• Journal of Ginseng Research
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• 제48권4호
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• pp.417-424
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• 2024

Background: This research main objective was to evaluate a proliposomes (PLs) formulation for the enhancement of oral bioavailability of ginsenosides, using ginsenoside Rg3 (Rg3) as a marker. Methods: A novel PLs formulation was prepared using a modified evaporation-on-matrix method. Soy phosphatidylcholine, Rg3-enriched extract, poloxamer 188 (Lutrol® F 68) and sorbitol were mixed and dissolved using a aqueous ethanolic solution, followed by the removal of ethanol and lyophilization. The characterization of Rg3-PLs formulations was performed by powder X-ray diffractometry (PXRD), transmission electron microscopy (TEM) and in vitro release. The enhancement of oral bioavailability was investigated and analyzed by noncompartmental parameters after oral administration of the formulations. Results: PXRD of Rg3-PLs indicated that Rg3 was transformed from crystalline into its amorphous form during the preparation process. The Rg3-encapsulated liposomes with vesicular-shaped morphology were generated after the reconstitution by gentle hand-shaking in water; they had a mean diameter of approximately 350 nm, a negative zeta potential (- 28.6 mV) and a high entrapment efficiency (97.3%). The results of the in vitro release study exhibited that significantly more amount of Rg3 was released from the PLs formulation in comparison with that from the suspension of Rg3-enriched extract (control group). The pharmacokinetic parameters after oral administration of PLs formulation in rats showed an approximately 11.8-fold increase in the bioavailability of Rg3, compared to that of the control group. Conclusion: The developed PLs formulation could be a favorable delivery system to improve the oral bioavailability of ginsenosides, including Rg3.

• 대한기계학회논문집A
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• 제37권10호
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• pp.1261-1267
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• 2013

다물체 기계시스템에서 핀조인트나 병진조인트 같은 저자유도 조인트는 고자유도 조인트보다 훨씬 빈번하게 사용된다. 저자유도 조인트에 대한 기구학적 구속조건식을 효율적이고 체계적으로 공식화하기 위해, 본 논문은 구속조건식을 표현하는 새로운 접근방법으로 파라메트릭 일반좌표를 이용한다. 제안된 방법에서는 직교좌표와 파라메트릭 일반좌표를 혼합하여 조인트 구속조건을 생성하는데, 이는 구속조건에 대한 자코비안과 같은 구속조건 편미분행렬을 매우 간단하게 표현되도록 하므로써 공식의 복잡성과 계산시간을 단축시킨다. 제안된 방법은 암시적 적분기를 바탕으로 실린더-크랭크시스템에서 검증되었다.

• 한국전산구조공학회논문집
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• 제19권4호
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• pp.407-418
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• 2006

본 논문에서는 일차전단변형이론(FSDT)을 이용한 복합재료 적층평판의 고정밀 해석기법을 소개한다. 전단수정계수가 자동적으로 포함되도록 횡방향 전단 변형에너지를 혼합변분이론(mixed variational theorem)을 이용하여 개선하였다. 혼합변분이론에서는 변분을 횡방향 응력들에 대해서만 취하였다. 가정된 횡방향 전단응력은 효율적인 고차이론(Cho and Parmerter, 1993)으로부터 구하였다 횡방향 수직응력은 3차 다항식으로 가정하였고, 무전단 응력조건과 평판의 윗면과 아랫면에서의 응력을 만족하는 조건을 부과함으로써 얻었다. 한편, 변위들에 대해서는 일차전단변형이론의 변위장을 사용하였다. 이렇게 해서 얻어진 변형 에너지를 본 논문에서는 EFSDTM3D이라고 명명 하였다. 본 논문에서 개발된 EFSDTM3D는 변위와 응력의 계산에서 고전적인 FSDT와 같은 정도의 계산 효율을 가지면서, 동시에 변위와 응력의 두께방향의 정확도를 면내 방향 응력들에 대한 최소오차자승법에 기초하여 응력 회복 과정을 적용함으로써 개선하였다. 계산된 결과는 고전적인 FSDT, 3차원 탄성해, 그리고 참고문헌 중에서 이용 가능한 결과들과 비교하여 검증하였다.

• 대한수학회지
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• 제44권5호
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• pp.1103-1119
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• 2007

We consider multiscale mortar mixed finite element discretizations for slightly compressible Darcy flows in porous media. This paper is an extension of the formulation introduced by Arbogast et al. for the incompressible problem [2]. In this method, flux continuity is imposed via a mortar finite element space on a coarse grid scale, while the equations in the coarse elements (or subdomains) are discretized on a fine grid scale. Optimal fine scale convergence is obtained by an appropriate choice of mortar grid and polynomial degree of approximation. Parallel numerical simulations on some multiscale benchmark problems are given to show the efficiency and effectiveness of the method.

• Journal of Mechanical Science and Technology
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• 제19권3호
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• pp.811-819
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• 2005

In this study, we present a new efficient hybrid-mixed composite laminated curved beam element. The present element, which is based on the Hellinger-Reissner variational principle and the first-order shear deformation lamination theory, employs consistent stress parameters corresponding to cubic displacement polynomials with additional nodeless degrees in order to resolve the numerical difficulties due to the spurious constraints. The stress parameters are eliminated and the nodeless degrees are condensed out to obtain the ($6{\times}6$) element stiffness matrix. The present study also incorporates the straightforward prediction of interlaminar stresses from equilibrium equations. Several numerical examples confirm the superior behavior of the present composite laminated curved beam element.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제6권1호
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• pp.1-15
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• 2002

Advection-dominated transport problems possess difficulties in the design of numerical methods for solving them. Because of the hyperbolic nature of advective transport, many characteristic numerical methods have been developed such as the classical characteristic method, the Eulerian-Lagrangian method, the transport diffusion method, the modified method of characteristics, the operator splitting method, the Eulerian-Lagrangian localized adjoint method, the characteristic mixed method, and the Eulerian-Lagrangian mixed discontinuous method. In this paper relationships among these characteristic methods are examined. In particular, we show that these sometimes diverse methods can be given a unified formulation. This paper focuses on characteristic finite element methods. Similar examination can be presented for characteristic finite difference methods.

• 대한전기학회논문지:전력기술부문A
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• 제52권6호
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• pp.347-353
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• 2003

In models of imperfect competition of deregulated electricity markets, the key task is to find the Nash equilibrium(NE). The approaches for finding the NE have had two major bottlenecks: computation of mixed strategy equilibrium and treatment of multi-player games. This paper proposes a payoff matrix approach that resolves these bottlenecks. The proposed method can efficiently find a mixed strategy equilibrium in a multi-player game. The formulation of the m condition for a three-player game is introduced and a basic computation scheme of solving nonlinear equalities and checking inequalities is proposed. In order to relieve the inevitable burden of searching the subspace of payoffs, several techniques are adopted in this paper. Two example application problems arising from electricity markets and involving a Cournot and a Bertrand model, respectively, are investigated for verifying the proposed method.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2005년도 추계학술발표대회 논문집
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• pp.194-197
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• 2005

In this work, a mixed beam approach is performed to identify the transverse shear behavior of thin-walled composite beams with closed cross-sections. The analytical model includes the effects of elastic couplings, shell wall thickness, and torsion warping. The distributions of shear flow across the section as well as the shear correction coefficients are obtained in a closed form in the beam formulation. The influence of transverse shear deformation on the static behavior of closed cross-section composite beams is also investigated in the analysis

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집A
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• pp.341-348
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• 2001

A Mixed Volume and Boundary Integral Equation Method is applied for the effective analysis of plane elastostatic problems in unbounded solids containing general anisotropic inclusions and voids or isotropic inclusions. It should be noted that this newly developed numerical method does not require the Green's function for anisotropic inclusions to solve this class of problems since only Green's function for the unbounded isotropic matrix is involved in their formulation for the analysis. This new method can also be applied to general two-dimensional elastodynamic and elastostatic problems with arbitrary shapes and number of anisotropic inclusions and voids or isotropic inclusions. Through the analysis of plane elastostatic problems in unbounded isotropic matrix with orthotropic inclusions and voids or isotropic inclusions, it will be established that this new method is very accurate and effective for solving plane elastic problems in unbounded solids containing general anisotropic inclusions and voids or isotropic inclusions.

• 대한기계학회논문집A
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• 제24권12호
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• pp.3003-3009
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• 2000

In this paper, we propose a new efficient hybrid-mixed C(sup)0 curved beam element with the optimal interpolation functions determined from numerical tests, which gives very accurate locking-free two-node curved beam element. In the element level, the stress parameters are eliminated from the stationary condition and the nodeless degrees of freedom are also removed by static condensation so that a standard six-by-six stiffness matrix is finally obtained. The numeri cal benchmark problems show that the element with cubic displacement functions and quadratic stress functions is the most efficient.