• Interdisciplinary Bio Central
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• 제2권4호
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• pp.16.1-16.4
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• 2010

Cryopreservation of mouse embryos and spermatozoa has become the foremost technique for preserving large numbers of different strains of mice with induced mutations. In 1998, our mouse bank was established in the Center for Animal Resources and Development (CARD), Institute of Resource Development and Analysis, Kumamoto University, Japan, based on the Preservation, supply and development of genetically engineered animals report published by the Ministry of Education, Culture, Sports, Science and Technology. We cryopreserve mouse embryos and sperm, supply these resources, organize training courses to educate people and form part of a domestic and international network of both mutagenesis and resource centers. We currently have over 1,500 mouse strains, 842,000 frozen embryos and 26,000 straws containing frozen sperm. Moreover, we disclose information about 1,300 deposited strains. Furthermore, over 400 strains of frozen embryos or mice produced from frozen embryos and sperm are being supplied to the requesters both domestically and internationally. Additionally we hold training courses on the cryopreservation of mouse germplasm 2~3 times a year, both domestically and internationally. In the course, we teach basic reproductive engineering techniques to trainees on a man-to-man basis. We have already held 28 training courses on the cryopreservation of mouse germplasm at our center and at other institutes.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.1-5
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• 2009

본 연구에서는 몰입형 인간 컴퓨터 상호작용을 위한 햅틱 마우스 시스템을 제작한다. 제작한 햅틱 마우스는 진동감각 뿐 아니라 온열감도 제공하기 때문에 사용자는 더욱 몰입감 있게 가상의 공간을 경험할 수 있다. 진동 감각과 온열감을 제공하기 위하여 편심모터들과 솔레노이드, 그리고 펠티어 엑츄에이터를 이용하였으며 제작한 시스템의 평가를 위하여 레이싱 게임 프로토타입을 구현하여 테스트를 수행한다. 실험결과로부터 본 햅틱 마우스는 가상 공간에서 사용자에게 사실감을 전달함을 알 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1075-1079
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• 2014

MicroRNA expression is a research focus in studies of tumors. This article concentrates attention on potential links between tumors caused by mouse mammary tumor virus (MMTV) and human breast cancer, in order to provide theoretical basis for using mouse model to search for miRNA effects mediated by Wnt/beta-catenin signaling in human breast cancer. By analyzing interactions between miRNAs and the Wnt/beta-catenin signaling pathway in breast cancer, we hope to casts light on more biological functions of miRNAs in the process of tumor formation and growth and to explore their potential value in cancer diagnosis, prognosis and treatment. Our endeavor aimed at providing theoretical basis for finding safer, more effective methods for treatment of human breast cancer at the miRNA molecular level.

• 한국멀티미디어학회논문지
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• 제14권9호
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• pp.1210-1220
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• 2011

본 논문에서는 PC 상의 가상환경과 사용자간의 몰입형 상호작용 인터페이스로서 햅틱 마우스 시스템을 제안한다. 제안하는 햅틱 마우스는 진동감각 및 온열감을 제공하여 몰입감을 높인다. 진동 모듈은 편심모터와 솔레노이드 액추에이터로 구성하였으며 온열감 모듈은 작은 필름형태의 온도 센서와 펠티어 효과기반의 열 펌프를 이용하여 구축한다. 본 햅틱 마우스 시스템의 효용성을 보이기 위해 레이싱 게임 어플리케이션을 제작한 후 이를 사용하여 실험을 수행한다. 실험 결과로부터 제안하는 햅틱 마우스가 가상환경에서 몰입감을 증가시키며 가상환경과 사용자간의 효과적인 인터페이스로 사용될 수 있음을 증명한다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.279.2-280
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• 2002

Ascorbic acid is very well known as one of various ntioxidants and is used very popular in man. Melatonin. an endogenous compound secreted by the pineal gland in human brain has been reported to act as an antioxidant nowadays. The present study was performed to obtain the differences of the radioprotective function of ascorbic acid and combination with melatonin according to the administration dose a day on radiation induced DNA damage in mouse spleen and blood. (omitted)

• 방송공학회논문지
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• 제15권6호
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• pp.715-722
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• 2010

본 논문에서는 증강현실 응용으로 진동촉각 햅틱 마우스를 이용하여 버블 포핑을 구현하는 버블포핑 증강현실 시스템을 제안한다. 이 시스템에서는 가상 그래픽 버블이 3차원 공간에서 랜덤하게 떠다닌다. 사용자의 진동촉각마우스가 버블과 접촉하면 버블이 터지는 포핑이 발생한다. 또한 포핑 효과와 더불어, 마우스가 진동을 함으로써 마우스를 잡고 있는 사용자의 손에 보다 실감나는 버블포핑을 전달한다. 제안 시스템은 진동촉각마우스, 비디오 입력용 웹캠, 마커 패턴 영상, 그래픽 구 버블 객체, 그래픽 마우스 등으로 구성된다. 버블과의 충돌이 발생하게 되면, 마우스 진동과 버블 포핑의 두가지 효과를 동시에 제공한다. 버블포핑 이벤트로 페이드 아웃 및 발산 이드 아웃 기법을 제안한다. 따라서 시각 및 촉각 버블 포핑은 단일 효과보다 실감있는 증강현실을 전달한다.

• Natural Product Sciences
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• 제19권2호
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• pp.173-178
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• 2013

The protective effect of SAPP, an extract from a novel herbal complex, on acute liver injury was investigated using mouse animal model in this study. The content of total phenol in SAPP was increased at dose dependent manner. Consistent with the content of total phenol, SAPP showed the significant anti-oxidative effects on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) method. Acute liver injury was induced by D-galactosamine (D-GalN) in mouse. Treatment with SAPP significantly reduced the level of alanine transaminase (ALT) and aspartate transaminase (AST) in serum. Histological observation revealed that whereas D-GalN treated mouse showed vacuolization of hepatocytes, sinusoidal dilation and congestion, loss of cell boundaries and ballooning degeneration, loss of architecture and cell necrosis, treatment with SAPP improved D-GalN-induced liver injury. These results suggest that SAPP shows protective effects against D-GalN-induced hepatotoxicity in vivo acute mouse model.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1992년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 19-21 Oct. 1992
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• pp.555-557
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• 1992

Recently, realization of an intelligent cooperative interaction system between a man and robot systems is required. In this paper, HyperCard with a voice control is used for above system because of its easy handling and excellent human interfaces. Clicking buttons in the HyperCard by a mouse device or a voice command means controlling each joint of a robot system. Robot teaching operation of grasping a bin and pouring liquid in it into a cup is carried out. This robot teaching method using HyperCard provides a foundation for realizing a user friendly cooperative interaction system.

• 한국미생물·생명공학회지
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• 제22권1호
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• pp.45-51
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• 1994

Antitumor polysaccharides were known to activate complement system and to increase specific serum proteins in mouse, and researcher reported that antitumor activity of polyasccharides might be correlated with their biological properties such as activation of complement system and increase of specific protein $L_{A}$, $L_{B}$ and $L_{C}$ within the mouse serum. In case of several Ganoderma lucidum, there was no correlation between their antitumor activities and their bioloical properties, but the antitumor activities against sarcoma 180 of the alkali extracted crude polysaccharide fractions of the Ganoderma lucidum IY 009. AS, T, AI and M were correlated with their bioloical properties such as anticomplementary activity and intensity of mouse serum protein $L_{A}$, $L_{B}$ and $L_{C}$.

• International Journal of Oral Biology
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• 제31권2호
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• pp.67-72
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• 2006

Nitric oxide(NO) is a labile, uncharged, reactive radical that functions as a sensitive mediator of intercellular communication in diverse tissues. It has been reported that NO is produced by osteoblast and these results may suggest that NO is integrally involved in the regulation of osteoclast formation and osteoclast resorption activity by osteoblastic cells. We examined the effect of cytokines on NO release by mouse bone marrow cell. We also examined the effects of cytokines and sodium nitroprusside(SNP) on the formation of osteoclast-like cell from mouse bone marrow cells in culture. Cytokines stimulated NO production of mouse bone marrow cells, and N-nitro-L-arginine methyl ester, a specific inhibitor of NO synthase, suppressed the cytokine-induced NO production. SNP showed dual action in the generation of osteoclasts. The addition of $30{\mu}M$ SNP inhibited the formation of tartrate resistant acid phosphatase(TRAP)(+) multinucleated cell, whereas lower concentration($3{\mu}M$) of SNP enhanced it. Although the precise action of NO remains to be elucidated in detail, the action of NO in osteoclast generation in our studies seems to be associated, at least in part, with bone metabolism and bone pathophysiology.