• 전기학회논문지
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• 제59권1호
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• pp.176-183
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• 2010

This paper presents some practical design issues that should be carefully considered when a notch filter is included in a linear feedback controller. A notch filter is generally used to compensate the effects of resonant modes that may result in poor performance. It is very common that the practical engineers prefer to add such a notch filter after having previously designed a feedback controller without the filter. It is known that the resulting performance by this approach is not seriously different from when a feedback controller is designed for a plant previously compensated by a notch filter. However, we will point out that there are some cases where both approaches have different performances. In order to show this, a low-order controller design using the partial model matching method has been applied to a linear time invariant (L Tn model. The results suggest that there is a tendency to achieve much better time responses in terms of reducing the overshoot and shortening the settling time, and in the frequency domain characteristics such as the sensitivity function and the stability margins when the design of a feedback controller after including a notch filter is carried out.

• 한국공작기계학회논문집
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• 제16권1호
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• pp.1-8
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• 2007

The present study examined the mechanical properties of the friction welding zone of solid and hollow shafts made with SM20C according to the depth of the notch. Friction welding was conducted at welding conditions of 2,000 rpm, friction pressure of 60MPa, friction time of 1.4 seconds, upset pressure of 100MPa, and upset time of 2.0 seconds. In the tensile strength test, the tensile strength decreased as the depth of the notch increased. Tensile strength was moderately high when the depth of the notch was 2mm. The tensile strength of the welding zone increased as the friction revolution radius increased, because the latter led to the generation of adequate friction heat. According to the hardness test, hardness likewise increased as e friction revolution radius increased. In the bending test, the bend strength of the solid shaft decreased when the depth of the notch was 0-2mm but increased when the latter was 3-5mm. With regard to the hollow shaft, the bend strength drastically decreased when the depth of the notch was 3-4mm. Upon examination it was found that the microstructure became finer when the friction revolution radius increased.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제54권10호
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• pp.477-482
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• 2005

In this paper, detent force is minimized using notch and slot-aputure width adjustment in a slotted PMLSM. This time, the moving model node technique has used to reduce the time and the effort for calculation according to changing design parameters. As the result, the detent force of proposed model is decreased from 9.44[N] to 0.97[N] compare with it of basic model greatly. The thrust Is decreased 1.3[$\%$] from 342.07[N] to 337.48[N] a little. The notch is applied to PMLSM simply, the detent force is reduced greatly.

• Journal of information and communication convergence engineering
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• 제1권4호
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• pp.189-193
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• 2003

A new algorithm is presented for adaptive notch filtering of narrow band or sine signals for embedded among broad band noise. The notch filter is implemented as a constrained infinite impulse response filter with a minimal number of parameters, Based on the recursive prediction error (RPE) method, the algorithm has the advantages of the fast convergence, accurate results and initial estimate of filter coefficient and its covariance is revealed. A convergence criterion is also developed. By using the information of the noise-to-signal power, the algorithm can self-adjust its initial filter coefficient estimate and its covariance to ensure convergence.

• 전자공학회논문지B
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• 제29B권10호
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• pp.19-26
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• 1992

Generally, When we calculate notch angle to eliminate some selected harmonics using PWM inverter, we put the previously analysed notch angle formed by look-up table into memory, or perform the program to claculate notch angle iteratively with Fourier series. But, these methods are very difficult to control the system in real-time. Now, in this paper, we propose a new method to calculate notch angle using Walsh series, design real-time logic circuits which can be applied in 3 phase circuits and make one chip to reduce complexity and size of circuits using VLSI design technique.

• 한국통신학회:학술대회논문집
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• 한국통신학회 1991년도 추계종합학술발표회논문집
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• pp.119-122
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• 1991

In this paper, a new adaptive IIR notch filter employing all pass filter is proposed. Proposed all pass filter is composed of all pole and all zero sections, each of which utilizes modulation lattice filter [11]. And, adaption algorithm for proposed notch filter is also derived. In addition, the error surface for proposed IIR adaptive notch filter is analyzed. Computer simulation results reveal that the proposed adaptation algorithm works well for low SNR(signal to noise ratio) single and multiple sinusoids. And it is shown that for estimation time varying frequency, the parameter which is related to notch bandwidth is important than any other parameters.

• Journal of Korean Neurosurgical Society
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• 제64권5호
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• pp.716-725
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• 2021

Objective : The anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity in glioblastoma is not well-evaluated. The Notch-Hes pathway is known to regulate cell differentiation, proliferation, and apoptosis. We investigated the effect of propranolol to human glioblastoma cell lines, and the role of Notch and Hes signaling in this process. Methods : We performed immunohistochemical staining on 31 surgically resected primary human glioblastoma tissues. We also used glioblastoma cell lines of U87-MG, LN229, and neuroblastoma cell line of SH-SY5Y in this study. The effect of propranolol and isoproterenol on cell proliferation was evaluated using the MTT assay (absorbance 570 nm). The impact of propranolol on gene expression (Notch and Hes) was evaluated using real-time polymerase chain reaction (RT-PCR, whereas protein levels of Notch1 and Hes1 were measured using Western blotting (WB), simultaneously. Small interfering RNA (siRNA) was used to suppress the Notch gene to investigate its role in the proliferation of glioblastoma. Results : Propranolol and isoproterenol caused a dose-dependent decrease in cell proliferation (MTT assay). RT-PCR showed an increase in Notch1 and Hes1 expression by propranolol, whereas WB demonstrated increase in Notch1 protein, but a decrease in Hes1 by propranolol. The proliferation of U87-MG and LN229 was not significantly suppressed after transfection with Notch siRNA. Conclusion : These results demonstrated that propranolol suppressed the proliferation of glioblastoma cell lines and neuroblastoma cell line, and Hes1 was more closely involved than Notch1 was in glioblastoma proliferation.

• The Korean Journal of Physiology and Pharmacology
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• 제17권4호
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• pp.291-297
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• 2013

Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis. Overexpression of mutant p53 increased Notch1 promoter activity, whereas knockdown of mutant p53 by small interfering RNA suppressed Notch1 expression, leading to the induction of cellular apoptosis. Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1. Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2485-2489
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• 2012

Purpose: Notch is an important signaling pathway that regulates cell fate, stem cell maintenance and the initiation of differentiation in many tissues. It has been reported that activation of Notch-1 contributes to tumorigenesis. However, whether Notch signaling might have a role in chemoresistance of prostate cancer is unclear. This study aimed to investigate the effects of Notch-1 silencing on the sensitivity of prostate cancer cells to docetaxel treatment. Methods: siRNA against Notch-1 was transfected into PC-3 prostate cancer cells. Proliferation, apoptosis and cell cycle distribution were examined in the presence or absence of docetaxel by MTT and flow cytometry. Expression of $p21^{waf1/cip1}$ and Akt as well as activation of Akt in PC-3 cells were detected by Western blot and Real-time PCR. Results: Silencing of Notch-1 promoted docetaxel induced cell growth inhibition, apoptosis and cell cycle arrest in PC-3 cells. In addition, these effects were associated with increased $p21^{waf1/cip1}$ expression and decreased Akt expression and activation in PC-3 cells. Conclusion: Notch-1 promotes chemoresistance of prostate cancer and could be a potential therapeutic target.

• 한국소음진동공학회논문집
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• 제12권12호
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• pp.935-942
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• 2002

When designing fluid mounts, design parameters can be varied in order to obtain a desired notch frequency and notch depth. The notch frequency is a function of the mount parameters and is typically selected by the designer to occur at the vibration disturbance frequency. Since the process of choosing these parameters can involve some trial and error, it seems to be a great application for obtaining optimal performance of the mount. Many combinations of parameters are possible to give us the desired notch frequency, but the question is which combination provides the lowest depth. Therefore. an automatic optimal technique is needed to optimize the performance of the fluid mount. In this study. the enhanced genetic algorithm (EGA) is applied to minimizing transmissibility of a fluid mount at the desired notch frequency, and at the notch and resonant frequencies. The EGA is modified genetic algorithm to search global and local optimal solutions of multi-modal function optimization. Furthermore. to reduce the searching time as compare to conventional genetic algorithm and Increase the precision of the solutions, the modified simplex method is combined with the algorithm. The results show that the performance of the optimized mount by using the hybrid algorithm is better than that of the conventional fluid mount.