• Preventive Nutrition and Food Science
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• 제16권4호
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• pp.394-407
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• 2011

Better understanding of the complex factors leading to human diseases will be necessary for both long term prevention and for managing short and long-term health problems. The underlying causes, leading to a global health crisis in both acute and chronic diseases, include finite global health care resources for sustained healthy human survival, the population explosion, increased environmental pollution, decreased clean air, water, food distribution, diminishing opportunities for human self-esteem, increased median life span, and the interconnection of infectious and chronic diseases. The transition of our pre-human nutritional requirements for survival to our current culturally-shaped diet has created a biologically-mismatched human dietary experience. While individual genetic, gender, and developmental stage factors contribute to human diseases, various environmental and culturally-determined factors are now contributing to both acute and chronic diseases. The transition from the hunter-gatherer to an agricultural-dependent human being has brought about a global crisis in human health. Initially, early humans ate seasonally-dependent and calorically-restricted foods, during the day, in a "feast or famine" manner. Today, modern humans eat diets of caloric abundance, at all times of the day, with foods of all seasons and from all parts of the world, that have been processed and which have been contaminated by all kinds of factors. No longer can one view, as distinct, infectious agent-related human acute diseases from chronic diseases. Moreover, while dietary and environmental chemicals could, in principle, cause disease pathogenesis by mutagenic and cytotoxic mechanisms, the primary cause is via "epigenetic", or altered gene expression, modifications in the three types of cells (e.g., adult stem; progenitor and terminally-differentiated cells of each organ) during all stages of human development. Even more significantly, alteration in the quantity of adult stem cells during early development by epigenetic chemicals could either increase or decrease the risk to various stem cell-based diseases, such as cancer, later in life. A new concept, the Barker hypothesis, has emerged that indicates pre-natal maternal dietary exposures can now affect diseases later in life. Examples from the studies of the atomic bomb survivors should illustrate this insight.

• 한국축산시설환경학회지
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• 제8권1호
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• pp.25-34
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• 2002

환경오염, 자연파괴와 자연순환원리에 의한 가축사육이 되지 않는 원인에 따른 광우병, 구제역 발생으로 현대축산에 대한 비판 이 제기되고 있다. 동물약품의 발달에도 불구하고 위험한 전염병은 사라지지 않고 있고 방제가 어려워지고 있다 독일에서는 20여년 전부터 이와 같은 현대축산의 문제점을 해소하기 위하여 환경과 조화를 이루는 유기축산이 연구되고 있으며 정부에서도 기업농 형태의 농장체계를 소규모 유기농 체제로 개편하고 있는 실정이다. 독일의 경우 1950년부터 1990년까지 산유량은 152% 증가한데 비하여 번식장애는 233%, 질병 발생은 200-300% 증가한 것으로 보고되었다. 이러한 원인은 사육환경의 불량, 부적절한 사료공급, 가축 병 발생증가에 원인이 있는 것으로 지적되고 있다. 유기축산에 의한 젖소사육의 중요한 기준은 지역 및 농장에서의 물질순환 구조로 자가사료 생산에 의한 토양-식물-가축의 통합된 순환농법을 이루는 것이다. 따라서 우리나라 축산물의 품질향상과 질병방지와 지속적인 저투입 축산을 위한 한국형 유기축산에 의한 젖소사육의 모델 설정이 요구된다 또한 국제적인 유기식품 규격인 Codex 규정과 부합하는 우리나라의 유기축산 모델설정이 필요하다

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1851-1857
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• 2014

Objective: The main purpose of this work was to investigate the effect of berberine hydrochloride (BH) on the proliferation, apoptosis, migration, and invasion of CNE-1 nasopharyngeal carcinoma cells. Our results shed light on the functional components of traditional Chinese herbs for potential use in modern medicine. Methods: The CNE-1 cell line was treated with different concentrations of BH and effects on cell viability and proliferation were evaluated using the Cell Counting Kit-8 (CCK-8) assay. Anti-migratory and anti-invasive actions of BH were investigated using wound healing assays and the Millicell Hanging cell culture insert system, respectively. Expression of the epithelial-mesenchymal transition (EMT)-related gene twist (Twist) was analyzed by real-time PCR and Western blotting. Apoptosis was estimated with an annexin-V fluorescein (FITC) apoptosis detection kit, as well as with reference to levels of activated caspase-3 of CNE-1 cells before and after treatment with BH utilizing fluorescence spectroscopy. Results: BH was capable of reducing proliferation and viability of CNE-1 cells in a dose- and time-dependent manner, also demonstrating anti-migratory and anti-invasive capacities which correlated with reduction in expression of Twist. Finally, BH was able to induce significant amounts of apoptosis in CNE-1 cells, as demonstrated by an increase in the activity of caspase-3 and in annexin-V staining following treatment. Conclusion: BH extracted from rhizoma coptidis demonstrated an ability to block proliferation, induce apoptosis, and impair the migration and invasion of the CNE-1 cell line Considering these properties, our results suggest that BH could be an important compound for consideration in the treatment of nasopharyngeal carcinoma.

• 대한방사선기술학회지:방사선기술과학
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• 제13권2호
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• pp.1-14
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• 1990

As the institute of education teaching radiologic technology in Korea, different from others, junior college is the only institute which has been managed for it as a two-year educational course for 27 years since 1963 when it was established for the first time in our country irrespective of the needs of the times. But according to the development of medical equipment, variety of medical skill, increase of medical demands now a days, the supply of radiologic technology in modern medicine not only makes it advance as an inevitable factor but also broadens the area of its business systematically. Therefore, we got the following results after we had considered the necessity to lengthen the term of education and searched for the most reasonable way. 1. The term of study of the radiologic technologists in junior college must be lengthened to 3 years from 2 or 3 years regulated in the law of education. 2. In three-year curriculum, the subjects like basic medical science, science and engineering and ultramodern science, etc., which are lated to the new radiologic science must be taught in the junior colleges, and hospital practice also must be a compulsory subject in curriculum. 3. As the school years becomes longer, a lot of programs to make the study effective must be searched, researched and propelled forward.

• Journal of Chest Surgery
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• 제16권2호
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• pp.190-198
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• 1983

The management of cardiac arrhythmias by cardiac pacing has increased greatly since the treatment of complete heart block with an external transcutaneous pacemaker in 1952, followed by the use of myocardial wires connected to an external pulse generation, by external transvenous pacing, and then by transvenous pacing with implantable components in thoracic wall.By now, the three bases of modern cardiac pacing for bradyarrhythmias had been established [1] an implantable device [2] the transvenous approach [3] the ability of the pacemaker to sense cardiac activity and modify its own function accordingly. In transvenous implantation of a pacemaker, any one of four vessels at the root of the neck is suitable for passage of the electrode - cephalic vein, external jugular vein, internal jugular vein, costo-axillary branch of the axillary vein. The new technique of direct puncture of the subclavian vein, either percutaneously or after skin incision only has been made, is invaluable & is used routinely. We have experienced one 25 years old patient who had rheumatic mitral stenosis & minimum aortic regurgitation with sinus bradycardia associated with premature atrial tachycardia & another 54 years old female patient who was suffered from sick sinus syndrome with sinus bradycardia & sinus arrest. The 1st patient was taken open mitral commissurotomy & aortic valvuloplasty and then was taken atrlal pace-maker implantation through If subclavian puncture method in post-op 14 days, and the second patient was taken atrial pacemaker implantation through If subclavian puncture method. Their postop course was in uneventful & were discharged, without complication. Their condition have been good to now.

• 대한약침학회지
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• 제21권3호
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• pp.177-184
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• 2018

Objectives: Auraptene, a natural citrus coumarin, found in plants of Rutaceae and Apiaceae families. In this study, we investigated the effects of auraptene on tumor migration, invasion and matrix metalloproteinase (MMP)-2 and -9 enzymes activity. Methods: The effects of auraptene on the viability of A2780 and Hela cell lines was evaluated by MTT assay. Wound healing migration assay and Boyden chamber assay were determined the effect of auraptene on migration and cell invasion, respectively. MMP-2 and MMP-9 activities were analyzed by gelatin zymography assay. Results: Auraptene reduced A2780 cell viability. The results showed that auraptene inhibited in vitro migration and invasion of both cells. Furthermore, cell invasion ability suppressed at $100{\mu}M$ auraptene in Hela cells and at 25, $50{\mu}M$ in A2780 cell line. Gelatin zymography showed that for Hela cell line, auraptene suppressed MMP-2 enzymatic activity in all concentrations and for MMP-9 at a concentration between 12.5 to $100{\mu}M$ in A2780 cell line. Conclusion: Auraptene inhibited migration and invasion of human cervical and ovarian cancer cells in vitro by possibly inhibitory effects on MMP-2 and MMP-9 activity.

• 한국지능시스템학회논문지
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• 제15권3호
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• pp.349-354
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• 2005

본 논문에서는 휴대용 개인정보 단말기를 이용하여 개인의 생체신호를 보다 쉽게 취득 하고 분석하는 시스템을 제안한다. 바쁘게 사는 현대인들이나, 거동이 불편한 환자들에게 병원을 직접 내원하여 검사를 받거나 진단을 받는 일은 큰 부담이 아닐 수 없다. 이에 본 연구에서는 원격지에서의 병원이나 타 의료장치에서 취득된 생체신호를 유비쿼터스 환경에서 블루투스로 전송하고 이 데이타를 블루투스가 내장된 PDA에서 획득하여 화면상에 다양한 표현방법으로 표현하는 생체신호 획득 시스템 구현을 목표로 한다. 이와 같은 시스템을 구현함으로서 이전의 생체신호와 현재의 생체신호를 쉽게 비교하고 분석할 수 있으며, 자신의 건강상태를 자가 점검하거나 의료기관의 의사에게 보내어짐으로서 검진 받을 수 있는 원격진료가 가능하다.

• Safety and Health at Work
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• 제4권3호
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• pp.156-159
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• 2013

Background: Cardiac pacemakers are known to be susceptible to strong electromagnetic fields (EMFs). This in vivo study investigated occurrence of electromagnetic interference with pacemakers caused by common environmental sources of EMFs. Methods: Eleven volunteers with a pacemaker were exposed to EMFs produced by two mobile phone base stations, an electrically powered commuter train, and an overhead high voltage transmission lines. All the pacemakers were programmed in normal clinically selected settings with bipolar sensing and pacing configurations. Results: None of the pacemakers experienced interference in any of these exposure situations. However, often it is not clear whether or not strong EMFs exist in various work environments, and hence an individual risk assessment is needed. Conclusions: Modern pacemakers are well shielded against external EMFs, and workers with a pacemaker can most often return to their previous work after having a pacemaker implanted. However, an appropriate risk assessment is still necessary after the implantation of a pacemaker, a change of its generator, or major modification of its programming settings.

• Journal of Microbiology and Biotechnology
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• 제20권5호
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• pp.935-941
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• 2010

The emergence of antibiotic-resistant bacterial strains is one of the most critical problems of modern medicine. Bacteriophages have been suggested as an alternative therapeutic agent for such bacterial infections. In the present study, we examined the therapeutic potential of phage Kpn5 in the treatment of Klebsiella pneumoniae B5055-induced burn wound infection in a mouse model. An experimental model of contact burn wound infection was established in mice employing K. pneumoniae B5055 to assess the efficacy of phage Kpn5 in vivo. Survival and stability of phage Kpn5 were evaluated in mice and the maximum phage count in various organs was obtained at 6 h and persisted until 36 h. The Kpn5 phage was found to be effective in the treatment of Klebsiella-induced burn wound infection in mice when phage was administered immediately after bacterial challange. Even when treatment was delayed up to 18 h post infection, when all animals were moribund, approximately 26.66% of the mice could be rescued by a single injection of this phage preparation. The ability of this phage to protect bacteremic mice was demonstrated to be due to the functional capabilities of the phage and not due to a nonspecific immune effect. The levels of pro-inflammatory cytokines (IL-$1{\beta}$ and TNF-${\alpha}$) and anti-inflammatory cytokines (IL-10) were significantly lower in sera and lungs of phage-treated mice than phage untreated control mice. The results of the present study bring out the potential of bacteriophage therapy as an alternate preventive approach to treat K. pneumoniae B5055-induced burn wound infections. This approach not only helps in the clearance of bacteria from the host but also protects against the ensuing inflammatory damage due to the exaggerated response seen in any infectious process.

• 한국병원경영학회지
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• 제21권4호
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• pp.55-62
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• 2016

Purposes: The industry has specialized and fragmented than in the past. As a factor of economic growth and industrialization, the number of people employed in primary industry decreased and the number of people employed in secondary and third industry continuously increased. In modern times, incidence of chronic disease is increasing according to industrial development. So, the purpose of this study was to analyze the chronic disease according to Clark's industrial classification. Methodology: Data were derived from the 2012 Korea Health Panel. The sample was made up of 7,132 adult participants aged 20 or over selected Korea Health Panel by probability sampling from Korea. Binary logistic regression analysis was conducted to examine the main factors associated with chronic disease. Findings: The significant factors associated with chronic disease were gender, age, marital status, household member, education level, insurance type, disability, BMI, and industrial classification. Female, elderly, divorced(including bereavement, missing and separation), one-person households, less than high school graduation, medical aid, disability, obese and primary industry were confirmed chronic disease increases. Practical Implications: The study finds that primary industry's prevalence of chronic disease was higher than secondary and third industry. Therefore, this study aims to management and effort of the worker who engaged in the primary industry. Policy development is required to address inequality or popularization of the differences in these factors by conducting a study to define the working conditions and socio-economic factors between industry.