Current Optics and Photonics

Optical Society of Korea (한국광학회)
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In Vivo Enhanced Indocyanine Green-Photothermal Therapy for a Subconjunctival Tumor

  • Kim, Chang Zoo (Department of Ophthalmology, Kosin University College of Medicine) ;
  • Lee, Sang Joon (Department of Ophthalmology, Kosin University College of Medicine) ;
  • Hwang, Sang Seok (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University) ;
  • Chae, Yu-Gyeong (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University) ;
  • Kwon, Daa Young (Kosin Innovative Smart Healthcare Research Center, Kosin University Gospel Hospital) ;
  • Ko, Taek Yong (Kosin Innovative Smart Healthcare Research Center, Kosin University Gospel Hospital) ;
  • Kim, Jun Hyeong (Department of Internal Medicine, Kosin University College of Medicine) ;
  • Jung, Min Jung (Department of Pathology, Kosin University College of Medicine) ;
  • Masanganise, Rangarirai (Department of Ophthalmology, University of Zimbabwe College of Medicine) ;
  • Oak, Chulho (Kosin Innovative Smart Healthcare Research Center, Kosin University Gospel Hospital) ;
  • Ahn, Yeh-Chan (Kosin Innovative Smart Healthcare Research Center, Kosin University Gospel Hospital)
  • Received : 2020.08.21
  • Accepted : 2021.02.02
  • Published : 2021.06.25
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Abstract

Indocyanine green (ICG) is a dye approved for use in clinical diagnostics. ICG remains in the intravascular space following intravenous administration, due to its ability to rapidly bind to the plasma proteins, and its therapeutic potential has been studied in well-vascularized cutaneous tumors. Here we have evaluated the clinical response of a subconjunctival tumor to photothermal therapy (PTT) using an ICG-enhanced near-infrared diode laser and its adverse effects, in a rabbit. 22 male New Zealand white rabbits with subconjunctival tumors were enrolled (control group 6, laser-only group 8, laser-with-ICG group 8). Rabbits in the laser-with-ICG group received ICG (twice, 2 mg/kg each time, intravenously) directly followed by irradiation with a diode laser (λ = 810 nm). Rabbits in the laser-only group were irradiated with the diode laser. ICG angiography, ultrasonography, and pathologic examination were performed to evaluate PTT response at specific time points (0, 2, and 4 weeks after PTT). Two weeks after initial treatment, the eight rabbits treated by laser with ICG showed a 100% response rate. There was no clinical response in both laser-only and control groups. ICG-PTT is a potential and effective palliative therapeutic modality for subconjunctival tumors.

Keywords

Acknowledgement

This study was supported by a grant from the National Research Foundation of Korea (NRF) (2019M3E5D1A02070860, 2019M3E5D1A02070862, 2019M3E5D1A02070866, 2017R1D1A1B03035048).

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