• Archives of Plastic Surgery
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• v.38 no.4
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• pp.369-375
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• 2011

Purpose: Many hemostatic agents and dressings have been tested with variable degree of success. Chitosan has a positive charge, it attracts red blood cells, which have a negative charge. Our goal is to test the efficacy of new developed chitosan-based hemostatic materials in providing durable hemostasis in a high-flow arterial wound model. Methods: We compared each group with SD rats motality tests and in vitro blood compatibility test by blood clotting index (BCI). We devided the SD rats into 6 groups (N =15) by type of hemostatic agents. A: 100% nonwoven chitosan (degree of the deacetylation: 90%). B: 50% N-acetylation on nonwoven of chitosan gel (degree of the deacetylation: 50%). C: 60% N-acetylation on nonwoven of chitosan ge (degree of the deacetylation: 40%)l. D: Cutanplast$^{(R)}$. E: HemCon$^{(R)}$ F: Gauze. In vivo test, a proximal arterial injury was created in unilateral femoral arteries of 90 anesthetized SD rats. Each materials was made same size and thickness then applied to the injury site for 3 minutes. In vitro test, we compared each group with BCI in human blood. Results: In vivo test, group A showed lower motality rate of 46% than any other groups, Group B and C showed lower motality rate of 60% than group D and E's motality rate of 66%. In vitro test, BCI of group A ($30.6{\pm}1.2$) and B ($29.3{\pm}1.0$) were showed nearly about group D ($29.1{\pm}1.8$) and E ($27.4{\pm}1.6$). Group C ($37.1{\pm}2.0$) showed higher BCI than group A and B, it means group C decreased blood clotting. Conclusion: In conclusion, this study suggests a newly developed chitosan-based hemostatic materials induced durable hemostasis and increased blood clotting, and are considered as effective biologic hemostatic agents.

• Nutrition Research and Practice
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• v.15 no.6
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• pp.798-806
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• 2021

BACKGROUND/OBJECTIVES: Obesity is associated with chronic inflammation. The spleen is the largest organ of the lymphatic system and has an important role in immunity. Obesity-induced inflammatory responses are triggered by Toll-like receptor (TLR)-myeloid differentiation primary response 88 (MyD88) pathway signaling. Phenethyl isothiocyanate (PEITC) and 3,3'-diindolylmethane (DIM), major dietary glucosinolates present in cruciferous vegetables, have been reported to produce anti-inflammatory effects on various diseases. However, the effects of PEITC and DIM on the obesity-induced inflammatory response in the spleen are unclear. The purpose of this study was to examine the anti-inflammatory effects of PEITC and DIM on the spleen and their mechanism in high fat/cholesterol diet (HFCD)-fed C57BL/6 mice. MATERIALS/METHODS: We established an animal model of HFCD-induced obesity using C57BL/6 mice. The mice were divided into six groups: normal diet with AIN-93G diet (CON), high fat diet (60% calories from fat) with 1% cholesterol (HFCD), HFCD with PEITC 30 mg/kg/day or 75 mg/kg/day (HFCD+P30, HFCD+P75), and HFCD with DIM 1.5 mg/kg/day or 7.5 mg/kg/day (HFCD+D1.5, HFCD+D7.5). Enzyme-linked immunosorbent assay was used to evaluate pro-inflammatory cytokine secretion. Western blot and quantitative polymerase chain reaction were used to analyze protein and mRNA levels of nuclear factor kappa B (NF-κB) p65, interleukin 6 (IL-6), cyclooxygenase 2 (COX-2), TLR2, TLR4, and MyD88 in spleen tissue. RESULTS: Serum IL-6 levels were significantly higher in the HFCD group than in groups fed a HFCD with PEITC or DIM. Levels of NF-κB p65 protein and TLR2/4, MyD88, NF-κB p65, IL-6, and COX-2 mRNA were significantly higher in the HFCD group than in the CON group and were reduced by the PEITC and DIM supplements. CONCLUSIONS: PEITC- and DIM-supplemented diets improved splenic inflammation by modulating the TLR2/4-MyD88 pathway in HFCD-fed mice. We suggest that dietary glucosinolates may at least partially improve obesity-induced inflammation of the spleen.

• Journal of the Korean Applied Science and Technology
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• v.38 no.1
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• pp.118-125
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• 2021

In this study Orostachys japonica A. Berger used is a medicinal herb that has long been used as a folk remedy for cancer treatment. In this study, the antioxidant efficacy of the ethyl acetate fraction of Orostachys japonica A. Berger was confirmed. The results of the Orostachys japonica A. Berge ethyl acetate fraction of antioxidant activity assays showed Antioxidant effect of Orostachys japonica A. Berger EtOAc fraction extract at 0.10 mg/mL was showed a DPPH radical scavenging rate of 78.54% and ABTS+ radical scavenging rate of 73.48%. Also, the toxicity result of Orostachys japonica A. Berger EtOAc fraction extracts using alternative experimental animal model zebrafish, confirmed a 100% the survival of the zebrafish embryo was shown that there was no coagulation and no hatching delay at all concentrations. also ROS generation induced by UV-B irradiation was confirmed that the fluorescence intensity decreased as a whole in all larvae treated with Orostachys japonica A. Berger EtOAc fraction extracts. In particular, it was confirmed that ROS generation was effectively suppressed by showing a 35.7% reduction rate compared to the positive control at a concentration of 3 ㎍/mL. These results were confirmed that Orostachys japonica A. Berger EtOAc fraction extracts has the possibility of application in the cosmetics field as a natural antioxidant.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.5B no.3
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• pp.258-261
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• 2005

The Preisach model needs a distribution function or Everett function to simulate the hysteresis phenomena. To obtain these functions, many experimental data obtained from the first order transition curves are usually required. In this paper, a simple procedure to determine the Preisach density function using the Gaussian distribution function and genetic algorithm is proposed. The Preisach density function for the interaction field axis is known to have Gaussian distribution. To determine the density and distribution, genetic algorithm is adopted to decide the Gaussian parameters. With this method, just basic data like the initial magnetization curve or saturation curves are enough to get the agreeable density function. The results are compared with experimental data and we got good agreements comparing the simulation results with the experiment ones.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.5B no.3
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• pp.253-257
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• 2005

By using a coupled circuit, time-stepping, two-dimensional finite element method (2-D FEM), the performance of a stand-alone permanent-magnet synchronous generator (PMSG) with inset rotor can be computed without involving the classical two-axis model. The effects of interpolar air gap length and armature resistance on the load characteristics are investigated. It is shown that the interpolar flux density, and hence the amount of voltage compensation, is affected by magnetic saturation. Validity of the coupled circuit and field analysis is confirmed by experiments on a prototype generator. The machine exhibits an approximately level load characteristic when it is supplying an isolated unity-power-factor load.

• Journal of computational fluids engineering
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• v.13 no.4
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• pp.45-49
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• 2008

The present paper describes the results of performance analysis for UH-60A rotor blade in hover. For the numerical simulations, commercial CFD software, FLUENT was used with Spalart-Allmaras turbulence model. The flow solver was based on node based scheme and second order spatial accuracy options was used for simulations. For the enhancement of wake capturing capability, high resolution grid was used around tip vortex region. Granting that somewhat over-prediction of thrust was observed near blade tip region, performance was well correlated with experimental data within 3% accuracy in the operating region. Finally it was shown that the present flow solver can be used as a preliminary performance analysis tool for hovering helicopter rotor blades.

• Journal of Integrative Natural Science
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• v.9 no.2
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• pp.121-127
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• 2016

CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. The neutrophilic inflammation in the lung diseases is found to be largely regulated through CXCR2 receptor. Antagonist of CXCR2 may reduce the neutrophil chemotaxis and alter the inflammatory response. Hence, in the present study, ligand based Comparative molecular field analysis (CoMFA) was performed on a series of CXCR2 antagonist named pyrimidine-5-carbonitrile-6-alkyl derivatives. The optimum CoMFA model was obtained with statistically significant cross-validated coefficients ($q^2$) of 0.568 and conventional coefficients ($r^2$) of 0.975. The contour maps suggest the important structural modifications and this study can be used to guide the development of potent CXCR2 antagonist.

• Proceedings of the IEEK Conference
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• 2002.07a
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• pp.533-535
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• 2002

This paper proposes a design of the racetrack microcavity resonator based on silicon substrate. The optimised dimensions of the structure were found by FDTD simulation. The characteristics were also found by the method, and further compared with another model of mode coupling theory. The optimised dimensions of straight guide at wavelength 1.55$\mu\textrm{m}$ are thickness and width of 0.4 $\mu\textrm{m}$. The curve guide provides the maximum at 1 $\mu\textrm{m}$ whereas the resonating section require small coupling section of about 3 $\mu\textrm{m}$.

• International Journal of Naval Architecture and Ocean Engineering
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• v.10 no.3
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• pp.307-317
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• 2018

In this study, numerical investigations of the tip clearance flow characteristics of a pumpjet propulsor based on Computational Fluid Dynamics (CFD) method have been presented. The Zwart-Gerber-Belamri (Z-G-B) cavitation model based on Reynolds Averaged Navier-Stokes (RANS) method is employed. The structured gird is applied. The formation and development of the tip clearance flows has been investigated and presented. The structure of the tip leakage vortex has been shown. The radial distributions of different velocity components with different Span along the axial direction have been carried out to present the influence of the tip clearance flow on the main flow. In addition, the influences of the tip clearance size on the pumpjet propulsor performance, including the impact on the velocity flow fields and the cavitation characteristic, have been presented.

• Journal of Korean Society for Quality Management
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• v.11 no.1
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• pp.44-50
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• 1983

The main factors of determining the Control Line of the Control Chart can be classified as follows: 1) sample size (n), 2) the factor that determines the spread of Control Limits (B), (3) sampling frequency (h). The determination of these factors can be explained according to the extent that occurrences of assignable cause should be detected. The purpose of this paper are two: one is for composing a model of which use should be designated for economic decision on the size of these factors leading to the Control Line of the Control Chart, the other is about what influence increasing or decreasing condition, according to changeability of the size of these factors, of expect cost can have on the economy when the Control Chart is used.