• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6745-6748
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• 2014

Background: Nowadays, molecular biomarkers have critical roles for cancer diagnosis and prognosis in clinical laboratories. Human papillomaviruses are the main agents for etiology of cervical carcinoma. The present survey was conducted to evaluate the genes methylation in cervical cancer and precancerous lesions involvement with HPV genotypes. Materials and Methods: C13orf18 and C10rf166 (MULl or Mulan) DNA methylation as potential biomarkers and risk factors was investigated in 112 liquid based cytology and Formalin-Fixed Paraffin-Embedded tissue specimens in Iranian females with cervical intraepithelial neoplasia and dysplasia. Results: In this survey, HPV18 (61.6%) and HPV16 (42.9%) proved to be the most common HPV genotypes identified by In-House Multiplex Real Time PCR. There were no significant relationship between HPV positivity and the methylated DNA genes mentioned above (p>0.05). Conclusions: Our MethyLight data demonstrated that these genes could not be considered as specific, sensitive and suitable prognostic biomarkers in cervical dysplasia related HPV. It is suggested that further studies with more patients should be done on candidate methylated markers in different countries in order to plan for cervical cancer prevention.

• The Korean Journal of Pain
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• v.23 no.1
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• pp.11-17
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• 2010

Background: The target of lumbar sympathetic ganglion block is the anterolateral surface of the L2, 3 and 4 vertebral bodies, where the lumbar sympathetic ganglion usually lies. In most cases, a block-needle is inserted approximately 5-8 cm lateral to spinous process on the skin and directed to the anterolateral surface of vertebral body obliquely. The purpose of this study is to determine the safe entry angle and entry point in Korean by using the abdominal CT scan images. Methods: The abdominal CT images of eighty five patients were recruited to this study. The minimal angle aimed at the lumbar sympathetic ganglion that can pass through the lateral aspect of body and maximal angle that avoids puncturing the kidney, ureter or retroperitoneal space were measured. The distance from midline to skin entry point was also measured. Results: There was no significant difference in entry angle among L2, 3, and 4 level. The entry angle was similar in the right and left side, and in males and females. The entry angle of old age group was significantly smaller than that of young age group. The calculated safe entry angle was $30.5{\pm}0.4^{\circ}$ and entry point was $7.7{\pm}0.2\;cm$ and $6.7{\pm}0.1\;cm$ lateral from midline in males and females respectively. Conclusions: These measurements can be used as a reference for lumbar sympathetic ganglion block and radiofrequency lesioning. Prior to performing the lumbar sympathetic ganglion block for cancer patients, the abdominal CT scan should be reviewed to prevent complications.

• Journal of Pharmaceutical Investigation
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• v.35 no.5
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• pp.355-360
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two cetirizine HCl tablets, Zyrtec tablet (UCB Pharm. Co., Ltd. Korea, reference product) and Zyrix tablet (Kukje Pharm. Co., Ltd., Korea, test product), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (diazepam), plasma samples were extracted using 1 mL of dichloromethane. Compounds extracted were analyzed by reverse-phase HPLC with ultra-violet detector. This method for determination cetirizine is proved accurate and reproducible with a limit of quantitation of 10 ng/mL in male plasma. Twenty-four healthy male Korean volunteers received each medicine at the cetirizine HCl dose of 10 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of cetirizine were monitored for over a period of 24 hr after the administration. AUC (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed AUC and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 $(e.g.,\;log\;0.93-log\;1.08\;for\;AUC_{0-t},\;log\;0.91-log\;1.08\;for\;AUC_{0-{\infty}}\;and\;log\;1.01-log\;1.11\;for\;C_{max})$. The major parameters, AUC and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that Zyrix tablet is bioequivalent to Zyrtec tablet.

• Journal of the Korean association of regional geographers
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• v.15 no.2
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• pp.204-214
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• 2009

The purpose of this paper is to elucidate the formation processes of Hwaeumneup in Cheonseong Mountain which was designated as Wetland Conservation Area in 2002, and to offer data essential to sustainable management of wetland. According to wetland core samples and carbon dating of humus, grassland of Hwaeumneup Wetland Reservation resulted from slash-and-burn agriculture in no reference with climatic changes of last glacial period. And Hwaeumneup is a alpine wetland that is formed as rain water over Cheonseong Mountain crest area infiltrates into bedrock, springs out along joint line below main ridge, and dampens gentle grassland. It needs to support dense vegetation of southwestern ridge of Wetland Reservation in order to sustain water volumn of Hwaeumneup wetland, and to keep from breakdown of block dam at downstream fringe of wetland. And it needs to measure and analyse micro-topography and hydrology changes in Hwaeumneup Wetland Reservation through periodic monitoring.

• Environmental Engineering Research
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• v.19 no.4
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• pp.309-316
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• 2014

The water quality improvement of golf course ponds, as representative stagnant stream channels, was evaluated by applying a biological activated carbon (BAC) process composed of four consecutive activated carbon reactors. The study was performed from autumn to winter in order to evaluate the feasibility of the BAC process under low temperature conditions. In the study, water quality of pond A (target pond) and pond B (reference pond) were monitored. Pond water was pumped into the BAC process, and was then returned to the pond after treatment. The optimal conditions were determined to be 2 hr of empty bed contact time (EBCT) at a temperature above $4^{\circ}C$, in which improvements of chemical oxygen demand (COD), total nitrogen (TN) and total phosphorus (TP) of pond A compared to pond B were 3.62%, 3.48% and 1.81%, respectively. On the other hand, as the temperature was below $4^{\circ}C$, some degree of water quality improvement was achieved even when EBCT were 1 or 0.5 hr, suggesting that the BAC process can be successfully applied for the improvement of pond water quality in winter months. The values of biomass concentration and microorganism activity in each condition were highest where 2 hr of EBCT was applied at a temperature above $4^{\circ}C$, but values were similar throughout all treatment conditions, and thus, adsorption is considered to be the dominant factor affecting process efficiency. From the denaturing gel gradient electrophoresis (DGGE) results, no significant differences were observed among the activated carbon reactors, suggesting that the number of reactors in the system could be decreased for a more compact application of the system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.6
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• pp.3944-3949
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• 2014

This paper provides a critical perspective in historic conservation with reference to Hanok (Korean Traditional Courtyard houses) built in central Taegu city, Korea. These Hanok houses began to emerge in the 1920s near the city castle during the Japanese occupation. The houses were shrewdly crafted into a small site in an urban context. Towards the end of 1980s, the demand for urban regeneration arose due to dilapidation of the timber structure and fire safety. Proposals were made to redevelop the areas, but they did not progress past this point. No attempts were made for conservation either and the urban fabric disintegrated continuously. The area is now largely unattended for conservation or redevelopment. This research intends to create an historic account of Hanok in an urban context for its enduring characteristics and historicity as charm and merit that deserve careful apprehension and conservation. This paper suggests that conservation not only serves to gentrify the cultural disruption of the early 20th century but also contributes towards urban regeneration.

• The Journal of Industrial Distribution & Business
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• v.10 no.5
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• pp.49-58
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• 2019

Purpose - Consumer behaviors or decision-making process has been changing recently as the consumer environment, including mobile everyday life, has changed. In view of this changing consumer smart environment, this study aims to investigate structural relation about the influence omni-channel propensity and regulatory focus on consideration set formation. Research design, data, and methodology - In order to proceed with this study, we review previous studies and setting hypotheses. The hypothesis was verified through a survey that was conducted for university students with experience in purchasing in less than three months. With reference to previous studies, operational definition was made for the questionnaire design. From 2018 Nov. to 2019 Feb. Survey was conducted on the panel consumers who purchase item within that period. 315 collected survey data were used to verify hypotheses except the data that had incorrect values. This data were used for SPSS/AMOS for confirm hypothesis which developed by researcher. Results - The results of this study are as follows. First, Consumers were considering a more heterogeneous alternatives if they were more omni-channel propensity in the process of forming consideration set. Second, Consumers were more conscious of the price if they were more omni-channel propensity Third, Consumers were considering a more newness alternatives if they were more omni-channel propensity in the process of forming consideration set. Meanwhile, The results of the study on regulatory focus and consideration set relationships are as follows. Consumers were considering a more heterogeneous alternatives if they were more promotion focus tendency in the process of forming consideration set. Second, Prevention focus tendency were more conscious of the price in the process of considering alternatives. Third, Consumers were considering a more newness alternatives if they were more promotion focus tendency. Conclusions - Depending on the changing consumer environment, the omni-channel propensity was shown to influence the formation of the consideration set. Also, Regulatory focus of consumers significantly influence to formation of consideration set. this study also contributes to the development of the theory as well as the practical approach with understanding consumer decision process on smart(mobile) environment.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.48 no.5
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• pp.789-797
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• 2015

The concentrations of trace metals (As, Cd, Cr, Cu, Fe, Hg, Mn, Pb, and Zn) were determined in 49 surface sediment samples collected in Yeoja and Gangjin Bays on the south coast of Korea, which contain many shellfish farms, in order to assess the contamination level and to understand the spatial distribution of trace metals. The average metal concentrations in the surface sediments of both bays decreased in the order Fe > Mn > Zn > Cr > Pb > Cu > As > Cd > Hg. There were no differences in metal concentrations between shellfish farms and reference sites. The metal concentrations were significantly higher in Gangjin Bay than in Yeoja Bay. Notably, the Cu, Cd, and Hg concentrations were nearly twice as high in Gangjin Bay as in Yeoja Bay. A multivariate analysis showed a strong correlation among Fe, Mn, Zn, Pb, and Cr in the sediments of both bays, implying that the metal concentrations in the sediments in the study area were mainly dependent on natural processes, such as crustal components and diagenesis. Based on the geoaccumulation index and marine sediment quality guidelines (SQGs), the surface sediments in Yeoja and Gangjin Bays are not polluted by trace metals.

• Journal of Microbiology and Biotechnology
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• v.20 no.2
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• pp.311-318
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• 2010

Antimicrobial finishing of textiles has been found to be an economical way to prevent (or treat) skin disorders. Hence, this research effort was aimed at elucidating the relationship between the molecular weight (MW) of chitosan and its antimicrobial activity upon six dermal reference microorganisms, as well as the influence of the interactions with cotton fabrics on said activity. Using 3 chitosans with different MWs, as well as two chitooligosaccharide (COS) mixtures, a relevant antimicrobial effect was observed by 24 h for the six microorganisms tested; it was apparent that the antimicrobial effect is strongly dependent on the type of target microorganism and on the MW of chitosan - being higher for lower MW in the case of E. coli, K. pneumoniae, and P. aeruginosa, and the reverse in the case of both Gram-positive bacteria. Furthermore, a strong antifungal effect was detectable upon C. albicans, resembling the action over Gram-positive bacteria. Interactions with cotton fabric resulted in a loss of COS activity when compared with cultured media, relative to the effect over Gram-negative bacteria. However, no significant differences for the efficacy of all the 5 compounds were observed by 4 h. The three chitosans possessed a higher antimicrobial activity when impregnated onto the fabric, and presented a similar effect on both Gram-positive bacteria and yeast, in either matrix. Pseudomonas aeruginosa showed to be the most resistant microorganism to all five compounds.

• Journal of the Korean Society for information Management
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• v.16 no.2
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• pp.81-104
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• 1999

Researchers commonly begin a project by studying past works in the area and deriving relevant information and ideas from their predecessors. In presenting their works researchers acknowledge their debts to preflecessors by carefully documenting each source to indicate what they borrowed. The obvious form of plagiarism is to cokx without crediting the sources. Students have to learn how to quote and how to make reference lists or works cited at the end of their reports which allow readers to locate and use the sources they used for their reports. Nowadays online information sources through the internet increase day by day, but there is no standard documentation style for citing these sources. In this paper up-to-date documentation styles recommened by APA(American Psychological Association) and MLA(Modern Language Association) are introduced. It was found that the graduate schools and the academic societies in Korea do not keep a certain documentation style consistently by checking the school catalogs and the policy statements on manuscript submisssion to the journals.