• BMB Reports
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• v.39 no.4
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• pp.464-467
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• 2006

Recently, the nucleotide sequences of entire genomes became available. This information combined with older sequencing data discloses the exact chromosomal location of millions of nucleotide markers stored in the databases at NCBI, EMBO or DDBJ. Despite having resolved the intron/exon structures of all described genes within these genomes with a stroke of a pen, the sequencing data opens up other interesting possibilities. For example, the genomic mapping of the end sequences of the human, murine and rat BAC libraries generated at The Institute for Genomic Research (TIGR), reveals now the entire encompassed sequence of the inserts for more than a million of these clones. Since these clones are individually stored, they are now an invaluable source for experiments which depend on genomic DNA. Isolation of smaller fragments from such clones with standard methods is a time consuming process. We describe here a reliable one-step cloning technique to obtain a DNA fragment with a defined size and sequence from larger genomic clones in less than 48 hours using a standard vector with a multiple cloning site, and common restriction enzymes and equipment. The only prerequisites are the sequences of ends of the insert and of the underlying genome.

• Sleep Medicine and Psychophysiology
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• v.8 no.2
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• pp.98-106
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• 2001

Auditory hallucinations are cardinal feature of psychosis. But the mechanism of hallucinated speech is unknown. The hypothesis that these hallucinations arise from pathologically altered brain monitoring system underlying speech perception is influential. With the help of rapidly developing neuroimaging study technologies, many researchers have been finding new organic deficits in the hallucinated schizophrenic patient's brain. In this article, we reviewed the general appearance of hallucination, a computer simulation model of hallucination and several neuroimaging study findings on hallucinating schizophrenic patients. In conclusion, we presented the presumptive mechanism of hallucination based on the anatomical dysfunction of schizophrenia.

• Korean Journal of Biological Psychiatry
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• v.3 no.1
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• pp.3-13
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• 1996

Many studies have been conducted to search for the anatomical abnormalities in the brain which ore etiologically related with schizophrenia. Generally schizophrenia in known to be related with decreased brain tissue, hypofrontality and abnormalities in the temporal lobe including the hippocamypus, the agmygdala and the entorhinal cortex. Other areas related with the disorder ore basal ganglia, thalamus, brain stem, pons and nucleus accumbens. Abnormality in brain asymmetry is one of the new areas of interest which needs further study. The results so for ore inconsistent and it is unlikely that the abnormality in one structure is the only cause of the disorder. Rather, schizophrenia develops from the impairment of the parallel processing of integrated and reciprocal information which is distributed to the multiple structures. Histopathologic studies in the postmortem brain suggest that schizophrenia is related with neurodevelopmental abnormality rather than neurodegenerative abnormality.

• Proceedings of the KSMRM Conference
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• 2005.09a
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• pp.64-64
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• 2005

• Korean Journal of Biological Psychiatry
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• v.9 no.2
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• pp.95-102
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• 2002

Objectives:Abnormalities in the frontal lobe have been consistently suggested in the pathophysiology of depression. The purpose of this review is to discuss the relationship between the frontal lobe and depression. Methods:Recent researches on the frontal lobe in depression were reviewed and abnormalities in this region were considered within the context of modern functional neuroanatomy. Results:This paper reviewed evidence strongly implicating the frontal lobe as a key brain structure in depression. Conclusion:Taken together, these abnormalities in the function of the frontal lobe implicate interconnected neural circuits in depression and offer suggestions for the themes of future research and treatment. Further research is needed to investigate the association between emotion and the brain in the paradigm of "affective neuroscience".

• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.71-78
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• 2001

The current understanding of the neurobiology of anxiety is generally based on experimental animal model, empirical effective psychopharmacological agents, chemical and naturalistic challenge paradigms, and psychoendocinological assessment. This article focuses on reviewing neuroanantomical, neuroendocinological and neurofunctional research of anxiety disorder. In the decade ahead, we anticipate that extension of current research and the new integrated approach promise novel insight into mechanism of anxiety.

• Therapeutic Science for Rehabilitation
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• v.6 no.1
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• pp.11-23
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• 2017

Spatial neglect is a neurological disorder following stroke, a lesion that usually affects the right hemisphere, fail to process or attention on the contralateral side of body and space. Functional neuroimaging studies report that spatial neglect is associated with lesions of large middle cerebral artery, perisylvian network and attention network. Spatial neglect is associated with a poor outcome. For optimal diagnosis and intervention, Types and theories of spatial neglect should be considered, in addition to clinical assessment with the conventional test and functional test. The treatment for spatial neglect could be consist of top-down approaches and bottom-up approaches. Recent trends in rehabilitation intervention for spatial neglect have reported prism adaptation.

• Sleep Medicine and Psychophysiology
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• v.4 no.1
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• pp.15-28
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• 1997

Longterm memory is encoded in the neuronal connectivities of the brain. The most successful models of human memory in their operations are models of distributed and self-organized associative memory, which are founded in the principle of simulaneous convergence in network formation. Memory is not perceived as the qualities inherent in physical objects or events, but as a set of relations previously established in a neural net by simultaneousy occuring experiences. When it is easy to find correlations with existing neural networks through analysis of network structures, memory is automatically encoded in cerebral cortex. However, in the emergence of informations which are complicated to classify and correlated with existing networks, and conflictual with other networks, those informations are sent to the subcortex including hippocampus. Memory is stored in the form of templates distributed across several different cortical regions. The hippocampus provides detailed maps for the conjoint binding and calling up of widely distributed informations. Knowledge about the distribution of correlated networks can transform the existing networks into new one. Then, hippocampus consolidats new formed network. Amygdala may enable the emotions to influence the information processing and memory as well as providing the visceral informations to them. Cortico-striatal-pallido-thalamo-cortical loop also play an important role in memory function with analysis of language and concept. In case of difficulty in processing in spite of parallel process of informations, frontal lobe organizes theses complicated informations of network analysis through temporal processing. With understanding of brain mechanism of memory and information processing, the brain mechanism of mental phenomena including psychopathology can be better explained in terms of neurobiology and meuropsychology.

• Journal of TMJ Balancing Medicine
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• v.7 no.1
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• pp.17-23
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• 2017

Functional neurology is a function-oriented clinical neurology with a focus on the viability, functionality, and balance of the neurologic system, which may be considered as a form of yin-yang balance medicine like Korean medicine. While it incorporates knowledge systems such as developmental neurology, neuropsychology, comparative neuroanatomy, and others, it views the neurologic system and the body as an individually different, self-regulating mechanism with the help of the active balancing mechanism within the nervous system and between the individual and the environment, which view is at the core of its effort to improve and serve the human dignity based on the best possible functioning nervous system. This article reviews core concepts of the functional neurology, discusses yin-yang balance medicine perspectives and clinical applications of it.

• The Journal of Korean Academy of Sensory Integration
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• v.5 no.1
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• pp.51-63
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• 2007

The purpose of this study is to provide definition of proprioception, foundations and roles of neuroanatomy, and systemical review of proprioceptive activities in sensory integration intervention. Proprioception exists in muscle, ligaments, joints and skin and it plays important role in controling body movements and interacting with environment during child development. Proprioception interacting with tactile and vestibular systems contributes to the change of muscle tone, postural control, refinements of planning and praxis. Children who are deficit in proprioceptive processing would seek hypo-responsive proprioceptive input or avoid hyperactive one. Outcome of poor proprioceptive input would cause the problems of praxis and postural control. Because proprioception provides information about the position and movement of body and limb it is important for development of body scheme and motor planning. It also influences the arousal and emotional tone. Sensory integration intervention which provides rich proprioceptive activities will improve the level of arousal and enhance motor planning.