• Journal of Communications and Networks
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• v.18 no.3
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• pp.420-428
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• 2016

In this paper, we investigate the scheduling and power allocation for coordinated multi-point transmission in downlink long term evolution advanced (LTE-A) systems, where orthogonal frequency division multiple-access is used. The proposed scheme jointly optimizes user selection, power allocation, and modulation and coding scheme (MCS) selection to maximize the weighted sum throughput with fairness consideration. Considering practical constraints in LTE-A systems, the MCSs for the resource blocks assigned to the same user need to be the same. Since the optimization problem is a combinatorial and non-convex one with high complexity, a low-complexity algorithm is proposed by separating the user selection and power allocation into two subproblems. To further simplify the optimization problem for power allocation, the instantaneous signal-to-interference-plus-noise ratio (SINR) and the average SINR are adopted to allocate power in a single cell and multiple coordinated cells, respectively. Simulation results show that the proposed scheme can improve the average system throughput and the cell-edge user throughput significantly compared with the existing schemes with limited feedback.

• Bulletin of the Korean Chemical Society
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• v.22 no.8
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• pp.903-908
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• 2001

The gene aeg-46.5, which is expressed under anaerobic condition, has putative triple -10 regions and four transcription start sites. The mRNA transcription level and its start point change depending on the aerobic/anaerobic growth condition. RNA polymerase and its regulatory proteins must choose which of three -10 region to use. The putative triple 10 region was mutated to make only one of them function with consensus -10 region sequence (TATAAT) and the other two as non-functional region. The results show that the second and third -10 regions are used for the aerobic/anaerobic expression. The third -10 region is responsible for the high aerobic to anaerobic switch ratio. This suggests that only the last two of the putative triple -10 region have functions on aeg-46.5 gene expression switch control. The phenotype of the mutated promoter was tested in the wild type cell and narL - cell. The results indicate that the control by NarL is independent from the selection of -10 region. The expression patterns on multi-copy plasmids and on single-copy chromosome were compared. These results show that the aerobic/anaerobic switch control of aeg-46.5 is through the choice of -10 region. The mechanism of choosing different -10 region remains to be seen.

• Molecules and Cells
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• v.45 no.11
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• pp.820-832
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• 2022

As a potential candidate to generate an everlasting cell source to treat various diseases, embryonic stem cells are regarded as a promising therapeutic tool in the regenerative medicine field. Cohesin, a multi-functional complex that controls various cellular activities, plays roles not only in organizing chromosome dynamics but also in controlling transcriptional activities related to self-renewal and differentiation of stem cells. Here, we report a novel role of the α-kleisin subunits of cohesin (RAD21 and REC8) in the maintenance of the balance between these two stem-cell processes. By knocking down REC8, RAD21, or the non-kleisin cohesin subunit SMC3 in mouse embryonic stem cells, we show that reduction in cohesin level impairs their self-renewal. Interestingly, the transcriptomic analysis revealed that knocking down each cohesin subunit enables the differentiation of embryonic stem cells into specific lineages. Specifically, embryonic stem cells in which cohesin subunit RAD21 were knocked down differentiated into cells expressing neural alongside germline lineage markers. Thus, we conclude that cohesin appears to control the fate determination of embryonic stem cells.

• Microbiology and Biotechnology Letters
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• v.51 no.4
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• pp.465-473
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• 2023

In this study, we aimed to evaluate the bioconversion ability of single (Lactiplantibacillus plantarum CBT LP3, Lactococcus lactis subsp. lactis CBT SL6, Streptococcus thermophilus CBT ST3) and multi-strain probiotics to convert rutin to quercetin in roasted tartary buckwheat, and to assess their biological activities. To evaluate the bioconversion efficiency, each strain was cultured for 24 h in MRS media with 5% roasted tartary buckwheat 'Hwangguem-Miso' powder. After then, rutin and quercetin contents were determined by HPLC. Additionally, the biological activities were compared before and after bioconversion of an ingredient. Anti-oxidant effects were measured by DPPH and ABTS assays. Anti-inflammatory effects were determined by measuring NO production, and levels of iNOS, TNF-α, IL-6 and IL-4 using an LPS-induced Raw 264.7 cell model. The bioconversion rate under the combination of three species of probiotics significantly increased more than single species. Antioxidant efficacy results showed the highest activity when the combination of three species of probiotics cultured. The pro-inflammatory factors such as nitric oxide, iNOS, TNF-a, and IL-6 were significantly decreased when the three types of probiotics were combined than single strain was cultured. In addition, level in the anti-inflammatory factor IL-4 was increased. The multi-strain probiotics showed increased bioconversion efficiency, effects of anti-oxidant and anti-inflammatory compared to the single strain. These findings suggest that the fermentation of tartary buckwheat by probiotics may be a valuable candidate for developing functional foods with anti-oxidation and anti-inflammation.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.4
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• pp.68-80
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• 2016

This study proposes the traffic prediction and optimal traffic control system based on cell transmission model and genetic algorithm in cloud environment. The proposed prediction and control system consists of four parts. 1) Data preprocessing module detects and imputes the corrupted data and missing data points. 2) Data-driven traffic prediction module predicts the future traffic state using Multi-level K-Nearest Neighbor (MK-NN) Algorithm with stored historical data in SQL database. 3) Online traffic simulation module simulates the future traffic state in various situations including accident, road work, and extreme weather condition with predicted traffic data by MK-NN. 4) Optimal road control module produces the control strategy for large road network with cell transmission model and genetic algorithm. The results show that proposed system can effectively reduce the Vehicle Hours Traveled upto 60%.

• Herbal Formula Science
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• v.13 no.2
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• pp.111-123
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• 2005

The purpose of this study was to investigate the anticancer effects of Caesalpiniae Lignum (Somok) on HepG2 cells, a human liver cancer cell line. To study the cytotoxic effect of Caesalpiniae Lignum methanol extract (CL-MeOH) on HepG2 cells, the cells were treated with various concentrations of CL-MeOH and then cell viability was determined by XTT reduction method and trypan blue exclusion assay. CL-MeOH reduced proliferation of HepG2 cells in a dose-dependent manner. To confirm the induction of apoptosis, HepG2 cells were treated with various concentrations of CL-MeOH. The activation of caspase 3 and the cleavage of poly ADP-ribose polymerase (PARP), a substrate for caspase-3 and a typical sign of apoptosis, was examined by western blot analysis. CL-MeOH decreased procaspase 3 level in a dose-dependent manner and induced the clevage of PARP at concentration> $200{\mu}/ml$. Mitogen-activated protein (MAP) kinase signaling cascades are multi-functional signaling networks that influence cell growth, differentiation, apoptosis, and cellular responses to stress. CL-MeOH-induced MAPK activation was examined by Western blot for phosphorylated ERK, p38 and JNK. CL-MeOH significantly increased p38 phosphorylation and JNK phosphorylation in a dose-dependent manner. Inhibition of p38 function using the selective inhibitor SB20358O results in inhibition of apoptosis by CL-MeOH. These results suggest that CL-MeOH-induced apoptosis is MAP kinase-dependent apoptoric pathway. These results suggest that CL-MeOH is potentially useful as a chemotherapeutic agent in human liver cancer.

• Biomolecules & Therapeutics
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• v.29 no.6
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• pp.658-666
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• 2021

Podophyllotoxin (PT), a lignan compound from the roots and rhizomes of Podophyllum peltatum, has diverse pharmacological activities including anticancer effect in several types of cancer. The molecular mechanism of the anticancer effects of PT on colorectal cancer cells has not been reported yet. In this study, we sought to evaluate the anticancer effect of PT on human colorectal cancer HCT116 cells and identify the detailed molecular mechanism. PT inhibited the growth of cells and colony formation in a concentration-dependent manner and induced apoptosis as determined by the annexin V/7-aminoactinomycin D double staining assay. PT-induced apoptosis was accompanied by cell cycle arrest in the G2/M phase and an increase in the generation of reactive oxygen species (ROS). The effects of PT on the induction of ROS and apoptosis were prevented by pretreatment with N-acetyl-L-cysteine (NAC), indicating that an increase in ROS generation mediates the apoptosis of HCT116 cells induced by PT. Furthermore, Western blot analysis showed that PT upregulated the level of phospho (p)-p38 mitogen-activated protein kinase (MAPK). The treatment of SB203580, a p38 inhibitor, strongly prevented the apoptosis induced by PT, suggesting that PT-induced apoptosis involved the p38 MAPK signaling pathway. In addition, PT induced the loss of mitochondrial membrane potential and multi-caspase activation. The results suggested that PT induced cell cycle arrest in the G2/M phase and apoptosis through the p38 MAPK signaling pathway by upregulating ROS in HCT116 cells.

• Journal of the Korea Society of Computer and Information
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• v.17 no.6
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• pp.83-92
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• 2012

This paper suggests an improved method of grouping minterms based on the Decimal-Valued Matrix (DVM) method. The DVM is a novel approach to Boolean logic minimization method which was recently developed by this author. Using the minterm-based matrix layout, the method captures binary number based minterm differences in decimal number form. As a result, combinable minterms can be visually identified. Furthermore, they can be systematically processed in finding a minimized Boolean expression. Although this new matrix based approach is visual-based, the suggested method in symmetric grouping cell values can become rather messy in some cases. To alleviate this problem, the enhanced DVM method that is based on multi-level groupings of combinable minterms is presented in this paper. Overall, since the method described here provides a concise visualization of minterm groupings, it facilitates a user with more options to explore different combinable minterm groups for a given Boolean logic minimization problem.

• Journal of Ship and Ocean Technology
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• v.10 no.4
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• pp.1-11
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• 2006

The finite volume based multi-block RANS code, WAVIS developed at MOERI is applied to the numerical self-propulsion test. WAVIS uses the cell-centered finite volume method for discretization of the governing equations. The realizable $k-{\epsilon}$ turbulence model with a wall function is employed for the turbulence closure. The free surface is captured with the two-phase level set method and body forces are used to model the effects of a propeller without resolving the detail blade flow. The propeller forces are obtained using an unsteady lifting surface method based on potential flow theory. The numerical procedure followed the self-propulsion model experiment based on the 1978 ITTC performance prediction method. The self-propulsion point is obtained iteratively through balancing the propeller thrust, the ship hull resistance and towing force that is correction for Reynolds number difference between the model and full scale. The unsteady lifting surface code is also iterated until the propeller induced velocity is converged in order to obtain the propeller force. The self-propulsion characteristics such as thrust deduction, wake fraction, propeller efficiency, and hull efficiency are compared with the experimental data of the practical container ship. The present paper shows that hybrid RANS and potential flow based numerical method is promising to predict the self-propulsion parameters of practical ships as a useful tool for the hull form and propeller design.

• The Magazine of the IEIE
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• v.42 no.7
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• pp.26-38
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• 2015

고집적화를 위한 Floating Gate NAND 개발과정에서 몇 차례 기술적 한계상황에 직면하였었지만, Air-Gap, Double patterning, Multi-level Cell, Error Correction Code과 같은 breakthrough idea 을 활용하여 1Xnm까지 성공적인 scale-down 을 하였고 10nm 까지도 바라보고 있지만, 10nm 미만으로는 적절한 방안을 찾지 못한 상황입니다. CTD 의 3D NAND Flash는 Aspect Ratio, Poly channel의 intrinsic 특성, Data 보존 능력 등 해결 해야 할 issue 들이 남아 있지만, F.G Flash 의 지난 20년간 Lesson-learn 과 Band engineering, Channel Si, PUC 의 요소기술 개발 및 System algorithm 개발, QLC 개발 등을 통하여 F.G Flash를 넘어 지속적인 Cost-down 이 가능할 것입니다.