• Advances in Computational Design
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• v.3 no.1
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• pp.49-69
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• 2018

This paper shows an optimal design for reinforced concrete rectangular combined footings based on a criterion of minimum cost. The classical design method for reinforced concrete rectangular combined footings is: First, a dimension is proposed that should comply with the allowable stresses (Minimum stress should be equal or greater than zero, and maximum stress must be equal or less than the allowable capacity withstand by the soil); subsequently, the effective depth is obtained due to the maximum moment and this effective depth is checked against the bending shear and the punching shear until, it complies with these conditions, and then the steel reinforcement is obtained, but this is not guaranteed that obtained cost is a minimum cost. A numerical experimentation shows the model capability to estimate the minimum cost design of the materials used for a rectangular combined footing that supports two columns under an axial load and moments in two directions at each column in accordance to the building code requirements for structural concrete and commentary (ACI 318S-14). Numerical experimentation is developed by modifying the values of the rectangular combined footing to from "d" (Effective depth), "b" (Short dimension), "a" (Greater dimension), "${\rho}_{P1}$" (Ratio of reinforcement steel under column 1), "${\rho}_{P2}$" (Ratio of reinforcement steel under column 2), "${\rho}_{yLB}$" (Ratio of longitudinal reinforcement steel in the bottom), "${\rho}_{yLT}$" (Ratio of longitudinal reinforcement steel at the top). Results show that the optimal design is more economical and more precise with respect to the classical design. Therefore, the optimal design presented in this paper should be used to obtain the minimum cost design for reinforced concrete rectangular combined footings.

• Korean Medical Education Review
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• v.20 no.3
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• pp.164-172
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• 2018

The aim of this study is to determine whether the 65 competencies, defined in "the role of Korean doctor, 2014", are suitable for basic medical education phase in Korea. It seeks to analyze the gap among the educational reality and expectation, assessment situation of the competencies above. We also try to define issues of the development, application and assessment phases of competency-based medical education (CBME) at individual medical schools. We designed survey tools based on the Miller's assessment pyramid (knowledge, explanation, demonstration, and performance) for each of the 65 competencies. The survey distributed to 41 medical schools in April 2015 and 38 replies were received (92.7%). Competencies that matched both the educational reality and expectation were numbers 1 (patient care), 33 (social accountability), and 49 (professionalism). However, all the other competencies ranked lower in current status than that of desirable level. 54 out of 65 competencies (83.07%) remained at the knowledge and explanation level when each competence were assessed. In the development, application, and assessment phases of CBME, common issues that medical schools commonly noted were difficulty linking competencies to curriculum preparation and student assessment, the lack of faculty's understanding, difficulty to reach consensus among faculties, and absence of teaching and learning methods and assessment tools that fits CBME. For the successful settle down of CBME, there is a need for efforts to develop the model of graduate outcomes, to share information and experience, and to operate faculty development program by the medical education communities.

• Journal of the Society of Naval Architects of Korea
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• v.39 no.2
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• pp.34-44
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• 2002

Approximately 70 percent of shop's hull plate consists of three-dimensional curved shell. Concerning with the research on the automation of plate forming many studies have been carried out for the last decade. The purpose of this study is to develop the simulator of heating on the basis of the reasonable mechanical model representing a heating phenomenon. The beating experiment has been carried out with varying parameters influencing on the results of heating information at the kinematics analysis, simulatorestimate the shape of deformed plate that process along the processing information. When we get the initial shape and the object shape, we calculate the processing information first, using kinematics analysis. In a simulator we estimate deformed shape from the processing information. After this we compare deformed shape and object shape. If the error of deformed shape and object shape is in the proper limits, that information is determined the final processing information. Else we repeat the process changing variable.

• Korean Journal of Plant Resources
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• v.24 no.3
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• pp.286-291
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• 2011

In this study we investigated effects of supplementation with ethyl acetate extracts of the brown alga Eisenia bicyclis on innate immune cells to evaluate the possibilities as an immunomoulator in exercise stress. Twenty male SD rats were divided into four groups and the treatments were as follows: A, no Eisenia bicyclis extract (EBE) (200 mg/kg) intake and maintained at rest ; B, no EBE intake and undergoing exercise ; C, EBE intake and undergoing exercise ; D, EBE intake and maintained at rest. After 5 weeks of oral supplementation, rats were undergoing intensive swimming exercises for 2 h and sacrificed to assess the effects on peritoneal macrophages, spleen cells and natural killer (NK) cells. We showed increasing effects on nitric oxide-inducible nitric oxide synthase (NO-iNOS) production by macrophages and no effects of NK tumoricidal activity and suppressive effects on spleen cell proliferation in exercise group. However, EBE supplementation suppressed NO-iNOS production by macrophages and increased NK tumoricidal activity and spleen cell proliferative response to mitogen in exercise group. Overall, these results that EBE supplementation has differential effects on innate immune response and could be useful as sports nutrition.

• Industrial Engineering and Management Systems
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• v.10 no.3
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• pp.185-190
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• 2011

A driver interacts directly with the car seat at all times. There are ergonomic characteristics that have to be followed to produce comfortable seats. However, most of previous researches focused on either static or dynamic condition only. In addition, research on car seat development is critically lacking although Malaysia herself manufactures its own car. Hence, this paper integrates objective measurements and subjective evaluation to predict seat discomfort. The objective measurements consider both static and dynamic conditions. Steven's psychophysics power law has been used in which after expansion; ${\psi}\;=\;a+b{\varphi}_s^{\alpha}+c{\varphi}_v^{\beta}$ where ${\psi}$ is discomfort sensation, ${\varphi}_s^{\alpha}$ is static modality with exponent ${\alpha}$ and ${\varphi}_v^{\beta}$ is dynamic modality with exponent ${\beta}$. The subjects in this study were local and the cars used were Malaysian made compact car. Static objective measurement was the seat pressure distribution measurement. The experiment was carried out on the driver's seat in a real car with the engine turned off. Meanwhile, the dynamic objective measurement was carried out in a moving car on real roads. During pressure distribution and vibration transmissibility experiments, subjects were requested to evaluate their discomfort levels using vehicle seat discomfort survey questionnaire together with body map diagram. From subjective evaluations, seat pressure and vibration dose values exponent for static modality ${\alpha}$ = 1.51 and exponent for dynamic modality ${\beta}$ = 1.24 were produced. The curves produced from the $E_{q.s}$ showed better $R_{-sq}$ values (99%) when both static and dynamic modalities were considered together as compared to Eq. with single modality only (static or dynamic only R-Sq = 95%). In conclusion, car seat discomfort prediction gives better result when seat development considered both static and dynamic modalities; and using ergonomic approach.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.11
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• pp.1491-1495
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• 2004

Small Tail Han Sheep has significant characteristics of high prolificacy and non-seasonal ovulatory activity and is an excellent local sheep breed in P. R. China. Recently a novel member of the transforming growth factor $\beta$ (TGF$\beta$) superfamily termed bone morphogenetic protein 15 (BMP15) was shown to be specifically expressed in oocytes and to be essential for female fertility. Therefore, BMP15 is a candidate gene for reproductive performance of Small Tail Han Sheep. The whole genomic nucleotide sequence of BMP15 gene in Small Tail Han Sheep was searched for polymorphisms by PCR-SSCP and direct sequencing, and only one polymorphism was found. The polymorphism was a result of a 3 base pair deletion, which eliminated a single Leu codon (CTT). The allelic frequencies for A (without deletion) and B (with a codon deletion) are 0.73 and 0.27 respectively. The effects of BMP15 genotype on litter size were evaluated using the least squares model. This indicated that there was a significant association between litter size of Small Tail Han Sheep and a deletion in BMP15 gene (p=0.02<0.05). Small Tail Han Sheep ewes with AA and AB genotype produce on average 0.5 and 0.3 more lambs per litter than those ewes with BB genotype.

• IMMUNE NETWORK
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• v.15 no.3
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• pp.135-141
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• 2015

Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a novel immune-modulatory peptide that was originally isolated from infected insects. It shows anti-inflammatory effects by the regulation of cytokine production by immune cells and their activities. Therefore, we investigated the effect of alloferon in a mouse model of colitis using dextran sulfate sodium (DSS). Colitis was induced by administration of DSS in drinking water for 7 consecutive days. It was confirmed by the presence of weight loss, diarrhea, hematochezia, and colon contraction. Alloferon was injected 4 days after DSS administration. We found that alloferon improved the pathogenesis of IBD based on the reduced disease activity index (DAI) and colon contraction. Edema, epithelial erosion, and immune cell infiltration were found in mice administered DSS, but the phenomena were reduced following alloferon treatment. The plasma level of IL-6, a classical pro-inflammatory cytokine in colitis, was also decreased by alloferon. Moreover, alloferon inhibited the TNF-${\alpha}$-induced degradation and phosphorylation of $I{\kappa}B$ in Colo205 colon cancer cells. Taken together, these results show that alloferon has anti-inflammatory effects and attenuates DSS-induced colitis.

• Journal of the Korean Society of Propulsion Engineers
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• v.12 no.5
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• pp.51-59
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• 2008

DLN-2.6 combustion tuning was carried out for the maintenance of GE 7FA+e gas turbine at Seo-Incheon combined cycle power plant. DLN-2.6 combustion system has the higher level of yellow plume and combustion vibration problem in the initial operating mode than that of the base mode($100{\sim}160MW$). The objectives of this study are to investigate the causes of yellow plume and combustion vibration problems at the starting mode and to suggest the best operating condition for the reliable working of the real combustors. By the analysis of tuning data, we could conclude that a yellow plume is caused by the rich mixture(${\phi}{\sim}1$) in a PM 1 nozzle at mode 3($20{\sim}30MW$). In addition, the combustion vibration($120{\sim}140Hz$) might be related to the cold flow characteristics of PM 3 nozzles at mode 6B($40{\sim}45MW$).

• Microbiology and Biotechnology Letters
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• v.41 no.1
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• pp.52-59
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• 2013

The nutritional requirements for the maximum production of lipopeptides by Bacillus subtilis N7 (B. subtilis N7) were investigated and optimized using response surface methodology (RSM) under shake flask fermentation. A one-factor-at-a-time experimental setup was used to screen carbon and nitrogen sources. A Plackett-Burman design (PBD) was employed to screen the most critical variables for lipopeptides production amongst ten nutritional elements. The central composite experimental design (CCD) was finally adopted to elucidate the composition of the fermentation medium. Statistical analyses (analysis of variance, ANOVA) of the results showed that KCl, $MnSO_4$ and $FeSO_4{\cdot}6H_2O$ were important components and that their interactions were strong. Lipopeptide production was predicted to reach 709.87 mg/L after a 60 h incubation using an optimum fermentation medium composed of glucose 7.5 g/L, peanut oil 1.25 g/L, $MgSO_4$ 0.37 g/L, $KH_2PO_4$ 0.75 g/L, monosodium glutamate 6.75 g/L, yeast extract and $NH_4Cl$ (5:3 w/w) 10 g/L, KCl 0.16 g/L, $FeSO_4{\cdot}6H_2O$ 0.24 mg/L, $MnSO_4$ 0.76 mg/L, and an initial pH of 7.0. Lipopeptide production ($706.57{\pm}3.70$ mg/L) in the optimized medium confirmed the validity of the predicted model.

• Journal of Biosystems Engineering
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• v.41 no.3
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• pp.255-262
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• 2016

Purpose: Fuji apples are one of the top selling exports for South Korea bringing in over $233.4 million in 2013. However, during the last few decades, about half of the Fuji apple orchards have been infected by Apple Marssonina Blotch disease (AMB), a fungal disease caused by Diplocarpon mali., which takes about 40 days to exhibit obvious visible symptoms. Infected leaves turn yellow and begin growing brown lesions. AMB promotes early defoliation and reduces the quality and quantity of apples an infected tree can produce. Currently, there is no prediction model for AMB on the market. Methods: The Precision Agriculture Laboratory (PAL) at the University of Florida (UF) has been working with the National Academy of Agricultural Science, Rural Development Administration, South Korea to investigate the use of hyperspectral data in creating an early detection method for AMB. The RDA has been researching hyperspectral techniques for disease detection at their Apple Research Station in Gunwi since 2012 and disseminates its findings to the local farmers. These farmers were surveyed to assess the state of knowledge of AMB in the area. Out of a population of about 750 growers, 111 surveys were completed (confidence interval of +/- 8.59%, confidence level of 95%, p-value of 0.05). Results: The survey revealed 32% of the farmers did not know what AMB was, but 45% of farmers have had their orchards infected by AMB. Twenty-five percent could not distinguish AMB from other symptoms. Overwhelmingly, 80% of farmers strongly believed an early detection method for AMB was necessary. Conclusions: The results of the survey will help to evaluate the outreach programs of the RDA so they can more effectively educate farmers on the identifying, treating, and mediating AMB.