• The Korean Journal of Malacology
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• v.28 no.3
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• pp.277-291
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• 2012

Aquaculture is challenged by a number of constraints with future efforts towards sustainable production. Global climate change has a potential damage to the sustainability by changing environmental surroundings unfavorably. The damaging parameters identified are water temperature, sea level, surface physical energy, precipitation, solar radiation, ocean acidification, and so on. Of them, temperature, mostly temperature elevation, occupies significant concern among marine ecologists and aquaculturists. Ocean acidification particularly draws shellfish aquaculturists' attention as it alters the marine chemistry, shifting the equilibrium towards more dissolved CO2 and hydrogen ions ($H^+$) and thus influencing signaling pathways on shell formation, immune system, and other biological processes. Temperature elevation by climate change is of double-sidedness: it can be an opportunistic parameter besides being a generally known damaging parameter in aquaculture. It can provide better environments for faster and longer growth for aquaculture species. It is also somehow advantageous for alleviation of aquaculture expansion pressure in a given location by opening a gate for new species and aquaculture zone expansion northward in the northern hemisphere, otherwise unavailable due to temperature limit. But in the science of climate change, the ways of influence on aquaculture are complex and ambiguous, and hence are still hard to identify and quantify. At the same time considerable parts of our knowledge on climate change effects on aquaculture are from the estimates from data of fisheries and agriculture. The consequences may be different from what they really are, particularly in the temperature region. In reality, bivalves and tunicates hung or caged in the longline system are often exposed to temperatures higher than those they encounter in nature, locally driving the farmed shellfish into an upper tolerable temperature extreme. We review recent climate change and following environment changes which can be factors or potential factors affecting shellfish aquaculture production in the temperate region.

• Korean Journal of Acupuncture
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• v.32 no.4
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• pp.151-159
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• 2015

Objectives : Pulse diagnosis is considered particularly important among several methods of diagnosis in DongUiBoGam. In spite of its importance, numerous and various pulse descriptions made it difficult to learn and practice pulse diagnosis. In this article, we tried to analyze properties of the twenty-seven pulses from pulse diagnosis cases from DongUiBoGam to enable the practical understanding of pulse diagnosis. Methods : We constituted the four axis according to the eight important pulses. And we analyzed properties of the twenty-seven pulses through the relationship between the four pairs of important pulses and the twenty-seven pulses. To quantify the relevances of important pulses to the twenty-seven pulses, we used the term frequency-inverse document frequency(TF-IDF) method. Results : We could elicit properties of the twenty-seven pulses according to the four axis. Also, we reexamined the categorization of the seven exterior pulses / the eight interior pulses and the similar pulses from DongUiBoGam with the analysis results. Conclusions : We could understand properties of the twenty-seven pulses more specifically with the eight important pulses. And we also could see the relationship among the twenty-seven pulses on each axis. However, the limitation arising from insufficient number of pulse diagnosis cases in this research requires further research with more sources such as other traditional medical records or clinical records in the present time.

• Asian Journal of Atmospheric Environment
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• v.6 no.4
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• pp.304-313
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• 2012

In this study, the ${\AA}$ngstrom exponent for polydispersed aerosol during dynamic processes was investigated. Log-normal aerosol size distribution was assumed, and a sensitivity analysis of the ${\AA}$ngstrom exponent with regards the coagulation and condensation process was performed. The ${\AA}$ngstrom exponent is expected to decrease because of the particle growth due to coagulation and condensation. However, it is difficult to quantify the degree of change. In order to understand quantitatively the change in the ${\AA}$ngstrom exponent during coagulation and condensation, different real and imaginary parts of the refractive index were considered. The results show that the ${\AA}$ngstrom exponent is sensitive to changes in size distribution and refractive index. The total number concentration decreases and the geometric mean diameter of aerosols increase during coagulation. On the while, the geometric standard deviation approaches monodispersed size distribution during the condensation process, and this change in size distribution affects the ${\AA}$ngstrom exponent. The degree of change in the ${\AA}$ngstrom exponent depends on the refractive index and initial size distribution, and the size parameter changes with the ${\AA}$ngstrom exponent for a given refractive index or chemical composition; this indicates that the size distribution plays an important role in determining the ${\AA}$ngstrom exponent as well as the chemical composition. Subsequently, this study shows how the ${\AA}$ngstrom exponent changes quantitatively during the aerosol dynamics processes for a log-normal aerosol size distribution for different refractive indices; the results showed good agreement with the results for simple analytic size distribution solutions.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.30-30
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• 2003

Without a definitive resolution of stoichiometry of cardiac Na$^{+}$-Ca$^{2+}$exchange (NCX), we cannot proceed to any quantitative analysis of exchange function as well as cardiac excitation-contraction coupling. The stoichiometry of cardiac NCX, however, is presently in doubt because reversal potentials determined by various groups range between those expected for a 3-to-1 and a 4-to-1 flux coupling. For a new perspective on this problem, we have used ion-selective microelectrodes to quantify directly exchanger-mediated fluxes of $Ca^{2+}$and Na$^{+}$in giant membrane patches. $Ca^{2+}$- and Na$^{+}$-selective microelectrodes, fabricated from quartz capillaries, are placed inside of the patch pipettes to detect extracellular ion transients associated with exchange activity. Ion changes are monitored at various distances from the membrane, and the absolute ion fluxes through NCX are determined via simulations of ion diffusion and compared with standard ion fluxes (Ca$^{2+}$ fluxes mediated by $Ca^{2+}$ ionophore, and Na$^{+}$ fluxes through gramicidin channels and Na$^{+}$/K$^{+}$pumps). Both guinea pig myocytes and NCX1-expressing BHK cells were employed, and for both systems the calculated stoichiometries for inward and outward exchange currents range between 3.2- and 3.4-to-1. The coupling ratios do not change significantly when currents are varied by changing cytoplasmic [Ca$^{2+}$] or by adding cytoplasmic Na$^{+}$. The exchanger reversal potentials, measured in both systems under several ionic conditions, range from 3.1- to 3.3-to-1. Taken together, a clear discrepancy from a NCX stoichiometry of 3-to-1 was obtained. Further definitive experiments are required to acquire a fixed number, and the present working hypothesis is that NCX current has an extra current via ‘conduction mode’.ent via ‘conduction mode’.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.1122-1127
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• 2003

For many years, engineers in the field of acoustics have used the A-weighted sound pressure level (SPL). Since they were interested just in a reduction of noise, the A-weighted SPL was considered good enough to quantify noise problems. This is reasonable because loudness is usually the most important parameter for most noise problems and A-weighted SPL is often reasonably well correlated with loudness. As the overall noise levels drop, however, other parameters become more important and must be considered, Advent of sound quality came from an understanding that A-weighted SPL only reflects the loudness of a sound. It is obviously impossible to characterize a complex sound with a single number. Although product mostly has revealed physical quantities created by the standpoint of engineers, consumers perceive and evaluate products on the non-physical characteristics, such as feelings, emotions, and experiences in different social and cultural situations. Especially, for the household appliances for instance air-conditioner or refrigerator, the sound is heavily related to the satisfaction of a customer who is a real user of the product and is very important factor to decide purchasing as well as visual design. Therefore, in this research, the general tendency of consumer's psychology was investigated for the appliances. And also, in order to obtain clear guidelines fur sound manipulation, the characteristics of the sound of air-conditioning systems and refrigerators were compared with competitors'. since it is important to overcome the discrepancy between engineering and marketing, the relevance of sound manipulation must be documented from the consumer's perspective. That is the reason why we conducted a consumer and marketing oriented study.

• The Journal of Internal Korean Medicine
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• v.40 no.1
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• pp.70-88
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• 2019

Objective: This study investigated the trends in pancreatic cancer research on Korean medicine in order to establish a direction for further study. Methods: Pancreatic cancer research on Korean medicine was reviewed using databases such as OASIS, KoreanTK, KISS, RISS, KISTI, and NDSL. The search terms were "pancreatic cancer" "Korean medicine," and "herbal medicine." There was no restriction on publication dates, and the reviewed studies were analyzed according to the type of research. Results: Nineteen studies were reviewed. The numbers and types of research were as follows: 9 clinical studies including case reports, 2 review studies, and 8 in vitro studies; there was no in vivo study. Among the clinical research were 3 descriptive studies and 6 case reports. The baseline characteristics and quality of life of pancreatic cancer patients were analyzed in the descriptive studies. In the case reports, interventions such as herbal medicine, pharmacopuncture, and acupuncture were used. Research articles on the review of pancreatic cancer were titled "Preliminary Study for Development of Korean Medicine Clinical Practice Guideline for Pancreatic Cancer" and "Systemic Review on the Tumor Dormancy Therapy." Cell lines such as PANC-1, MIA PaCa-2, and AsPC-1 were used for in vitro studies. These studies have reported decreased cell viability, induced apoptosis, and changes in cancer-related gene expression. Conclusion: Through this review, we found that using Korean medicine for treating pancreatic cancer is applicable. However, due to overall limited the number of study, the benefit of Korean medicine for pancreatic cancer may be substantiated to a limited degree. Better methodological quality and large controlled trials are expected to further quantify the therapeutic effect of Korean medicine.

• Entomological Research
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• v.48 no.5
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• pp.390-399
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• 2018

In order to precisely assess gene expression levels, the suitable internal reference genes must be served to quantify real-time reverse transcription polymerase chain reaction (RT-qPCR) data. For armyworm, Mythimna separata, which reference genes are suitable for assessing the level of transcriptional expression of target genes have yet to be explored. In this study, eight common reference genes, including ${\beta}$-actin (${\beta}$-ACT), 18 s ribosomal (18S), 28S ribosomal (28S), glyceraldehyde-3-phosphate (GAPDH), elongation fator-alpha ($EF1{\alpha}$), TATA box binding protein (TBP), ribosomal protein L7 (RPL7), and alpha-tubulin (${\alpha}$-TUB) that in different developmental stages, tissues and insecticide treatments of M. separata were evaluated. To further explore whether these genes were suitable to serve as endogenous controls, three software-based approaches (geNorm, BestKeeper, and NormFinder), the delta Ct method, and one web-based comprehensive tool (RefFinder) were employed to analyze and rank the tested genes. The optimal number of reference genes was determined using the geNorm program, and the suitability of particular reference genes was empirically validated according to normalized HSP70, and MsepCYP321A10 gene expression data. We found that the most suitable reference genes for the different experimental conditions. For developmental stages, 28S/RPL7 were the optimal reference genes, both $RPL7/EF1{\alpha}$ were suitable for experiments of different tissues, whereas for insecticide treatments, $28S/{\alpha}-TUB$ were suitable for normalizations of expression data. In addition, $28S/{\alpha}-TUB$ were the suitable reference genes because they have the most stable expression among different developmental stages, tissues and insecticide treatments. Our work is the first report on reference gene selection in M. separata, and might serve as a precedent for future gene expression studies.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.12
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• pp.1199-1206
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• 2015

In this study, the exhaust gas of a diesel engine operating on biodiesel(BD) fuel(a mixture of diesel and soybean oil) was investigated for different fuel mixing ratios in the range of BD3 to BD100. The experiments were conducted using injection pressures of 400, 600, 800, 1000, and 1200 bar. The Pearson correlation coefficient and Spearman rank-order correlation coefficient were used to quantify the NOx and Soot emissions based on the fuel mixing ratio and injection pressure. Consequently, the Pearson correlation coefficient obtained for NOx and Soot emissions according to the mixing ratio and injection pressure was -0.811 and the corresponding Spearman rank-order correlation coefficient was -0.884, which indicated that the correlation of the NOx and Soot emissions was linear. Thus, the NOx and Soot have a trade-off relationship. Moreover, at each injection pressure, the Pearson correlation coefficient was a negative number, which indicated an inversely proportional relationship between NOx and Soot.

• Journal of Environmental Impact Assessment
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• v.19 no.3
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• pp.347-356
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• 2010

Forests are being seriously fragmented as a result of land development. Land development with disregard to its subsequent environmental impacts is a primary threat to biodiversity by incurring massive habitat losses and changes in structure and composition of forests. The purpose of this study was to develop the impact assessment model for quantitative distance or degree of disturbance by land developments. This study conducted a survey about structure and composition of forest species to determine degree of impact from land development. The edge effect of forest fragmentation on the number of bird species, population size, and bird diversity was obvious. In particular, the bird diversity sharply declines around the forest edge where intensive land development projects take place. To assess the disturbance of forest species, the factors selected were the bird diversity and the rate of edge species. The impact assessment model about bird diversity was explained by type of forest fragmentation and type of vegetation ($R^2$=0.23, p<0.005). The other model about edge species explained by a distance, type of forest fragmentation, type of vegetation, and width of road ($R^2$=0.34, p<0.001). In order to test the applicability of the model developed in this study, the models was applied to the Samsong housing development in Goyang-si, Gyunggi-do. The impacts of land development on the bird species were reasonably quantified to suggest effective mitigation measure. The impact assessment model developed in this study is useful to assess the magnitude of disturbance of bird species. Particularly, the model could be applied to the current Environmental Impact Assessment practices to predict and quantify the impacts of land developments projects on forest bird species.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.12
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• pp.921-925
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• 2015

The number of people suffering from renal disease increases every year. One of the most common treatments (clinical care options) for renal diseases is hemodialysis. However it takes a long time and has a high cost. Therefore, the importance of artificial kidney research has risen. Filtering creatinine from blood is one of the prime renal functions. Thus, we designed a novel two channel microfluidic chip focused on that function. In order to bond the individual polydimethylsiloxane layers, we have developed a housing system using acrylic plastic frame. This method has significant advantages in changing filter membranes. We use anodic aluminum oxide for the filter membrane. We analyzed the difference in the absorbance values for various creatinine concentrations using the Jaffe reaction. For the purpose of acquiring a standard equation to quantify the creatinine concentration, we interpolated the measured data and confirmed the concentration of the filtered solution. Through this experiment, we determined how the filtration efficiency depended on the flow rate and creatinine concentration.