• Journal of Ginseng Research
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• v.47 no.4
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• pp.561-571
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• 2023

Background: Escalating evidence shows that ginseng possesses an antiaging potential with cognitive enhancing activity. As mountain cultivated ginseng (MCG) is cultivated without agricultural chemicals, MCG has emerged as a popular herb medicine. However, little is known about the MCG-mediated pharmacological mechanism on brain aging. Methods: As we demonstrated that glutathione peroxidase (GPx) is important for enhancing memory function in the animal model of aging, we investigated the role of MCG as a GPx inducer using GPx-1 (a major type of GPx) knockout (KO) mice. We assessed whether MCG modulates redox and cholinergic parameters, and memory function in aged GPx-1 knockout KOmice. Results: Redox burden of aged GPx-1 KO mice was more evident than that of aged wild-type (WT) mice. Alteration of Nrf2 DNA binding activity appeared to be more evident than that of NFκB DNA binding activity in aged GPx-1 KO mice. Alteration in choline acetyltransferase (ChAT) activity was more evident than that in acetylcholine esterase activity. MCG significantly attenuated reductions in Nrf2 system and ChAT level. MCG significantly enhanced the co-localization of Nrf2-immunoreactivity and ChAT-immunoreactivity in the same cell population. Nrf2 inhibitor brusatol significantly counteracted MCG-mediated up-regulation in ChAT level and ChAT inhibition (by k252a) significantly reduced ERK phosphorylation by MCG, suggesting that MCG might require signal cascade of Nrf2/ChAT/ERK to enhance cognition. Conclusion: GPx-1 depletion might be a prerequisite for cognitive impairment in aged animals. MCG-mediated cognition enhancement might be associated with the activations of Nrf2, ChAT, and ERK signaling cascade.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.26-31
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• 2003

Korean Ginseng is a medicinal herb which grows naturally in korea. an ancient country situated in north-eastern Asia. Its medical use was already well known to herb doctors in this region about five thousand years ago since the effectiveness of korean ginseng has been recognized through practical use for a long time. Korean Ginseng has always been regarded as a devine cure. The name "Ginseng" can be found in various medicinal books. many of which were written as early as B.C. 100. In the records of many chinese medical books. dating from the inception of publishing, it was noted that Korean Ginseng was of the highest level of quality. Korean Ginseng originally grew in the mountains of korea. However, this wild Korean Ginseng(js called SANSAM) could not meet the ever-increasing demands. and from the 16th century. it has been cultivated on farms for mass processing and supplying in korea(js called INSAM). It was already recognized in korea a long time ago(B.C. 57 - A.D. 668) that Korean Ginseng possessed the qualities of panacea, tonic and rejuvenator, and had other medicinal properties as well. The effectiveness of Korean Ginseng is widely recognized among south-eastern Asians as well as Chinese. As its effect has been proved scientifically. Korean Ginseng is now becoming the ginseng for all human beings in the world. Korean ginseng is differently called according to processing method. Dried thing is Insam(white ginseng), boiled or steamed is Hongsam(red ginseng). 장뇌삼(long headed ginseng) is artificially grown in the mountain no in field for a long time. So the body is thin and some long. but ingredients are concentrated. Korean wild ginseng(SANSAM) is rare in these days but we developed cosmetic ingredient. The scientific name of Korean Ginseng is Panax Ginseng. It has acknowledge as a natural mysterious cure among the notheastern peoples. because of its broad medicinal application. The origin of the word" Panax" derived from panacea. a Greek word meaning cure-all. According to the classification method of herb medicines in the Chinese medicinal book. "God-Farmer Materia Medica(A.D. 483-496) korean Ginseng was described as the superlative drug: panacea. tonic and rejuvenator. We studied skin immunological effect. collagen synthesis. cell growth and whitening effect of SANSAM extract. IN cosmetics.. SANSAM extract had skin fibroblast cell growth effect. recover damaged skin in the sun and protect fine wrinkle. Also. In hair product.. inhibits hairless, white hair.its hairless, white hair.

• Korean Journal of Environment and Ecology
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• v.16 no.3
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• pp.321-337
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• 2002

This study was carried out to draw up the planting plan of bridge type ecological corridor for animals migration at Hakgogae(ridge) destroyed by road construction in Yongin, Gyeonggi-do, South Korea. It was conducted with two steps, survey and planting master plan. We surveyed the structure of topography, plant community, and animal habitat. We also selected the target species migrate ecological corridor and suggested a concept of each planting area, the planting species, and the planting density based on the analyzed data and finally drew up the planting plan. The structure of topography was a steep slope due to the mountain ridge destruction so the bridge type ecological corridor was could be applied in this study and we supposed that the animals migrate along the both edge of corridor. As the results of analyzed plant community structure in two sides, the dominant woody species, Quercus serrata and Q. variabilis were distributed on the bottom and the belly of a mountain, while Pinus densiflora community was distributed on the mountain ridge as edaphic climax. The similarity between Q. serrata -Q. mongolica -Q. variabilis community on the West of survey site and Q. serrata -Q. mongolica community on the East of survey site was high in 71.0 percentages. As the results of surveying birds and some mammalia, seven species and fifty-seven individuals of birds were founded in survey area, and two species and two individuals of rodents were founded. We selected birds and some mammals for the migration species that supposed to migrate ecological corridor in drawing up the planting plan. And then we divided the planting areas into bird corridor and habitat, and mammals corridor, also suggested the planting areas in detail as follows: community planting area of shrub at slope adjacent to the bridge exit as a buffer zone, screen planting area, community planting area of herb at steep slope connected with mountain areas, inducement planting area of the animals, community planting area for bird migration, community planting area for mammals migration, and community planting area for bird habitat. We selected the planting woody species which were the constancy ratio based on the analyzed data of plant community around mountain areas was high, and suggested the planting master plan each space.

• Korean Journal of Plant Resources
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• v.6 no.2
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• pp.99-124
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• 1993

Plant in chollabuk-do have investded 105 family, 442 species. 2. The order of distribution of the most family was the Compositae 43, Leguminosae Gramineae each 28, Rosaceae 17, Liliaceas 22, Labiatae 17, Ranunculaceae 12, Betulaceae 11, Violaceae 10, Polygonaceae Aspidiaceae each 9, Cruciferae${\cdot}$Caryothyllaceae${\cdot}$Celastraceae each 8, Fagaceae, Rubiaceae each 6, Ulmaceae 5. 3. Medical plants have invested 56 family, 116 species. 4. The order of the most family was the Compositae 8, Liliaceae Rosaceae${\cdot}$Umbelliferae${\cdot}$Labiatae each 6, Leguminosae${\cdot}$Rutaceae each 5, Campanulaceae${\cdot}$Ranunculaceae each 3, Simaroubaceae${\cdot}$Euphorbiaceae${\cdot}$Araliaceae each 2, Scrophulariaceae${\cdot}$Plantaginaceae each 1.

• Bulletin of the Korean Chemical Society
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• v.35 no.10
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• pp.3015-3020
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• 2014

The behavior of benzo[a]pyrene-7,8-dione (BPQ) in aqueous solution and its interaction with native DNA was investigated using conventional absorption and linear dichroism (LD) spectroscopy. The appearance of a broad absorption maximum at long wavelengths and its proportional relationship to solvent polarizability suggested that BPQ adopts a aggregated state for all solutions examined. Disappearance of this absorption band at higher temperatures in aqueous solution also supported BPQ aggregation. When associated with DNA absorption spectral properties were essentially the same as that in aqueous solution. However, two isosbestic wavelengths were found in the concentration-dependent absorption spectrum of the BPQ-DNA complex, suggesting the presence of at least two or more DNA-bound BPQ species. Both species produced $LD^r$ spectra whose magnitude in BPQ absorption region is larger or comparable to that in the DNA absorption region, suggesting that the molecular BPQ plane is near perpendicular relative to the local DNA helical axis. Therefore, BPQ molecules are aligned along the DNA stem in both DNA-aggregated BPQ species.

• The Korean Journal of Ecology
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• v.4 no.3_4
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• pp.68-79
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• 1981

We discovered following on our surveys to the island six times in May, August (1978), in April, May, June, July (1979). There are 73 families, 158 genera, 189 species, 31 varieties over Tracheophyta Fuller & Tippo. Till early or middle age of Lee Dynasty, the island's dominant plants was evergreen broad-leaved trees, mainly consisted with Camellia japonica L. and Castanopsis cuspidata Schot, var. sieboldii Nakai but due to the population growth and increased exiles constant ground burnt off fr cultivation, the number of evergreen broad-leaved trees was decreased and that of P. densiflora S. et Z. replaced position. That is to say, the island was dominated by the flora of the subtropical zone era, but it has been complicated by flora of the temperate zone whose reproductivity is more vivid, in modern era. Recently Pinus thunbergiana Franco, Robinia pseudo-acasasia L. Amoroha fructicasia L. invaded and reserved inthe island. During a decade of the end of Japanes rule and after liberation about all of Pinus densiflora S. et Z. were cut downed, and after that, under the Forest Bureau, there have being sucessed to Pinus thunbergiana France. Camellia japonica L. other 20 species of evergreen broad-leaved trees are distributed in Island Wi, a tutelary shrine of Dae Ri, a mountain at the back of a village of Chi Do Ri and a mountain at the back of Jin Ri administrative office of a township. The special plants of the island are 1) state of Lycoris aurea Herb which of foun in a ridge between fields and forest around Jin Ri and 2) stock of Cmbidium virescens Lindly bloomed under the Pinus densiflora forest of Keun Tan Chi Do.

• Journal of Plant Biology
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• v.2 no.2
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• pp.1-21
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• 1959

1. The plant communities on Mt. Sulak, a typical alpine mountain in central Korea was researched from the standpoint of ecological survey. 2. The plant on this mountain can largely be classified into 2 categories, the warm zone (below 1100m) and the frigid zone. The former is again classified into a broad-leaved tree formation and a needle-leved tree formation, and the latter is calssified into a broad-leaved tree formation and needle-leaved tree formation, and shrub formation. 3. The broad-leaved tree formation in the warm zone can largely be classified into a Carpinus laxiflora-syringa Palibiniana var. kanibayashi association(1), a Carpinus erosa-Acer Pseudo-sieboldianun association(2), and a Quercus mongolica- Tripterygium Regelii association(3). 4. The needle-leaved tree formation in the warm zone can also largely ben classified into a Pinus densiflora- Miscanthus sinensis association(4), Abies holophylla- Tripterygium regelii association(5), Pinus kordiensis- Rhododendron schlippenbachii association(6) In the association(4), the canopy of the Pinus densiflora is gradually being occupied by the Quercus mongolica which is one kind of broad-leaved trees. 5. We can fully see a DryoPteris type of the flour layer plant type in the association (3) and also see a Sasamorpha type in the association (5). 6. The broad-leaved tree formation in the frigid zone can largely be classified into Quercus mongolica- Rhododendron schlippenbachii association (8). The constituents of tree and subtree layers in (7) and (8) associations are similar to those association (3), but the constituents of the shrub layer are different from those of associtation (3) due to the difference in height. 7. The needle-leaved formation in the frigid zone can largely be classified into Thuja koraiensisRodgersia podophylla var. viritis association (9) and Abies nephrolepis-Acer tschonoskii var. rubripes asscciation (10). The species of alpine plants or subalpine plants are gradually increased in this formation. 8. The shrub formation can also largely be classified into a Rhododendron mucronulatum- Patrinia saniculaefolia association (11) and Pinus pumila associatio (12). Association (12) has largely developed on the windy place. Association (12) was burned due to the bombing during the Korean war, but now we recoginized there occurred an invasion of Tripterygium Regelii in such a place. 9. The herb layer species which constitute the shrub formation are mostly alpine or subalpine plants of small size, and their kinds are also very few. 10. The growth of the Moss layer is especially good because of the varied conditions of the habitat. The kinds which can easily be seen are the genus of Thunidium, Haplocladium, Brachythecium, Macromitrium, Holonitrium, Atrichum, Schwstchkeopsis, Grimmia, Hedwigia, Rhynchostegium and Mnium. 11. The genus of the Sphagnum densly grows like a mat at the acid and moisturous place above 1100m. The authors should express their thanks to father. Yang Kisup, Dean of Catholic Medical College, Prof. Yoon Doksuen, from their valuable advice. Thanks arealso due to Prof. Numata, Chiba University, Prof. Takagi, Nagoya University and Prof. Ando, Hiroshima University in Japan for his kind help and identification of Bryophytes.

• Korean Journal of Agricultural and Forest Meteorology
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• v.7 no.4
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• pp.303-310
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• 2005

Vegetation composition and structure of forest community around Mt. Kumbong, Uiseong-Gun, Korea, were studied using a qualitative and a quantitative approach. Vegetation types and various ecological characteristics including constancy classes, relative coverage, species diversity and interspecific similarity of the major component species were analyzed. Seventy relatives were sampled in $100 m^2$ plots. Forest communities were grouped into mountain vegetation and lower-valley vegetation. The former were divided into 3 communities (Quercus mongolica, Quercus variabilis and Quercus dentata communities). The latter was an Acer mono community. Vegetation units were classified into ten groups. Woody vegetation coverage was $50\~65\%$. The lower-valley vegetation type showed from $2.06\pm0.25\;to\;2.31\pm0.26$ in the species diversity. The species showing interspecific similarity over 0.5 with Quercus mongolica appeared to be Pinus densiflora, Quercus dentata and Tilia amurensis in the tree and subtree layer, and Lindera obtusiloba, Fraxinus sieboldiana, Carex humilis and Carex siderostica in the shrub and herb layer, The species showing higher interspecific similarity with Acer mono were Cornus controversa and Ulmus davidiana in the tree and subtree layer, and Philadelphus schrenchkii and Aristolochia manshuriensis in the shrub and herb layer.

• Korean journal of food and cookery science
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• v.17 no.5
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• pp.421-425
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• 2001

This study was carried out to develop a traditional Korean snack, Dasik, using Angelica gigas Nakai. Angelica gigas Nakai has been used as a medicinal herb which is grown wild in mountain areas or cultivated in Korea, and known to have various functional effects, especially on a women's disease. As an useful food resource, Angelica gigas Nakai was used to prepare Dasik along with soybean powder and black sesame seeds powder. The quality characteristics of Dasik were measured by sensory evaluation and food compositions and antioxidant activity were analyzed. In the results, Dasik prepared with black sesame seeds powder with 20% Angelica gigas Nakai powder was the most favored. especially by the women's group of 30∼40s in age. The composition of this Dasik was water 11.85%, ash 3.4%, crude protein 14.10% and crude fat 23.44% . The functional components of Angelica gigas Nakai were 2.23 ㎎/g of phenolic compounds and 9.9 ㎎/g of flavonoids. Antioxidant activity of Angelica gigas Nakal was 53.14% at 0.1 g/㎎ concentration.

• Korean Journal of Environment and Ecology
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• v.25 no.6
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• pp.819-827
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• 2011

Climate change is recognised as the best serious environmental problem in recent time, and high alpine or high latitudinal organisms especially endangered by its change. Leontice microrhyncha is recorded one of the endangered species by the Ministry of Environment Korea. We surveyed ten L. microrhyncha populations distributed at Taebaek Mountains, high mountain area in Kangwon province. L. microrhyncha is distributed 940m~1350m high altitude which equivalent of Warmth Index $53^{\circ}C{\cdot}month$ to $75^{\circ}C{\cdot}month$, the range of conspicuous cool temperate forest zone. The plant species distributed at slope of $5^{\circ}{\sim}23^{\circ}$ on northeast slopes. The vegetation structure at tree layer of L. microrhyncha distribution area is dominated by Quercus mongolica, Betula costata, Cornus controversa, Acer mono in tree layer, and by Staphylea bumalda, Deutzia glabrata, Stephanandra incisa in shrub layer. The species diversity of herb layer of each L. microrhyncha population showed from 0.21 to 0.98, and the importance value of L. microrhyncha in each population was the highest at blooming time of L. microrhyncha. These results will provide the basic information for the development of conservation strategies for this endangered species.