Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxic Compounds from the Flowers of Paulownia coreana

오동나무꽃의 항암성분

  • Oh, Joa-Sub (Pharmacognosy Lab, College of Pharmacy, SungKyunKwan University) ;
  • Zee, Ok-Pyo (Pharmacognosy Lab, College of Pharmacy, SungKyunKwan University) ;
  • Moon, Hyung-In (Pharmacognosy Lab, College of Pharmacy, SungKyunKwan University)
  • 오좌섭 (성균관대학교 약학대학 생약학연구실) ;
  • 지옥표 (성균관대학교 약학대학 생약학연구실) ;
  • 문형인 (성균관대학교 약학대학 생약학연구실)
  • Published : 2000.12.30
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Abstract

In search for plant-derived cytotoxic compounds, it was found that the $CHCl_3$ and EtOAC extracts obtained from the flowers of Paulownia coreana Uyeki (Scrophulariaceae) exhibited significant cytotoxic activity against human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15. Activity-guided fractionation on the basis of the inhibitory activity against the growth of human tumor cell lines, in vitro, and repeated column chromatography afforded several cytotoxic compounds from P. coreana. The structures and stereochemistry of these compounds were established, on the basis of analysis of spectra including IR, UV, EI-MS, $^{1}H-NMR,\;^{13}C-NMR$ and some chemical transformations, as Compound PCCl $(2-hydroxy-4(15),11(13)-eudesmadien-8{\beta},12-olide)$, Compound $PCC2(2,3-dihydro-4-hydroxy-1(15),11(13)-xanthadien-8{\beta},12-olide)$, Compound PCE1 (chrysophanol), Compound PCE2 (emodin), Compound PCE3 (physcion). Cytotoxic activity of compounds obtained from P. coreana. on five tumor cells lines was evaluated by procedure of SRB methods.

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