by procedure of SRB methods.

• Cross-Cultural Studies
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• v.24
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• pp.19-31
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• 2011

This article examines the historical view of Benito $P{\acute{e}}rez$ $Gald{\acute{o}}s$ in his historical novel named "Zaragoza" and "$C{\acute{a}}novas$" by comparing with Numancia of Cervantes. In front of the national survival crisis, $Gald{\acute{o}}s$ recognizes that it is necessary that Spain should recover humanity and morality on basis of the krausist ideal. The krausists warned subjective idealism, stressing on free-will and moral conscience in a harmonious balance of rationality. Without refusing patriotism, they warned egoistic patriotism deformed by national selfishness or nationalism. Giner de los Ríos insisted on a necessity of harmonizing national inclination and universal one. $Gald{\acute{o}}s$ emphasizes that the identity of Spain is not possession of privileged class but sweat and tears of the mass of people in daily life. He represents Efemera as the ideal history on the basis of Unamuno's 'intrahistoria', by which, instead of $Luk{\acute{a}}cs^{\prime}$ progressive history, we can peep into a historical poetics of human free nature and vividness of discontinuous and endless shifting. According to the sub-history, we come to the conclusion that $Gald{\acute{o}}s$ and Cervantes would lay emphasis on sub-history, aiming to essence of Spanish soul originated from national landscape and people's daily life.

• International Journal of Computer Science & Network Security
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• v.22 no.2
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• pp.394-398
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• 2022

The article determines that the study of the development of scientific and didactic knowledge about the educational process in higher education should be built mainly on the basis of qualitative research methods that ensure the identification and understanding of the changes taking place in didactic knowledge, in the unity of their internal and external manifestations. On the basis of the epistemological model of the study of science, a generalized model of didactic knowledge about the educational process in higher education, including didactic relations as a theoretical core, subject of research, research methods and positions of researchers, ways of interaction between science and educational practice, and thematic structures of didactic knowledge; scientific and methodological problems of didactic knowledge about the educational process in higher education at the present stage of its developments due to the post-nonclassical transformation and orientation of research towards the humanitarian ideal of scientific character.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.975-978
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• 2012

P63 is a gene product required in cell cycle regulation which plays vital roles in tumor differentiation. Aims of the present study were to assess the frequency, pattern, sensitivity and specificity of two p63 protein clones P63 4A4 and P63 4A4+Y4A3 in squamous cell carcinomas (SCCs). Thirty cases of head and neck region SCC diagnosed on the basis of H&E staining were examined along with 60 cases of head and neck region biopsies other than squamous cell carcinoma, negative on H&E staining, were taken as control. Immunostaining was performed on slides according to the Thermo Scientific UltraVision LP detection System. P63 4A4+Y4A3 clone is more sensitive 96.6% in comparison to 86% in P63 4A4 with having greater NPV of 98.3%. The results signify the importance of P63 4A4+Y4A3 marker over the old markers and may be used as a confirmatory marker of squamous cell carcinoma.

• Journal of Microbiology and Biotechnology
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• v.17 no.9
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• pp.1527-1532
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• 2007

Lysine produced during microbial fermentation is usually recovered by an ion-exchange process, in which lysine is first converted to the cationic form (by lowering the pH to less than 2.0 with sulfuric acid) and then fed to a cationexchange column containing an exchanger that has a sulfone group with a weak counterion such as NH;. Ammonia water with a pH above 11 is then supplied to the column to displace the purified lysine from the column and allow its recovery. To enhance the adsorption capacity and for a possible reduction in chemical consumption, monovalent lysine fed at pH 4 was investigated in comparison with conventional divalent lysine fed at pH 1.5. The adsorption capacity increased by more than 70% on a mass basis using pH 4 feeding compared with pH 1.5 feeding. Lysine adsorbed at pH 4 started to elute earlier than that adsorbed at pH 1.5 when ammonia water was used as the eluant solution, and the extent of early elution became more notable at lower concentrations of ammonia. Moreover, the elution of monovalent lysine fed at pH 4 displayed a stiffer front boundary and higher peak concentration. However, when the ammonium concentration was greater than 2.0 N, complete saturation of the bed was delayed during adsorption and the percent recovery yield from elution was lowered., both drawbacks that were considered inevitable features originating from the increased adsorption of monovalent lysine.