• The Korea Journal of Herbology
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• v.26 no.1
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• pp.21-27
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• 2011

Objectives : This study aimed to design manual of guideline book for combined medicaion of the oriental and the western drugs in the disease of the aged. Method : First, we collected informations about guideline book for drug medication, and we investigated wishes of professors who are working for an oriental medicine at universities. Result & Conclusion : 1. The greater part of professors recognized necessity of guideline book for combined medicaion of the oriental and the western drugs. 2. The basic stages of framing guideline book for combined medicaion of the oriental and the western drugs are as follows. The first step is planning of framing guideline book for combined medicaion of the oriental and the western drugs. The second step is organization of framing group and advisory committee for guideline book. The next steps are searching the core of items and making a searching all the literature and estimating the literature. And then, we should complete basic contents of guideline book in a row, and those must be examined thoroughly by external experts. Finally we can make public the guideline book for combined medicaion of the oriental and the western drugs. If there are reform contents in the guideline book, we can amend contents and make public the revision guideline book again. 3. We need guideline information center for combined medicaion of the oriental and the western drugs in the disease of the aged for framing, wide-spread and development of guideline book. 4. We think that the guideline information center should be composed of a steering committee, a committee of controlling informations and advisory committee for guideline book.

• Korean Journal of Pharmacognosy
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• v.4 no.3
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• pp.105-152
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• 1973

Modern pharmaceutical scientists and medicinal chemists have shown only sporadic interest in mineral drugs of oriental medicine, although the use of minerals in medicine dates from early ancient cultures. The mineral, until recently, has been relatively neglected by the natural product and medicinal chemists. At this moment in time it is appropriate to review briefly the status of mineral oriental drugs in Korea, and eighty items of mineral drugs were listed in this review. This review is also concerned with those references, classic or current, pertaining to application, origin, and constituent of those mineral drugs. It is the aim of this review to facilitate presentation of useful informations in an attempt to entice the natural product and medicinal chemists to seek rediscovery and further application of mineral oriental drugs in Korea.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1666-1672
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• 2005

Oriental medicinal drugs have a broad spectrum of clinical use for the cure of nervous system diseases including brain ischemic damages or neuropathies. Yet, specific drugs or drug components used in the oriental medicine in relation to none fiber regeneration are not known. In the present study, possible growth promoting effects of oriental medicinal drugs were investigated in the injured sciatic nerve system in the rat. By immunofluorescence staining, we found that Jahageo (JHG, Hominis placenta) increased Induction levels of axonal growth associated protein GAP-43 in the rat sciatic none. Small growth promoting activity was found in Golsebo (GSB, Drynariae rhizoma) and Baikhasuo (BHSO, Polygoni multiflori radix) drugs. JHG also increased cell cycle protein Cdc2 levels in the injured area of the sciatic nerves. Immunofluorescence staining indicated that induced Cdc2 protein was mostly localized in the Schwann cells in the injury area, implying that JHG activity might be related to increased Schwann cell proliferation during axonal regeneration. Moreover, levels of phospho-extracellular signal-regulated (ERK) pathway in the injured neNes were elevated by JHG treatment while levels of total ERK were unaltered. In vivo measurement of axonal regeneration using retrograde tracer showed that JHG, GSB and BHSO significantly enhanced Dil-labeled regenerating motor neurons compared with saline control. The present data suggest that oriental medicinal drugs such as JHG, GSB, and BHSO may be a useful target for developing specific drugs of axonal regeneration.

• Korean Journal of Pharmacognosy
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• v.30 no.2
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• pp.145-150
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• 1999

To explain the theory of KIMI which is the theory of therapeutics in oriental medicine, monoamine oxidase(MAO) activities were measured in the brain and liver of mice which were orally administered oriental medicinal herbs which were classified into cold and hot drugs. Rheum palmatum, Anemarrhena asphodeloides, Gardenia jasminoides, Scutellaria baicalensis and Coptis japonica were considered as the cold drugs and Zingiber officinale, Aconitum carmichaeli, Asiasarum sieboldi, Evodia officinalis and Cinnamomum cassia were included in the hot drugs. The effects of cold and hot drugs on in vitro enzyme activities were measured and compared with the in vivo effects. Serotonin is important neurotransmetter involved in the control of body temperature. The MAO plays a central role in the metabolism of many neurotransmetter monoamines including serotonin. MAO is a flavoprotein found exclusively in the mitochondrial outer membrane, occuring in the MAO-A and MAO-B subtypes. MAO-A deaminates serotonin and noradrenaline, whereas MAO-B prefers phenylethylamine and benzylamine as substrates. Coptis japonica and Aconitum carmichaeli elevated the in vivo MAO activities and especialy, in vivo MAO-B activities were significantly increased. In vitro MAO-A activities were increased by hot drugs, whereas the in vitro MAO-B activities were inhibited. Cold drugs inhibited both enzyme activities in vitro.

• Korean Journal of Pharmacognosy
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• v.14 no.3
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• pp.102-106
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• 1983

As many crude drugs are used in the oriental medical field problems on the side effects of these drugs come to the front. To conduct delayed-type hypersensitivity we selected 29 kinds of drugs used frequently for therapeutic agents in oriental medical hospitals (Table I). The cell-mediated immune response was evaluated by measuring the foot pad swelling reaction and humoral immune response by measuring the antibody formation to these crude drugs. Mice were given these drugs intraperioneally for sensitization and challenged with same drug as used for sensitization respectively by intral dermal injection on the left and righ hind foot pad 4 days after senstization and then the foot pads were measured with the dial micrometer. The results were as follow; 1) Gentianae Scabrae Radix, Arecae Semen, Corydalis Tuber, and Paeoniae Radix were significant as delayed-type hypersensitivity inducers. 2) None of the crude drugs tested had effect on the induction of humoral immune response.

• Korean Journal of Pharmacognosy
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• v.6 no.4
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• pp.219-250
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• 1975

The consumptions of oriental drugs are increasing year by year in Korea. However, there is no official standards or even proposal of the professional organizations. One hundred and twenty usual profitable items of oriental drugs are selected and attempted to standardize their origins, appearances, properties, purities and identification reactions in order to evaluate those qualities.

• Herbal Formula Science
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• v.12 no.1
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• pp.93-104
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• 2004

Recently, more and more natural herbal products are investigated and used popularly. Pharmaceutical companies of Korea are very interested in developing herbal new drugs. And oriental doctors also need popular, modernized form of oriental drugs. The objective of this article is, first, to examine current situations of drug development in Korea, second, to know general concepts of patent and third, to think about new drug development and patent in oriental medicine's point of view. With consideration of oriental medicine's characteristics, concepts of new drug and patent should be improved. Therefore, the oriental pharmaceutical industry and developments of oriental new drugs could be inspired to further efforts.

• Journal of Society of Preventive Korean Medicine
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• v.5 no.1
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• pp.31-40
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• 2001

Legal permissible limit of herbal drugs metal level in Korea is define 'less 30.0ppm in total(except mineral drugs)' including Pb Hg Cd As Cr Ni etc. This limit has a lot of problems in several factors, that is, not divide hazard and essential elements, not consider high and low toxic effect in each metal, not calculate dose-response relationship and average health behavior in Korean etc. As a that result, It has strong limits and weakness in the basic toxicology and Oriental medicine. To improve and correct these factors, We need to several new approach as like below. It must be radical study following problems in short and middle-long period in the future, toxic metal and essential element must be divide to basic toxicology and also be diverse toxic effect. But mineral drugs that included a amount of severe toxic metals is being used as active prescription drug until now. If toxic, safety and side-effect of metals will be considered, mineral drugs must prohibit instantly or use at least after examined toxic effect. But one of the most important things about herbal drugs contamination, all people and department (government, farmer and trader, oriental medicine doctors and association) will be participate cooperative and collection for preventive or the least contamination in herbal drugs.

• Herbal Formula Science
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• v.10 no.1
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• pp.13-28
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• 2002

From the study of the definition of and intoxication, detoxication poisonous drug, the symptom and treatment of intoxication, andantidotes with DONG YUI BO GAM etc, it can be concluded as follows. 1. In ancint times, the poisonous drug was a drug which could treat diseases but after that it has been a drug which can injure one's health because it has severe property, poison or side effects 2. Intoxication means that poison goes and works in the body. Detoxication means treatment which clears the symptom of intoxication and removes the toxin in the body or on the body 3. At the intoxication's symptom, vomiting, madness, diarrhea, abdomianl pain, consumption are frequent in order 4. At the intoxication's treatment, vomiting method is used when poison is in the stomach, purgative method is used when poison is the intestine. 5. Mostly Hei-dou is used in drugs and Gan-kao. Qing-yan are used in order. 6. Mostly drugs of reliving fever are used in drugs. 7. Mostly cold drugs are used in drugs and warm, even, hot, cool drugs are used in order and mostly mild drugs are used in drugs and bitter, hot, salty, sore drugs are used in order.

• Journal of Oriental Neuropsychiatry
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• v.8 no.1
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• pp.111-125
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• 1997

This study was done in order to investigate Oriental Medicine's meaning on stress, the stress is due to animal experiments.Methods:This research was done by animal experiments's results based on 41 animal experiment treatises carried out by 24 prescriptions about stress control. Each experiments were compared with same conditions, minimizing the experiments differences. The results were analyzed by p-value and Increas e·Decrease percentage of experiments result's numerical value. Results:1. Inquire into frequency in use of each stress stimulus and measuring items, the restriction stimulus stress and measuring the content of catecholamines are numerous.2. Significance of stress stimuluses based on experments's results is good by restriction stimulus.3. Oriental Medicine's meaning for stress is pathological phenomenon of Seven Emotion(七情). Stagnant the Energy(氣鬱), the Fire(火), Dam(痰), Lack of the general Blood thing(血虛), and reaction of an individual body.4. Inguire into the effects of frequency in use of experiments's Herb drugs, Herb Drugs of Tonifing the general Blood thing depend on stabilized Mind(補血安神), Circulated the Energy and Digest(理氣消導), Tonifing the general Blood thing(補血), Clearing the Mind(淸心), Removing the Dam(祛痰) are numerous.5. From a Sasang Medical point of view, experimental use of Herb Drugs are Soeum-in(少陰人) Herb Drugs are numerous.According to above results, it is considered that Herb Drugs of Tonifing the general Blood thing depend on stabilized Mind(補血安神), Circulated the Energy and Digest(理氣消導), Tonifing the general Blood thing(補血), Clearing the Mind(淸心), Removing the Dam(祛淡), and Soeum-in(少陰人) Herb Drugs are used to prevent stress and related diseases.