• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.8
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• pp.693-701
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• 2016

In this study, notch defects are evaluated using fracture mechanics. To understand the effects of notch defects, FE analysis is conducted to predict the limit load and J-integral for middle-cracked and single-edge cracked plates with various sizes of notch under tension and bending. As the radius of the notch increases, the energy release rate also increases, although the limit load remains constant. The values of fracture toughness($J_{IC}$) of SM490A are determined for various notch radii through FE simulation instead of conducting an experiment. As the radius of the notch increases, the energy release rate also increases, together with a more significant increase in fracture toughness. To conclude, as the notch radius increases, the resistance to crack propagation also increases.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 1995.11a
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• pp.35-35
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• 1995

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.2
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• pp.244-250
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• 2015

We propose a simulation technique to estimate the reduction effect of the pressure/flow pulsation by analysis of the pulsation variables and notch shape of the valve plate of a swash-plate-type variable piston pump. First, using SimulationX$^{(R)}$, we perform a theoretical kinematic analysis according to the variable swash-plate angle and rotational velocity in order to design a single-piston pump. In designing the notch shape of the valve plate of the swash-plate-type variable piston pump as one of the pulsation variables, we investigate the effect of the pulsation by comparing two notch types (circular type and V type). Then, we extend our analysis to a nine-piston pump model. This paper not only confirms the effect of the pressure/flow pulsation according to pulsation variables but can also be applied to the development of a SimulationX$^{(R)}$-based simulation technique for notch-shape optimization for a swash-plate-type variable piston pump.

• Korean Journal of Bronchoesophagology
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• v.5 no.2
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• pp.113-118
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• 1999

Background & Objectives : Nasal resistance which is halfly responsible for airway resistance is known to be influenced by hypoxia, hypercapnia, exercise, pregnancy, alcohol, ammonia and smoking. Smoking is a common part of our sociocultural environment and we have many a times been introduced to its various adverse effects, which have usually been more focused on lung problems. The purpose of this study is to determine any relationship between smoking and nasal resistance and to evaluate it's effective sites. Materials and Methods : Acoustic rhinometry was performed in 25 smokers and 25 nonsmokers who had no nasal symptoms nor abnormal rhinoscopic findings, and used an acoustic rhinometry to measure the distance from nose-piece to the C-notch, cross sectional area at the C-notch, and volume of the nasal cavity from nose-piece to 7cm. The authors compared the data between the two groups. Results : The cross sectional area at the C-notch was significantly decreased(p<0.05) in smoking group. The distance to the C-notch and the volume of nasal cavity were decreased likely in smoking group but there were no significant difference(p>0.05). Conclusion : Smoking reduced the cross sectional area at the C-notch, so increased the nasal resistance. The underlying mechanisms seems to be decreased nasal mucosal reactivity and congestion of the nasal mucosa. The authors believe there should follow more studies on pathophysiologic mechanisms and the histopathologic changes which involve the effect of smoking on nasal structures.

• Proceedings of the KWS Conference
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• v.43
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• pp.275-277
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• 2004

Fictitious notch radius approach is based on the Neuter's microstructural support hypothesis which assumes that fatigue crack is governed by highly stressed volume of the material right on the weld toe area rather than the surface stress at a pin point of weld toe area. Variety of successes have been achieved in applying this methodology to the fatigue of welded joint, hence, it became one of recommended design procedure in IIW's recommendation as well as many ship classification societies. 1mm fictitious notch radius approach was applied to the various fatigue problems of welded joints in this study covering the effect of weld size, notch stress calculation for 3D geometry and low cycle fatigue problem. It was found that fictitious notch radius approach fumed out to be very effective and accurate in dealing with fatigue strength of welded joint.

• Proceedings of the KSME Conference
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• 2000.11a
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• pp.238-243
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• 2000

The effect of the temperature, the fatigue and the test speed on DEN(double edged notch) specimen which was made by the pp-rubber composites during fracture was stuied. DEN specimen was made on PP-rubber composites through the injection molding. With increasing temperature the fracture strength is linearly decrease and the fracture energy is first increase by $0^{\circ}C$ and after that decrease. In the same temperature the fracture strength during increasing the notch radius is hardly increase. The fracture behaviour at low and high test speed is different entirely. At high test speed plastic region is small and fracture behaviour was seen to brittle fracture tendency. The deformation mechanism of polypropylene-rubber composites during fracture was studied by SEM fractography. A strong plastic deformation of the matrix material ahead of the notch/crack occured. The deformation seem to be enhanced by a thermal blunting of the notch/crack.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.4
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• pp.291-297
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• 2013

Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis. Overexpression of mutant p53 increased Notch1 promoter activity, whereas knockdown of mutant p53 by small interfering RNA suppressed Notch1 expression, leading to the induction of cellular apoptosis. Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1. Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.

• Journal of the korean Society of Automotive Engineers
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• v.10 no.2
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• pp.46-53
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• 1988

Effect of Notch Shape and Hardness Ratio on Characteristics of Impact Fracture in Dual Phase Steels. In this study, it is investigated the effect of notch shape and hardness ratio on the characteristics of impact fracture in dual phase steels. The impact test was carried out at the temperature range from -40.deg. C to room temperature with Instrumented Charpy Impact Tester. The main results obtained are as follows; 1, The maximum impact bending strength (.sigma.$_{max}$) increases with the tensile strength. Also, the impact energy depends on .sigma.$_{max}$. 2, In room temperature, the impact energy depends on crack-initiation energy (E$_{i}$) in case of the high hardness ratio (R=3.4), whereas depends on crack-propagation energy (E$_{p}$) in case of the low hardness ratio (R=1.8) and the dependence of crack-initiation energy of the impact characteristics decreases with increasing test temperature. These phenomena are result from the difficulty of cleavage facet formation.ion.ion.

• Restorative Dentistry and Endodontics
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• v.26 no.2
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• pp.162-170
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• 2001

The purpose of this study was to investigate the effect of cavity configurations on the marginal leakage of class 5 glass ionomer cement and composite resin restorations. Four types of cavities such as saucer shape. notch shape. combined shape(notch shape occlusally and saucer shape gingivally). and U shape were prepared on the buccal and lingual surfaces of 80 extracted premolars(40 cavities for each shape). Occlusal cavity margins were placed at enamel and cervical margins were placed at dentin. 10 cavities of each shape were restored with Ketac Fil as a conventional glass ionomer cement. Fuji II LC improved as a resin modified glass ionomer cement, Z 100 as a hybrid composite resin. and Tetric Flow as a flowable composite resin (40 cavities for each material). After thermocycling, teeth were immersed in 5% basic fuchsin solution for 6 hours and sectioned longitudinally in a buccolingual direction through the center of the restoration. The dye penetrations at the tooth restoration interface were examined by stereomicroscope. The Result were as follows 1. In saucer shape, notch shape and combined shape, composite resin restorations showed lesser leakage than glass ionomer restorations(p<0.05) and in U shape. Tetric Flow showed the least marginal leakage and others were decreased as Z 100. Fuji II LC improved, Ketac Fil in that order. There were statistically significant difference between Tetric Flow and Fuji II LC improved. Ketac Fil and between Z 100 and Ketac Fil(p<0.05). 2. In Ketac Fil restoration group, saucer shape showed the highest marginal leakage and U shape showed the least marginal leakage and others were decreased as notch shape, combined shape in that order. There were statistically significant difference between saucer shape and combined shape, U shape and between notch shape and U shape(p<0.05). 3. In Fuji II LC improved restoration group, U shape showed the least marginal leakage. There were statistically significant difference between U shape and other three shapes(p<0.05). 4. The cavity configuration had no significant effect on marginal leakage of composite resin restorations(p>0.05).

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.12 s.243
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• pp.1605-1614
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• 2005

For the last four decades, tension test of notched bars has been performed to investigate the effect of stress triaxiality on ductile fracture. To quantify the effect of the notch radius on stress triaxiality, the Bridgman equation is typically used. However, recent works based on detailed finite element analysis have shown that the Bridgman equation is not correct, possibly due to his assumption that strain is constant in the necked ligament. Up to present, no systematic work has been performed on fully plastic stress fields for notched bars in tension. This paper presents fully plastic results for tension of notched bars and plates in plane strain, via finite element limit analysis. The notch radius is systematically varied, covering both un-cracked and cracked cases. Comparison of plastic limit loads with existing solutions shows that existing solutions are accurate for notched plates, but not for notched bars. Accordingly new limit load solutions are given for notched bars. Variations of stress triaxiality with the notch radius and depth are also given, which again indicates that the Bridgman solution for notched bars is not correct and inaccuracy depends on the notch radius and depth.