• Journal of Veterinary Science
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• v.21 no.6
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• pp.91.1-91.15
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• 2020

Background: Sulforaphane (SFN) is an isothiocyanate compound present in cruciferous vegetables. Although the anti-inflammatory effects of SFN have been reported, the precise mechanism related to the inflammatory genes is poorly understood. Objectives: This study examined the relationship between the anti-inflammatory effects of SFN and the differential gene expression pattern in SFN treated ob/ob mice. Methods: Nitric oxide (NO) level was measured using a Griess assay. The inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels were analyzed by Western blot analysis. Pro-inflammatory cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and IL-6) were measured by enzyme-linked immunosorbent assay (ELISA). RNA sequencing analysis was performed to evaluate the differential gene expression in the liver of ob/ob mice. Results: The SFN treatment significantly attenuated the iNOS and COX-2 expression levels and inhibited NO, TNF-α, IL-1β, and IL-6 production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. RNA sequencing analysis showed that the expression levels of 28 genes related to inflammation were up-regulated (> 2-fold), and six genes were down-regulated (< 0.6-fold) in the control ob/ob mice compared to normal mice. In contrast, the gene expression levels were restored to the normal level by SFN. The protein-protein interaction (PPI) network showed that chemokine ligand (Cxcl14, Ccl1, Ccl3, Ccl4, Ccl17) and chemokine receptor (Ccr3, Cxcr1, Ccr10) were located in close proximity and formed a "functional cluster" in the middle of the network. Conclusions: The overall results suggest that SFN has a potent anti-inflammatory effect by normalizing the expression levels of the genes related to inflammation that were perturbed in ob/ob mice.

• Journal of the Korea Society of Computer and Information
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• v.27 no.11
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• pp.29-38
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• 2022

This paper proposes a system for classifying gait types using an ensemble deep learning network for gait data measured by a smart insole equipped with multi-sensors. The gait type classification system consists of a part for normalizing the data measured by the insole, a part for extracting gait features using a deep learning network, and a part for classifying the gait type by inputting the extracted features. Two kinds of gait feature maps were extracted by independently learning networks based on CNNs and LSTMs with different characteristics. The final ensemble network classification results were obtained by combining the classification results. For the seven types of gait for adults in their 20s and 30s: walking, running, fast walking, going up and down stairs, and going up and down hills, multi-sensor data was classified into a proposed ensemble network. As a result, it was confirmed that the classification rate was higher than 90%.

• Journal of Ginseng Research
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• v.19 no.1
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• pp.31-38
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• 1995

Antioxidant effect of Korean ginseng (Panax ginseng C.A. Meyer) was investigated in rats. Long-term administration of ginseng water extract protected the activity of liver cytosotic SOD, catalase and glutathione peroxidase from being significantly decreased with advancing age (p<0.05). It was more effective toward glutathione peroxidase than other antioxidant enzymes. However, the level of sulfhydryl compounds and its related enzymes such as glutathione reductase and glutathione-5-transferase was not significantly changed by the administration of ginseng. Liver microsomal formation of reactive oxygen species such as superoxide and hydrogen peroxide did not show a significant difference between two groups although it was slightly decreased with age, but lipid peroxidizability of microsomal membrane induced by a prooxidant was slightly lower in ginseng-treated rats. Interestingly, antioxidant capacity of plasma from ginseng treated rats on autooxidation of ok-brain homogenates was much higher than that of normal ones. However, resistance of RBC membrane against oxidative stress showed a similar tendency. The content of serum TBA reactive substances lowered consistently in the rats treated with r ginseng at all corresponding age and a significant difference between two groups was found at 24 months of age (p<0.05). Ginseng extract protected lipid peroxidation in brain and liver. This protection was more effective in the stressed rats imposed by immobilization than normal ones. In conclusion, ginseng water extract protected the age related deterioration of major antioxidant enzymes, and this effect was more striking with increasing duration of treatment. This comprehensive antioxidant action of ginseng seems to be bra certain action of ginseng other than a direct antioxidant action, which might be a long term normalizing effect through the harmony of various components.

• Korean Journal of Social Welfare Studies
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• v.42 no.2
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• pp.155-177
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• 2011

This study set out to investigate the effect of internet environment and gender on online sexual violence. The final sample size was 436 college students in Gwangju city, South Korea. Hierarchical regression analysis was used for analysis. The major findings of this study are as follows. First, more frequent usage of internet influenced directly increase of online sexual violence, and influenced also indirectly through favorable attitudes to deviance. Third, gender did not influence online sexual violence directly, but influenced indirectly. Male students' more favorable attitude to deviance affected more frequent online sexual violence. These results suggest that internet environment play a role in facilitating online sexual violence through normalizing or justifying online sexual deviance. And gender also affect online sexual violence indirectly through male students' more favorable attitudes to deviance rather than female. And limitations and implications of this study were discussed with respect to further studies.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.792-799
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• 2022

Building Information Modeling (BIM) technology is a key component of modern construction engineering and project management workflows. As-is BIM models that represent the spatial reality of a project site can offer crucial information to stakeholders for construction progress monitoring, error checking, and building maintenance purposes. Geometric methods for automatically converting raw scan data into BIM models (Scan-to-BIM) often fail to make use of higher-level semantic information in the data. Whereas, semantic segmentation methods only output labels at the point level without creating object level models that is necessary for BIM. To address these issues, this research proposes a hybrid semantic-geometric approach for clutter-resistant floorplan generation from laser-scanned building point clouds. The input point clouds are first pre-processed by normalizing the coordinate system and removing outliers. Then, a semantic segmentation network based on PointNet++ is used to label each point as ceiling, floor, wall, door, stair, and clutter. The clutter points are removed whereas the wall, door, and stair points are used for 2D floorplan generation. A region-growing segmentation algorithm paired with geometric reasoning rules is applied to group the points together into individual building elements. Finally, a 2-fold Random Sample Consensus (RANSAC) algorithm is applied to parameterize the building elements into 2D lines which are used to create the output floorplan. The proposed method is evaluated using the metrics of precision, recall, Intersection-over-Union (IOU), Betti error, and warping error.

• Journal of Ginseng Research
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• v.48 no.2
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• pp.190-201
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• 2024

Background: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable component of ginseng, possesses nephritis benefits in lupus-prone mice; however, the underlying mechanisms involving B cell subpopulations remain elusive. Methods: Female MRL/lpr mice were administered CK (40 mg/kg) intragastrically for 10 weeks, followed by measurements of anti-dsDNA antibodies, inflammatory chemokines, and metabolite profiles on renal samples. Podocyte function and ultrastructure were detected. Publicly available single-cell RNA sequencing data and flow cytometry analysis were employed to investigate B cell subpopulations. Metabolomics analysis was adopted. SIRT1 and AMPK expression were analyzed by immunoblotting and immunofluorescence assays. Results: CK reduced proteinuria and protected podocyte ultrastructure in MRL/lpr mice by suppressing circulating anti-dsDNA antibodies and mitigating systemic inflammation. It activated B cell-specific SIRT1 and AMPK with Rhamnose accumulation, hindering the conversion of renal B cells into plasma cells. This cascade facilitated the resolution of local renal inflammation. CK facilitated the clearance of deposited immune complexes, thus reinstating podocyte morphology and mobility by normalizing the expression of nephrin and SYNPO. Conclusions: Our study reveals the synergistic interplay between SIRT1 and AMPK, orchestrating the restoration of renal B cell subsets. This process effectively mitigates immune complex deposition and preserves podocyte function. Accordingly, CK emerges as a promising therapeutic agent, potentially alleviating the hyperactivity of renal B cell subsets during LN.

• Journal of Korean Medical classics
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• v.37 no.2
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• pp.11-30
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• 2024

Objectives : Not many studies have been done on the mechanism of the Gangeum or Gangpyoeum method which treats the Soyang Exterior Pattern, nor on which collective or individual roles the Gangeum medicinals play. Therefore in this study, four medicinals categorized as Gangpyoeum which are Jingjie, Fangfeng, Qianghuo, Duhuo, were analyzed in terms of their individual and collective effects. Methods : Content analysis based on the verses in the Donguisusebowon, and medicinal analysis on contents from the Donguibogam, Bencaogangmu, and Benjingshuzheng were carried out followed by a medicinal combination analysis using the InSAm 1.1 program. Results : The four medicinals Jingjie, Fangfeng, Qianghuo, Duhuo had the common effect of normalizing the Wei qi, allowing for unobstructed Qi flow to prevent production of dampness and phlegm, which ultimately lowers Yin[降陰, gangeum] and helps to preserve the Kidney Yin Qi. Jingjie works at the highest position of the upper body; Fangfeng, the most basic medicinal of the Soyangin pattern, works mostly at the upper body although it defends the entire body from wind-dampness. Qianghuo and Duhuo are more or less similar. The difference is that Qianghuo mostly pulls Yang qi upwards while eliminating pathological byproducts, and Duhuo stabilizes the lower body that pulls Wei qi upwards. Conclusions : Analysis on the relationship between Gangpyoeum of the Soyangin pattern and Wei qi, the individual and collective effects of the four Gangpyoeum medicinals were carried out. Further research on other major Soyangin medicinals, along with those of other constitution patterns is anticipated.

• Anatomy and Cell Biology
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• v.56 no.1
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• pp.69-85
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• 2023

Depression is one of the most common neuropsychiatric disorders and is associated with dysfunction of the neuroendocrine system and alterations in specific brain proteins. Boophone disticha (BD) is an indigenous psychoactive bulb that belongs to the Amaryllidacae family, which is widely used in Southern Africa to treat depression, with scientific evidence of potent antidepressant-like effects. The present study examined the antidepressant effects of BD and its mechanisms of action by measuring some behavioural parameters in the elevated plus maze, brain content of corticosterone, brain derived neurotropic factor (BDNF), and neuroblast differentiation in the hippocampus of Balb/c mice exposed to the five day repeated forced swim stress (5d-RFSS). Male Balb/c mice were subjected to the 5d-RFSS protocol to induce depressive-like behaviour (decreased swimming, increased floating, decreased open arm entry, decreased time spent in the open arms and decreased head dips in the elevated plus maze test) and treated with distilled water, fluoxetine and BD. BD treatment (10 mg/kg/p.o for 3 weeks) significantly attenuated the 5d-RFSS-induced behavioural abnormalities and the elevated serum corticosterone levels observed in stressed mice. Additionally, 5d-RFSS exposure significantly decreased the number of neuroblasts in the hippocampus and BDNF levels in the brain of Balb/c mice, while fluoxetine and BD treatment attenuated these changes. The antidepressant effects of BD were comparable to those of fluoxetine, but unlike fluoxetine, BD did not show any anxiogenic effects, suggesting better pharmacological functions. In conclusion, our study shows that BD exerted antidepressant-like effects in 5d-RFSS mice, mediated in part by normalizing brain corticosterone and BDNF levels.

• Advances in materials Research
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• v.13 no.3
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• pp.183-194
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• 2024

D3 tools steel and 440C stainless steel (SS) are normally being employed for application such as knife blade and cutting tools. These steels are iron alloys which have high carbon and high chromium content. In this study, lab work focused on the microstructural and corrosion behavior of D3 tools steel and 440C SS after went through heat treatment processes. Heat treatments for both steels were started with normalizing at 1020 ℃, continue with hardening at 1000 ℃followed by oil quenching. Cryogenic treatment was carried out in liquid nitrogen for 24 hours. The addition of cryogenic heat treatment is believed to increase the hardness and corrosion resistance for steels. Both samples were then tempered at two different tempering temperatures, 160 ℃ and 426 ℃. For corrosion test, the samples were immersed in NaCl solution for 30 days to study the corrosion behavior of D3 tool steel and 440C SS after heat treatment. The mechanical properties of these steels have been investigated using Rockwell hardness machine before heat treatment, after heat treatment (before corrosion) and after corrosion test. Microstructure observation of samples was carried out by scanning electron microscopy. The corrosion rate of these steels was calculated after the corrosion test completed. From the results, the highest hardness is observed for D3 tool steel which tempered at 160 ℃(54.1 HRC). In terms of microstructural analysis, primary carbide and pearlite in the as-received samples transform to tempered martensite and cementite after heat treatment process. From this research, for corrosion test, heat treated 440C SS sample tempered with 426 ℃possessed the excellent corrosion resistance with corrosion rate 0.2808 mm/year.

• Journal of Internet Computing and Services
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• v.20 no.4
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• pp.63-72
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• 2019

As a sub-concept of corporate or organization governance, business governance and IT governance have become major research topics in academia. However, despite the importance of process as a construct for mediating the domain between business and information technology, research on process governance is relatively inadequate. Process Governance focuses on activities that link business strategy with IT system implementation and explains the creation of corporate core values. The researcher studied the basic conceptual governance models of political science, sociology, public administration, and classified governance styles into six categories. The researcher focused on the series of metamodels. For examples, the traditional Strategy Alignment Model(SAM) by Henderson and Venkatraman which is replaced by the neo-SAM model, organizational governance network model, sequential organization governance model, organization governance meta model, process governance CUBE model, COSO and process governance CUBE comparison model, and finally Process Governance Framework and etc. The Major difference between SAM and neo-SAM model is Process Governance domain inserted between Business Governance and IT Governance. Among several metamodels, Process Governance framework, the core conceptual model consists of four activity dimensions: strategic aligning, human empowering, competency enhancing, and autonomous organizing. The researcher designed five variables for each activity dimensions, totally twenty variables. Besides four activity dimensions, there are six driving forces for Process Governance cycle: De-normalizing power, micro-power, vitalizing power, self-organizing power, normalizing power and sense-making. With four activity dimensions and six driving powers, an organization can maintain the flexibility of process governance cycle to cope with internal and external environmental changes. This study aims to propose the Process Governance competency model and Process Governance variables. The situation of the industry is changing from the function-oriented organization management to the process-oriented perspective. Process Governance framework proposed by the researcher will be the contextual reference models for the further diffusion of the research on Process Governance domain and the operational definition for the development of Process Governance measurement tools in detail.