Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Research Trends of Fermented Medicinal Herbs - Based on Their Clinical Efficacy and Safety Assessment

발효한약의 최근 연구 동향 - 안전성과 유효성 기반

  • Choi, Yun-Kyung (School of Korean Medicine, Pusan National University) ;
  • Sul, Jae-Uk (Chung-Youn Hospital) ;
  • Park, Seoul-Ki (Department of Microbiology and Immunology, Pusan National University School of Medicine) ;
  • Yu, Sun-Nyoung (Department of Microbiology and Immunology, Pusan National University School of Medicine) ;
  • Kim, Sang-Hun (Department of Microbiology and Immunology, Pusan National University School of Medicine) ;
  • Rhee, Moon-Soo (Korea Research Institute of Bioscience & Biotechnology) ;
  • Ahn, Soon-Cheol (Department of Microbiology and Immunology, Pusan National University School of Medicine) ;
  • Shin, Mi-Sook (Department of Oriental Rehabilitation Medicine, School of Korean Medicine, Pusan National University)
  • 최윤경 (부산대학교 한의학전문대학원) ;
  • 설재욱 (청연한방병원) ;
  • 박슬기 (부산대학교 의학전문대학원 미생물학 및 면역학 교실) ;
  • 유선녕 (부산대학교 의학전문대학원 미생물학 및 면역학 교실) ;
  • 김상헌 (부산대학교 의학전문대학원 미생물학 및 면역학 교실) ;
  • 이문수 (한국생명공학연구원 생명자원센터) ;
  • 안순철 (부산대학교 의학전문대학원 미생물학 및 면역학 교실) ;
  • 신미숙 (부산대학교 한의학전문대학원 한방재활의학과교실)
  • Received : 2012.11.16
  • Accepted : 2012.12.06
  • Published : 2012.12.30
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Abstract

The aim of this study was to evaluate the clinical efficacy and safety of fermented medicinal herbs. A search of the China National Knowledge Infrastructure (CNKI), PubMed databases and Korean Journal of Oriental Medicine in 2000-2011 located 11 randomized controlled trials (RCTs) that investigated the clinical efficacy of fermented medicinal herbs. Domestic RCTs reported clinical efficacy on improvement of immune responses and clinical safety on usage of fermented medicinal herbs in subjects suffering from cerebral hemodynamics. Countries other than Chinareported studies on the cause of esophageal cancer and on local inflammatory reactions. In China, studies were reported on the effectiveness of fermented medicinal herbs on scapulohumeral periarthritis of the stasis type, chronic superficial gastritis, dysuria induced by benign prostatic hyperplasia of deficiency of kidney yang, diabetic nephropathy, essential hypertension, and benign prostate hyperplasia. These results indicate that fermented medicinal herbs have obvious clinical effects in some diseases and no adverse reactions. Therefore, we need to initiate more fermentation research with useful bacteria, fungi, and mushrooms to produce fermented medicinal herbs. Both governments and research authorities should focus on research involving fermentation of medicinal herbs.

발효 한약의 안전성과 유효성을 평가하기 위하여 CNKI, PubMed, 국내 한의학 저널에서 2000년부터 2011년까지 이루어진 관련 연구를 검색하였다. 발효 한약에 대한 유효성을 검증하기 위한 11개의 무작위 대조군 임상 연구로 국내에서는 면역 기능과 심혈관 기능에 대한 연구가 있었고, 중국에서는 만성 천표성 위염을 비롯한 각종 질환에 대한 임상 연구가 이루어졌다. 그 외의 국가에서는 식도암이나 국소 면역 반응에 대하여 검증하였다. 결과, 발효 한약은 특정 질환에 있어 명백한 효과를 보이고 있으며 부작용 또한 발견되지 않았다. 따라서 발효 한약에 대한 지속적인 관심과 연구가 필요할 것으로 사료된다.

Keywords

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