• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2767-2773
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• 2016

Human glioma, arising from glial cells of the central nervous system, accounts for almost 30%of all brain tumours, neoplasms with a poor prognosis and high mortality rates worldwide. In the present study we assessed tissue architectural modifications associated with macrophage lineage cells, controversial major immune effector cells within the brain, in human glioma tissue samples from eastern India. Ethically cleared post-operative human glioma samples from our collaborative neurosurgery unit with respective CT/MRI and patient history were collected from the Nodal Centre of Neurosciences in Kolkata, over 9 months. Along with conventional histopathology, samples were subjected to silver-gold staining and fluorescence tagged immunophenotyping for the detection of electron dense brain macrophage/microglia cells in glioma tissue, followed by immune-phenotyping of cells. With higher grades, CD11b+/Iba-1+ macrophage/microglia architecture with de-structured boundaries of glioma lesions indicated malfunction and invasive effector state. Present study documented a contribution of microglia to glioma progression in Eastern India.

• Structural Engineering and Mechanics
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• 제13권2호
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• pp.135-154
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• 2002

This paper presents the convected material frame approach to study the nonlinear behavior of inelastic frame structures. The convected material frame approach is a modification of the co-rotational approximation by incorporating an adaptive convected material frame in the basic definition of the displacement vector and strain tensor. In the formulation, each discrete element is associated with a local coordinate system that rotates and translates with the element. For each load increment, the corresponding strain-displacement and nodal force-stress relationships are defined in the updated local coordinates, and based on the updated element geometry. The rigid body motion and deformation displacements are decoupled for each increment. This modified approach incorporates the geometrical nonlinearities through the continuous updating of the material frame geometry. A generalized nonlinear function is used to derive the inelastic constitutive relation and the kinematic hardening is considered. The equation of motion is integrated by an explicit procedure and it involves only vector assemblage and vector storage in the analysis by assuming a lumped mass matrix of diagonal form. Several numerical examples are demonstrated in close agreement with the solutions obtained by the ANSYS code. Numerical studies show that the proposed approach is capable of investigating large deflection of inelastic planar structures and providing an excellent numerical performance.

• Nuclear Engineering and Technology
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• 제53권9호
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• pp.2803-2815
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• 2021

This paper addresses the uncertainty quantification and sensitivity analysis of a depleted light-water fuel assembly of the Turkey Point-3 benchmark. The uncertainty of the fuel assembly decay heat and isotopic densities is quantified with respect to three different groups of diverse parameters: nuclear data, assembly design, and reactor core operation. The uncertainty propagation is conducted using a two-step analysis code system comprising the lattice code STREAM, nodal code RAST-K, and spent nuclear fuel module SNF through the random sampling of microscopic cross-sections, fuel rod sizes, number densities, reactor core total power, and temperature distributions. Overall, the statistical analysis of the calculated samples demonstrates that the decay heat uncertainty decreases with the cooling time. The nuclear data and assembly design parameters are proven to be the largest contributors to the decay heat uncertainty, whereas the reactor core power and inlet coolant temperature have a minor effect. The majority of the decay heat uncertainties are delivered by a small number of isotopes such as ²⁴¹Am, ¹³⁷Ba, ²⁴⁴Cm, ²³⁸Pu, and ⁹⁰Y.

• Nuclear Engineering and Technology
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• 제51권1호
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• pp.13-30
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• 2019

This paper presents the recent improvements in the DeCART code for HTGR analysis. A new 190-group DeCART cross-section library based on ENDF/B-VII.0 was generated using the KAERI library processing system for HTGR. Two methods for the eigen-mode adjoint flux calculation were implemented. An azimuthal angle discretization method based on the Gaussian quadrature was implemented to reduce the error from the azimuthal angle discretization. A two-level parallelization using MPI and OpenMP was adopted for massive parallel computations. A quadratic depletion solver was implemented to reduce the error involved in the Gd depletion. A module to generate equivalent group constants was implemented for the nodal codes. The capabilities of the DeCART code were improved for geometry handling including an approximate treatment of a cylindrical outer boundary, an explicit border model, the R-G-B checker-board model, and a super-cell model for a hexagonal geometry. The newly improved and implemented functionalities were verified against various numerical benchmarks such as OECD/MHTGR-350 benchmark phase III problems, two-dimensional high temperature gas cooled reactor benchmark problems derived from the MHTGR-350 reference design, and numerical benchmark problems based on the compact nuclear power source experiment by comparing the DeCART solutions with the Monte-Carlo reference solutions obtained using the McCARD code.

• Steel and Composite Structures
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• 제47권5호
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• pp.569-585
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• 2023

This paper proposes an efficient approach for the structural topology optimization of bi-directional functionally graded structures by incorporating popular radial basis functions (RBFs) into an implicit level set (ILS) method. Compared to traditional element density-based methods, a level set (LS) description of material boundaries produces a smoother boundary description of the design. The paper develops RBF implicit modeling with multiquadric (MQ) splines, thin-plate spline (TPS), exponential spline (ES), and Gaussians (GS) to define the ILS function with high accuracy and smoothness. The optimization problem is formulated by considering RBF-based nodal densities as design variables and minimizing the compliance objective function. A LS-RBF optimization method is proposed to transform a Hamilton-Jacobi partial differential equation (PDE) into a system of coupled non-linear ordinary differential equations (ODEs) over the entire design domain using a collocation formulation of the method of lines design variables. The paper presents detailed mathematical expressions for BiDFG beams topology optimization with two different material models: continuum functionally graded (CFG) and mechanical functionally graded (MFG). Several numerical examples are presented to verify the method's efficiency, reliability, and success in accuracy, convergence speed, and insensitivity to initial designs in the topology optimization of two-dimensional (2D) structures. Overall, the paper presents a novel and efficient approach to topology optimization that can handle bi-directional functionally graded structures with complex geometries.

• 대한조선학회논문집
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• 제43권3호
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• pp.351-361
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• 2006

The fatigue strength analysis of VLFS is carried out by using a 3-dimensional plate finite element model with a zooming technology which performs the modeling of wide portions of the structure by a coarse mesh but the concerned parts by a very fine mesh of t by t level. And a stepwise substructure modeling technique for global loading conditions is applied which uses the motion response of the global structure from 2-D plate hydroelastic analysis as the enforcing nodal displacements of the concern 3-D structural zooming model. Seven incident wave angles and whole ranges of frequency domains of wave spectrum are considered. In order to consider the effect of breakwater, the modified JONSWAP wave spectrum is used. Applying the wave data of installation region, the longterm spectrum analysis is done based on stochastic process and the fatigue life of the structure is estimated. Finally some design considerations from the view point of fatigue strength analysis of VLFS are discussed.

• Nuclear Engineering and Technology
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• 제51권2호
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• pp.356-368
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• 2019

This paper presents the verification and validation (V&V) of the STREAM/RAST-K 2.0 code system for a pressurized water reactor (PWR) analysis. A lattice physics code STREAM and a nodal diffusion code RAST-K 2.0 have been developed by a computational reactor physics and experiment laboratory (CORE) of Ulsan National Institute of Science and Technology (UNIST) for an accurate two-step PWR analysis. The calculation modules of each code were already verified against various benchmark problems, whereas this paper focuses on the V&V of linked code system. Three PWR type reactor cores, OPR-1000, three-loop Westinghouse reactor core, and APR-1400, are selected as V&V target plants. This code system, for verification, is compared against the conventional code systems used for the calculations in nuclear design reports (NDRs) and validated against measured plant data. Compared parameters are as follows: critical boron concentration (CBC), axial shape index (ASI), assembly-wise power distribution, burnup distribution and peaking factors. STREAM/RAST-K 2.0 shows the RMS error of critical boron concentration within 20 ppm, and the RMS error of assembly power within 1.34% for all the cycles of all reactors.

• 한국구조물진단유지관리공학회 논문집
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• 제19권2호
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• pp.76-83
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• 2015

본 연구의 목적은 고충진 합성목재를 이용하여 친환경 모듈러 돔 구조시스템을 개발하고 부재와 절점을 모듈화하여 실제 구조체을 제작하는 것이다. 기존의 합성목재에 비해 높은 70% 목분함량 합성목재를 돔 구조모델의 부재로 이용하였고, 정이십면체 기반 지오데직 돔의 기하학적 특성을 분석하여 절점과 부재를 모듈화 하였다. 돔의 제작을 위한 모듈화와 실제 구조물의 제작과정의 연구결과로부터 6가지 절점과 3개의 부재종류의 모듈러 돔에 대한 적용성을 검토할 수 있었다. 또한 해석결과에서 최저차 좌굴모드는 경계부의 절점에서 절점좌굴이 예상되었다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 추계학술대회논문집
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• pp.776-785
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• 2006

Ship builder's requirement for a higher power output rating has lead to the development of super large two stroke low speed diesel engines. Usually a large-sized bore ranging from 8-14 cylinders, this engine group is capable of delivering power output of more than 100,000 bhp at maximum continuous rating. Other positive aspects of this engine type include higher thermal efficiency, reliability, durability and mobility. This all playa vital role in meeting the propulsion requirement of vessels, specifically for large container ships, of which speed is a primary concern to become more competitive. Consequently, this also resulted in the modification of engine parameters and new component designs to meet the consequential higher mean effective pressure and higher maximum combustion pressure. Even though the fundamental excitation mechanism unchanged, torsional vibration stresses in the propulsion shafting are subsequently perceived to be higher. As such, one important viewpoint in the initial engine design is the resulting vibration characteristic expected to prevail on the propulsion shafting system(PSS). This paper investigated the torsional vibration characteristics of these super large engines. For the two node torsional vibration with a nodal point on the crankshaft, a tuning damper is necessary to reduce the torsional stresses on the crankshaft. Hence, the tuning torsional vibration damper design and compatibility to the shafting system was similarly reviewed and analyzed.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1991년도 하계학술대회 논문집
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• pp.753-756
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• 1991

This paper aimed to analyse dose sensitivity to the controllable parameters of in-door radon $(^{222}Rn)$ and its decay products(Rn-D) by applying the input-output linear system theory. Physical behaviors of $^{222}Rn$ & Rn-D were analyzed in terms of $^{222}Rn$ gas generation, -migation and - infiltration to indoor environments, and the performance output-function(i.e. mean dose equivalent to Tracho-Bronchial(TB) lung region was assessed to the following ranges of the controllable parameters; a) the ventilation rate constant $({\lambda}_v)$ : $0{\sun}500[h^{-1}]$. b) the attachment rate constant$({\lambda}_a)$ : 0-500 $[h^{-1}]$. c) deposition rate constant $({\lambda}{_{d}^{u}})$: 0-50$[h^{-1}]$. A linear input-output model was reconstructed from the original models in literatures, as follows, which was modified into the matrices consisting of 111 nodal equations. a) indoor ${222}Rn$ & Rn-D Behaviour: jacobi- Porstendorfer- Bruno model. b) lung dosimerty : Jacobi-Eisfeld model. Some of the major findings, which identify the effectiveness of this model, were as follows. a) ${\lambda}_v$ is most effective, dominant controllable parameters in dose reduction, if mechanical ventilation is applied. b) ${\lambda}_v$, depending on the air particle-concentration, reduces the dose somewhat within ${\lambda}_v$<1 $h^{-1}R range. However, the dose increases conversely, ${\lambda}_v$>1 $h^{-1}R range range. c) ${\lambda}{_{d}^{4}}$ reduces the dose linearly as ${\lambda}_v$ dose. Such dose(z-axis) sentivities are shown with three-dimensional plots whoes x,y-axes are combined 2out the 3 parameter${\lambda}_v{\lambda}_s,\;{\lambda}_d^s$.