Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Survival of Cholangiocarcinoma Patients in Northeastern Thailand after Supportive Treatment

  • Published : 2013.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Cholangiocarcinoma (CCA) is a very common cancer in Northeastern Thailand. Most CCA patients see a physician at a late stage when curative surgery is not possible. After diagnosis, they generally are treated by partial surgery/percutaneous drainage, chemotherapy and supportive treatment. Objective: This study aimed to assess the survival rates of CCA patients after supportive treatment. Methods: A retrospective cohort design was applied in this study. Data for 746 CCA patients were extracted from the hospital-based cancer registry of Srinagarind Hospital, Khon Kaen University. The patients were diagnosed (at least by ultrasonography) between 1 January, 2009 and 31 December, 2009 and then followed up for current status until 30 June, 2011. The cumulative survival rate was calculated by the Kaplan-Meier method, and independent prognostic factors were investigated using Cox regression. Results: The total follow-up time was 5,878 person-months, and the total number of deaths was 637. The mortality rate was therefore 10.8 per 100 person-year (95%CI : 10.1-11.7). The cumulative 3, 6, 9, 12 and 24 month survival rates were 59%, 39%, 31%, 24% and 14%, respectively. The median survival time after supportive treatment was 4 months. After adjusting for gender, age, stage, distant metastasis, histological grading and treatment, stage was a significant predictor of survival of CCA patients. Those in stage III and stage IV had a 6.78 fold higher mortality than the stage I and stage II cases (95% CI : 1.6-28.7). Conclusion: It is very important to encourage patients to see health personnel at an early stage.

Keywords

References

  1. Craig JR, Peter RL, Edomondson HA (1989). Tumors of the liver and intrahepatic bile ducts. Washington DC: Armed forces Institute of Pathology, 197-211.
  2. Kawarada Y, Yamagiwa K,DasBC (2002). Analysis of the relationships between clinicopathologic factors and survival time in intrahepatic cholangiocarcionma. Am J Surg, 183, 679-85. https://doi.org/10.1016/S0002-9610(02)00853-X
  3. Khuhaprema T, Srivatanakul P, Sriplung H, et al (2007). Cancer in Thailand: Vol. IV, 1998-2000. Bangkok: Bangkok Medical Publisher.
  4. Khuhaprema T, Srivatanakul P, Attasara P et al (2010). Cancer in Thailand Vol. V, 2001-2003. Bangkok: National Cancer Institute.
  5. Knuppel M, Kubicka S, Vogel A, et al (2011). Combination of conservative and interventional theraphy strategies for intra- and extrahepatic cholangiocellular carcinoma: a retrospective survival analysis. Gastroenterol Res Practice, 19, 1-8.
  6. Madariaga JR, Iwatsuki S, Todo S, et al (1998). Liver resection for hilar and peripheral cholangiocarcinomas: A study of 62 cases. Ann Surg, 227, 70-9. https://doi.org/10.1097/00000658-199801000-00011
  7. Mihalache F, Tantau M, Diaconu B, et al (2010). Survival and quality of life of cholangiocarcinoma patients: a prospective study over a 4 year period. J Gastrointestill Liver Dis, 19, 285-90.
  8. Park H, Choi KH, Choi S, et al (2011).Clinicopathological characteristics in combined hepatocellular cholangiocarcinoma: a single center study in Korea. Yonsei Med J, 52, 753-760. https://doi.org/10.3349/ymj.2011.52.5.753
  9. Pattanathien P, Khuntikeo N, Promthet S, et al (2013). Survival rate of extrahepatic cholangiocarcinoma patients after surgical treatment in Thailand. Asian Pacific J Cancer Prev., 13, 231-34.
  10. Sripa B, Pairojkul C (2008). Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroeneterol, 24, 349-56. https://doi.org/10.1097/MOG.0b013e3282fbf9b3
  11. Sriputtha S, Khuntikeo N, Promthet S, et al (2013). Survival rate of intrahepatic cholangiocarcinoma patients after surgical treatment in Thailand. Asian Pacific J Cancer Prev, 14, 1107-10. https://doi.org/10.7314/APJCP.2013.14.2.1107
  12. StataCorp LP (2007). Stata Release 10: User's Guide. College Station TX: Stata Press.
  13. Vatanasapt V, Tangvoraphonkchai V, Titapant V, et al (1990). A high incidence of liver cancer in Khon Kaen province, Thailand. Southeast Asian J Trop Med Public Health, 21, 489-94.
  14. Vern-Gross TZ, Shivnani AT, Chen K, et al (2010). Survival outcomes in resected extrahepathic cholangiocarcinoma: effect of adjuvant radiotheraphy in a surveillance, epidemiology and end result analysis. Int J Radiation Oncology Biol Phy, 5, 1-10.

Cited by

  1. Analysis of Different Ways of Drainage for Obstructive Jaundice Caused by Hilar Cholangiocarcinoma vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5617
  2. In vitro and In vivo Antitumor Activity of Tiliacorinine in Human Cholangiocarcinoma vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7473
  3. Utilization of Google Earth for Distribution Mapping of Cholangiocarcinoma: a Case Study in Satuek District, Buriram, Thailand vol.16, pp.14, 2015, https://doi.org/10.7314/APJCP.2015.16.14.5903
  4. Comparison of Infection between Internal-External and External Percutaneous Transhepatic Biliary Drainage in Treating Patients with Malignant Obstructive Jaundice vol.16, pp.6, 2015, https://doi.org/10.7314/APJCP.2015.16.6.2543
  5. High Expression of Matrix Metalloproteinase-11 indicates Poor Prognosis in Human Cholangiocarcinoma vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3697
  6. Ultrasound screening for cholangiocarcinoma could detect premalignant lesions and early-stage diseases with survival benefits: a population-based prospective study of 4,225 subjects in an endemic area vol.16, pp.1, 2016, https://doi.org/10.1186/s12885-016-2390-2
  7. Benefits of Metformin Use for Cholangiocarcinoma vol.16, pp.18, 2015, https://doi.org/10.7314/APJCP.2015.16.18.8079
  8. Helicobacter Species are Possible Risk Factors of Cholangiocarcinoma vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.37
  9. Spatial Distribution of the Population at Risk of Cholangiocarcinoma in Chum Phaung District, Nakhon Ratchasima Province of Thailand vol.17, pp.2, 2016, https://doi.org/10.7314/APJCP.2016.17.2.719
  10. GIS Database and Google Map of the Population at Risk of Cholangiocarcinoma in Mueang Yang District, Nakhon Ratchasima Province of Thailand vol.17, pp.3, 2016, https://doi.org/10.7314/APJCP.2016.17.3.1293
  11. Surveillance of Populations at Risk of Cholangiocarcinoma Development in Rural Communities of Thailand Using the Korat-CCA Verbal Screening Test vol.17, pp.4, 2016, https://doi.org/10.7314/APJCP.2016.17.4.2205
  12. Evaluating a preoperative protocol that includes magnetic resonance imaging for lymph node metastasis in the Cholangiocarcinoma Screening and Care Program (CASCAP) in Thailand vol.15, pp.1, 2017, https://doi.org/10.1186/s12957-017-1246-9
  13. A significant cancer burden and high mortality of intrahepatic cholangiocarcinoma in Thailand: a nationwide database study vol.17, pp.1, 2017, https://doi.org/10.1186/s12876-016-0565-6
  14. Cohort profile: cholangiocarcinoma screening and care program (CASCAP) vol.15, pp.1, 2015, https://doi.org/10.1186/s12885-015-1475-7