• Title/Summary/Keyword: optimizing

Search Result 2,946, Processing Time 0.038 seconds

Improvement of Growth and Benzo[c]phenanthridine Alkaloids Production by Modifying Nitrogen Source in Suspension Cell Culture of Eschscholtzia californica (Eschscholtzia californica의 현탁 세포배양에서 질소원 조절에 의한 세포 성장 및 Benzo[c]phenanthridine Alkaloids 생산량 향상)

  • Lee, Song-Eun;Rhee, Hong-Soon;Son, Seok-Young;Park, Jong-Moon
    • KSBB Journal
    • /
    • v.24 no.2
    • /
    • pp.195-200
    • /
    • 2009
  • The effect of nitrogen source on cell growth and benzo[c]phenanthridine alkaloids production by modifying $NO_3\;^-:NH_4\;^+$ ratio in cell suspension culture of Eschscholtzia califarnica was investigated. When total nitrogen concentration is maintained (60 mM), maximum benzo[c]phenanthridine alkaloids production is about 60.72 mg/L at 50:10 (mol/mol). This productivity was 3.8 times higher than that obtained when cells were grown instandard MS medium. The decrease of $NO_3\;^-:NH_4\;^+$ ratio at 60 mM of total nitrogen caused the decline of both growth and benzo[c]phenanthridine alkaloids production. Under the same concentration of $N0_3\;^-$ (50 mM), higher concentration of $NH_4\;^+$ inhibited cell growth strongly but induced alkaloids production slightly. Also, under the same concentration of $NH_4\;^+$ (25 mM), higher concentration of $N0_3\;^-$ induced alkaloids production strongly but high concentration of $N0_3\;^-$ (${\geq}$100 mM) interfered alkaloids instead. Maximum benzo[c]phenanthridine alkaloids production is about 62.71 mg/L at 50:25 (mol/mol). These results suggest that higher biomass and higher alkaloids production could be obtained by optimizing each nitrogen concentration as well as $NO_3\;^-:NH_4\;^+$ ratio in the culture medium. Nitrate and ammonium in culture medium have distinct role in the regulation of growth and alkaloids production; ammonium had a strong influence on growth while nitrate had an influence on alkaloids production.

A case study on the importance of non-intrusiveness of mobile devices in an interactive museum environment (인터랙티브 전시환경에서 모바일 디바이스의 비간섭적 특성의 중요성에 대한 사례 연구)

  • Rhee, Boa
    • Journal of the Korea Society of Computer and Information
    • /
    • v.18 no.1
    • /
    • pp.31-42
    • /
    • 2013
  • This research sheds light on the non-intrusive traits of mobile devices (Electronic Guidebook, Rememberer, I-Guides and eXspot) deployed in Exploratorium for enhancing visitor experience via case studies. In an interactive exhibition environment, non-intrusiveness was the key to supporting the immersive experience and meaning-making for visitors. The usability of hand-held devices directly impacted on the non-intrusiveness, thereby reshaping the form-factors of mobile devices. The change in from-factor has also minimized the functions of devices as the remember of museum experience. Furthermore, the role of mobile devices, which turned from a supposed multi-media guide to a mere rememberer, made them virtually impossible for realizing the "seamless visiting model" originally planned. An array of projects carried out in Exploration have achieved some degree of success such as increasing viewing time as well as reinforcing post-visit activities. However, taken from musicological perspective, increase in viewing time is by all means insufficient to be taken as proof since it is assumed to be achieved by photo-taking (i.e. MyExploratorium) rather than by interacting between visitors and exhibits. This issue --increased viewing time -- needs to be analyzed in depth. All in all, mobile devices used in Exploratorium can be defined as a learning tool/educational supporting medium based on personalization for (visitors') optimizing extended museum experience.

A LQR Controller Design for Performance Optimization of Medium Scale Commercial Aircraft Turbofan Engine (II) (중형항공기용 터보팬 엔진의 성능최적화를 위한 LQR 제어기 설계 (II))

  • 공창덕;기자영
    • Journal of the Korean Society of Propulsion Engineers
    • /
    • v.2 no.3
    • /
    • pp.99-106
    • /
    • 1998
  • The performance of the turbofan engine, a medium scale civil aircraft which has been developing in Rep. of Korea, was analyzed and the control scheme for optimization the performance was studied. The dynamic and real-time linear simulation was performed in the previous study The result was that the fuel scedule of the step increase overshoot the limit temperature(3105 $^{\cire}R$) of the high pressure turbine and got small surge margine of the high pressure compressor. Therefore a control scheme such as the LQR(Linear Quadratic Regulator) was applied to optimizing the performance in this studies. The linear model was expected for designing controller and the real time linear model was developed to be closed to nonlinear simulation results. The system matrices were derived from sampling operating points in the scheduled range and then the least square method was applied to the interpolation between these sampling points, where each element of matrices was a function of the rotor speed. The control variables were the fuel flow and the low pressure compressor bleed air. The controlled linear model eliminated the inlet temperature overshoot of the high pressure turbine and obtained maximum surge margins within 0.55. The SFC was stabilized in the range of 0.355 to 0.43.

  • PDF

A Study of the Construction in order to 24/25 I-NRZI Modulator Designs for DVCR (DVCR용 24/25 I-NRZI 변조기의 설계를 위한 구조 고찰)

  • Park, Jong-Jin;Kook, Il-Ho;Kim, Eun-Won;Cho, Won-Kyung
    • Journal of the Institute of Electronics Engineers of Korea TE
    • /
    • v.37 no.1
    • /
    • pp.35-41
    • /
    • 2000
  • This paper considers the consturction of 24/25 I-NRZI (Interleaved - Non Return to Zero Inverse) modulator designs for DVCR (Digital Video Cassette Recorder), and size of validity bit in order to store the amplitude value of square-wave and the standard data ( sine and cosine coefficients) at ROM Table that to acceptable the spectrum standard. The validity bit size of the standard data and the amplitude value of square-wave that to store at ROM Table are affected the size of pilot signal on the output spectrum, and the hardware size of modulator. At the designable 24/25 I-NRZI modulator, we simulated using random pattern (F0,F1,F2) that to verification the output data of the spectrum. Moreover, the resultant of the spectrum analysis, at the optimizing value, is 0.065 on the amplitude value of square-wave, and 3bit on the size of bit in order to store the standared data at ROM Table. In order to verify the hardware of designable 24/25 I-NRZI modulator, we perform to modeling of C-language firstly, and coding to Verilog HDL (Cadence Verilog XL) and synthesized using Synopsys (Library "Samsung KG75") tool as a base of spectrum results. In a foundation of this result, we are considered the size of hardware. In this paper, a considerable 24/25 I-NRZI modulator designable less than 10,000 gates as that is improved consturction as regards the path method of pre-coder etc, and able to application digital camcorders as now practical use.

  • PDF

Measurement of EMC/PCB Interfacial Adhesion Energy of Chip Package Considering Warpage (휨을 고려한 칩 패키지의 EMC/PCB 계면 접합 에너지 측정)

  • Kim, Hyeong Jun;Ahn, Kwang Ho;Oh, Seung Jin;Kim, Do Han;Kim, Jae Sung;Kim, Eun Sook;Kim, Taek-Soo
    • Journal of the Microelectronics and Packaging Society
    • /
    • v.26 no.4
    • /
    • pp.101-105
    • /
    • 2019
  • The adhesion reliability of the epoxy molding compound (EMC) and the printed circuit board (PCB) interface is critical to the quality and lifetime of the chip package since the EMC protects PCB from the external environment during the manufacturing, storage, and shipping processes. It is necessary to measure adhesion energy accurately to ensure product reliability by optimizing the manufacturing process during the development phase. This research deals with the measurement of EMC/PCB interfacial adhesion energy of chip package that has warpage induced by the coefficient of thermal expansion (CTE) mismatch. The double cantilever beam (DCB) test was conducted to measure adhesion energy, and the spring back force of specimens with warpage was compensated to calculate adhesion energy since the DCB test requires flat substrates. The result was verified by comparing the adhesion energy of flat chip packages come from the same manufacturing process.

Optimization of PRISM Parameters and Digital Elevation Model Resolution for Estimating the Spatial Distribution of Precipitation in South Korea (남한 강수량 분포 추정을 위한 PRISM 매개변수 및 수치표고모형 최적화)

  • Park, Jong-Chul;Jung, Il-Won;Chang, Hee-Jun;Kim, Man-Kyu
    • Journal of the Korean Association of Geographic Information Studies
    • /
    • v.15 no.3
    • /
    • pp.36-51
    • /
    • 2012
  • The demand for a climatological dataset with a regular spaced grid is increasing in diverse fields such as ecological and hydrological modeling as well as regional climate impact studies. PRISM(Precipitation-Elevation Regressions on Independent Slopes Model) is a useful method to estimate high-altitude precipitation. However, it is not well discussed over the optimization of PRISM parameters and DEM(Digital Elevation Model) resolution in South Korea. This study developed the PRISM and then optimized parameters of the model and DEM resolution for producing a gridded annual average precipitation data of South Korea with 1km spatial resolution during the period 2000-2005. SCE-UA (Shuffled Complex Evolution-University of Arizona) method employed for the optimization. In addition, sensitivity analysis investigates the change in the model output with respect to the parameter and the DEM spatial resolution variations. The study result shows that maximum radius within which station search will be conducted is 67km. Minimum radius within which all stations are included is 31km. Minimum number of stations required for cell precipitation and elevation regression calculation is four. Optimizing DEM resolution is $1{\times}1km$. This study also shows that the PRISM output very sensitive to DEM spatial resolution variations. This study contributes to improving the accuracy of PRISM technique as it applies to South Korea.

Seismic Performance-based Design using Computational Platform for Structural Design of Complex-shaped Tall Building (전산플랫폼을 이용한 비정형 초고층 건축물 성능기반 내진설계기술의 실무적용)

  • Lee, Dong-Hun;Cho, Chang-Hee;Youn, Wu-Seok;Kang, Dae-Eon;Kim, Taejin;Kim, Jong-Ho
    • Journal of the Computational Structural Engineering Institute of Korea
    • /
    • v.26 no.1
    • /
    • pp.59-67
    • /
    • 2013
  • Complex-shaped tall building causes many structural challenges due to its structural characteristics regarding inclined members and complexed shape. This paper is aimed at development of design process using computational-platform which is effective design tool for responding frequent design changes, particularly as to overseas projects. StrAuto, a parametric structural modeling and optimizing system, provides the optimized alternatives according to design intent and realize a swift process converting a series of structural information necessary to nonlinear analytical models. The application of the process was to a 45-story hotel building in Ulanbator, Mongolia adopting shear wall and special moment frame with outrigger systems. To investigate the safety of lateral force resisting system against maximum considered earthquake(MCE), nonlinear response history analysis was conducted using StrAuto.

Optimization for the Phytosterol Extraction and Production of Structured Lipids from Safflower seed (홍화씨로부터 Phytosterol 추출의 최적화 및 재구성지질의 합성)

  • 박래균;이기택
    • Food Science and Preservation
    • /
    • v.10 no.2
    • /
    • pp.219-223
    • /
    • 2003
  • Response surface methodology was used for monitoring and optimizing the extraction conditions of campesterol, stigmasterol, ${\beta}$ -sitosterol, and total sterols from the safflower seed. The conditions of phytosterol extraction were optimized by using central composite design with the temperature(35∼75$^{\circ}C$, X$_1$), the time (1∼11hr, X$_2$), and the preheating temperature(60∼100$^{\circ}C$, X$_3$) as three variables. The extraction conditions for maximum campesterol content were 59.01$^{\circ}C$(X$_1$), 2.88hr(X$_2$), and 75.04$^{\circ}C$(X$_3$). But stigmasterol, ${\beta}$ -sitosterol and total sterols were not significantly different under designed extraction condition in this study. Besides, oil was extracted from safflower seed at various conditions and yields were 23.44% at 35$^{\circ}C$ and 20.05% at 80$^{\circ}C$, respectively. Total tocopherol content increased from 0.172% to 0.207% as the extraction temperature increased from 35$^{\circ}C$ to 80$^{\circ}C$. A structured lipids(SL) was synthesized enzymatically by extracted safflower oil and conjugated linoleic acid(CLA). After 24hr reaction, 31.79 mol% CLA was incorporated into the extracted safflower oil.

A study on the oxide etching using multi-dipole type magnetically enhanced inductively coupled plasmas (자장강화된 유도결합형 플라즈마를 이용한 산화막 식각에 대한 연구)

  • 안경준;김현수;우형철;유지범;염근영
    • Journal of the Korean Vacuum Society
    • /
    • v.7 no.4
    • /
    • pp.403-409
    • /
    • 1998
  • In this study, the effects of multi-dipole type of magnets on the characteristics of the inductively coupled plasmas and $SiO_2$ etch properties were investigated. As the magnets, 4 pairs of permanent magnets were used and, to etch $SiO_2, C_2F_6, CHF_3, C_4F_8, H_2$, and their combinations were used. The characteristics of the magnetized inductively coupled plasmas were investigated using a Langmuir probe and an optical emission spectrometer, and $SiO_2$ etch rates and the etch selectivity over photoresist were measured using a stylus profilometer. The use of multi-dipole magnets increased the uniformity of the ion density over the substrate location even though no significant increase of ion density was observed with the magnets. The use of the magnets also increased the electron temperature and radical densities while reducing the plasma potential. When $SiO_2$ was etched using the fluorocarbon gases, the significant increase of $SiO_2$ etch rates and also the increase of etch uniformity over the substrate were obtained using the magnets. In case of gas combinations with hydrogen, $C_4F_8/H_2$ showed the highest etch rates and etch selectivities over photoresist among the gas combinations with hydrogen used in the experiment. By optimizing process parameters at 1000 Watts of inductive power with the magnets, the highest $SiO_2$ etch rate of 8000 $\AA$/min could be obtained for 50% $C_4F_8/50% H_2$.

  • PDF

Development of Glucoamylase & Simultaneous Saccharification and Fermentation Process for High-yield Bioethanol (고효율 바이오 에탄올 생산을 위한 당화효소 개발 및 동시당화발효 공정 연구)

  • Choi, Gi-Wook;Han, Min-Hee;Kim, Yule
    • KSBB Journal
    • /
    • v.23 no.6
    • /
    • pp.499-503
    • /
    • 2008
  • The bioethanol for use as a liquid fuel by fermentation of renewable biomass as an alternative to petroleum is important from the viewpoint of global environmental protection. Recently, many scientists have attempted to increase the productivity of bioethanol process by developing specific microorganism as well as optimizing the process conditions. In the present study, which is based on our previous investigation on the pretreatment process, theproductivity of bioethanol obtained from simultaneous saccharification and fermentation (SSF) process was compared between various domestic materials including barley, brown rice, corn and sweet potato. Additionally, Solid glucoamylase (SGA; developed in Changhae Co.), from modified strain with UV, was used. The result was compared to commercial glucoamylase (GA). It was observed that the fermentation rate was increased together with the yield which can be derived from the final ethanol concentration. Especially, in the case of brown rice, compared to the experimental results using GA, the final ethanol concentration was 1.25 times higher and 18.4 g/L of the yield was increased. Also, the time required for reaching 95% of the maximum ethanol concentration is significantly reduced, which is approximately 36 hours, compared to 88 hours using GA. It means that SGA has excellent saccharogenic power.