• Journal of Pharmaceutical Investigation
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• v.35 no.3
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• pp.157-163
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• 2005

The pellets with multiple drug release system (MDRS) of Diltiazem. HCl which consist of immediate drug release layer, drug reservoir layer and controlled release rate membrane, were prepared by using CF-Coater. As main factors for more effective MDRS of Diltiazem. HCl, ethylcellulose was used for the controlling drug release rate, and diethylphthalate was used for plasticizer, respectively. In vitro evaluation study was performed by comparative dissolution test between our test MDRS and reference Diltiazem. HCl preparation. The physical tests were performed using FT-IR and SEM. In vivo evaluation was also performed by observing the behavior of a plasma drug concentration after oral administration. The bioavailability was determined by analyzing the blood sample after oral administration to healthy, male volunteers once a day. As a result, there were no significant differences in bioequivalence parameters $(AUC_{\infty},\;C_{max},\;t_{1/2})$ between two systems. It might be concluded that our MDRS of Diltiazem. HCl could be an alternative delivery system to reference drug preparation.

• Journal of Pharmaceutical Investigation
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• v.39 no.2
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• pp.111-115
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• 2009

The pharmacokinetics of cyclosporin A (CsA) after single and multiple oral dosing of new CsA self-micro-emulsifying drug delivery system (SMEDDS) in dogs were estimated. A single dose study was performed following a two-way crossover design against six dogs with reference SMEDDS. For a multiple dose study, three dogs were allocated for each drug, and 100 mg of drug was administered daily for 6 days. Whole blood concentration of CsA was analyzed by radio-immunoassay. Both drug showed identical blood concentration profiles in both studies, and no statistical difference was detected in pharmacokinetic parameters. The relative bioavailabilities of test SMEDDS were 91.4% and 89.1%, respectively, in the single dose study and the last day of multiple dose study. Especially, multiple dose study proved the good relationship between C-0/C-2 and AUC for reference SMEDDS, which is an indispensable part of therapeutic drug monitoring. These results suggest newly formulated CsA SMEDDS possibly shows identical pharmacokinetics and pharmacodynamic behaviors in clinical trials.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.1-13
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• 2010

Numerous landslides had occurred in Kangwondo in July 2006 and several restoration works had been done. A-day-accumulative rainfalls from July 12 to July 13 and July 15 to July 16 were 176mm and 202mm respectively. Disaster sites at which slope failures were studied to main causes of slope failures by investigating characteristics of rainfall, geological formation, topography and ground surface exploration around the boundary of landslides. In this study, a series of slope restoration work process is presented for reference which about the landsliding area in Han-Gye-Ryeong to O-Saek in Kwangwon-do where one of the most severe damaged area in 2006. The slope restoration work process includes site investigation, analysis on affected factor, restoration or reinforcing method design, construction procedure and recent status of that area. Also several considering points are suggested while design and construction for the reference at the other restoration works.

• International Journal of Knowledge Content Development & Technology
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• v.9 no.4
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• pp.31-45
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• 2019

In this study, a database was established by analyzing the record data research produced in ice hockey sports. The deployed data verification with Ice hockey reference service was demonstrated with ice hockey officials and players. This research utilized the data stored in the KNSU Datanest data repository and developed PDF parsers for batch processing of records. Among the types of records, the game summary, team roster, team statistics, and player statistics files were collected, and tables were extracted from the records. PDF records were converted to text in CSV format which are converted to DataFrame and loaded into the database. Out of the total 22 types of records, 4 types were constructed with OO data parsed as element values. Data verification has found no problems with the quality of the data deployed, showing a high satisfaction with providing 66 factors against the 30 factors provided by the service previously used.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.924-925
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• 2008

There are many types of grid-connected inverter controllers, PI controller based is the most popular methods. But, a common PI control is produced zero-steady state error and phase delay in sinusoidal reference. Synchronous reference frame or DQ transform based controller is capable for reducing both of zero-steady state error and phase delay is. But DQ transform based controller has cross-coupling component which difficult to analyze the system in single phase model. In this paper, to obtained single phase model of the system, DQ transform based controller is analyzed in two techniques. The first is by neglecting cross-coupling. The second is eliminated cross-coupling component by decoupling method. By these two techniques, single phase model is obtained. Then, the single phase model is analyzed to evaluate its performance in stability and frequency response, through Root Locus and Bode diagram, respectively. MATLAB and PSIM simulation is used to verify the analysis. Simulation result is shown; cross-coupling component has no significant influent to the controller.

• Journal of Korea Multimedia Society
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• v.12 no.3
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• pp.397-408
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• 2009

Image training is a very important yet difficult state for automated visual inspection using computers. Because the size of parts for the recently produced PCB (Printed Circuit Board) becomes smaller and circuit patterns gradually become more complex, a difficult and complex training process is becoming a big problem within an industry where development cycle for new products is short and various products must be inspected. This research produced a reference image by using CAD (Gerber) file which becomes a standard for PCB automatic visual inspection. Reference image from a Gerber file guarantees PCB patterns with no defects. Through system implementation and experimentation, Gerber file is used in order to propose a plan which allows an easy training process for PCB automatic visual inspection system.

• 유체기계공업학회:학술대회논문집
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• 2005.12a
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• pp.244-249
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• 2005

Flow distribution and pressure drop analysis for an inlet plenum of a Pebble Bed Modular Reactor (PBMR) have been performed using Computational Fluid Dynamics. Three-dimensional Navier-Stokes equations have been solved in conjunction with $k-{\epsilon}$ model as a turbulence closure. Non-uniformity in flow distribution is assessed for the reference case and parametric studies have been performed for rising channels diameter, Reynolds number and angle between the inlet ports. Also, two different shapes of the inlet plenum namely, rectangular shape and oval shape, have been analysed. The relative flow mal-distribution parameter shows that the flow distribution in the rising channels for the reference case is strongly non-uniform. As the rising channels diameter decreases, the uniformity in the flow distribution as well as the pressure drop inside the inlet plenum increases. Reynolds number is found to have no effect on the flow distribution in the rising channels for both the shapes of the inlet plenum. The increase in angle between the inlet ports makes the flow distribution in the rising channels more uniform.

• Korean Journal of Veterinary Research
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• v.46 no.4
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• pp.387-393
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• 2006

Progressing to the iron deficiency anemia was experimentally induced in 4 clinically healthy dogs by repeated phlebotomy to characterize hematologic features, serum iron values, and RBC indices. Abnormal RBC morphologies were also evaluated semiquantitatively on Wright's-stained blood films. Hematologic abnormalities in early stage of anemia included decreased both hematocrit and hemoglobin, and reticulocytosis, with no changes in mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were represented. In intermediate stage, decreased serum iron concentration with microcytosis and hypochromia were prominent. In late stage, red cell distribution width and Mentzer's index were out of reference ranges in the majority of dogs. In this study microcytic anemia was appeared at the hemoglobin range of 5.1-7.2 g/dl. On most sampling days, platelet counts and white blood cells were within the reference ranges, with some minor variations. Iron deficiency was not necessarily associated with microcytic anemia. Judging from the sequential changes of both MCV and MCHC, 3 patterns of anemia were sequentially observed: initially normocytic normochromic, intermediate normocytic hypochromic or normocytic normochormic, and finally microcytic hypochromic. The most frequent morphologic abnormalities were target cells. Occasional elliptocyte, acanthocyte, stomatocyte, kinzocyte, dacrocyte and schistocyte were also noted on the blood films.

• Food Science and Biotechnology
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• v.18 no.5
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• pp.1118-1123
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• 2009

Event-specific real-time polymerase chain reaction (PCR) detection method for genetically modified (GM) maize MIR604 was developed based on integration junction sequences between the host plant genome and the integrated transgene. In this study, 2 primer pairs and probes were designed for specific amplification of 100 and 111 bp DNA fragments from the zSSIIb gene (the maize endogenous reference gene) and MIR604. The quantitative method was validated using 3 certified reference materials (CRMs) with levels of 0.1, 1, and 10% MIR604. The method was also assayed with 14 different plants and other GM maize. No amplification signal was observed in real-time PCR assays with any of the species tested other than MIR604 maize. As a result, the bias from the true value and the relative deviation for MIR604 was within the range from 0 to 9%. Precision, expressed as relative standard deviation (RSD), varied from 2.7 to 10% for MIR604. Limits of detections (LODs) of qualitative and quantitative methods were all 0.1%. These results indicated that the event-specific quantitative PCR detection system for MIR604 is accurate and useful.

• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3128-3132
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• 2010

A disposable solid-state pH sensor was realized by utilizing two nanoporous Pt (npPt) electrodes and a copolyelectrolytic junction. One nanoporous Pt electrode was to measure the pH as an indicating electrode (pH-IE) and the other assembled with copolyelectrolytic junction was to maintain constant open circuit potential ($E_{oc}$) as a solid-state reference electrode (SSRE). The copolyelectrolytic junction was composed of cationic and anionic polymers immobilized by photo-polymerization of N,N'-methylenebisacrylamide, making buffered electrolytic environment on the SSRE. It was expected to make. The nanoporous Pt surrounded by a constant pH excellently worked as a solid state reference electrode so as to stabilize the system within 30 s and retain the electrochemical environment regardless of unknown sample solutions. Combination between the SSRE and the pH-IE commonly based on nanoporous Pt yielded a complete solid-state pH sensor that requires no internal filling solution. The solid state pH sensing chip is simple and easy to fabricate so that it could be practically used for disposable purposes. Moreover, the solid-state pH sensor successfully functions in calibration-free mode in a variety of buffers and surfactant samples.