• Journal of Agricultural Extension & Community Development
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• v.21 no.2
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• pp.29-56
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• 2014

This study conduct for 200 farmhouses who didn't accept new technology like mulberry Protected Cultivation. Through research model combined Innovation diffusion theory(IDT) and Technology Acceptance Model(TAM), it analysed which factors affect for new technology acceptance and diffusion. To verify relations between external factors which affect new technology acceptance and diffusion by endogenous variables such as perceived usefulness, perceived ease of use and perceived riskiness, with external factors, mothed used to analyse it. Most of adopted variables were showed positive results except for individual innovativeness and reliability. Based on the results of these analyses, we can suggest rapid. First, technique diffusion agents should have heighten the level of expertise and technology, and build up the network to solve difficulties with technique supply with mulberry farmhouses. Secondly farmhouses of mulberry outdoor cultivation showed positive attitude protected cultivation, but negative attitude it bacause of the burden of facilities investment. Thus, it is needed to capital investment for individual farmhouse hold. Finally, through cultivation technology education, field trip about mulberry protected cultivation, we can diffuse technology receive for negative farmers.

• IMMUNE NETWORK
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• v.1 no.3
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• pp.221-229
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• 2001

Background: Inactivation of tumor suppressor genes is believed to be important in the development of many human malignancies. Recently, several lines of evidence have indicated that the wild type p53 gene located at 17p13.3, may function as a tumor suppressor gene and that a mutant p53 gene could promote transformation by inactivating normal p53 function in a dominant negative fashion. These broad spectrum of p53 mutation in human cancers provide that mutant p53 and their protein may be potential targets of tumor diagnostic and therapeutic interventions. Method: Colony formation was performed to investigate growth suppressional ability. p53 expression pattern was examined by western blot and p53-mediated transactivation ability was assessed by CAT activity. SNU C2A cells were observed in apoptotic aspects induced by etoposide and $H_2O_2$ treatment, detecting sensitivity on agent, DNA fragmentation through agarose gel, chromatin condensation by fluorescence microscope, and cell cycle distribution by FACS. Result: 1) p53 mutant his179arg ($histidine{\rightarrow}arginine$) detected in SNU C2A cells lost transcriptional activity and growth suppression ability, showing dominant negative effect on its wild type p53. 2) Etoposide-treated SNU C2A cells induced apoptosis, exhibiting dramatic reduction of cell growth, DNA fragmentation, nuclear condensation formation of apoptotic body and increment of sub-G1 cell fraction. 3) Etoposide and $H_2O_2$-treated SNU C2A cells have no high increase of p53 expression and overexpressed p53 protein changed localization, from cytoplasm to nucleus. Also, p53-mediated transcriptional activity was increased by agents-treatment. Conclusion: SNU C2A cells coexpress wild-type and mutant p53 protein induced apoptosis in the condition on DNA damage, through localizational shift from cytoplasm to nucleus of p53 protein rather than the induction of p53 protein. SNU C2A cells derived mutant p53 his179arg abrogated both the growth supression ability and transactivational activity, showing inhibition effect on transcriptional activity of wild type p53, but did not repress the activity of wild type p53 in SNU C2A cells owing to dominant activity of wild type. These cell condition may provide new gene therapeutic implications leading effective antiproliferation of cell when mutant and wild-type p53 protein were co-expressed in cell.

• Informatization Policy
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• v.18 no.2
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• pp.3-22
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• 2011

The study of online social movements is basically concerned about the impact of the Internet on the existing social movements. More specifically, researchers have paid attention to changes in participants, leadership style and movement strategies caused by the Internet. Due to the Internet, networks of the individuals who are geographically scattered or a network of networks have emerged as new movement agents. Researchers have also analyzed a repertoire of collective action adopted by the online social movements. The increase in online social movements calls for a new interpretation of the existing social movement theories such as resource mobilization, collective identity and political opportunity structure. There are still a lot of debate about the impact of the internet on social movement and the resulting changes. Not only the early debate of cyber-optimism and cyber-scepticism, many studies done by the mid-range perspective also suggested different arguments on the impact of the Internet. This discrepancy comes from a relatively short history of online social movement study, which leads to a limited number of case studies and a shortage of date accumulations. In the future, researchers need to place more attention on the unique characteristics of different technologies and comparative studies of online social movements. The study should also extend its focus to a wide range of political systems in order to explain the impact of online social movements on political intermediary organizations and the democracy itself.

• Polymer(Korea)
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• v.34 no.6
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• pp.565-573
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• 2010

Copoly(2-(dimethylamino)ethyl methacrylate)(DAEMA)/butyl acrylate (BA) and copoly(methyl methacrylate)(MMA)/BA/2-(cinnamoyloxy)ethyl methacryate (CEMA), which were cross-linked with dibromoalkane and UV irradiation, respectively, were prepared for the precursors of interpenetrating polymer network (IPN) humidity-sensitive films. 3-(Triethoxysilyl)propyl cinnamate (TESPC) was used as a surface-pretreating agent for the attachment of IPN-polyelectrolyte to the electrode surface by UV irradiation. Humidity sensitive polymeric thin films with an IPN structure were prepared by crosslinking reactions of copoly(DAEMA/BA) with 1,4-dibromobutane (DBB) and copoly(MMA/BA/CEMA) by UV-irradiation. The anchoring of an IPN-polyelectrolyte into the substrate was carried out via the photochemical $[2{\pi}+2{\pi}]$ cycloaddition. The resulting humidity sensors showed a high sensitivity in the range of 20~95%RH and a small hysteresis (<1.5%RH). The response time for adsorption and desorption process at 33~94%RH was 48 and 65 s, respectively, indicating a fast response. The effects of the concentration of copolymers, molar ratio of crosslinking agents and time of the precursor solution for dip-coating on their humidity sensitive properties including water durability were investigated.

• KIPS Transactions on Software and Data Engineering
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• v.7 no.3
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• pp.99-106
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• 2018

In the process of acquiring information through the cyber ISR (Intelligence Surveillance Reconnaissance) and research into the agent to help decision-making, periodic communication between the C&C (Command and Control) server and the agent may not be possible. In this case, we have studied how to effectively surveillance and reconnaissance. Due to the network configuration, agents planted on infiltrated computers can not communicate seamlessly with C&C servers. In this case, the agent continues to collect data continuously, and in order to analyze the collected data within a short time in When communication is possible with the C&C server, it can utilize limited resources and time to continue its mission without being discovered. This research shows the superiority of incremental learning method over batch method through experiments. At an experiment with the restricted memory of 500 mega bytes, incremental learning method shows 10 times decrease in learning time. But at an experiment with the reuse of incorrectly classified data, the required time for relearn takes twice more.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.432-443
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• 2018

This study aims to present the direction of development of a policy framework to solve the problems associated with Smart Cities. For this purpose, first, after investigating the development process of domestic smart cities, we examined various cases of smart city policies being established overseas. Second, we analyzed the existing research into smart cities, in order to understand the relationship between the major issues. Third, an expert interview was conducted based on the identified issues. Fourth, we presented the direction of development of a Smart City policy framework to solve the major problems associated with domestic and foreign smart cities. In the policy framework presented in this research, after subdividing the elements used for solving each problem, we linked them with the smart city components and selected matching executable agents to prepare solutions. Then, once the deliberation process of the National Smart City Committee and the Smart Urban Service Support Organization has been completed, the government will support it financially and politically. It also suggested that it is necessary to perform continuous information gathering and monitoring work, along with the construction of a control tower to strengthen the network effect between smart city related markets. This research has significance in that it presents the procedures required for efficiently responding to the problems arising in the smart city promotion process. It is expected that it will serve as the basis for establishing policies dealing with the development and advancement of domestic smart cities in the future.

• Journal of KIISE:Databases
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• v.34 no.6
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• pp.528-545
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• 2007

Recently ontology has been an attractive technology along with the business strategy of providing a plenty of more intelligent services. The essential problem in application domains using ontology is that all members, agents, and application programs in the domains must share the same ontology concepts. However, a variety of mobile devices, sensing devices, and network components manufactured by various companies, a variety of common carriers, and a variety of contents providers make multiple heterogeneous ontologies more likely to coexist. We can see many past researches fallen into resolving this semantic interoperability. Such methods can be broadly classified into by-mapping, by-merging, and by-translation. In this research, we focus on by-translation among them which uses a translation rule directly made between two heterogeneous ontology data like OntoMorph. However, the manual composition of the direct translation rule is not convenient by itself and if there are N ontologies, the direct method has the rule composition complexity of $O(N^2)$ in the worst case. Therefore, in this paper we introduce the cascade composition of translation rules based on web openness in order to improve the complexity. The research result made us recognize some important factors in an ontology translation system, that is speediness of translation, and conveniency of translation rule composition, and some experiments and comparing analysis with existing methods showed that our cascade method has more conveniency with insuring the speediness and the correctness.

• IMMUNE NETWORK
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• v.3 no.4
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• pp.310-319
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• 2003

Inflammatory mediators has been recognized as an important role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is increasingly recognized as an important regulator of immune and inflammatory responses, including induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence of the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. However, the signaling pathways that regulate IL-17 production remain unknown. In the present study, we investigated the role of the phosphatidylinositol 3 kinase (PI3K)-Akt pathway in the regulation of IL-17 production in RA. PBMC were separated from RA (n=24) patients, and stimulated with various agents (anti CD3, anti CD28, PHA, ConA, IL-15). IL-17 levels were determined by sandwich ELISA and RT-PCR. The production of IL-17 was significantly increased in cells treated with anti-CD3 antibody, PHA, IL-15 or MCP-1 (P<0.05). ConA also strongly induced IL-17 production (P<0.001), whereas TNF-alpha, IL-1beta, IL-18 or TGF-beta did not. IL-17 was detected in the PBMC of patients with osteoarthritis (OA) but their expression levels were much lower than those of RA PBMC. Anti-CD3 antibody activated the PI3K-Akt pathway and activation of the PI3K-Akt pathway resulted in a pronounced augmentation of nuclear factor kappaB ($NF-{\kappa}B$). IL-17 production by activated PBMC in RA is completely or partially blocked in the presence of $NF-{\kappa}B$ inhibitor PDTC and PI3K-Akt inhibitor, wortmannin and LY294002, respectively. Whereas the inhibition of AP-1 and extracellular signal-regulated kinase (ERK)1/2 did not affect IL-17 production. These results provide new insight into that PI3K/Akt and $NF-{\kappa}B$ dependent signal transduction pathway could be involved in the overproduction of key inflammatory cytokine, IL-17 in rheumatoid arthritis.

• Journal of the Korean Geographical Society
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• v.41 no.1 s.112
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• pp.1-21
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• 2006

Abstract The purpose of this paper is to analyze production and innovation networks of manufacturers in the rural, long-live areas of Gangwon Jeju and to suggest an ideal regional development model of rural areas in the knowledge-based information age. For this purpose, we compared the areas of Gangwon Jeju with the long-live belt areas in the rural pan of the Honan region and Gwangju Jeonju, the urban part of Honam. The findings from the study are summarized as follows. Firstly, the stronger the local networks in terms of supply of the necessary input materials and labor, the more successful the manufacturing industry is in the given area. Secondly, the more diverse and lasting the networks (in terms of the location of manufacturers, local area and national area) and cooperation agents(businesses, research institutions, the local government, the central government) they have, the more prosperous the manufacturing industry is. These results indicate that the successful development model for rural areas requires that we take the approach of fostering potential innovation capabilities of total areas by fully utilizing their innate resources so as to create an internal cooperative network and further build extensive networks encompassing external entities to create a virtual innovation cluster.

• Convergence Security Journal
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• v.17 no.3
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• pp.41-49
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• 2017

According to a research by global IT market research institute IDC, CSIM(Converged Security Information Management) market of Korea was estimated to be 1.7 trillion KRW in 2010, and it has grown approximately 32% every year since. IDC forcasts this size to grow to 12.8 trillion KRW by 2018. Moreover, this case study exemplifies growing importance of CSIM market worldwide. Traditional CSIM solution consists of various security solutions(e.g. firewall, network intrusion detection system, etc.) and devices(e.g. CCTV, Access Control System, etc.). With this traditional solution, the the data collected from these is used to create events, which are then used by the on-site agents to determine and handle the situation. Recent development of IoT industry, however, has come with massive growth of IoT devices, and as these can be used for security command and control, it is expected that the overall amount of event created from these devices will increase as well. While massive amount of events could help determine and handle more situations, this also creates burden of having to process excessive amount of events. Therefore, in this paper, we discuss potential events that can happen in CSIM system and classify them into 3 groups, and present a model that can categorize and process these events effectively to increase overall efficieny of CSIM system.