• Ocean and Polar Research
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• 제29권4호
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• pp.283-295
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• 2007

We investigated the longitudinal variations in zooplankton abundances and their related physicochemical properties at nine stations located between $136^{\circ}W$ and $128^{\circ}W$ at $10.5^{\circ}N$ in the northeastern Pacific in summer 2004. Temperature, salinity, inorganic nutrients, chlorophyll-a (hereafter chl-a) and zooplankton ($>200\;{\mu}m$) were sampled within the depth from the surface to 200 m depth at $1^{\circ}$ longitude intervals. Zooplankton($>200\;{\mu}m$) samples were vertically collected at two depth intervals from surface to 200 m, consisting of surface mixed and lower layers (thermocline$\sim$200 m). Longitudinal distributional pattern of hydrological parameters (especially salinity) was physically influenced by the intensity of westward geostrophic current passage relating to the NEC (North Equatorial Current). Data from the longitudinal survey showed clear zonal distributions in the hydrological parameters(temperature, salinity and nutrients). However, spatial patterns of the chl-a concentrations and zooplankton abundances were mostly independent of the zonal distributions of hydrological parameters. The two peaks of zooplankton abundance in the surface mixed layer were characterized by different controlling factors such as bottom-up control from nutrients to zooplankton ($129^{\circ}W$) and accumulation by increment of friction force and taxonomic interrelationship ($133^{\circ}$ and $134^{\circ}W$). Divergence-related upwelling caused introduction of nutrients into surface waters leading to the increment of chl-a concentration and zooplankton abundances ($129^{\circ}W$). Increased friction force in relation to reduced flow rates of geostrophic currents caused accumulation of zooplankton drifting from eastern stations of study area($133^{\circ}$ and $134^{\circ}W$). Besides, high correlation between immature copepods and carnivorous groups such as chaetognaths and cyclopoids also possibly contributed to the enhanced total abundance of zooplankton in the surface mixed layer (p<0.05). Zooplankton community was divided into three groups (A, B, C) which consecutively included the eastern peak of zooplankton($129^{\circ}W$), the western peak($133^{\circ}$ and $134^{\circ}W$) and high nutrient but low chl-a concentration and zooplankton abundance ($136^{\circ}W$). Moreover, Group B corresponded to the westward movement of low saline waters(<33.6 psu) from 128 to $132^{\circ}W$. In summary, longitudinal distributions of zooplankton community was characterized by three different controlling factors: bottom-up control ($129^{\circ}W$), accumulation by increased friction force and relationships among zooplankton groups ($133^{\circ}$ and $134^{\circ}W$), and mismatch between hydrological parameters and zooplankton in the high nutrient low chlorophyll area ($136^{\circ}W$) during the study period.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1935-1937
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• 2015

The potential association between the GSTM1 deletion polymorphism and risk of cervical cancer was investigated in Northeastern Thailand. DNA was extracted from buffy coat specimens of 198 patients with squamous cell carcinoma of the cervix and 198 age-matched healthy controls. Genotyping of the GSTM1 was conducted by using two PCR methods, a short- and a long-PCR. Distribution of the GSTM1 genotypes in between the cases and the controls was not significantly different (p>0.5 by ${\chi}^2$ test). The results suggest that the GSTM1 deletion polymorphism is not a risk factor for squamous cell carcinoma of the cervix in the northeast Thai women.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.857-862
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• 2016

Background: The prevalence of infection by the liver fluke, Opisthorchis viverrini (O. viverrini), has remained high in Northeast Thailand where it is a major risk factor for the eventual development of cholangiocarcinoma (CCA). The infection is acquired by the consumption of dishes containing unsafely prepared freshwater fish, a dietary tradition which has proved resistant to change. Since many people are aware that dosing with praziquantel (PZQ) is a successful treatment for an episode of the infection, there is a risk that, to avoid the long term consequences, they will engage in a cycle of infection, dosing and reinfection. Objectives: There is a dearth of studies of reinfection by O. viverrini, and the aims of this study were to assess re-infection rates in a typical province of Northeastern Thailand where O. viverrini infection is likely and to investigate factors associated with reinfection. Materials and Methods: A total of infected 607 villagers were treated with PZQ, and those found to be no longer infected were followed up at six-monthly intervals over 12 months. Results: At the end of this period data on 457 subjects were available for analysis using descriptive statistics and logistic regression, and 50 were found to have become reinfected, giving a cumulative reinfection rate of 10.9%. The results of a multiple logistic regression analysis showed that the only factor found to be associated with reinfection was past use of PZQ. Conclusions: Recommendations are made for future larger scale and better designed reinfection studies in the light of limitations of the current study. Further efforts are needed to discourage people from eating fish dishes likely to contain viable metacariae.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.739-742
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• 2016

Risks with GSTM1 genotypes and potential roles of smoking in the susceptibility to oral squamous cell carcinoma (OSCC) were studied in Northeastern Thailand. Study subjects were 79 histologically-confirmed OSCC cases (31 men, 48 women) and 79 age- and sex-matched healthy controls ranging in age from 25 to 84 years. GSTM1 genotyping was achieved by two independent PCR assays. The GSTM1 null allele and the homozygous genotype did not increase risk of OSCC vs the wild type allele and the remaining genotypes. When the focus was on the smoking habit, male subjects who smoked ${\geq}10$ or ${\geq}35$ years were at significantly increased risk for OSCC with adjusted ORs of 4.88 [95%CI, 1.41-16.87, p=0.012] or 4.94 [95%CI, 1.62-15.12, p=0.005], respectively. A higher risk for OSCC was found for smoking amount; those who smoked >5 or >10 pack-years were at a higher risk with adjusted OR of 4.46 [95%CI; 1.45-13.74, p=0.009] or 3.89 [95%CI; 1.34-11.28, p=0.012], respectively. There are certain smoking patterns that give greater risks and thus both smoking duration and pack-years should be taken into consideration in tobacco related cancer prevention.

• Ocean and Polar Research
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• 제26권2호
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• pp.351-360
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• 2004

To investigate latitudinal variations in the zooplankton community along the meridian line ($5^{\circ}N-12^{\circ}N$, $131.5^{\circ}W$), we measured temperature, salinity, nitrate, chlorophyll-a and zooplankton at depths above 200 m from July $10^{th}$ to $25^{th}$, 2003. For comparative analysis, data of the physico-chemical properties and chl-a were matched to the two sampling depths (surface mixed layer and thermocline depth-200 m) of zooplankton. Latitudinal differences in the mesozooplankton distribution were mainly influenced by divergence formed at a boundary line formed by currents of opposing directions, consisting of North Equatorial Current (NEC) and North Equatorial Counter Current (NECC). High concentrations of chl-a south of $9^{\circ}N$, caused by equatorial upwelling related nutrients, is thought to be affected by the role of this divergence barrier, supported by relatively low concentrations in waters north of $9^{\circ}N$. The latitudinal differences of the chl-a were significantly associated with the major groups of zooplankton, namely calanoid and cyclopoid copepods, appendicularians, ostracods, chaetognaths, invertebrate larvae, and others. And temperature significantly affected the latitudinal variation of radiolarians, siphonophores, salps and immature copepods. The latitudinal differences in the two factors, temperature and chl-a, which explained 71.0% of the total zooplankton variation, were characterized by the equatorial upwelling as well as the divergence at $9^{\circ}N$. The physical characteristics also affected the community structure and abundance of zooplankton as well as average ratios of cyclopoid versus calanoid copepods. The abundance of dominant copepods, which were consistent with chl-a, were often associated with the carnivorous zooplankton chaetognaths, implying the relative importance of bottom-up regulation from physical properties to predatory zooplankton during the study period. These results suggested that latitudinal distribution of zooplankton is primarily controlled by current-related divergences, while biological processes are of secondary importance in the northeastern Equatorial Pacific during the study period in question.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4025-4029
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• 2015

Background: Gastrointestinal tract cancers are among the most common cancers in Iran and comprise approximately 38% of all the reported cases of cancer. This study aimed to describe the epidemiology and to investigate spatial clustering of common cancers of the gastrointestinal tract across the counties of Iran using full Bayesian smoothing and Moran I Index statistics. Materials and Methods: The data of the national registry cancer were used in this study. Besides, indirect standardized rates were calculated for 371 counties of Iranand smoothed using Winbug 1.4 software with a full Bayesian method. Global Moran I and local Moran I were also used to investigate clustering. Results: According to the results, 75,644 new cases of cancer were nationally registered in Iran among which 18,019 cases (23.8%) were esophagus, gastric, colorectal, and liver cancers. The results of Global Moran's I test were 0.60 (P=0.001), 0.47 (P=0.001), 0.29 (P=0.001), and 0.40 (P=0.001) for esophagus, gastric, colorectal, and liver cancers, respectively. This shows clustering of the four studied cancers in Iran at the national level. Conclusions: High level clustering of the cases was seen in northern, northwestern, western, and northeastern areas for esophagus, gastric, and colorectal cancers. Considering liver cancer, high clustering was observed in some counties in central, northeastern, and southern areas.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.7029-7032
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• 2013

Background: Cholangiocarcinoma (CCA) is a very common cancer in Northeastern Thailand. Most CCA patients see a physician at a late stage when curative surgery is not possible. After diagnosis, they generally are treated by partial surgery/percutaneous drainage, chemotherapy and supportive treatment. Objective: This study aimed to assess the survival rates of CCA patients after supportive treatment. Methods: A retrospective cohort design was applied in this study. Data for 746 CCA patients were extracted from the hospital-based cancer registry of Srinagarind Hospital, Khon Kaen University. The patients were diagnosed (at least by ultrasonography) between 1 January, 2009 and 31 December, 2009 and then followed up for current status until 30 June, 2011. The cumulative survival rate was calculated by the Kaplan-Meier method, and independent prognostic factors were investigated using Cox regression. Results: The total follow-up time was 5,878 person-months, and the total number of deaths was 637. The mortality rate was therefore 10.8 per 100 person-year (95%CI : 10.1-11.7). The cumulative 3, 6, 9, 12 and 24 month survival rates were 59%, 39%, 31%, 24% and 14%, respectively. The median survival time after supportive treatment was 4 months. After adjusting for gender, age, stage, distant metastasis, histological grading and treatment, stage was a significant predictor of survival of CCA patients. Those in stage III and stage IV had a 6.78 fold higher mortality than the stage I and stage II cases (95% CI : 1.6-28.7). Conclusion: It is very important to encourage patients to see health personnel at an early stage.

• 한국해양학회지:바다
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• 제1권2호
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• pp.73-79
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• 1996

본 연구는 북동 태평양의 심해저 퇴적물에 서식하는 대형저서동물의 군집 구조와 수평적 및 수직적 분포양상을 보기 위해 1996년 5월에 수행되었다. 생물 시료는 25개 정점에서 box corer를 사용하여 채취된 퇴적물을 0.3 mm 망목의 체 로 걸러 채집하였다. 총 9개 동물문의 17개 분류군에 속하는 363개체의 저서동물이 출현하였고, 이들은 선형동물(30.0%), 유공충류(25.1%), 저서성 요각류(10.2%), Xenophyophorea(5.2%), 다모류(4.7%)순으로 우점하였다. 전형적인 중형동물 분류군 들을 제외하면 다모류가 가장 우점한 동물군이었다. 출현종의 수는 0.01 m$^{2}$ 당 평균 6종류였고, 서식밀도는 1,288개체/m$^{2}$ 로서 심해역으로는 밀도가 높았다. 퇴적물 깊이별 수직분포를 보면 표층에서 최대출현량을 보이고 깊이에 따 라 감소한다. 퇴적물 깊이 10 cm 층 이내에 전체 저서생물의 98% 이상이 출현 하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.341-345
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• 2016

Background: Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population. Materials and Methods: A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations. Results: The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 - 3.86), p < 0.01]. Patients with Helicobacter pylori - associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 - 7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status. Conclusions: This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2973-2977
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• 2016

Opisthorchis viverrini is still a serious problem in Northeastern and Northern Thailand. Active surveillance is required to determine updated data for further prevention and control planning. Therefore, this study aimed to examine the prevalence and risk factors for O. viverrini in three provinces, Northeastern Thailand. A cross-sectional survey was conducted during October 2015 to March 2016 at Kaeng Sanam Nang district of Nakhon Ratchasima province, Waeng Noi district of Khon Kaen province, and Khon Sawan district of Chaiyaphum province, Thailand. Stool samples were examined by using a modified Kato-Katz Thick smear technique. From a total of 978 participants screened, O. viverrini infection was found in 1.74%, the majority opf positive cases being male (6.62%), age group 51-60 years old (4.21%), educated at primary school (8.43%), occupied with agriculture (9.62%),having an income <4,000 baht per month (4.82%), and living in Khon Sawan district (8.43%). Participants had a high knowledge level (42.43%), good attitude level (34.76%), and fair level (38.04%). The present study indicates the O. viverrini infection rate is low, but elderly males with primary school education involved in agriculture are still frequently effected particularly in Khon Sawan district. Therefore, this risk group requires behavior modification and continued monitoring.