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Comparative Analysis of 3 Experimental Mouse Model for Blood Hematology and Chemistry

  • Kong, Dae Young;Park, Jung Hwan;Lee, Kyo Won;Park, Ho;Cho, Jung Ah
    • Biomedical Science Letters
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    • v.22 no.3
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    • pp.75-82
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    • 2016
  • The immune system and neuroendocrine systems are the two key components that maintain bodily homeostasis. Peripheral blood specimens can indicate abnormalities in a body, which often cause various threats to human health, including devastating autoimmune or metabolic diseases. To develop a treatment regimen for such diseases, experimental animal models are indispensable to researchers in academic fields. In this study, we examined the peripheral blood of 3 representative mouse strains (ICR, Balb/c, and C57Bl/6), which are widely used, to investigate whether there is a difference in reference range according to animal model. We performed hematological and chemistry analysis on individuals of both genders. The results of hematology analysis showed that the number of most types of blood cells was lower in ICR than in the other two strains. The results of chemical analysis revealed no specific pattern, but different patterns according to the individual indicator. Although the distinction between ICR and B6 was prominent, differences between Balb/c and B6 were also observed for several indicators. For some indicators, totally different patterns existed between females and males. Conclusively, this study provides the information that 3 experimentally representative mouse models have their own basal levels of blood components, suggesting the importance of a careful choice of a proper mouse model in research into immune or metabolic diseases, to exclude any biases.

Evaluation of Critical Flow Factor in Natural Gas Flow Measurement Using Sonic Nozzle and International Comparison Results (소닉노즐을 이용한 천연가스 유량측정에서 임계유동인자 계산 및 국제비교 결과)

  • Ha, Youngcheol;Her, Jaeyoung
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.23 no.7
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    • pp.911-917
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    • 1999
  • The sonic nozzle is widely used as reference device for calibrating flowmeters In gas flow measurement and its use requires the Critical Flow Factor(CFF) based on the thermodynamic properties of the gas at the nozzle throat. ISO-9300 provides the calculating method of the factor. But since the CFF from this method show an error over ${\pm}0.5%$ In specific conditions and of ${\pm}0.1{\sim}{\pm}0.2%$ in common Natural Gas(NG) custody transfer condition. this method cannot be applied for gas flow measurement with sonic nozzle. Each research bodies or organizations of the world have joined in order to calculate the CFF more accurately. They have performed these works using their own method and compared the results with each other under the management of ISO. KOGAS have joined those works, because the high-pressure natural gas flow calibration facility of KOGAS will be constructed in late 1999, and then had necessities to calculate a CFF accurately. The calculation method of KOGAS was using the equation of state from AGA-8('94), high accuracy model of ideal gas properties and the solutions of thermodynamic equations. The evaluation results have had a very good consistency within ${\pm}0.05%$ in most NO custody transfer conditions compared to the speed of sound for methane and also shown that the CFF was within ${\pm}0.1%$ compared to the results of other works of the world.

Performance Evaluation of Caching in PON-based 5G Fronthaul (PON기반 5G 프론트홀의 캐싱 성능 평가)

  • Jung, Bokrae
    • Journal of Convergence for Information Technology
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    • v.10 no.1
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    • pp.22-27
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    • 2020
  • With the deployment of 5G infrastructure, content delivery network (CDN) will be a key role to provide explosive growing services for the independent media and YouTube which contain high-speed mobile contents. Without a local cache, the mobile backhaul and fronthaul should endure huge burden of bandwidth request for users as the increase number of direct accesses from contents providers. To deal with this issue, this paper fist presents both fronthaul solutions for CDN that use dark fibers and a passive optical network (PON). On top of that, we propose the aggregated content request specialized for PON caching and evaluate and compare its performance to legacy schemes through the simulation. The proposed PON caching scheme can reduce average access time of up to 0.5 seconds, 1/n received request packets, and save 60% of backhaul bandwidth compared to the no caching scheme. This work can be a useful reference for service providers and will be extended to further improve the hit ratio of cache in the future.

Comparing Efficiencies of R&D Projects Using DEA : Focused on Industrial Technology Program (DEA를 활용한 R&D 프로젝트의 효율성 비교 : 산업기술사업을 중심으로)

  • Kim, Heung-Kyu;Kang, Won-Jin;Bae, Jin-Hee
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.38 no.3
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    • pp.29-38
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    • 2015
  • In this paper, scale efficiencies and relative efficiencies of R&D projects in Industrial Technology Program, sponsored by Ministry of Trade, Industry and Energy, Korea, are calculated and compared. For the process, various DEA (Data Envelopment Analysis) models are adopted as major techniques. For DEA, two stage input oriented models are utilized for calculating the efficiencies. Next, the calculated efficiencies are grouped according to their subprograms (Industrial Material, IT Fusion, Nano Fusion, Energy Resources, and Resources Technology) and recipient types (Public Enterprise, Large Enterprise, Medium Enterprise, Small Enterprise, Lab., Univ., and etc.) respectively. Then various subprograms and recipient types are compared in terms of scale efficiencies (CCR models) and relative efficiencies (BCC models). In addition, the correlation between the 1st stage relative efficiencies and the 2nd stage relative efficiencies is calculated, from which the causal relationship between them can be inferred. Statistical analysis shows that the amount of input, in general, should increase in order to be scale efficient (CCR models) regardless of the subprograms and recipient types, that the 1st and 2nd stage relative efficiencies are different in terms of the programs and recipient types (BCC models), and that there is no significant correlation between the 1st stage relative efficiencies and the 2nd stage relative efficiencies. However, the results should be used only as reference because the goal each and every subprogram has is different and the situation each and every recipient type faces is different. In addition, the causal link between the 1st stage relative efficiencies and the 2nd relative efficiencies is not considered, which, in turn, is the limitation of this paper.

An Analysis of User Satisfaction of K University's Library Service

  • Noh, Young-Hee;Choi, Min-Ju;Choi, Yong-Wog;Jeong, Sin-Won;Jung, Eun-Ji;Kang, Mi-So;Kim, Jin-Young;Lee, Kyung-Won;Lee, Sung-Jae;Oh, Seon-Hye;Park, So-Yeon;Shin, Sung-Chul;Suh, Da-Jeong
    • International Journal of Knowledge Content Development & Technology
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    • v.1 no.1
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    • pp.61-79
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    • 2011
  • This study purposed to discover whether or not academic libraries reflect these changing roles. We selected K University as the research target and surveyed user satisfaction of materials, staff services, facilities, electronic devices, media, and so on. The research findings are as follows: 1) the frequency of library visits of University K was on the high side, 2) the primary purpose of using the academic library was associated with learning or reading, therefore, the most used library spaces were related to that, 3) the most used library materials were 'general books', the most unused were 'reference books', 4) the most preferred way to obtain needed materials when failing to find wanted materials was 'Contact librarian'. A similar phenomenon occurred in terms of facility use, 5) university K's users were usually satisfied with the loan policy, 6) the rate of users who don't know whether there is user education was very high, the rate of users who have no experience with user education was extremely low. These research findings can be referenced by library management to improve libraries' service quality and take advantage of complex spatial configurations.

The Way to Improve the English Writing Ability Based on the Performance Assessment (수행 평가를 적용한 영어 쓰기 능력 향상 방안)

  • Song, Myeong-Seok
    • English Language & Literature Teaching
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    • v.8 no.1
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    • pp.165-198
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    • 2002
  • The purpose of this research is to improve the writing ability of students by an ideal test model of English writing based on strategies of procedural learning stages enhancing the level of students' writing ability. Assessment of writing in the field of English education has been limited so far to very restricted areas with no appropriate scientific scrutiny. Assessment is really meaningful only when it exactly estimates the ability of students. Since English writing competence has become indispensable in this era of global village, writing instruction should be most emphasized. The most forceful method of busting writing instruction is to utilize the so-called washback effect of testing. So, to develop a good test model of writing, the first thing that is required is to inspect writing strategy in steps and, then, testing itself. First of all, analyzed with a special reference to the 6th high school English curriculum were the goals and contents of the syllabus reflected in one kind of junior high textbook and eight different kinds of senior high textbooks. Then questionnaires on the whole area of writing and tendencies of English writing classes were given to 100 English teachers, 300 students. The results of questionnaires were statistically analyzed. Then, some suggestions and opinions about the questioning method were made: the procedural strategy in steps, English writing instruction and test model of assessment were applied to the syllabus referring to teaching plans. On the bases of the results of the questionnaires, three pretests and a final test of English writing were administered to verify the effect of enhanced English writing competence which had been gradually promoted and, through the promotion, produced the test criteria of English writing. In conclusion, guidance and evaluation of English writing through in steps are really indispensable to increase student's practical ability and, accordingly, we are in need of the development of a testing method of useful writing practiced in school class above anything else. So, it is necessary to further the study on methods to assess writing ability on the bases of participation and fluency of students with their keen interest in English. Also, to intensify the effect of the test model, more accommodating reorganization of syllabus is required in our education. For instance, we need a flexible operation in organizing time units from the current 50 minutes to 100-130 minutes.

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The Effects of Preparatory Nursing Information and Information Offered by Short Message Service on Anxiety and Nursing Satisfaction among Family Members of the Intensive Care Unit In-patients (사전 간호정보제공과 단문 문자 메시지 서비스를 활용한 정보제공이 중환자실 환자 가족의 불안 및 간호만족도에 미치는 영향)

  • Choi, Jung Hoon;Kim, Ju Ae;Hong, Nam Soon;LEE, Bo Hye;LEE, Eun Hee
    • Journal of Korean Clinical Nursing Research
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    • v.19 no.3
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    • pp.383-394
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    • 2013
  • Purpose: This study was conducted to investigate the effects of preparatory nursing information and information offering by SMS on anxiety and nursing satisfaction among family members of ICU (Intensive Care Unit) inpatients. It utilized a quasi-experimental research design with a non-equivalent and non-synchronized control group. Methods: The experimental group and the control group were offered a booklet guiding ICU and were offered face-to-face information by nurses using Power Point. The experimental group was additionally offered SMS (short message service) message on patient's safety at night every morning during the hospital stay between 8 and 9 am. All participants in the experimental group and the control group were measured in reference to anxiety at the point of hospitalization and were surveyed anxiety and nursing satisfaction on the third day of hospital stay. Results: The anxiety demonstrated no significant difference between the groups, while the nursing satisfaction was significantly higher in the experimental group than that of the control group. Conclusion: Proving direct information and indirect information via SMS message were considered effective in improving the family member's satisfaction with nursing care. The frequencies of SMS message and the contents of the message and information need to be defined and specified in the given population.

Quantitative Analysis of Quality Control of Natural Medicine by $^1H-NMR$ Spectrometry-Quantitative Analysis of Hesperidin from Citrus unshiu ($^1H-NMR$을 이용한 한약재의 품질 평가 방법 확립;진피의 Hesperidin 정량분석)

  • Ahn, Eun-Mi;Baek, Mi-Young
    • The Korea Journal of Herbology
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    • v.23 no.3
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    • pp.27-32
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    • 2008
  • Objectives : In this paper, we describe that $^1H-NMR$ spectroscopy may be superior to the conventional HPLC for the quantitative analysis of hesperidin from Citrus unshiu. Methods : $^1H-NMR$ spectra (400 MHz) were recorded in $DMSO-d_6$ using a Varian UNITY Inova AS 400 FT NMR spectrometer. One hundred milligram of powdered Citrus unshiu was weighed out and mixed with 1 ml of $DMSO-d_6$ with sonication for 30 min (room temperature). The extracts were filtrated through a 0.45 ${\mu}m$ PVDF filter and 0.5 ml of filtrated extract used for quantitative $^1H-NMR$ measurement (added 1 mg of dimethyl terephthalate as internal standard). The quantity of hesperidin was calculated by the ratio of the intensity of the compound to the known amount of internal standard. For HPLC analysis, the half gram of plant material was extracted with 60 ml of MeOH for 2 hours. The extracts were made 100 ml volume and analyzed by a Waters HPLC system using a YMC ODS column. The total flow rate was 1.0 ml/min with a sample volume 10 ${\mu}l$ and UV detection at 280nm. Results : The contents of hesperidin in Citrus unshiu was determined $5.33{\pm}0.06$% in the quantitative $^1H-NMR$ method and $5.15{\pm}0.12%$ in HPLC method. Using the quantitative $^1H-NMR$ the contents of hesperidin can be determined in much shorter time than the conventional HPLC measurements. Conclusions : From those results, the advantages of quantitative $^1H-NMR$ analysis are that can be analyzed to identify and quantify, and no reference compounds required for calibration curve. Besides, it allows rapid and simple quantification for hesperidin with an analysis time for only 10 min without any pre-purification steps.

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South Korea's Ten-Year Experience with CISG and its Prospects (한국 CISG 가입 10주년 회고와 전망)

  • Oh, Won-Suk
    • Journal of Arbitration Studies
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    • v.25 no.4
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    • pp.77-95
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    • 2015
  • CISG provides a uniform framework for contracts of sale of goods between parties whose places of business are in different States. In 2004 South Korea became the 63th State around world to adopt CISG. Starting next year CISG goes into effect as the law that governs the contracts for international sale of goods, in respect of which CISG displaces the existing domestic civil and commercial codes of Korea. By its provision Article 1(a), CISG applies directly between Contracting States without reference to private international law. As South Korea's biggest trade partners including China, the U.S. and Japan are also parties to CISG, the number of such direct applications continuously increases. Now it is estimated, though roughly, that CISG governs about two-thirds of Korea's import and export trade of goods. The private survey of the author shows that up to now in South Korea there are 39 court cases decided by the first instance courts, 29 cases by the appellate court and six cases by the Supreme Court of South Korea. In nearly all these cases, CISG applied directly. Furthermore, currently CISG is, in several respects, influencing upon the revision of Korean civil code which is designed to modernize it: The revised draft published in 2013 adopts the rules on the revocation of offers provided in articles 15 and 16, the rule on the termination of offers provided in article 17 and the rule on the time that an acceptance takes its effect provided in article 18 of CISG. More importantly, in accordance with the rules taken by CISG, the revision draft no longer requires the existence of fault or negligence on behalf of the breaching party in order for the aggrieved party to void the contract, and the revised draft denies the right of avoidance for trivial, not fundamental, breaches of contract.

Effect of Anterior Guidance Change on the Condylar Path in Skeletal Class I Young Adult Women Using a Splint with Flat or Steep Anterior Guidance

  • Choi, Byung-Taek;Baek, Seung-Hak
    • Journal of Korean Dental Science
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    • v.5 no.1
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    • pp.29-36
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    • 2012
  • Purpose: To investigate the effects of anterior guidance (AG) change on the working (WCP) and non-working condylar paths (NWCP), and lower incisor path (LIP) using a splint with flat (FAG) or steep AG (SAG). Materials and Methods: The samples consisted of six young adult women (mean age=$23.5{\pm}3.3$ years). Inclusion criteria were skeletal Class I and normodivergent pattern, normal overbite/overjet, minimal slide from retruded cuspal position to intercuspal position, no temporomandibular disorder signs and symptoms, mutually protected occlusion, and minimal tooth wear. After the values of natural AG (NAG) were obtained as a reference for each patient, two types of splints ($15^{\circ}$ flatter and steeper than NAG) were made. After insertion of the splints with FAG or SAG, the WCP, NWCP, and LIP were recorded five times for each patient using an ultrasonic AQR (SAM, Munich, Germany) and statistical analysis was subsequently performed. Result: NAG exhibited postero-superior movement in the WCP and did not show a noticeable immediate side shift (ISS) or difference between the eccentric (EP) and returning paths (RP) in the NWCP. FAG was associated with an irregular and excessive WCP, an increase in ISS, and a difference between EP and RP in the NWCP. SAG showed minimal WCP movement and a decrease in the extent of difference between EP and RP in the NWCP. LIP showed significant differences in EP and in RP (P<0.001, all; FAG