• 보건의료산업학회지
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• 제10권2호
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• pp.133-144
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• 2016

Objectives : This study sought to identify the predisposing factors which influence the adolescent oral health enhancement behavior by analyzing controlling effects depending on the parents' oral health care behaviors in the relationship between the predisposing factors and adolescent behavior improvements which enhance oral health. Methods : A structured, self-administered questionnaire was given from July 6 through July 24, 2016. The collected data were analyzed with the SPSS 18.0 program. Results : Parents' oral health behaviors in terms of discipline and guidance showed a controlling effect in terms of importance (${\beta}$=.116) and benefits (${\beta}$=.133). In addition, the analysis showed that the parents' oral health care behavior had a controlling effect in terms of benefits (${\beta}$=.164) and susceptibility (${\beta}$=-.116). Conclusions : From the results of this study, the development of materials and education courses to lead to behavior changes are thought to be necessary in order to enhance the importance and benefits of the factors of oral health beliefs and to reduce psychological discomfort. Moreover, the role of parents with regard to desirable habits and beliefs to maintain oral health in their children is essential.

• 한국치위생학회지
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• 제21권2호
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• pp.141-150
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• 2021

Objectives: This study aimed to investigate oral health-related knowledge in adults and to determine the effect of oral health knowledge on correct brushing and use of dental care products. Methods: The subjects of this study were 552 adults who visited dental clinic, and a self-administered questionnaire was administered. Statistical analysis was performed using the t-test, ANOVA, and multiple regression using the SPSS statistics program (ver. 23.0, IBM Co., Chicago, IL, USA). Results: The oral health knowledge level, correct brushing, and dental care product usage scores were found to be positively correlated (r=0.015, 0.016), and both correlation coefficients were statistically significant (p<0.05). Oral health knowledge was found to have a significant effect on correct brushing among oral health promotion behaviors (β=0.116, p=0.006), but it was not found to have a significant effect on the use of dental care products (β=0.053, p=0.214). Conclusions: Oral health promotion behavior is closely related to oral health knowledge, and it is thought that oral health promotion behavior can be improved by raising oral health knowledge levels.

• International Journal of Oral Biology
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• 제32권4호
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• pp.135-141
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• 2007

Anti-proliferation of methanol extract of Curcuma rhizome on oral squamous cell carcinoma (KB) and osteosarcoma (HOS) cells were investigated. In order to elucidate the involvement of telomerase inhibitory activity as a part of anti-proliferative effect of Curcuma rhizome on cancer cells, we measured telomerase activity in Curcuma rhizome extract-treated cancer cells. The concentration inhibited cell proliferation to 50% $(IC_{50})$ of the methanol extract of Curcuma rhizome against oral squamous cell carcinoma (KB) cells and osteosarcoma (HOS) cells were 21.30 ${\mu}g/ml$ and 39.3${\mu}g/ml$, respectively. The methanol extract of Curcuma rhizome showed inhibitory telomerase inhibitory effect which is required for cancer cell immortality. Therefore, it seems that the anticancer effect of methanol extract of Curcuma rhizome is at least partially due to telomerase inhibitory effect. Five fraction samples were prepared according to its polarity differences and analyzed anti-proliferative effects of each fraction samples on oral squamous cell carcinoma and osteosarcoma cells. Anticancer effect was observed in dichloromethane, and ethylacetate fractions. The highest anticancer effect was found in dichloromethane fraction which had $IC_{50}$ value of 23.3 ${\mu}g/ml$ and 10.5${\mu}g/ml$ against oral squamous cell carcinoma (KB) cells and osteosarcoma (HOS) cells, respectively.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권6호
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• pp.583-590
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• 2007

Anticancer effect of methanol extract of Caesalpinia sappan L. on oral carcinoma(KB) and osteosarcoma(HOS) cells were investigated in this study. In order to elucidate the anticancer mechanism of Caesalpinia sappan L, we analyzed telomerase inhibitory effect of the methanol extract of Caesalpinia sappan L. In addition, we prepared 5 fraction samples according to its polarity differences and analyzed anticancer effects on oral carcinoma and osteosarcoma cells. Following results are obtained in this study. 1. 50% cell proliferation inhibitory value($IC_{50}$) of the methanol extract of Caesalpinia sappan L. against oral carcinoma(KB) cells and osteosarco ma(HOS) cells were $9.0{\mu}g/ml\;and\;10.9{\mu}g/ml$, respectively. 2. The methanol extract of Caesalpinia sappan L. showed inhibitory effect of telomerase which is required for cancer cell immortality. Therefore, it seems that the anticancer effect of methanol extract of Caesalpinia sappan is at least partially due to telomerase inhibitory effect. 3. Five fraction samples were prepared according to its polarity and 88.7% of ingredient of total methanol extract was transferred to ethylacetate fraction. Thin layer chromatography analysis showed that dichloromethane fraction contained ingredient with relatively high polarity and ethylacetate fraction contained similar ingredient found in total methanol extract. 4. Anticancer effect was observed in n-hexane, dichloromethane, and ethylacetate fractions. The highest anticancer effect was found in dichloromethane fraction which had $IC_{50}$ value of $4.4{\mu}g/ml$ and > $4.0{\mu}g/ml$ against oral carcinoma(KB) cells and osteosarcoma(HOS) cells, respectively.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제27권4호
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• pp.281-288
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• 2001

Anticancer effect of methanol extract of Caesalpinia sappan L. on oral carcinoma (KB) and osteosarcoma (HOS) cells were investigated in this study. In order to elucidate the anticancer mechanism of Caesalpinia sappan L, we analyzed telomerase inhibitory effect of the methanol extract of Caesalpinia sappan L. In addition we prepared 5 fraction samples according to its polarity differences and analyzed anticancer effects on oral carcinoma and osteosarcoma cells. Following results are obtained in this study. 1. 50% cell proliferation inhibitory value ($IC_{50}$) of the methanol extract of Caesalpinia sappan L. against oral carcinoma (KB) cells and osteosarcoma (HOS) cells were $9.0{\mu}g/ml$ and $10.9{\mu}g/ml$, respectively. 2. The methanol extract of Caesalpinia sappan L. showed inhibitory effect of telomerase which is required for cancer cell immortality. Therefore, it seems that the anticancer effect of methanol extract of Caesalpinia sappan is at least partially due to telomerase inhibitory effect. 3. Five fraction samples were prepared according to its polarity and 88.7% of ingredient of total methanol extract was transferred to ethylacetate fraction. Thin layer chromatography analysis showed that dichloromethane fraction contained ingredient with relatively high polarity and ethylacetate fraction contained similar ingredient found in total methanol extract. 4. Anticancer effect was observed in n-hexane, dichloromethane, and ethylacetate fractions. The highest anticancer effect was found in dichloromethane fraction which had $IC_{50}$ value of 4.4 and $>4.0{\mu}g/ml$ against oral carcinoma (KB) cells and osteosarcoma (HOS) cells, respectively.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제34권1호
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• pp.1-10
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• 2008

Oral squamous cell carcinoma (OSCC) is the most frequent form of oral cancer and holds the eighth position in the cancer incidence ranking. OSCC patients are treated by classical therapeutic modalities consisting of surgery, radiotherapy, and/or chemotherapy. But OSCC still shows significant mortality rates. Thus, new therapeutic approaches have been investigated and the most promising one is naturally acquired agents with known anti-cancer effects. Genistein is a compound extracted from soy bean. Its anti-cancer effect on breast cancer is well established now and it is investigated whether it has similar effect on OSCC. It inhibited the growth and invasive-ness of OSCC cells in vitro, but these effects did not work in living animals in vivo. Catechin is a compound from green tea and its anti-cancer effect on OSCC is known better than other agents. Catechin showed its anti-cancer effect in vitro via induction of apoptosis, cell cycle arrest, inhibition of growth, and down-regulation of invasion/metastasis. These effects were confirmed in vivo with mouse model. Cordycepin is one of major pharmacologically important components in Cordyceps Militaris and may exert its anti-cancer effect as an adenosine receptor agonist. In recent study, it inhibited the proliferation of OSCC cells via A3 adenosine receptor. But because there is very scarce evidence on this effect, more researches are needed on this theme.

• International Journal of Oral Biology
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• 제39권2호
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• pp.75-79
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• 2014

The aim of this study was to investigate antimicrobial effect of oleanolic acid (OA), ursolic acid (UA), and sophoraflavanone G against Enterococcus faecalis and Propionibacterium acnes, which are the major causative bacteria of endodontic infections. The antimicrobial activity was evaluated by the minimal inhibitory concentration (MIC). The data showed that the OA, UA, and sophoraflavanone G had antimicrobial effect on all the strains use in the study with $16-64{\mu}g/ml$, $8-64{\mu}g/ml$, and $1-8{\mu}g/ml$ of MIC values, respectively. These results indicate that OA, UA, and sophoraflavanone G could be useful in the development of antiseptic solution for washing the root canal in endodontic treatments.

• 보건교육건강증진학회지
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• 제25권2호
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• pp.31-46
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• 2008

The purpose of this research is to increase adults' quality of life by improving oral health. Total 572 people participated in this study in Young-Nam area. Survey research method was used to measure various tools of participants' general index, subjective view of oral health status, oral health knowledge, oral health practice, dietary pattern, OHIP-14, THI, QOL for analyzing the effect on quality of life. The result of the study is summarized as follows; 1. Oral health knowledge has positive effects on oral health practice (0.442), dietary pattern(0.343). Diet has positive effects on OHIP-14(0.187) and OHIP-14 has significant positive effects on THI(0.564). THI also has positive effects on QOL(0.380). But oral health practice index has slight effects on OHIP-14(0.056). 2. Indirect effect indexes on QOL are OHIP-14(0.214), diet(0.040), oral health knowledge(0.019), oral health practice(0.012) listed in order of effect size, and the biggest direct effect on QOL is from THI(0.308). The result of this study shows oral health and total health are important to improve the quality of life. And the knowledge about oral health dietary pattern should be important to improve oral health. But, even with high level of oral health knowledge, the oral health practice is at low level. Health education developing program should be needed. It is required to present basic data which represent adults with national view by extracting groups using sample probability methods as of next task of this study.

• 한국치위생학회지
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• 제21권5호
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• pp.621-628
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• 2021

Objectives: The purpose of this study was to determine the differences in quality of life between groups that promote oral health and those that treat oral diseases using data from the National Health and Nutrition Examination Survey. Methods: Data analysis was performed using IBM SPSS ver. 21.0 (IBM Co., Armonk, NY, USA). A total of 3,338 subjects were selected as subjects for the study before applying oral health promotion (OHP; 1,132 persons) and oral disease treatment (ODT; 2,206 persons). Complex sample logistic regression analysis was performed to determine the effects of OHP and ODT on health-related quality of life. Results: As a result of confirming the effect of OHP and ODT on the quality of life, which are indicators of the quality of life, HINT-8 had a significant effect even in Model 2, adjusted for demographic characteristics, with a significant difference (p<0.01). Conclusions: The above results confirmed that persons who promote oral health have a significant effect on HINT-8, a quality of life scale developed for Koreans. Therefore, continuous oral care is required to improve quality of life.

• 보건의료산업학회지
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• 제8권2호
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• pp.221-232
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• 2014

This research aims to improve oral health knowledge through oral health education by investigating and analyzing the effect of subjective oral health knowledge and oral health behavior on personal oral hygiene management ability targeted for adults who visited a dental hygiene laboratory at B University in Busan for comprehensive dental hygiene management and procedure from September 23, 2013 to December 12, 2013, and provide basic data to improve adults' personal oral hygiene management ability by inducing behavior on oral health. Results derived from the research are as follows. Oral health education is a prerequisite to improve personal oral hygiene management ability through improvement in oral health knowledge and oral health behavior, which leads to improved personal oral health and furthermore promotion of national oral health through not just simply transmitting oral health knowledge, but desirable change in oral health behavior based on oral health knowledge.