• 제목/요약/키워드: novel analysis

검색결과 4,874건 처리시간 0.03초

Novel pan-lineage VP1 specific degenerate primers for precise genetic characterization of serotype O foot and mouth disease virus circulating in India

  • Sagar Ashok Khulape;Jitendra Kumar Biswal;Chandrakanta Jana;Saravanan Subramaniam;Rabindra Prasad Singh
    • Journal of Veterinary Science
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    • 제24권3호
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    • pp.40.1-40.6
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    • 2023
  • Analysis of the VP1 gene sequence of the foot and mouth disease virus (FMDV) is critical to understanding viral evolution and disease epidemiology. A standard set of primers have been used for the detection and sequence analysis of the VP1 gene of FMDV directly from suspected clinical samples with limited success. The study validated VP1-specific degenerate primer-based reverse transcription polymerase chain reaction (RT-PCR) for the qualitative detection and sequencing of serotype O FMDV lineages circulating in India. The novel degenerate primer-based RT-PCR amplifying the VP1 gene can circumvent the genetic heterogeneity observed in viruses after cell culture adaptation and facilitate precise viral gene sequence analysis from clinical samples.

새로운 피라졸린카르보티오아미드 화합물의 합성과 항암효과 (Synthesis of Novel Pyrazolinecarbothioamide and Evaluation of Its Anti-Cancer Activity)

  • 고동수
    • Journal of Applied Biological Chemistry
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    • 제55권3호
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    • pp.191-194
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    • 2012
  • Novel pyrazolinecarbothioamide (5) was synthesized from chalcone (3) which was prepared from 2'-hydroxy-1'-acetonaphthone (1) and 2-methoxy benzaldehyde (2). Treatment of pyrazolinecarbothioamide (5) on HCT116 cancer cell showed upregulation of p21 and downregulation of cyclin D1 protein. Flowcytometer analysis revealed that pyrazolinecarbothioamide (5) controls the expression of cell cycle regulatory proteins, which blocks cell cycle progression of HCT116 cancer cell at the G1 phase.

A Novel and Efficient Feature Extraction Method for Iris Recognition

  • Ko, Jong-Gook;Gil, Youn-Hee;Yoo, Jang-Hee;Chung, Kyo-Il
    • ETRI Journal
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    • 제29권3호
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    • pp.399-401
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    • 2007
  • With a growing emphasis on human identification, iris recognition has recently received increasing attention. Iris recognition includes eye imaging, iris segmentation, verification, and so on. In this letter, we propose a novel and efficient iris recognition method which employs a cumulative-sum-based grey change analysis. Experimental results demonstrate that the proposed method can be used for human identification in efficient manner.

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높은 latch-up 전류특성을 갖는 트랜치 캐소드 삽입형 IGBT (A Novel Inserted Trench Cathode IGBT Device with High Latching Current)

  • 조병섭;곽계달
    • 전자공학회논문지A
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    • 제30A권7호
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    • pp.32-37
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    • 1993
  • A novel insulated gate bipolar transister (IGBT), called insulated trench cathode IGBT (ISTC-IGBT), is proposed. ISTC-IGBT has a trenched well with the shallow P$^{+}$ juction in the conventional IGBT structure. The proposed structure has the capability of effectively suppressing the parasitic thyristor latchup. The holding current of ISTC-IGBT is about 2.2 times greater than that of the conventional IGBT. Detailed analysis of the latchup characteristics of ISTC-IGBT is performed by using the two-dimensional device simulator, PISCES-II B.

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