• Journal of Pharmacopuncture
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• v.20 no.4
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• pp.230-234
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• 2017

Objective: Neurasthenia is a disease which consists of increased fatigue or bodily weakness and exhaustion plus pantalgia, dizziness, headache and other symtoms relevant to autonomic nerve dysfunction. There are plenty of studies investigating the history of diagnostic criteria of neurasthenia, which is influenced by diverse cultural(or social) environment. The obejective of this study is to provide review of the previous studys on the changes of neurasthenia diagnoses in the context of local area to find meanings of these transition and improve health care for psychiatric patient. Methods: Literature review was conducted on studies demonstrating diagnostic criteria of neurasthenia with cultural(or social) environment. We investigated the literature reviews or observative studies which described alteration of diagnostic criteria of neurasthenia and assessed its significance. After selecting eligible studies, the authors read the articles and summarized the meaningful contents those were significant in clinical practice. Results: Transformation of Chinese Classification of Mental Disorder(CCMD) integrated with internationally utilized DSM-IV or ICD-10 is controversial about its significance in that it had limited effect on public health care due to the variables of sociocultural context, but primarily differentiated neurasthenia from other disorders. The latter one can be the directing point of the diagnostic criteria of other culture-bound diseases, which is the traits of not outstanding mood(or affect) than other neurotic disorders. Conclusion: As diagnostic criteria of neurasthenia varies, the significance of this variation is controversial, but could be the paragon of other culture-bound diseases.

• The Journal of Korean Medical History
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• v.34 no.2
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• pp.11-23
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• 2021

In this study, we examine Cho Heon-yeong's medical theory about neurasthenia by looking at the contents and prescriptions of 『Neurasthenia Treatment (神經衰弱症治療法)』. Discourse about neurasthenia caused many problems in Joseon society during Japanese colonial period. This book consists of fist volume about general summary, second volume about treatment and prescription list. Cho Heon-yeong's theory in this book has following characteristics. First, eclecticism of Korean Medicine and Western medicine appears in the reinterpretation of Western medicine diseases and the acceptance of some Western medical theories and treatments. Second, the Korean medical disease name of neurasthenia is 'Simgizeung (心氣證)' for relevance with seven emotions (七情) and mind (神). Third, he evaluates neurasthenia as not a dangerous and incurable disease, but rather a positive phenomena of the mind and body. Fourth, he treated neurastenia by compromising dispersion (解鬱) and invigoration (補虛).

• Journal of Oriental Neuropsychiatry
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• v.14 no.1
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• pp.117-131
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• 2003

SCL-90-R is a multidimensional self-report symptom inventory devoloped by Derogatis and his coworkers. Since it was standardized into Korean version in 1978 by Won and Kim et aI., but it has been rarely studies for the clinical groups. Objectives : This study sought to define a diagnotic character of SCL-90-R of tension headache and insomnia inpatients groups. Methods : We determined a diagnotic character of 17 tension headache and 23 insomnia patients by means of SCL-90-R, and compared with normal groups in order to characterize subscale of SCL-90-R in patients with tension headache and insomnia from Neurasthenia. Results : 1. Male tension headache group has significant difference in Somatization and Depression subscales, female group in Somatization, Obsessive-Compulsive, Depression and Hostility subscales. 2. Female insomnia group has significant difference in Anxiety subscale. Although there are a little significiant, many subscales such as Somatization, Obsessive-Compulsive, Depression and Hostility are higher than normal group. 3. There are significant difference in GSI and PDSI of Global index, which means that we use that for objective index of tension headache and insomnia from Neurasthenia. Conclusions : All of these results show that SCL-90-R is useful inventory to characterize and screening for Neurasthenia.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.140-142
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• 2002

The fruiting body of Ganoderma lucidum (Polyporaceae) is one of the valuable crude drugs, which has been used clinically in Korea, China, and Japan for a long time as a tonic and sedative, and for the treatment of hepatopathy, chronic hepatitis, nephritis, gastric ulcer, hypertension, arthritis, neurasthenia, insomnia, asthma, and poisoning and chronic bronchitis. Nowadays, this mushroom is used for leukopenia and paid much attention as a home remedy. (omitted)

• Journal of Korean Medical classics
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• v.22 no.2
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• pp.107-126
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• 2009

King Seonjo, the second son of King Jeongjo, is the twenty-third King of the Joseon Dynasty. He suffered mainly from spleen-stomach weakness syndrome[脾胃虛弱], neurasthenic neurosis and abscess according to the Annals of the Joseon Dynasty[朝鮮王朝實錄]. He experienced chicken pox at the age of twelve, measles at thirteen, smallpox at sixteen. In his twenties he was ill with chronic breakdown due to the spleen-stomach weakness[脾胃虛弱], accompanied by neurasthenia. Abscess occurred during his twenties and the septicemia induced by abscess worsening led him to death. Most treatments were herb-extract medication taken orally, and to some extent ointment care was applied as a cure for abscess.

• The Journal of Korean Medical History
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• v.35 no.1
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• pp.119-134
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• 2022

This study is about Cho Heon-yeong's 『Eastern Medicine Series (東洋醫學叢書)』. It consists of 5 clinical books, 『Therapy for People (民衆醫術理療法)』, 『Tuberculosis Eastern Medical Treatment (肺病漢方治療法)』, 『Neurasthenia Treatment (神經衰弱症治療法)』, 『Gastrointestinal Disease Treatment (胃腸病治療法)』 and 『Gynecological Treatment (婦人病治療法)』, which were published between 1935-1941. This series mainly succeeded 『Donguibogam (東醫寶鑑)』, and was influenced by 『Kyeongakjeonseo (景岳全書)』, and 『Hwangjenegyeong (黃帝內經)』. Cho Heon-yeong's medical philosophy appears in two ways. First, he emphasized invigoration in treatment for the people who lacked nutrition and medical care at the time. Second, eclecticism of Korean Medicine and Western medicine is specifically revealed through this series. He aimed for a comprehensive medicine that consists mainly of Korean medicine and includes only a part of Western medicine.

• Journal of Acupuncture Research
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• v.17 no.1
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• pp.67-74
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• 2000

Hominis Placenta has been used as a medicinal stuff for a long time in Oriental Medicine. And further, aqua-acupuncture solution of Hominis Placenta has produced in South Korea recently. Bibliographical study was carried on to investigate the nature of Hominis Placenta and possible indications by aqua-acupuncture as well. The nature of Hominis Placenta is warm and its taste sweet-salty. It is non-poisonous. It has correspondence to the meridians of lung, liver and kidney. Hominis Placenta is mainly effective on recuperation of infirmity and the disease related to infirmity. Aqua-acupuncture solution of Hominis Placenta can be applied to the disease as chronic hepatitis, liver cirrhosis, asthma, pulmonary tuberculosis, sterility, insufficient lactation, degenerative change, neurasthenia and cerebrovascular disease.

• YAKHAK HOEJI
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• v.56 no.5
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• pp.299-303
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• 2012

Homosyringaldehyde was isolated and identified from the 80% methanol extract of roots of Cynanchum paniculatum. C. paniculatum has been widely used for the treatment of various diseases such as neurasthenia, insomnia, dysmenorrheal and toothache. This compound exerted significant neuroprotective activities against glutamate-induced neurotoxicity in hippocampal HT22 cell line by 37.53% (at the concentration of $100{\mu}M$). We investigated mode of action of this compound. Homosyringaldehyde ($100{\mu}M$) significantly decreased the ROS level and $Ca^{2+}$ concentration in the oxidative stress induced HT22 cells by oxidative glutamate toxicity. Thus, our results suggest that homosyringaldehyde significantly protect HT22 cells against glutamate-induced oxidative stress, via antioxidative activities. As the results, we suggest that homosyringaldehyde may be useful in the treatment of neurogenerative disorders.

• Journal of Oriental Neuropsychiatry
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• v.7 no.1
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• pp.65-75
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• 1996

This paper is for studying stress condition of apprentice doctors who were in Oriental Medical Hospital. This study was done on 35 apprentice doctors who were in Kyungsang University Oriental Medical Hospital and Bulgy Oriental Medical Hospital. The Seven-Minute Stress Test of Thomas E. Sttats and 10 questions which were made by the present writer shows the following results.1. The Body stress scale was the highest point. In order of high percent, this shows Whole scale, Mind scale, Situation scale. 2. In comparison of the stress scale of men and women doctors, all the stress scale of women doctors were higher than men doctors. 3. In comparison of the stress scale of Interne and Resident doctors, Whole and Situation stress scale of Resident doctors were higher than Interne doctors, Body and Mind stress scale of Interne doctors were higher than Resident doctors. 4. The personal relation with other people was harmonious, the worst relation of the other colleague was the administrative staff, the next were nurses, senior apprentice doctors orderly. 5. In order of high percent of stressors, this shows personal relation, many works and troubles of care, the lack of private life, unsatisfactory administration system and equipment, the class system and overbearing atmospheres, education and continuous stress, bad conditions and fatigue, economic problems. 6. In order of high percent of systemic stress diseases, this shows musculo- skeletal disease, nervous disease, digestive disease, neurosis, urinary and genital disorder, opthalomo-otolaryngo disease, immunity disorder and vascular disease. In order of high percent of stress symptom, this show headache, fatigue, shoulder pain, back and leg pain, pantalgia and abdominal pain, diarrhea and dismenorrhea, stiffness of neck dizziness indigestion languor after a meal insomnia, neurasthenia lacking interest constipation menorrhalgia bloodshot eyes otitis media allergy thirst flushing edema. 7. In order of the seven mode of emotions in relation to stress, this shows anger, anxiety, isolation, melancholy, fright, sorrow, terror, overjoy.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.4
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• pp.628-634
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• 2011

The roots of Polygala tenuifolia Willd. is a well-known traditional medicine used as expectorant, tonic, tranquilizer in Asia including China and Korea. And also have been used to treat amnesia, neurasthenia, palpitation, insomnia, and disorientation. Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as Parkinson's disease, Alzheimer's disease, epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. NNMBS269, acid hydrolysis EtOAc fraction of the P. tenuifolia showed dominant neuroprotective effects on glutamate-induced neurotoxicity in mouse hippocampal HT22 cells while general EtOAc fraction of the P. tenuifolia (NNMBS268) not shown. NNMBS269 induced the expression of HO-1 protein that has been proposed to play an important cellular defense role against oxidant injury. In addition increased HO activity. In mouse hippocampal HT22 cells, NNMBS269 makes the nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2). In conclusion, acid hydrolysis EtOAc fraction the P. enuifolia. (NNMBS269) significantly protect glutamate-induced oxidative damage by induction of HO-1 via Nrf2 translocation in mouse hippocampal HT22 cells.