Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand

  • Published : 2015.03.18
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Abstract

The potential association between the GSTM1 deletion polymorphism and risk of cervical cancer was investigated in Northeastern Thailand. DNA was extracted from buffy coat specimens of 198 patients with squamous cell carcinoma of the cervix and 198 age-matched healthy controls. Genotyping of the GSTM1 was conducted by using two PCR methods, a short- and a long-PCR. Distribution of the GSTM1 genotypes in between the cases and the controls was not significantly different (p>0.5 by ${\chi}^2$ test). The results suggest that the GSTM1 deletion polymorphism is not a risk factor for squamous cell carcinoma of the cervix in the northeast Thai women.

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References

  1. Agodi A, Barchitta M, Cipresso R, et al (2010). Distribution of p53, GST, and MTHFR polymorphisms and risk of cervical intraepithelial lesions in Sicily. Int J Gynecol Cancer, 20, 141-6. https://doi.org/10.1111/IGC.0b013e3181c20842
  2. Chen C, Madeleine MM, Weiss NS, Daling JR (1999). Glutathione S-transferase M1 genotypes and the risk of squamous carcinoma of the cervix: A population-based case-control study. Am J Epidemiol, 150, 568-72. https://doi.org/10.1093/oxfordjournals.aje.a010054
  3. Duell EJ, Holly EA, Bracci PM, et al (2002). A populationbased, case-control study of polymorphisms in carcinogenmetabolizing genes, smoking, and pancreatic adenocarcinoma risk. J Natl Cancer Inst, 94, 297-306. https://doi.org/10.1093/jnci/94.4.297
  4. Gao LB, Pan XM, Li LJ, et al (2011). Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: an evidence-basedmeta-analysis. PLoS ONE, 6, 20157. https://doi.org/10.1371/journal.pone.0020157
  5. Garte S, Gaspari L, Alexandrie AK, et al (2001). Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev, 10, 1239-48.
  6. Liu X, Li Z, Zhang Z, et al (2014). Meta-analysis of GSTM1 null genotype and lung cancer risk in Asians. Med Sci Monit, 20, 1239-45. https://doi.org/10.12659/MSM.890490
  7. Matic M, Pekmezovic T, Djukic T, et al (2013). GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study. Urol Oncol, 31, 1184-92. https://doi.org/10.1016/j.urolonc.2011.08.005
  8. Niwa Y, Hirose K, Nakanishi T, et al (2005). Association of the NAD(P)H: quinone oxidoreductase C609T polymorphism and the risk of cervical cancer in Japanese subjects. Gynecol Oncol, 96, 423-9. https://doi.org/10.1016/j.ygyno.2004.10.015
  9. Palma S, Novelli F, Padua L, et al (2010). Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk. J Cancer Res Clin Oncol, 136, 1101-9. https://doi.org/10.1007/s00432-009-0757-3
  10. Parl FF (2005). Glutathione S-transferase genotypes and cancer risk. Cancer Lett, 221, 123-9. https://doi.org/10.1016/j.canlet.2004.06.016
  11. Roodi N, Dupont WD, Moore JH, Parl FF (2004). Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk. Cancer Res, 64, 1233-6. https://doi.org/10.1158/0008-5472.CAN-03-2861
  12. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S (2013). Association of genetic polymorphism of glutathione S-transferase (GSTM1, GSTT1, GSTP1) with bladder cancer susceptibility. Urol Oncol, 31, 1193-203. https://doi.org/10.1016/j.urolonc.2011.11.027
  13. Sanyal S, Festa F, Sakano S, et al (2004). Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis, 25, 729-34.
  14. Schnakenberg E, Breuer R, Werdin R, Dreikorn K, Schloot W (2000). Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer. Cytogenet Cell Genet, 91, 234-8. https://doi.org/10.1159/000056851
  15. Settheetham-Ishida W, Yuenyao P, Kularbkaew C, Settheetham D, Ishida T (2009). Glutathione S-transferase (GSTM1 and GSTT1) polymorphisms in cervical cancer in Northeastern Thailand. Asian Pac J Cancer Prev, 10, 365-8.
  16. Singh H, Sachan R, Devi S, Pandey SN, Mittal B (2008). Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population. Am J Obstet Gynecol, 198, 303
  17. Sobti RC, Kaur S, Kaur P, et al (2006). Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India. Cancer Genet Cytogenet, 166, 117-23. https://doi.org/10.1016/j.cancergencyto.2005.10.001
  18. Stosic I, Grujicic D, Arsenijevic S, Brkic M, Milosevic- Djordjevic O (2014). Glutathione S-transferase T1 and M1 polymorphisms and risk of uterine cervical lesions in women from central Serbia.Asian Pac J Cancer Prev, 15, 3201-5. https://doi.org/10.7314/APJCP.2014.15.7.3201
  19. Tiwawech D, Srivatanakul P, Karalak A, Ishida T (2005). Glutathione S-transferase M1 gene polymorphism in Thai nasopharyngeal carcinoma. Asian Pac J Cancer Prev, 6, 270-5.
  20. Zhang ZY, Jin XY, Wu R, et al (2012). Meta-analysis of the association between GSTM1 and GSTT1 gene polymorphisms and cervical cancer. Asian Pac J Cancer Prev, 13, 815-9. https://doi.org/10.7314/APJCP.2012.13.3.815

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