• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.9 no.1
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• pp.65-73
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• 2003

The researches for tumor and the developments for new anti-tumor medicine are being continuously developed in the oriental as well as the west. The principles therapy of anti-tumor activity was based on knowledge of the method of support the healthy energy and strengthen the body resistance, promote blood circulation to remove blood stasis, clear away heat and toxic materials, dissipate phlegm and disperse the accumulation of evils. But the major clinical features of tumor was to be considered in developing a treatment plan include (1) distinguish between clinical and pathologic staging - acute and chronic, (2) classification of pathologic pattern, and (3) distinction of body situation : for examples asthenia - sthenia etc. It was most important to distinguish between supporting the healthy and eliminating the evil factors and to treat differently at the root and the branch cause of a neoplasm. In clinical study and experimental study, the effects of oriental medicine could be summarized as three that were decreasing toxicity of chemo-therapy, directly suppressing and killing cancerous cell and increasing chemo-effect through preventing metastasis. Improving organic immunity with oriental medicine could be summarized as five that were promoting phagocytosis of macrophage, inducing interferon, promoting formation of immnoglobulin, increasing number of T-cell and promoting transformation of lymphocyte. It is suggested that effective use of immune activating herbs inhibited metastasis and decreased recurrence and then we were able to expect increasing survival rate and improving clinical symptoms and quality of life(QOL) of tumor patients.

• Journal of Oriental Neuropsychiatry
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• v.29 no.3
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• pp.145-163
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• 2018

Objectives: The study was designed to provide clinical evidence of homogeneity in analysis of the herbal medicine, Guipi decoction in treating insomnia, using a t-test of randomized controlled trials (RCTs). Methods: This study included RCTs that verified homogeneity of Guipi decoction in treating insomnia. Literature studies of CNKI (Chinese National Knowledge Infrastructure Database) were performed. The basic components group was made to the Guipi decoction of the Yixuerumen?s text. The excluded group was created with the number of herbs excluded from the basic components group. T-test performed that the effective rate in the basic components group and excluded groups. Results: The basic components of Guipi decoction contain Atractylodis Rhizoma Alba, Poria Sclerotium (Poria Sclerotium Cum Pini Radix), Polygalae Radix, Astragali Radix, Zizyphi Semen, Angelicae Gigantis Radix, Aucklandiae Radix, Glycyrrhiza uralensis Fischer, Ginseng Radix (Codonopsis Pilosulae Radix), Longanae Arillus. Herbs excluded from the basic components group were Longanae Arillus, Ginseng Radix (Codonopsis Pilosulae Radix), Glycyrrhiza uralensis Fischer and herbs added to the basic components group were Polygonum multiflorum Thunberg, Schisandrae Fructus, Salviae Militiorrhizae Radix, Paeoniae Radix Alba (in order from the most used to the least). T-test revealed the effective rate in the basic components group was not statistically significant compared to the excluded groups (p=0.161/p=0.162/p=0.103). Conclusions: Effectiveness in treatment of basic components of Guipi decoction and excluded groups were revealed to be homogeneous in treating insomnia. As the number of herbs in the basic components group decreased, mean value in effectiveness of treatment also decreased consequentially. However, there were no statistical significances.

• Journal of Haehwa Medicine
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• v.13 no.2
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• pp.123-129
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• 2004

We observed the efficacy of natural herbs and mixture in treating atopic dermatitis using anti-human IgE treated Human HMC-I cell model. We selected three herbs, Cynonchum witfordii, Diospyros kaki, Ilite which were used to treat skin disease in Traditional Korea Medicine. Using Human HMC-I cell treated with anti-human IgE, we investigate in vitro whether each herb effects on IL-4, IL-13, TNF-a expression and TNF-a, Histamine secretion value. The results show the possibility that the mixture of three herbs may be better in improving atopic dermatitis condition.

• The Journal of Korean Medicine
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• v.34 no.3
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• pp.1-12
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• 2013

Objectives: This was study about identifying fine seed herbs that are highly mixed together: Celosiae Semen, Celoisae Cristatae Semen, Cuscutae Semen, Perillae Semen. Methods: In non-distinctive herbs through sensory test, we can find accurate discriminative points by using a stereoscope. As a result, a new discriminative key was completed. Results: We identified a comparison of herbs which are mixed up in distribution. 1) In the case of Celosiae Semen and Celoisae Cristatae Semen, Celoisae Cristatae Semen which is mixed up is bigger and more glossy and especially have the sunk umbilicus. 2) In the case of Cuscutae Semen and Perillae Semen, Perillae Semen is discriminated by characteristic morado netting surface and impression of fruit stalk in the single-ended. 3) In the case of Cuscutae Semen which is distributed in three species, we discriminated by beak shape, location of umbilicus and vomiting thread shape or not when put in water. (1) Cuscuta chinensis has a weak beaky shape, an umbilicus in center and is vomiting thread shape when put in water. (2) C. australis has very weak beaky shape, an umbilicus beneath and is vomiting thread shape when put in water. (3) C. japonica has clear beaky shape, an umbilicus beneath and is not vomiting thread shape when put in water. Conclusions: A stereoscope can be effectively used for identifying fine seed herbs hardly distinguishable by sensory tests.

• Herbal Formula Science
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• v.19 no.1
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• pp.113-130
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• 2011

Objectives : This study was performed to investigate 93 prescriptions which are all affiliated Phlegm-Fluid Substances chapter depending on Symptoms in Dongeuibogam. Methods : The following conclusions are reached through investigations on the applications of prescriptions which are all affiliated Phlegm-Fluid Substances chapter Depending on Symptoms in Dongeuibogam. Results : 1. Fluid detention disease article represents that Byukeum(癖飮), Hyuneum(懸飮) and Yueum(流飮) have the same treat criteria, in effect, there is not any problem left in case it is reached fluid detention disease is not 8 but 6. 2. Strong water-utilization herbs can be mainly used in treating Fluid detention disease, eliminating phlegm warm herbs are almost used two times more than eliminating phlegm cold herbs in eliminating phlegm disease. 3. Arisamatis Rhizoma is only used by itself in Chongmongseok-hwan, the others are used at the same time with Pinelliae Rhizoma. As a result of this, Arisamatis Rhizoma has an effects on eliminating Wind relative dusease but eliminating phlegm disease which can cause upper body phlegm disease. 4. Fritillariae Cirrhosae Bulbus and Tricosanthis Radix are able to get rid of obstinate phlegm-Fluid disease in eliminating phlegm cold herbs. 5. Gamisachil-tang and Gamieejin-tang which are located in throat chapter are more proper prescriptions to treat phlegm at throat than Gwache-san or Jeoljehwadam-hwan which is located in Phlegm-Fluid Substances chapter in Dongeuibogam. 6. Glycyrrhizae Radix is used 46 times(49%) at total 93 prescriptions in eliminating phlegm disease herbs. It seems to be needed more study whether Glycyrrhizae Radix can control the Phlegm-Fluid disease or not. Conclusions : The 93 prescriptions for eliminating Phlegm-Fluid Substances in Dongeuibogam are mainly composed of Sobanha-tang, Eejin-tang and Baeksang-hwan, etc.

• Journal of Sasang Constitutional Medicine
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• v.18 no.3
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• pp.38-48
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• 2006

1. Objects This paper was written in order to understand the formative process of Soyangin pharmacology. 2. Methods We analysis Soyangin pharmacology through pathology and new prescription in ${\ulcorner}$Gabobon(甲午本)${\lrcorner}$ and ${\ulcorner}$Sinchukbon(辛丑本)${\lrcorner}$ of ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$. 3. Results and Conclusions New prescription of Soyangin in ${\ulcorner}$Gabobon${\lrcorner}$ is same or similar to that in ${\ulcorner}$Chobonkwon${\lrcorner}$. So we can recognize that almost Soyangin pharmacology of ${\ulcorner}$Gabobon${\lrcorner}$ is made when Dongmu write ${\ulcorner}$Chobonkwon${\lrcorner}$. And the maintenance of Yin-Qi is key point of Soyangin's pharmacology New prescription of Soyangin is made by regular rules in ${\ulcorner}$Sinchukbon${\lrcorner}$. Dongmu say that Hyungkae(荊芥) Bangpung(防風) Kanghwal(羌活) Dokhwal(獨活) is herbs for descending-Yin, and Sukjihwang(熟地黃) Sansuyoo(山茱萸) Bokryung Taeksa(澤瀉) or Saengjihwang(生池黃) Sukgo(石膏) Jimo(知母) is herbs for ascending-Yang And all new prescription except Sukjihwangkosam-tang(熟地黃苦蔘湯) is composed of asneding-Yang and descending-Yin's herbs. New prescription of the exterior disease contained all descending-Yin's herbs and that of the interior disease contained all ascending-Yang's herbs completly. Namely when ${\ulcorner}$Gabobon${\lrcorner}$ was written Soyangin pharmacology is the maintenance of Yin-Qi by selecting prescription of cold character. And when ${\ulcorner}$Sinchukbon${\lrcorner}$ was written, base sprit of Soyangin pharmacology was not changed. Pharmacology was added ascending-Yang and descending-Yin at a time.

• Journal of Life Science
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• v.22 no.12
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• pp.1729-1739
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• 2012

The aim of this study was to evaluate the clinical efficacy and safety of fermented medicinal herbs. A search of the China National Knowledge Infrastructure (CNKI), PubMed databases and Korean Journal of Oriental Medicine in 2000-2011 located 11 randomized controlled trials (RCTs) that investigated the clinical efficacy of fermented medicinal herbs. Domestic RCTs reported clinical efficacy on improvement of immune responses and clinical safety on usage of fermented medicinal herbs in subjects suffering from cerebral hemodynamics. Countries other than Chinareported studies on the cause of esophageal cancer and on local inflammatory reactions. In China, studies were reported on the effectiveness of fermented medicinal herbs on scapulohumeral periarthritis of the stasis type, chronic superficial gastritis, dysuria induced by benign prostatic hyperplasia of deficiency of kidney yang, diabetic nephropathy, essential hypertension, and benign prostate hyperplasia. These results indicate that fermented medicinal herbs have obvious clinical effects in some diseases and no adverse reactions. Therefore, we need to initiate more fermentation research with useful bacteria, fungi, and mushrooms to produce fermented medicinal herbs. Both governments and research authorities should focus on research involving fermentation of medicinal herbs.

• Herbal Formula Science
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• v.8 no.1
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• pp.11-37
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• 2000

This is a study on the methods of decocting prescriptions in SANGHANRON (傷寒論), and after this, numbers of results have been obtained. SANGHANRON was written by Chang-Ki (張機) in the 2nd century, so it reflexes the usage of prescriptions of previous age indirectly. And gave affects on the methods of decocting prescriptions to the oriental medicine doctors of next generation.Berore Han-DYnasty(漢代), there were not so many publications connected with Oriental Medicine. Besides, some books couldn't hand down to next generation due to the gap of time and space. As time goes by, letters in medical books changed little by little, so contents connected with decocting methods changed too. The effects of decoction and herb tea can be changed by the flexibility of methods of decocting medicines, so we have to decide what kinds of decocting methods should be taken and adapted to patients by the most effective way.In SANGHANRON, there are many kiny kinds of boiling methods, so DHAMG-Ki selected the most appropriate method considering deree and position of disease and condition of patient. But nowadays, due to inconvenient procedure of boiling and taking medicines, some methos are not in common in clinical medicin. So this study was started to look back upon the changes of decocting prescriptions and gave deffort to find out the propriety of variation of boiling prescriptions.The common method of decocting prescriptions in SANGHANRON is boiling down all the herbs at the same time. Except the commom method, there are some kinds of other methods - boiling down twice the prescription, boiling down some special herbs earlier of later than other herbs, complicated or special boiling methods of extract, etc. These kinds of decoting methods simplified as time pass by, but this expected therapeutic value. So we have to distinguish the methods -though complicated and troublesome- in clinical medicine to make perfection more perfect in treating patients, and further studies have to be followed to prove the propriety of these complicated methods.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.6
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• pp.935-941
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• 2010

Fragrance(aroma) have many effects on body. Recently, aromatherapy was used to treat dementia, atopicdermatitis, alopecia areata, perineal disease, lymphatichydrops, and articularrheumatism. And people are interested in physical and mental effects of aroma, especially in mental. People empirically have been known the effects of aroma on soul and used aroma in life from long ago. They have had a meditation and had a sacrificial rites burning incense. Scholars also burned incense when reading books or tasting tea. Until now, there is no physiological study about recognition process and effects of aroma on body, but only many clinical studies using aromatherapy. Fragrance(aroma) is different from smell and good flavors of herbs. And it goes through nose and has effects on body in harmony on So-mun(素問). Also flavors of herbs are spreaded ki of herbs and have many effects on body. Aroma coming through the nose is recognized by co-operation of five-viscera(五臟), especially heart and lung. The nose and pectoral qi(宗氣) are related with lung. The lung opens into the nose, reflect its physiological and pathological conditions. Pectoral qi(宗氣) is the combination of the essential qi derived from food with the air inhaled, stored in the chest, and serving as the dynamic force of blood circulation, respiration, voice, and bodily movements. Because of the heart-spirit(心神), Heart is the organ can recognize the aroma, although the nose is the first organ of receiving aroma. Five spirits(五神: ethereal soul(魂), spirit(神), ideation(意), corporeal soul(魄), will(志)) and seven emotions(七情: joy(喜), anger(怒), anxiety(憂), thought(思), sorrow(悲), fear(恐), fright(驚)) are rerated with five-viscera(五臟) and essence-spirit (精神) processing steps and express of emotions. And aroma effects on five-viscera(五臟). So aroma have many effects on body, especially mentally.

• Journal of the East Asian Society of Dietary Life
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• v.18 no.1
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• pp.104-110
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• 2008

This research was designed and implemented to evaluate how the composition of yaksuncha can affect the health of individuals suffering from diet-related diseases such as obesity and hyperlipidemia by prescribing Yaksun as a nutritional supplement with daily meals. The yaksunucha was prepared as Koekac, Sansa, Heshouwu and Woolong tea and the tea's effects on serum lipids and oxidative stress were evaluated by clinical procedures. The yaksuncha significantly increased HDL-cholesterol and decrease of LDL-cholesterol concentrations in serum. It also had significant effects on decreasing oxidative stress and homocystein levels. The physical characteristics of the yaksunucha were also examined, showing. Brix, pH and titratable acidity values of 1.4, 5.50 and 0.05% respectively. It is thought that scientific and objective evaluations were completed on the components of the yaksuncha prescription. Thus one can concluded that the components could be applied not only in the form of tea, but also various food. The data derived from this study provides basic information that will aid in the application of oriental medicinal resources to other foods as well as facilitate the study of medicinal herbs within the field of functional food research, which already draws sizable attention worldwide.