• 한국인터넷방송통신학회논문지
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• 제20권1호
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• pp.141-148
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• 2020

뇌혈관 손상으로 인해 발생하는 신경학적 질환인 뇌졸중과 관련이 있는 편측무시(Unilateral neglect)는 대뇌반구의 반대측 자극에 대하여 인지 또는 반응하지 못하는 증상으로, 주로 우측 대뇌반구 손상에서 나타난다. 본 논문에서는 편측무시에 대한 행동적 평가 척도로 사용되고 있는 한국형 캐서린 버지고 척도(Korean Catherine Bergego Scale)의 10가지 문항과 내용을 기반으로 가상현실(Virtual Reality)을 이용한 콘텐츠를 구현하였다. 구현된 콘텐츠는 편측무시 환자의 증상으로 나타나는 신체 무시, 운동성 무시, 시각 및 공간 무시, 청각 주의 등을 평가할 수 있으며, 시각적으로 인지하고 반응하는 동안의 시간과 머리 회전각을 측정함으로써 질환의 진행 정도를 정량적으로 확인하였다. 이 방법을 이용하여 편리한 편측무시 진단과 이를 응용한 콘텐츠를 활용하여 재활 훈련에 유용하게 사용될 수 있을 것으로 기대된다.

• Parasites, Hosts and Diseases
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• 제47권3호
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• pp.213-218
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• 2009

Leishmaniasis is a neglected disease and endemic in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The aim of this study was to investigate the effect of RT-01, an organotellurane compound presenting biological activities, in 2 experimental systems against Leishmania amazonensis. The in vitro system consisted of promastigotes and amastigotes forms of the parasite, and the in vivo system consisted of L.amazonensis infected BALB/c mice, an extremely susceptible mouse strain. The compound proved to be toxic against promastigotes and amastigotes. The study also showed that treatment with RT-01 produces an effect similar to that treatment with the reference antimonial drug, Glucantime, in L.amazonensis infected mice. The best results were obtained following RT-01 intralesional administration (720 ${\mu}g$/kg/day); mice showed significant delay in the development of cutaneous lesions and decreased numbers of parasites obtained from the lesions. Significant differences in tissue pathology consisted mainly of no expressive accumulation of inflammatory cells and wellpreserved structures in the skin tissue of RT-01-treated mice compared with expressive infiltration of infected cells replacing the skin tissue in lesions of untreated mice. These findings highlight the fact that the apparent potency of organotellurane compounds, together with their relatively simple structure, may represent a new avenue for the development of novel drugs to combat parasitic diseases.

• 한국지역사회생활과학회지
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• 제18권1호
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• pp.189-204
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• 2007

This review was to suey the status of agricultural diseases, injuries and accidents among England, the USA, France, Japan, and Korea. For this purpose, detailed research objectives were to analyze the current national status of agricultural diseases, injuries and accidents in Korea and four foreign countries. To do so, related literature such as books, theses, articles, and web documents were collected and analyzed. The implications for industry and agricultural safety and health, diseases, occupational injuries and accidents of farmers thereby derived were as follows: 1) efforts on unifying administrative systems, 2) special support and management systems focusing on neglected subjects, 3) committees for collecting opinions and suggesting alternative policies on the behalf of various financiers, 4) aligned strategies including vision, goals, and long-term plans about national safety and health projects, 5) development of supporting systems considering the features of agriculture, 6) systematized national surveys about occupational injuries and accidents for basic statistics and national studies, 7) active prevention efforts against occupational injuries and accidents, and 8) specialized funds for the safety and health of farmers.

• Parasites, Hosts and Diseases
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• 제54권4호
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• pp.447-453
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• 2016

Acanthamoeba, a free-living amoeba, is widely distributed in the environment, water sources, soil, dust, and air. It can cause keratitis in contact lens wearers with poor hygiene and also fatal granulomatous amebic encephalitis (GAE) in immunocompromised hosts. The aim of this study was to gain some insights into the distribution and genotypes of the potentially pathogenic species of Acanthamoeba present in water sources in north of Iran. Total 43 Acanthamoeba species were isolated from 77 water samples taken from different water sources within the Mazandaran province in Northern Iran (Sari city and suburbs). Isolates were identified based on cyst and trophozoite morphological characteristics as well genetics. PCR fragments corresponding to the small-subunit 18S rRNA gene were sequenced for 20 of 43 positive isolates. The results revealed that 83.3% of sequenced isolates belonged to the T4 genotype and the rest belonged to the T2 genotype. Our results indicated that Acanthamoeba is widely distributed in Sari city. As the incidence in Iran of amoebic keratitis has increased in recent years, the exact estimation of the prevalence of this amoeba and its predominant genotype may play a crucial role in prevention of the disease. Sari city has several rivers, seashores, and natural recreational amenities, which attract visitors during the year. This is the first report of Acanthamoeba genotypes from water sources in Sari city, Mazandaran province of Iran, and the results suggest that more attention is needed to protect the visiting population and immunocompromised individuals.

• Clinical and Experimental Pediatrics
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• 제58권11호
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• pp.440-445
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• 2015

Purpose: Chest pain is common in children and adolescents and is a reason for referral to pediatric cardiologists. Although most cases of chest pain in these age groups are benign and do not require treatment, timely diagnosis is important not to miss life-threatening diseases requiring prompt treatment. We investigated certain clinical characteristics that may be useful in the diagnosis of such critical diseases. Methods: Patient medical records between July 2006 and September 2013 were retrospectively examined. We included 517 patients who presented with chest pain to the Department of Pediatrics at Kyung Hee University Hospital in Gangdong. Results: Most cases of chest pain were idiopathic in origin (73.6%), followed by cases with respiratory (9.3%), musculoskeletal (8.8%), cardiac (3.8%), gastrointestinal (2.9%), and psychiatric (1.4%) causes. In 6 patients (1.2%) with air-leak syndrome including pneumothorax or pneumomediastinum, the pain was abrupt, continuous, and lasted for a short period of 1-2 days after onset in the older adolescents. Of the patients with cardiac pain, 13 had cardiac arrhythmias (65.0%), 6 had congenital heart diseases (30%), and 1 had coronary aneurysms caused by Kawasaki disease (5.0%). One patient with atrial flutter had only symptoms of syncope and chest pain. Conclusion: The abrupt, continuous chest pain of a short duration in the older children was characteristic of air-leak syndrome. In patients with pneumomediastinum, radiological diagnosis was difficult without careful examination. Combined syncope should not be neglected and further cardiac workup is essential in such patients.

• 한국산업보건학회지
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• 제17권2호
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• pp.89-100
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• 2007

Object: The purpose of this study was to survey the government official support status of the agricultural diseases, injuries and accidents among Korea and foreign countries and to suggest the agricultural policy of Korea. Methods: For this purpose, we analyzed the current national management support status among four foreign countries and Korea about agricultural diseases, injuries and accidents of farmers. For the foreign countries and the national support current status of agricultural diseases, injuries and accidents, related literature such as books, theses, articles, and web documents from the government organization of each countries were collected and analyzed. Key words for web-site and web documents were agricultural diseases, injuries, and accidents, government official system, safety and health, farmer's welfare, and farmer's official support system. UK, United States of America, France, and Japan were selected as the foreign countries' cases. Results and Conclusions: Implications for the agricultural diseases, injuries and accidents derived from the reviews among foreign countries and Korea were as follows: governmental supports should include (1) efforts on unifying administrative systems, (2) special support and management systems focusing on special subjects such as the agriculture that have been neglected, (3) aligned strategies including vision, goals, long-term plans about national safety and health projects, (4) development of supporting systems considering the features of agriculture, (5) systemized national surveys about occupational injuries and accidents for basic statistics and national studies, (6) active prevention efforts of agricultural diseases, injuries and accidents, and (8) specialized funds for safety and health of Korean farmers.

• Clinical and Experimental Reproductive Medicine
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• 제38권2호
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• pp.115-118
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• 2011

A 58-year-old woman who presented with inguinal hernia for the first time was diagnosed as seminoma and complete androgen insensitivity syndrome (CAIS). The patient received a late diagnosis, and therefore she could not take a proper management. CAIS is a rare X-linked recessive disease with an XY karyotype that is caused by androgen receptor defects. It usually present with primary amenorrhea or inguinal hernia. The risk of malignant transformation of undescended testis increases with age, thus gonadectomy should be performed after puberty. We present a case of large advanced seminoma in a woman with CAIS who was neglected and diagnosed lately.

• 대한골관절종양학회지
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• 제4권1호
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• pp.30-36
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• 1998

Squamous cell carcinoma is a neglected disease entity in orthopedic oncology. The purpose of this study was to analyze overall survival and the role of surgery on survival and to evaluate the significance of possible prognostic factors. From Oct, 1986 to Aug, 1996, 57 patients were enlisted and 42 patients ere eligible. Inclusion criteria included more than one year follow-up and no distant metastasis at the first visit. Staging and survival followed AJC classification and Kaplan-Meier plot. Stage II included 17 cases and stage III, 25 cases. Thirty-eight patients underwent operations, chemotherapy, and/or radiotherapy, and the remaining four had operations only. The chemotherapeutic regimen was adriamycin-cisplatin. The average follow-up period was 45 months. The ten-year actuarial survival rate of whole patients was 65.4%. Location of primary lesion, stage, pathologic grading, and intensity of chemotherapy in the same stage showed a significant difference in survival. Nine out of 42 patients had local recurrence. Seven patients had inadequate wide margins and two had intralesional margins. Average period of recurrence from operation was 13(4-35)months. The operation itself had no impact on survival but a surgical margin of no less than 3cm from the lesion was important for local control. Pathological grade and staging were significant variables for long term survival. Acral lesion had a significantly higher chance of regional and distant metastasis but actual survival showed no difference. In stage II, aggressive chemotherapy could delay or reduce the chance of regional or distant metastasis.

• 임상이비인후과
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• 제29권2호
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• pp.316-320
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• 2018

Esophageal diverticulum is very rare disease. Since it usually has no symptoms, it is hard to find and diagnose. Moreover, if the diverticulum is located nearly to thyroid gland, surgeons sometimes misdiagnose as a thyroid nodule. Here, we represent our case which has papillary thyroid cancer and esophageal diverticulum together. In this case, we experienced the surgical procedure and postoperative complications of the esophageal diverticulum. Even though esophageal diverticulum was in preoperative computed tomography and ultrasound, it was neglected before the surgery so that found during the operation. The purpose of this study was to know the preoperative radiological findings of the esophageal diverticulum and to find out what to be aware of during surgery and how to manage the complications after surgery.

• 대한정형외과학회지
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• 제55권5호
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• pp.359-365
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• 2020

소아 고관절 이형성증은 비구 또는 근위 대퇴골, 혹은 양쪽 모두를 포함하는 고관절의 부적절한 발달을 지칭하는 광범위한 개념이다. 초음파적 검사로 영아기의 고관절 탈구 진단이 간과되거나 수술적인 치료가 필요한 경우는 감소하고 있으나 모든 고관절 이형성증을 찾아내지는 못하고 있다. 아탈구가 없는 고관절 이형성증은 우연히 진단되며, 40대 이후 여자에서 퇴행성 관절염과 강한 연관성을 가진다. 아탈구를 동반한 고관절 이형성증은 아탈구의 정도에 따라 증상이 다양한 시기에 걸쳐 나타나며, 특히 여성에서 임신 중 발현되는 경우가 많다. 신생아에 대한 정확한 이학적 검사와 조기 치료는 이 질환의 양호한 결과를 위해 매우 중요하다. 진단의 간과를 막고 조기 치료의 기회를 제공하기 위해 저자는 고관절 이형성증이 의심스러운 2세 이하 영아 모두에게 고관절 검사를 추천한다. 본 연구에서는 고관절 이형성증의 진단 및 초기 치료에 대해 고찰해 보고자 한다.