• Journal of Ginseng Research
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• 제42권4호
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• pp.524-531
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• 2018

Background: Fermented black ginseng (FBG) is produced through several cycles of steam treatment of raw ginseng, at which point its color turns black. During this process, the original ginsenoside components of raw ginseng (e.g., Re, Rg1, Rb1, Rc, and Rb2) are altered, and less-polar ginsenosides are generated (e.g., Rg3, Rg5, Rk1, and Rh4). The aim of this study was to determine the effect of FBG on wound healing. Methods: The effects of FBG on tube formation and on scratch wound healing were measured using human umbilical vein endothelial cells (HUVECs) and HaCaT cells, respectively. Protein phosphorylation of mitogen-activated protein kinase was evaluated via Western blotting. Finally, the wound-healing effects of FBG were assessed using an experimental cutaneous wounds model in mice. Results and Conclusion: The results showed that FBG enhanced the tube formation in HUVECs and migration in HaCaT cells. Western blot analysis revealed that FBG stimulated the phosphorylation of p38 and extracellular signal-regulated kinase in HaCaT cells. Moreover, mice treated with $25{\mu}g/mL$ of FBG exhibited faster wound closure than the control mice did in the experimental cutaneous wounds model in mice.

• 인간식물환경학회지
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• 제24권3호
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• pp.301-309
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• 2021

Background and objective: The purpose of this study is to analyze the case of healing experience for lifestyle and environmental diseases through life and activities in the forest from the perspecitive of critical realism, and how the causal power and mechanism of the healing experience relate to forest healing factors and programs. Methods: 93 video data of people who started living in the forest for disease treatment were analyzed using a qualitative content analysis method from the perspective of critical realism. Categories for analysis include general categories (age, duration, occupation, disease name), forest therapy categories (climate therapy, plant therapy, water therapy, diet therapy, kinesiotherapy, psychotherapy), and other categories (ecology, learning and management, life tools), etc., and the unit of analysis is the context unit. Results: 1) The diseases that motivated life in the forest were digestive system diseases, lung diseases, cardiovascular diseases, endocrine system diseases, and various lifestyle-related diseases and environmental diseases in similar proportions. This indicates that forest life does not have specificity to respond to specific diseases, but provides treatment and recovery for all lifestyle and environmental diseases. 2) Among the forest therapies, climate therapy and plant therapy are related to the climatic and residential environment in the forest where 'natural persons' live. And others such as water therapy, diet therapy, kinesiotherapy, psychotherapy indicate the change from the lifestyle that caused the disease to the lifestyle for treatment and recovery. Conclusion: Life and activities in the forest provide an environment for treatment and recovery in which the healing principles such as aromatherapy, nutritional and dietary therapy, kinesiotherapy, and emotional psychotherapy are integrated in the 'real world'.

• 통합자연과학논문집
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• 제12권2호
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• pp.47-57
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• 2019

Staphylococcus epidermidis is well-known not only as an innocuous normal flora species commonly isolated from human skin, but also as an important bacterial species to keep skin healthy, because this species can protect the human skin from pathogenic microorganisms. However, S. epidermidis turns into a potential pathogen in damaged skin, because these bacteria can easily form a biofilm on the wound area and provide antimicrobial resistance to other microorganisms embedded in the biofilm. Thus, it is important to kill S. epidermidis in the early stage of wound treatment and block the formation of biofilms in advance. In the present study, hydrogel wound dressings were fabricated using polyvinyl alcohol/polyethylene glycol containing silver citrate nanorods, which have been proven to have strong antimicrobial activity, especially against S. epidermidis, and their wound-healing efficacy was investigated in vivo using a rat experiment.

• 한국구조물진단유지관리공학회 논문집
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• 제25권2호
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• pp.16-22
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• 2021

본 논문에서는 수화반응이 가능한 결정성장형 무기재료를 사용하여 고상 캡슐을 제조하였다. 고상 캡슐을 시멘트 질량 기준으로 8:2, 7:3, 및 6:4의 조성비에 따라 3, 5 및 10% 혼합하여 자기치유 모르타르 배합을 진행 하였으며, 정수위투수시험을 통해 내구적 치유 특성을 평가하였다. 정수위투수시험 실험결과, 고상 캡슐의 조성비 7:3으로 제조된 고상 캡슐을 혼합함에 따라 자연 치유성능을 최적으로 향상시키는 효과가 나타났다. 0.3 mm 이하 균열폭의 경우 약 90% 이상 자기치유 성능을 확보할 수 있을 것으로 판단된다. 이러한 결과, 고상 캡슐의 자기치유 성능은 정수위투수시험을 통하여 내구적 치유 특성에 영향이 있는 것으로 판단되며, 고상 캡슐의 혼합에 따라서 자기치유 성능을 향상시키는 경향이 있다고 판단된다.

• 한국지리정보학회지
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• 제24권2호
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• pp.29-39
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• 2021

세계적 고령화 현상과 새로운 라이프 스타일로 인하여 새로운 관광 형태인 헬스투어리즘은 전세계적으로 주목 받고 있다. 이 연구의 목적은 헬스투어리즘의 경쟁 요인을 분석하고 이에 맞는 제주지역 헬스투어리즘 모델을 제안하는 것이다. 문헌 연구를 통해 헬스투어리즘의 개념과 유형에 대한 이론적 고찰과 경쟁 요인 도출, 그리고 의료간섭 위계공간에 대한 고찰을 진행하였다. 이어서 제주 지역 관광, 의료, 정책에 관한 전문가를 대상으로 설문 조사를 실시하였으며 이를 바탕으로 하여 제주지역 헬스투어리즘의 경쟁 요인을 분석 한 결과, 제주지역 헬스투어리즘은 건강 서비스 공간보다 자연 치유 공간에서 중요성이 더 높은 것으로 확인되었다. 이러한 분석을 바탕으로 제주지역 헬스투어리즘은 자연치유공간과 비의료치유공간을 기반으로 자연자원, 치유자원, 활동자원 등 3가지 관광자원을 활용하는 모델을 제시하였다.

• 한국조경학회지
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• 제43권3호
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• pp.43-51
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• 2015

삭막한 도시환경으로부터 오는 스트레스는 도시민들에게 다양한 질병을 발생시키거나 건강을 악화시키는 반면, 자연은 인간에게 긍정적인 치유효과를 준다. 자연을 통한 치유프로그램은 활동공간의 특성에 따라 숲치유와 원예치료로 구분할 수 있다. 그러나 치유프로그램에 대한 연구는 독립적으로 이루어져 다양한 프로그램의 적용과 연계에 따른 효과를 파악하는데 한계가 있다. 따라서 본 연구는 숲치유와 원예치료의 생리적 심리적 효과를 비교 분석하여 각 프로그램의 효과와 차이점을 밝혀 향후 치유프로그램 개발과 치유공간 설계의 기초자료를 제공하고자 한다. 실험은 숲치유 5명, 원예치료 5명의 피험자를 대상으로 5일간의 프로그램에 대한 사전사후검사를 실시하였다. 생리적 반응은 혈압, 맥박, 코티솔 변화량으로 측정하였고, 심리적 반응은 기분상태검사로 측정하였다. 분석방법은 통계프로그램 SPSS 18.0 for windows의 분산분석(ANOVA)과 대응표본 T-test를 실시하였다. 연구결과, 1) 숲치유와 원예치료는 생리적, 심리적으로 모두 긍정적 효과를 보이며, 2) 숲치유는 원예치료보다 생리적 이완과 스트레스 감소에 더 효과적이고, 3) 원예치료는 숲치유보다 우울감 감소에 더 효과적인 경향이 있는 것으로 나타났다. 위 결과는 각 치유프로그램의 특징을 파악함으로써, 향후 치유프로그램 개발과 치유공간 설계를 위한 기초자료와 지침 설정에 도움이 될 것으로 기대한다.

• 한국건설순환자원학회논문집
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• 제8권4호
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• pp.581-589
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• 2020

본 논문에서는 수화반응이 가능한 결정성장형 무기재료를 사용하여 고상 캡슐을 제조하였으며, 고상 캡슐 혼합에 따른 자기치유 모르타르의 품질 및 역학적 치유 특성을 평가하였다. 고상 캡슐은 시멘트 질량에 대하여 5% 혼합하였다. 압축하중 재부하 실험결과 Plain의 자연 치유 효과에 대하여 평균적으로 약 20% 수준을 향상시키는 것으로 나타났으며, 탄성범위의 경우 치유재령 7일에 약 79% 및 치유재령 28일에 98%의 치유율이 나타났다. 휨하중 재부하 실험결과, 탄성범위의 경우 치유재령 7일에 약 79% 및 치유재령 28일에 98%의 치유율이 나타났다. 이러한 결과를 통하여, 고상 캡슐의 치유성능은 투수시험에 의한 내구적 특성 외에도 강도와 같은 역학적 치유 특성에도 영향이 있는 것으로 판단되며, 고상 캡슐의 혼합에 따라 강도가 감소하는 경향이 있으므로 이에 대한 보완이 필요하다고 판단된다.

• Journal of Microbiology and Biotechnology
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• 제20권4호
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• pp.803-808
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• 2010

Poly-${\gamma}$-glutamic acid (${\gamma}$-PGA) is a natural edible polypeptide in which glutamate is polymerized via ${\gamma}$-amide linkages. First, we assessed the eye irritancy potential of ${\gamma}$-PGA in rabbits. Additionally, we studied the effects of ${\gamma}$-PGA on corneal wound healing, due to the anti-inflammatory properties and water retaining abilities of ${\gamma}$-PGA. In this study, the effects of ${\gamma}$-PGA on corneal wound healing after an alkali burn were evaluated. Thirty eyes wounded by alkali burning in 30 white rabbits were divided into three groups: group A was treated with 0.1% 5,000 kDa ${\gamma}$-PGA for 2 days; group B was treated with 0.1% hyaluronic acid; and group C was not treated, as a control. The area of corneal epithelial defect was examined at 12, 24, 30, 36, 42, and 48 h after corneal alkali wounding to determine initial wound healing. We found that ${\gamma}$-PGA promoted corneal wound healing, compared with controls, and showed similar effects to hyaluronic acid. These results indicate that ${\gamma}$-PGA stimulates corneal wound healing by an anti-inflammatory effect and enhancing cell migration and cell proliferation. ${\gamma}$-PGA is a promising biomaterial that may be a substitute for hyaluronic acid in corneal wound healing treatment.

• 대한건축학회논문집:계획계
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• 제36권2호
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• pp.43-52
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• 2020

With the advent of the Fourth Industrial Revolution, people need healing. Research in neuroarchitecture shows that people feel happy and stable when working with nature, and patients heal quickly. Therefore, This study aims to quantitatively analyze the colors that help psychological healing in the painting images depicting nature by setting 'Natural Colors' of Biophilic Design as the subject of research. So the purpose of this study was to measure Biophilic Color and to develop Biophilic Color Palette. We extracted Biophilic colors using Impressionist Monet's Landscape painting. After extracting colors using Photoshop Color Picker, we converted RGB color code to NCS color code and Munsell color code. The results of this study were as follows; The ratio of Y was high in the GY-series and YR-series. This is due to the characteristic of impressionism that expresses the change of color by light in close relationship with light. Y is universally considered to be pleasant, representing happiness, sunshine and optimism. Therefore, it is possible to create an environment that helps psychological healing by utilizing the Y-series color palette. Average Blackness was 28. Average Chromaticness was 34.61. The significance of this study is to propose a biophilic color palette that is useful for psychological healing by quantifying the color code of biophilic colors depicted and expressed with adjective images and idiomatic color names. Quantitative and empirical studies on healing colors are needed continuously and should be actively utilized in healing environment planning.

• 인간식물환경학회지
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• 제23권3호
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• pp.277-291
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• 2020

Background and objective: The purpose of this study is to investigate the effects of visitors' positive emotions on satisfaction and loyalty with the perception of restorative environment of a healing garden created in an urban agriculture expo. Methods: The psychological indicators to the images of the healing garden were analyzed by the visitors' demographic variables and the three factors of plant cultivation activity level: plant cultivation experience, plant preference, and plant-related event. Results: Between age groups and occupational groups, significant differences were found statistically. The Perceived Restorativeness Scale(PRS) showed significantly differences between age groups in repose, fascination and legibility. The Positive Affect & Negative Affect Schedule(PANAS) showed statistically significant differences between age groups in positive emotions. In addition, we investigated the correlation between the PANAS and the three factors of plant cultivation experience level, the four factors of the PRS, satisfaction and loyalty. The three factors of plant cultivation experience level, the four factors of the PRS, satisfaction and loyalty showed a positive correlation with positive emotions and were inversely correlated with negative emotions significantly. Multiple regression analysis with dummy variables was conducted to examine the effects of plant cultivation activity level, attention restoration, and the PANAS on healing garden visitors' satisfaction and loyalty. As a result, among the four factors of the PRS, fascination and positive affectivity were significant variables that affect healing garden visitors' satisfaction and loyalty. Conclusion: The results indicated that the higher the attention restoration of visitors due to the fascination of the healing garden and the higher their positive affectivity and the more they have plant-related memories, the higher their impact on healing garden visitors' satisfaction and loyalty. Therefore, fascinating natural environments or greenery landscapes like healing gardens where people can contact plants would reduce negative emotions such as anger and sadness but to increase positive emotions such as pleasure, joy and satisfaction.