• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.264.2-264.2
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• 2008

• Advances in aircraft and spacecraft science
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• v.1 no.1
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• pp.15-25
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• 2014

The developed concept of smart flow control based on turbulence scale modification was applied to control a flow around a circular cylinder. The concept was realized using arrays of vortex-generators regularly spaced along a cylinder generatrix with a given step. Mechanical and thermal vortex-generators were tested, the latter having been based on the localized surface heating or plasma discharges initiated with microwave radiation near the surface. Thus depending on a particular engineering solution, flow transport properties could be modified in passive or active ways. Matched numerical and experimental investigations showed a possibility to delay flow separation and, accordingly, to improve the aerodynamic performance of blunt bodies.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2001.10a
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• pp.201-210
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• 2001

In this study, large-scale distributed design approach for a life cycle cost (LCC) optimization of steel box girder bridges was implemented. A collaborative optimization approach is one of the multidisciplinary design optimization approaches and it has been proven to be best suited for distributed design environment. The problem of optimum LCC design of steel box girder bridges is formulated as that of minimization of the expected total LCC that consists of initial cost maintenance cost expected retrofit costs for strength, deflection and crack. To discuss the possibility of the application for the collaborative optimization of steel box girder bridges, the results of this algorithm are compared with those of single level algorithm. From the numerical investigations, the collaborative optimization approach proposed in this study may be expected to be new concepts and design methodologies associated with the LCC approach.

• Investigative Magnetic Resonance Imaging
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• v.25 no.4
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• pp.218-228
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• 2021

Due to their high degree of freedom to transfer and acquire light, fiber optics can be used in the presence of strong magnetic fields. Hence, optical sensing and imaging based on fiber optics can be integrated with magnetic resonance imaging (MRI) diagnostic systems to acquire valuable information on biological tissues and organs based on a magnetic field. In this article, we explored the combination of MRI and optical sensing/imaging techniques by classifying them into the following topics: 1) functional near-infrared spectroscopy with functional MRI for brain studies and brain disease diagnoses, 2) integration of fiber-optic molecular imaging and optogenetic stimulation with MRI, and 3) optical therapeutic applications with an MRI guidance system. Through these investigations, we believe that a combination of MRI and optical sensing/imaging techniques can be employed as both research methods for multidisciplinary studies and clinical diagnostic/therapeutic devices.

• Earthquakes and Structures
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• v.24 no.3
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• pp.155-163
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• 2023

The purpose of this paper is to investigate the coupled effect of SSI and pounding on dynamic responses of unequal height adjacent buildings with insufficiently separation distance subjected to seismic loading. Numerical investigations were conducted to evaluate effect of the pounding coupling SSI on a Reinforced Concrete Frame Structure system constructed on different soil fields. Adjacent buildings with unequal height, including a 9-storey and a 3-storey reinforced concrete structure, were considered in numerical studies. Pounding force response, time-history and root-mean-square (RMS) of displacement and acceleration with different types of soil and separations were presented. The numerical results indicate that insufficient separation could lead to collisions and generate severe pounding force which could result in acceleration and displacement amplifications. SSI has significant influence of the seismic response of the structures, and higher pounding force were induced by floors with stiffer soil. SSI is reasonable neglected for a structure with a dense soil foundation, whereas SSI should be taken into consideration for dynamic analysis, especially for soft soil base.

• Journal of the Korean Chemical Society
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• v.64 no.2
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• pp.79-83
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• 2020

A novel pharmacophore with epinastine (1) and NSAID moieties (2-5) was designed by molecular hybridization approach. The hybrid compounds 6-9 were synthesized by EDCI/HOBt or HATU-mediated coupling of 1 with salicylic acid (2), mefenamic acid (3), indomethacin (4) and naproxen (5), respectively, and were assessed for their inhibitory effect against NO production in LPS-induced RAW-264.7 macrophages in vitro. The Hybrids were found to exhibit significant NO production inhibitory effects with half-maximal inhibitory concentration (IC₅₀) values ranging in between 15.96 ± 1.32 and 36.68 ± 2.53 μM and were non-cytotoxic to macrophages. Comparing the inhibition concentration (IC₅₀), cytotoxicity concentration (CC₅₀) and in vitro efficacy index (iEI), 6 (IC₅₀ = 17.97 ± 1.92 μM; iEI = 11.13) and 9 (IC₅₀ = 15.96 ± 1.32 μM; iEI = 12.53) were better suited than other hybrids as well as their parent compound. Our findings signify that hybrids 6 and 9 may serve as platforms for continued investigations for the development of more efficient anti-inflammatory agents.

• Advances in concrete construction
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• v.14 no.3
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• pp.153-167
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• 2022

The interaction between blast load and structures, as well as the interaction among structural members may well affect the structural response and damages. Therefore, it is necessary to analyse more realistic reinforced concrete structures in order to gain an extensive knowledge on the possible structural response under blast load effect. Among all the civilian structures, columns are considered to be the most vulnerable to terrorist threat and hence detailed investigation in the dynamic response of these structures is essential. Therefore, current research examines the effect of blast loads on the reinforced concrete columns via development of Pressure- Impulse (P-I) diagrams. In the finite element analysis, the level of damage on each of the aforementioned RC column will be assessed and the response of the RC columns when subjected to explosive loads will also be identified. Numerical models carried out using LS-DYNA were compared with experimental results. It was shown that the model yields a reliable prediction of damage on all RC columns. Validation study is conducted based on the experimental test to investigate the accuracy of finite element models to represent the behaviour of the models. The blast load application in the current research is determined based on the Lagrangian approach. To develop the designated P-I curves, damage assessment criteria are used based on the residual capacity of column. Intensive investigations are implemented to assess the effect of column dimension, concrete and steel properties and reinforcement ratio on the P-I diagram of RC columns. The produced P-I models can be applied by designers to predict the damage of new columns and to assess existing columns subjected to different blast load conditions.

• Journal of Ecology and Environment
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• v.47 no.4
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• pp.228-240
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• 2023

Growing complexity in ecosystem structure and functions, under impacts of climate and land-use changes, requires interdisciplinary understandings of processes and the whole-system, and accurate estimates of the changing functions. In the last three decades, observation networks for biodiversity, ecosystems, and ecosystem functions under climate change, have been developed by interested scientists, research institutions and universities. In this paper we will review (1) the development and on-going activities of those observation networks, (2) some outcomes from forest carbon cycle studies at our super-site "Takayama site" in Japan, and (3) a few ideas how we connect in-situ and satellite observations as well as fill observation gaps in the Asia-Oceania region. There have been many intensive research and networking efforts to promote investigations for ecosystem change and functions (e.g., Long-Term Ecological Research Network), measurements of greenhouse gas, heat, and water fluxes (flux network), and biodiversity from genetic to ecosystem level (Biodiversity Observation Network). Combining those in-situ field research data with modeling analysis and satellite remote sensing allows the research communities to up-scale spatially from local to global, and temporally from the past to future. These observation networks oftern use different methodologies and target different scientific disciplines. However growing needs for comprehensive observations to understand the response of biodiversity and ecosystem functions to climate and societal changes at local, national, regional, and global scales are providing opportunities and expectations to network these networks. Among the challenges to produce and share integrated knowledge on climate, ecosystem functions and biodiversity, filling scale-gaps in space and time among the phenomena is crucial. To showcase such efforts, interdisciplinary research at 'Takayama super-site' was reviewed by focusing on studies on forest carbon cycle and phenology. A key approach to respond to multidisciplinary questions is to integrate in-situ field research, ecosystem modeling, and satellite remote sensing by developing cross-scale methodologies at long-term observation field sites called "super-sites". The research approach at 'Takayama site' in Japan showcases this response to the needs of multidisciplinary questions and further development of terrestrial ecosystem research to address environmental change issues from local to national, regional and global scales.

• Journal of Yeungnam Medical Science
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• v.21 no.2
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• pp.133-142
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• 2004

Chronic obstructive pulmonary disease(COPD) is characterized by a not entirely reversible limitation in the airflow. An airflow limitation is progressive and associated with an abnormal inflammatory response of the lung to gases and harmful particles. In COPD, the weight loss is commonly observed and there is a negative impact on the respiratory as well as skeletal muscle function. The pathophysiological mechanisms that result in weight loss in COPD are not fully understood. However, the mechanisms of weight loss in COPD may be the result of an increased energy expenditure unbalanced by an adequate dietary intake. The commonly occurring weight loss and muscle wasting in COPD patients adversely affect the respiratory and peripheral muscle function, the exercise capacity, the health status, and even the survival rates. Therefore, it is very valuable to include management strategies that the increase energy balance in order to increase the weight and fat free mass. A Better understanding of the molecular and cellular pathological mechanisms of COPD can improve the many new directions for both the basic and clinical investigations. The Nutritional supply is an important components of a multidisciplinary pulmonary rehabilitation program. Future studies combining an exercise program, the role of anabolic steroids, nutritional individualization, a more targeted nutritional therapy, and the development of new drugs including anti-cytokines is needed for the effective management of COPD.

• Journal of Oral Medicine and Pain
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• v.48 no.4
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• pp.181-185
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• 2023

We present a case report of a 52-year-old male patient who suffered head trauma in a car accident and subsequently experienced taste and smell disorders. Following the accident, the patient reported difficulty detecting salty and sour tastes and diminished olfactory perception. Neurosurgical evaluation revealed subarachnoid and subdural hemorrhages, while otolaryngology investigations revealed hyposmia-a decreased sense of smell. Upon referral to the Department of Oral Medicine, a comprehensive assessment revealed a general bilateral reduction in taste sensation, particularly ageusia for salty taste. Electric taste-detection thresholds significantly exceeded the normal ranges. Integrating our findings from neurosurgery, otolaryngology, and oral medicine resulted in a diagnosis of mixed chemosensory disorder attributed to head trauma. This case highlights the intricate interplay of alterations in taste and smell following head injury, emphasizing the significance of multidisciplinary evaluations in diagnosing mixed chemosensory disorders resulting from traumatic brain injury.