Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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A Study on Homogeneity Analysis of the Guipi Decoction for Treatment of Insomnia Disorder -Focusing on Randomized Controlled Clinical Trials in CNKI

불면장애에 사용된 귀비탕의 동질성 연구 -CNKI에서 검색한 무작위배정 임상연구를 중심으로-

  • Kim, Dong-Hee (Department of Oriental Neuropsychiatry, Dong-Eui University Korean Medical Hospital) ;
  • Sakong, Jong-Won (Department of Oriental Neuropsychiatry, Dong-Eui University Korean Medical Hospital) ;
  • Kang, Chang-Wan (College of Production Information Technology Engineering Major, Dong-Eui University) ;
  • Lee, Sang-Hyup (Department of Korean Medical Classics, School of Korean Medicine, Dong-Eui University) ;
  • Ha, Ji-Won (Department of Oriental Neuropsychiatry, Graduate School of Korean Medicine, Dong-Eui University) ;
  • Kim, Bo-Kyung (Department of Oriental Neuropsychiatry, School of Korean Medicine, Dong-Eui University)
  • 김동희 (동의대학교 부속한방병원 한방신경정신과) ;
  • 사공종원 (동의대학교 부속한방병원 한방신경정신과) ;
  • 강창완 (동의대학교 산업융합시스템공학부 생산정보기술공학) ;
  • 이상협 (동의대학교 한의과대학 원전학교실) ;
  • 하지원 (동의대학교 한의과대학원 한방신경정신과교실) ;
  • 김보경 (동의대학교 한의과대학 한방신경정신과교실)
  • Received : 2018.09.02
  • Accepted : 2018.09.19
  • Published : 2018.09.30
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Abstract

Objectives: The study was designed to provide clinical evidence of homogeneity in analysis of the herbal medicine, Guipi decoction in treating insomnia, using a t-test of randomized controlled trials (RCTs). Methods: This study included RCTs that verified homogeneity of Guipi decoction in treating insomnia. Literature studies of CNKI (Chinese National Knowledge Infrastructure Database) were performed. The basic components group was made to the Guipi decoction of the Yixuerumen?s text. The excluded group was created with the number of herbs excluded from the basic components group. T-test performed that the effective rate in the basic components group and excluded groups. Results: The basic components of Guipi decoction contain Atractylodis Rhizoma Alba, Poria Sclerotium (Poria Sclerotium Cum Pini Radix), Polygalae Radix, Astragali Radix, Zizyphi Semen, Angelicae Gigantis Radix, Aucklandiae Radix, Glycyrrhiza uralensis Fischer, Ginseng Radix (Codonopsis Pilosulae Radix), Longanae Arillus. Herbs excluded from the basic components group were Longanae Arillus, Ginseng Radix (Codonopsis Pilosulae Radix), Glycyrrhiza uralensis Fischer and herbs added to the basic components group were Polygonum multiflorum Thunberg, Schisandrae Fructus, Salviae Militiorrhizae Radix, Paeoniae Radix Alba (in order from the most used to the least). T-test revealed the effective rate in the basic components group was not statistically significant compared to the excluded groups (p=0.161/p=0.162/p=0.103). Conclusions: Effectiveness in treatment of basic components of Guipi decoction and excluded groups were revealed to be homogeneous in treating insomnia. As the number of herbs in the basic components group decreased, mean value in effectiveness of treatment also decreased consequentially. However, there were no statistical significances.

Keywords

References

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