• Transactions on Electrical and Electronic Materials
• /
• v.13 no.6
• /
• pp.310-316
• /
• 2012

A new method for early caries diagnosis was proposed and tested through a home-made optical examination system that used quantitative light fluorescence (QLF) and digital imaging fiber optic transillumination (FOTI) (DIFOTI), with light sources across a wide spectral range, from 350 nm to 1,000 nm. The front-illuminated infrared light scattering image (FIR) showed similar diagnostic abilities to that of DIFOTI. The FIR method was invented based on the observation that caries lesions lose the high transmittance and low scattering properties of benign enamel tissue. There are various methods for the early diagnosis of caries, such as visual examination, exploration, X-ray radiography, QLF, FOTI, and infrared fluorescence (diagnodent). Among them, methods based on optical properties are regarded as having the most potential. A comparative study was performed between the FOTI, QLF, diagnodent, optical coherence tomography, and FIR scattering image methods, using 20 extracted teeth samples with early caries. A scale of lesion measurement based on optical image contrast was proposed. The statistical analysis showed a significant correlation between the DIFOTI and FIR methods (r = 0.35, p < 0.05). However, the QLF and diagnodent methods showed little association with FIR images, as they have different detection principles as compared with FIR. Tomographic images obtained by OCT, using 1,330 nm super luminescent LED as a gold standard of tooth structure, verified that the FOTI and FIR results correctly represented the lack of homogeneity in dental tissue. The newly proposed FIR method attained similar diagnostic results to those of FOTI, but with an easier approach.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2015.08a
• /
• pp.223.1-223.1
• /
• 2015

본 연구에서는 지름이 다른 두 개의 디스크가 적층된 구조를 갖는 금 나노 구조체를 제작하고 그 광학적 특성에 대해 연구하였다. 나노임프린팅을 통하여 패턴된 폴리머 포어 어레이에 금 박막을 증착하고, 포어 내부에 증착된 금 나노구조체를 선택적으로 수거하는 방법을 이용하였다 [1]. 특히 금 증착 시, 빗각으로 증착 (oblique-angle deposition)을 하여 지름이 다른 두 개의 디스크가 적층되어 있는 구조를 형성하는 것이 가능하였다. 증착 각도의 조절을 통해 적층된 두 디스크의 지름 비율을 변화시킬 뿐만 아니라, 2차원 디스크 형태의 나노구조체부터 3차원 디쉬 형태의 구조체도 제작이 가능함을 확인하였다. 제안된 하향식 나노공정을 통하여 합성된 금 나노구조체를 이용하여 광열 전환(photothermal heat conversion)과 광 간섭성 단층 (optical coherence tomography) 측정을 진행하였고, 서로 다른 두 개의 디스크가 적층된 형태의 금 나노구조체는 상용 금 나노로드 (Au nanorod) 보다 높은 광 열 전환 효율을 갖을 뿐 아니라 우수한 OCT 이미징 특성을 보였다. 광열 전환 및 OCT 이미징 실험 결과는 각각 플라즈모닉 나노구조의 광흡수, 광산란 특성에 기반하므로, 본 연구를 통하여 제안된 금 나노구조체는 광흡수 및 광산란을 기반한 바이오이미징 나노프로브로 유용하게 사용될 수 있을 것으로 전망된다.

• Parasites, Hosts and Diseases
• /
• v.52 no.5
• /
• pp.537-540
• /
• 2014

We present a case of ocular toxocariasis treated successfully with oral albendazole in combination with steroids. A 26-year-old male visited the authors' clinic with the chief complaint of flying flies in his right eye. The fundus photograph showed a whitish epiretinal scar, and the fluorescein angiography revealed a hypofluorescein lesion of the scar and late leakage at the margin. An elevated retinal surface and posterior acoustic shadowing of the scar were observed in the optical coherence tomography, and Toxocara IgG was positive. The patient was diagnosed with toxocariasis, and the condition was treated with albendazole (400 mg twice a day) for a month and oral triamcinolone (16 mg for 2 weeks, once a day, and then 8 mg for 1 week, once a day) from day 13 of the albendazole treatment. The lesions decreased after the treatment. Based on this study, oral albendazole combined with steroids can be a simple and effective regimen for treating ocular toxocariasis.

• Journal of IKEEE
• /
• v.15 no.2
• /
• pp.122-128
• /
• 2011

Although conventional analog linescan cameras are used widely, high-speed, high-resolution Cameralink standard will lead the area of frame grabber industry such as factory automation. In this paper, we are developing embedded frame grabber testbed without PC which will give an another solution to image processing applications. Therefore, we designed hardware schematics and programmed FPGA device with VHDL in order to interface Cameralink standard linescan CCD camera. In the future, our embedded on-chip controller could be applied to various image processing systems such as medical imaging, especially optical coherence tomography, machine vision and industrial electronics.

• Journal of Korea Multimedia Society
• /
• v.22 no.11
• /
• pp.1269-1279
• /
• 2019

In medical image analysis, segmentation is considered as a vital process since it partitions an image into coherent parts and extracts interesting objects from the image. In this paper, we consider automatic segmentations of OCT retinal images to find six layer boundaries using convolutional neural networks. Segmenting retinal images by layer boundaries is very important in diagnosing and predicting progress of eye diseases including diabetic retinopathy, glaucoma, and AMD (age-related macular degeneration). We applied well-known CNN architecture for general image segmentation, called Segnet, U-net, and CNN-S into this problem. We also proposed a shortest path-based algorithm for finding the layer boundaries from the outputs of Segnet and U-net. We analysed their performance on public OCT image data set. The experimental results show that the Segnet combined with the proposed shortest path-based boundary finding algorithm outperforms other two networks.

• Journal of Biomedical Engineering Research
• /
• v.32 no.4
• /
• pp.285-288
• /
• 2011

In this study, we developed an optical coherence tomography(OCT) using a sweep-source laser whose center wavelength is 1310 nm and a probe of hand-held type. The developed hand-held probe targets to diagnose the middle ear, so it is miniaturized for ease and convenience of control. For the first time, we performed in-vivo clinical experiments on tympanic membrane(TM) perforation patients not reported from previous studies about OCT. The high-resolution sectional images of tympanic membrane perforation can be obtained. There aren't many studies about diagnostic instrument of the middle ear and diagnosis with sectional image of the middle ear, so the developed OCT system and hand-held probe are applicable to tympanic membrane perforation and other pathologic diagnosis in the middle ear.

• Korean Journal of Optics and Photonics
• /
• v.18 no.5
• /
• pp.345-350
• /
• 2007

The characteristics of the supercontinuum generated in photonic crystal fibers were investigated by using the generalized nonlinear $Schr\"{o}dinger$ equation and the split-step Fourier method. Based on the simulated results, we generated the supercontinuum spectrum with the flatness of ${\pm}4dB$ in the wavelength range of 650 to 900 nm by employing a 200-fs pulse of Ti:sapphire laser and a commercial photonic crystal fiber.

• Current Optics and Photonics
• /
• v.5 no.3
• /
• pp.311-321
• /
• 2021

Indocyanine green (ICG) is a dye approved for use in clinical diagnostics. ICG remains in the intravascular space following intravenous administration, due to its ability to rapidly bind to the plasma proteins, and its therapeutic potential has been studied in well-vascularized cutaneous tumors. Here we have evaluated the clinical response of a subconjunctival tumor to photothermal therapy (PTT) using an ICG-enhanced near-infrared diode laser and its adverse effects, in a rabbit. 22 male New Zealand white rabbits with subconjunctival tumors were enrolled (control group 6, laser-only group 8, laser-with-ICG group 8). Rabbits in the laser-with-ICG group received ICG (twice, 2 mg/kg each time, intravenously) directly followed by irradiation with a diode laser (λ = 810 nm). Rabbits in the laser-only group were irradiated with the diode laser. ICG angiography, ultrasonography, and pathologic examination were performed to evaluate PTT response at specific time points (0, 2, and 4 weeks after PTT). Two weeks after initial treatment, the eight rabbits treated by laser with ICG showed a 100% response rate. There was no clinical response in both laser-only and control groups. ICG-PTT is a potential and effective palliative therapeutic modality for subconjunctival tumors.

• Journal of Yeungnam Medical Science
• /
• v.34 no.1
• /
• pp.111-114
• /
• 2017

Central serous chorioretinopathy may induce poor eyesight and serous retinal detachment. However, its exact cause has not been well established thus far. It can be associated with systemic high-dose corticosteroid treatment mainly for young and middle-aged men and may spontaneously regress or recur after withdrawal from corticosteroid. After corticosteroid administration for Behcet's disease, it is necessary to identify any ocular symptoms. Behcet's disease can lead to the development of ocular complications, such as uveitis, hypopyon, retinal vasculitis, optic neuritis, angiogenesis, secondary cataract, and glaucoma. It is possible to diagnose any of these complications via optical coherence tomography and digital indocyanine green angiography. It is easy to neglect an ocular symptom that may appear after a low-dose corticosteroid treatment as an ocular complication in patients with Behcet's disease. Thus, we report on a case concerning high-dose corticosteroid treatment with a literature review.

• 한국균학회소식:학술대회논문집
• /
• 2014.10a
• /
• pp.36-36
• /
• 2014

Apple blotch, caused by Marssonina coronaria, induce early defoliation in apple and leading to critical economic losses in apple orchards in Korea. Since M. coronaria is difficult to culture, we developed isolation and cultural method. We collected M. coronaria isolates from Gyeongbuk Province and then constructed phylogentic tree based on ITS regions. As the results, phylogenetic relationship indicated that all Korean isolates formed a same cluster and closely related to Chinese isolates [1]. Ecological characteristic of M. coronaria have been observed in apple orchards which located in Gyeongbuk Province from 2011 to present. As the results, the typical apple blotch symptoms were observed from July, and then the infected leaves were discolored and formed acervuli on the leaves. After rainfall, severe infection of symptoms such as discoloration and early defoliation were continuously observed until October. Also overwintered conidia were observed in next March on the fallen diseased leaves [2]. In the last 5 years, ascopores of M. coronaria were not observed in apple orchards which were severely infected by M. coronaria in Korea. Thus, it is assumed that overwintered conidia could be a primary inoculum of M. coronaria. Meanwhile, apple blotch has long latent periods compare to other apple disease. During the latent period, early diagnosis of apple blotch is the most important to control the disease by spray fungicide. In this reason, we developed novel diagnostic method to detect M. coronaria during latent period using optical coherence tomography (OCT) and Loop-mediated isothermal amplification (LAMP) method [2, 3]. In this presentation, it will introduce ecological characterization of M. coronaria in Korea and unique detection technique of M. coronaria in apple. It will be helpful to develop new strategies to control apple blotch in Korea.