• Journal of Life Science
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• v.22 no.10
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• pp.1428-1433
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• 2012

Longevity is an exciting but difficult subject to study because it is determined by complex processes that require the coordinated action of several genetic factors as well as physiological and environmental influences. Genetic approaches have been applied to animal models to identify the molecular mechanism responsible for longevity. Several experimental model organisms obtained over the last decades suggest that the complete deletion of a single gene by gene targeting has proven to be an invaluable tool for the discovery of the mechanisms underlying longevity. The first discovery of long-lived mutants came from Caenorhabditis elegans research, which identified the insulin/IGF-1 pathway as responsible for longevity in this worm. IGF-1 is a multifunctional polypeptide that has sequence similarity to insulin and is involved in normal growth and development of cells. Several factors in the IGF-1 system have since been studied by gene targeting in the control of longevity in lower species, including nematode and fruit fly. In addition, significant progress has been made using mice models to extend the lifespan by targeted mutations that interfere with growth hormone/IGF-1 and IGF-1 signaling cascades. A recent finding that IGF-1 is involved in aging in mice was achieved by using liver-specific knockout mutant mice, and this clearly demonstrated that the IGF-1 signal pathway can extend the lifespan in both invertebrates and vertebrate models. Although the underlying molecular mechanisms for the control of longevity are not fully understood, it is widely accepted that reduced IGF-1 signaling plays an important role in the control of aging and longevity. Several genes involved in the IGF-1 signaling system are reviewed in relation to longevity in genetically modified mice models.

• Journal of the Korea Society for Simulation
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• v.32 no.3
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• pp.23-31
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• 2023

Software development involves a series of stages, including requirements analysis, design, implementation, unit testing, and integration testing, similar to those used in the system engineering process. This study utilized MathWorks' model-based design platform to develop multi-function radar software and evaluated its feasibility and efficiency. Because the development of conventional radar software is performed by a unit algorithm rather than in an integrated form, it requires additional efforts to manage the integrated software, such as requirement analysis and integrated testing. The mode-based platform applied in this paper provides an integrated development environment for requirements analysis and allocation, algorithm development through simulation, automatic code generation for deployment, and integrated requirements testing, and result management. With the platform, we developed multi-level models of the multi-function radar software, verified them using test harnesses, managed requirements, and transformed them into hardware deployable language using the auto code generation tool. We expect this Model-based integrated development to reduce errors from miscommunication or other human factors and save on the development schedule and cost.

• Journal of Periodontal and Implant Science
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• v.32 no.1
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• pp.199-211
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• 2002

Digital substraction technique and computer-assisted densitometirc analysis detect minor change in bone density and thus increase the diagnostic accuracy. This advantage as well as high sensitivity and objectivity which precludes human bias have drawn interest in radiologic research area. The objectives of this study are to verify if Radiographic density can be recognized in linear pattern when density profile of standard periapical radiograph with the aluminium stepwedge as the reference, was investigated under varies circumstances which can be encountered in clinical situations, and in addition to that to obtain mutual relationship between the existing standard radiographic system, and future digital image systems, by confirming the corelationship between the standard radiograph and Digora system which is a digital image system currently being used. In order to make quantitative analysis of the bone tissue, digital image system which uses high resolution automatic slide scanner as an input device, and Digora system were compared and analyzed using multifunctional program, Brain3dsp. The following conclusions were obtained. 1. Under common clinical situation that is 70kVp, 0.2 sec., and focal distance 10cm, Al-Equivalent image equation was found to be Y=11.21X+46.62 $r^2=0.9898$ in standard radiographic system, and Y=12.68X+74.59, $r^2=0.9528$ in Digora system, and linear relation was confirmed in both the systems. 2. In standard radiographic system, when all conditions were maintained the same except for the condition of developing solution, Al-Equivalent image equation was Y=10.07X+41.64, $r^2=0.9861$ which shows high corelationship. 3. When all conditions were maintained the same except for the Kilovoltage peak, linear relationship was still maintained under 60kVp, and Al-Equivalent image equation was Y=14.60X+68.86, $r^2=0.9886$ in the standard radiograhic system, and Y=13.90X+80.68, $r^2=0.9238$ in Digora system. 4. When all conditions were maintained the same except for the exposure time which was varied from 0.01 sec. to 0.8 sec., Al-Equivalent image equation was found to be linear in both the standard radiographic system and Digora system. The R-square was distributed from 0.9188 to 0.9900, and in general, standard radiographic system showed higher R-square than Digora system. 5. When all conditions were maintained the same except for the focal distance which was varied from 5cm to 30cm, Al-Equivalent image equation was found to be linear in both the standard radiographic system and Digora system. The R-square was distributed from 0.9463 to 0.9925, and the standard radiographic system had the tendency to show higher R-square in shorter focal distances.

• Microbiology and Biotechnology Letters
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• v.20 no.4
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• pp.384-389
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• 1992

Bacillus sp. YBL-7 which had been isolated from ginseng root-rot suppressive soil was able to antagonize Fusarium solani causing ginseng root-rot by their antibiotic substance. In order to develop multifunctional antagonist on Bacillus sp. YBL-7 as a biocontrol agent against Fusarium salam', optimal conditions for protoplast transformation system of Bacillus sp.YBL-7 by the vector plasmid pE194 were investigated. The protoplasts of Bacillus sp. YBL-7 were obtained at best efficiency by treatment with 200${\mu}g$/ml of lysozyme in the pH 7.0 of SMM buffer for 90 minutes at $40^{\circ}C$. The cell wall of the protoplast was regenerated on the agar plate containing 1.2% agar and 0.7 M mannitol. Under the best condition for protoplast formation and regeneration, the optimal transformation was achieved with 40% polyethylene glycol (M.W. 4000) treatment for 10minutes. The vector plasmid pE194 showed the best transformation frequency at 5$\mu$g/ml of final concentration. The pE194 was very stable over 80% in the transformants.

• The Korean Journal of Zoology
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• v.39 no.4
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• pp.337-351
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• 1996

Melatonin Is a multifunctional hormone secreted from the pineal gland in the middle of cerebrum and cerebellum. Its synthesis and release reflect photopedod;Photopedod is a yearly predictable ambient factor that most animals utilize as an environmental cue for maximum survival. Hamsters maintaln reproductive activity in summer during which day length exceeds night time. Upon the advent of autumnal equinox they undergo gonadal regression. The photoperiodic effects are prevented by removal of the pineal gland and restored by the timed repiacument of melatonin. The results suggest that melatonin constitutes part of control mechanism whereby environmental information is transduced to neuroendocrine signal responsIble for the functional integrity of the reproductive system. From the studies for the action site of melatonin following the treatment of photopedod or melatonin in the lesion of a spedflc portion of hypothalamus, suprachiasmatic nuclei and pars tuberalis are shown to be a consensus site for melatonIn. The action of melatonin. In the regulation of reproduction is largely unknown. It is mainly due to the lack of acute effect of melatonin on gonadotropin secretion. However, reduction of the gonadotropln release and augmentation of the hypothalamic gonadotropin-releasing hormone (GnRH) content by long-term treatment of melatonln Indicate that constant presence of melatonln may partidpate in the regulation of sexual activity via the GnRH neuronal system. The action mechanism by which melatonin exerts Its effect on GnRH neuron needs to be eluddated. The inability of opiold analogues to affect the reproductive hormones in sexually regressed animals by inhibftory photopedod and melatonin suggests that the opioldergic neuron may be a prime intervening mediator. Recent cloning of melatonin receptor will contribute to investigate its anatomical Identification and the action mechanism of melatonin on target tissues at the molecular level.

• Food Science of Animal Resources
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• v.29 no.6
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• pp.659-667
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• 2009

Casein is considered to be the main source of protein in milk; therefore, many studies have been conducted to identify casein-derived bioactive peptides and their physiological effects. Casein is inactive within the parent protein but can be liberated by various proteases and enzymatic hydrolysis during microbial fermentation and gastrointestinal digestion. Once absorbed, casein exhibits different bioavailabilities in the body. Specifically, casein-derived peptides function as angiotensin converting enzyme (ACE) inhibitor in the cardiovascular system; thus, they are expected to reduce and prevent hypertension. Additionally, casein-derived peptides behave as opioid-like peptides in the nervous system, which impacts relaxation. These peptides are also expected to modulate various aspects of immune functions. Finally, caseinophosphopeptide (CPP) and glycomacropeptide (GMP) may exhibit a number of nutritional effects such as the absorption of calcium, iron or zinc. Many studies have been conducted to evaluate casein-derived peptides due to their multifunctional properties and the results of these studies have contributed to the development of a wide variety of functional dairy products. The purpose of this paper was to review the generation of bioactive peptides, their absorption and metabolism, and their specific bioactive effects.

• Korean Journal of Heritage: History & Science
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• v.46 no.4
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• pp.64-77
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• 2013

In China, archaeological research on Xiongnu started later than in foreign countries. In the late $19^{th}$ century, several Russian archaeologists started to study Xiongnu's archaeological culture. However, since the late $20^{th}$ century, archaeological research of the Xiongnu in China quickly gained speed. The Xiongnu culture has been reported in Mongolia, northern steppe of China and eastern part of Eurasian steppe. Mainly, Xiongnu sites, dated from the late 2nd century B.C. to the 1st century A.D., are reported on the west side of Baikal Lake(Zabaikal), Mongolia and the Inner Mongolia of China. Based on the historical records and the archaeological remains, the North Xiongnu culture is defined to be the remains of Zabaikal, and the South Xiongnu culture the archaeological remains of Northern China. The expelled North Xiongnu, while fleeing to the western part of Eurasia, left traces of their own archaeological remains in southern Kazakhstan, Xinjiang of China, Altai, and finally appeared in the Europe as Huns. In order to adapt to the environment of northern steppe of China, Xiongnu used a nomadic economic system, giving uniqueness to its iron works. The most characteristic iron works of the Xiongnu is the highly-sophisticated iron weapons. Compared with the iron works of agricultural economic society, Xiongnu iron-works are short of production tools and various vessels. The "Nomadic type" iron works found in Xiongnu area date back to the Warring Country period or slightly later. Further research need to be conducted on "Nomadic type" Xiongnu iron works.

• Journal of the Korean Institute of Rural Architecture
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• v.24 no.4
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• pp.85-95
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• 2022

This study is about the story of 'Saemi', existing in the Sacheon Alluvial fan area. Saemi is a local word for Dumbeong, which is the traditional water irrigation facilities in this area that could be formed according to the geographical characteristics of a Alluvial fan site. In the meantime, although Saemi has been an important source of water, related research has been mainly done from an ecological point of view. Accordingly, the researcher paid attention to the functional aspects of Saemi itself, grasped its location, distribution status, and usage including the construction method, and considered its intrinsic value through classification and characteristic analysis of Saemi. As a result of five field surveys from September 2021 to October 2022, 129 Saemies remained in the Sacheon alluvial fan area. According to the structure and shape, Saemi could be divided into basic type, complex type, and buried type. The basic type was subdivided into bucket-type and stairs-type along with the complex type, and the buried type was subdivided into all buried-type and some buried-type. Saemies were mainly distributed at the distal end of the Sacheon alluvial fan site, individual Saemies were built on farmland, and common Saemies were usually built along roadsides adjacent to villages. The reason why the Saemies are concentrated at the distal end is the geographical characteristics of the alluvial fan where the water underflows. Saemi was an important multifunctional water supply source equivalent to the main water source for people at the distal end of the pond who did not receive a stable supply of water from the reservoir. Saemi was at the center of the underground water irrigation network agricultural system in the Sacheon alluvial fan area according to the principles of 'bbaeim(drop out)' and 'gaepim(pooling)' It has provided a foundation for establishing itself as an appropriate technology in this area. Such Saemi contributed to the rural landscape and agricultural biodiversity through its own system and served as a public interest function. It is necessary to know, conserve, manage, and continuously utilize the value of this Saemi as an agricultural heritage.

• Korean Security Journal
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• no.33
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• pp.27-49
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• 2012

"Do not ask crimes", such as "child sexual abuse" and according to the known through media reports, the people's fear and worry increasingly severe become and the damage increasing day by day and is Still unable to find effective countermeasures that national security policy is a reality. In this study, the result was the development of new security equipment for the purpose of the research team to the solution of the problem of domestic policing these sexual offenses prevention of GPS applications and existing smartphone to suit the era of 20 million development in the online and offline sales and is proposed to complement the problems of the samdanbong multifunction smart samdanbong. First, the function will be applied according to the trend due to the increase of heinous crime, both online and offline sales surge in self-defense products that are being sold on the market, finding problems samdanbong of smart multifunctional smart samdanbong the actual crime and the corresponding effective products were planning to have a secure management system, through a legal review on the current law. Second, sexual offenses, such as Internet use, travel, residential location, and management of sexual offenses Felon Felon's daily life strictly sexual offenses prevention of GPS applications to the characteristics of the sexual offenses scrutinized nearly enough to the frequency of recurrence of 50% is high, look at the case of foreign proposed the streets of sex offenders and the development of applications that can be checked in real-time by considering the basic characteristics to manage.

• Applied Chemistry for Engineering
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• v.10 no.7
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• pp.1028-1034
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• 1999

Poly(lactic acid) is expected to be one of the most promising biodegradable polymers. However, the high molecular weight polymer could be obtained by ring-opening polymerization process conventionally, which raises the production cost and decreases the final yield. In this study, linear and star-shaped poly(L-lactic acid)s were prepared by direct solution polycondensation method and their physical and thermal properties were examined. Tin compounds were found to be effective catalyst for the preparation of high molecular weight polymers. When 0.2g (0.5 wt % of monomer) of $SnCl_2$ and 100 mL of p-xylene were used, the polymer yield and molecular weight were relatively high. As a means to obtain higher molecular weight polymer easily in the direct polycondensation system, dipentaerythritol(dipet) or pentaerythritol(pet) was introduced as a multifunctional branching monomer to provide a star-shaped poly(lactic acid). Moderately high molecular weight polymers with the inherent viscosity values up to 1.14 dL/g(weight-average molecular weight of about 140000 by GPC) were obtained and could be cast strong and transparent films.