• 약학회지
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• 제45권5호
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• pp.468-475
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• 2001

Fenofibrate is a fibric acid derivative that is a strong reducer of triglyceride. Micronozed formulation of fenofibrate has improved bioavailability compared to non-micrornized formulation. This study performed a retrospective comparison of micrornized and non-micrornized fenofibrate (28 in micronized and 51 in non-micronized group) by comparing the means of changes in total triglyceride, total cholesterol, HDL-cholesterol and TC/HDL ratio in type 2 diabetics with dyslipidemia The result skewed that after 12 weeks of treatment both drugs produced a significant reduction in total triglyceride levels (62% with micronized, 37% with non-micronized). The mean decrease observed for total triglyceride levels were significantly lower for micronized fenofibrate (p<0.001). Both drugs showed a significant reduction for total cholesterol levels (-22% with micronized, -14% with non-micronized fenofibrate). The mean decrease observed for total cholesterol was not significantly different between the two drugs (p>0.05). HDL-cholesterol levels increased by 24% and 15%) with micronized and non-micronized, respectively and the differences from the baseline were statistically significant for both drugs (p<0.05). The mean change of HDL-cholesterol was not significantly different between the two drugs. There was a statistically significant reduction in TC/HBL-cholesterol ratio from baseline for both drugs (7.1 to 4.8 with micronized and 5.1 to 4.5 with non-micronized), and the reduction of TC/HDL-cholesterol ratio tended to be significantly greater with micronized fenofibrate (p<0.05). This study shows that short-term treatment with micronized fenofibrate is more effective than non-micronized fenosbrate in type 2 diabetes patients with dyslipidemia.

• Preventive Nutrition and Food Science
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• 제18권1호
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• pp.60-66
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• 2013

The whole saltwort plant (Salicornia herbacea) was micronized to develop the table salt substitute. The micronized powder was mixed with distilled water and made into a spherical granule by using the fluid-bed coater (SGMPDW). The SGMPDW had superior flowability to powder; however, it had low dispersibility. To increase the dispersibility of SGMPDW, the micronized powder was mixed with the solution, which contained various soluble solid contents of saltwort aqueous extract (SAE), and made into a spherical granule (SGMPSAE). The SGMPSAE prepared with the higher percentages of solid content of SAE showed improved dispersibility in water and an increase in salty taste. The SGMPSAE prepared with 10% SAE was shown to possess the best physicochemical properties and its relative saltiness compared to NaCl (0.39). In conclusion, SGMPSAEs can be used as a table salt substitute and a functional food material with enhanced absorptivity and convenience.

• Archives of Plastic Surgery
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• 제35권1호
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• pp.1-6
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• 2008

Purpose: In tissue engineering, it is important that the scaffolds have high affinity with cells for making efficient use of cells. The authors studied the binding affinity of human adipose stem cells(ASCs) to micronized acellular dermal matrix(alloderm) using biotin and avidin linkages.Methods: Human ASCs were harvested from adipose tissue obtained by abdominoplasty. ASCs($1{\times}10^4$, $5{\times}10^4$, $1{\times}10^5$, $5{\times}10^5$, $1{\times}10^6$, $5{\times}10^6$ cells) were attached to micronized alloderm(1mg) in three groups; 1) control group in which no ASCs and alloderm was treated; 2) serum group in which alloderm was exposed to fetal bovine serum; and 3) biotin group in which biotinylated cells were attached to biotinylated alloderm. The binding affinities were determined 1 day after making ASC-alloderm complexes. The proliferation rates were determined by XTT assays in 4, 7, 14, and 21 days and scanning electron microscopic examination was performed in 7 and 21 days after culture of ASC-alloderm complexes.Results: The binding affinities of the biotin group were significantly increased in all cell concentrations. Maximum binding affinity was observed at $5{\times}10^4/mg$ of micronized dermal matrix in biotin group. The viabilities were lowest in biotin group in contrast to binding affinity, but the difference was not significant. SEM showed well attachment of cells to micronized dermal matrix in all groups. Conclusion: The use of avidin/biotin facilitated human ASCs attaching to micronized acellular dermal matrix. This attachment would not disturb adipose stem cells viabilities. The present study suggests that avidin/ biotin can be used as making efficient use of cells in adipose tissue engineering.

• 한국초지조사료학회지
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• 제37권4호
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• pp.308-314
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• 2017

본 연구에서는 옥수수의 가공방법 및 옥수수의 두께의 차이가 반추위 in situ 소화율 및 in vitro 반추위 발효와 메탄 발생에 미치는 영향에 대하여 알아보고자 실시하였다. Micronized corn(2.5 mm thickness) 처리구는 다른 처리구들에 비하여 in situ 48시간 건물 분해율이 모든 배양시간대에서 높게(P<0.05) 나타났다. 반면, steam flaked corn(3.3 mm thickness) 처리구는 모든 배양시간대에서 가장 낮은(P<0.05) in situ 건물 분해율을 보였다. 반추위 내에서 미생물에 의해 분해되는 b fraction은 이와 상반되는 결과인 steam flaked corn(3.1 mm thickness)과 steam flaked corn(3.3 mm thickness) 처리구에서 높게(P<0.05) 나타났다. b fraction이 반추위를 통과하는 속도인 건물 분해상수 k값은 micronized corn(2.5 mm thickness) 처리구에서 가장 높게 (P<0.05) 나타났고 steam flaked corn(3.3 mm thickness) 처리구에서 가장 낮게 (P<0.05) 나타났다. 반추위내 시간당 통과속도를 0.05로 적용한 유효 건물 분해도는 건물 분해상수와 유사하게 micronized corn(2.5 mm thickness) 처리구에서 가장 높게 (P<0.05), steam flaked corn(3.3 mm thickness) 처리구에서 가장 낮게(P<0.05) 나타났다. In vitro 반추위 48시간 건물 소실율은 micronized corn(2.5 mm thickness) 처리구에서 가장 높은 경향을(P=0.088) 보인 반면 steam flaked corn 처리구들 사이에서는 두께에 따른 건물 소실율의 상관관계는 나타나지 않았다. 총 가스발생량 및 메탄 발생량에 있어서도 건물 소실율과 같은 결과인 micronized corn(2.5 mm thickness) 처리구에서 가장 높게 나타났으며(P=0.001), 총 휘발성지방산은 steam flaked corn(2.9 mm thickness)의 처리구에서 가장 높게 나타났으나(P=0.015) 나머지 처리구들에서는 유의적인 차이를 보이지 않았다. aectate: propionate의 비율 또한 steam flaked corn(2.9 mm thickness)의 처리구에서 가장 높게, micronized corn(2.5 mm thickness) 처리구에서 가장 낮게 나타났다(P=0.008). 본 연구의 결과를 종합하면 steam flaked corn 처리구들에서 in vitro 휘발성지방산 농도에 있어 in situ 반추위내 건물 분해상수와 유효 건물 분해도의 결과와 비교하여 상관관계가 나타나지 않은 결과로 유추해 보면 옥수수 가공방법에 의한 두께의 차이는 반추위 메탄 발생량에 영향을 미치지 않은 것으로 판단된다.

• Clinical and Experimental Reproductive Medicine
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• 제37권2호
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• pp.153-158
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• 2010

목 적: 과배란유도 후 자궁강내 인공수정 시술시 황체기 보강으로서 경구 미분화 프로게스테론 투여법과 경구 디드로게스테론 투여법의 임상적 효용성을 비교하고자 하였다. 연구방법: 2007년 1월부터 2009년 8월까지 시행된 과배란유도 후 자궁강내 인공수정 시술 183주기를 후향적으로 분석하였다. 과배란유도는 성선자극호르몬 단독 또는 클로미펜과 성선자극호르몬의 병합요법을 사용하였다. 136주기에서는 황체기 보강으로서 경구 미분화 프로게스테론을 하루 300 mg으로 투여하였고 47주기에서는 디드로게스테론을 일일 20 mg으로 투여하였다. 결 과: 여성의 연령, 불임 인자, 성숙난포수 ($\geq$16 mm), 총운동성정자수, triggering 날의 자궁내막 두께는 두 군간 유의한 차이가 없었다. 자궁내 태낭이 확인되는 임상적 임신율은 미분화 프로게스테론 투여군에서 21.3%, 디드로게 스테론 투여군에서 19.1%로 차이가 없었다 (p=0.92). 유산율은 미분화 프로게스테론 투여군에서 다소 높은 경향을 보였으나 통계학적인 차이는 없었다 (34.5% vs. 11.1%, p=0.36). 결 론: 황체기 보강으로서 경구 디드로게스테론 투여법은 경구 미분화 프로게스테론 투여에 비하여 비슷한 임신율과 유산율을 보였다. 그러나 상대적으로 디드로게스테론 투여군의 수가 적어 좀더 많은 환자를 대상으로 한 전향적 연구가 필요하다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2008년도 추계 학술논문 발표대회
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• pp.67-71
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• 2008

Blast Furnace slag a pigiron waste that is produced more than 800 thousand tons per year, and micronized double quenching blast furnace slag improves flexibility of concrete, and even shows improvement effect of long-term intensity. However, the concrete that used micronized double quenching blast furnace slag is restricted in its use because of many problems to assure early intensity. Even micronized blast furnace slag can assure its early intensity of concrete when maximizing, and is considered that can be applied in high strength of blast furnace slag as an alternation material for Silica-fume that depends on overall import. Hereby this paper is revised activity index and fluidity of mortar that used Nano Slag that is produced by rotten Nano crush equipment to propose its size, and possible utility of Nano Slag that was produced by blast furnace slag made in Korea as an alternation material, with the conclusion as following. 1. To measure micronized Nano slag, it is judged that it should be in progress with BET method that is based on micronized Silica-fume for concrete. 2. As a result, the test based on KS L ISO 679 is shown to satisfy the basic additive size of KS F 2563 and of KS F 2567, and to determine new combination of stipulations. 3. The strength development of Nano Slag was shown excellent in the daily initial installment of 1, 3, 7 days against the basic additive. This is judged that contains CaO controlling initial strength against Silica-fume, and contributes to higher fineness than the basic blast furnace slag 1 type.

• Asian-Australasian Journal of Animal Sciences
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• 제28권10호
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• pp.1471-1478
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• 2015

The present study aimed to assess the effect of dietary substitution of soybean meal (SBM) with dehulled-micronized faba bean (Vicia faba var. minor) in guinea fowl broilers on their growth traits, carcass quality, and meat fatty acids composition. In this trial, 120 day-old guinea fowl keets were randomly assigned to two treatments which were fed from hatch to 12 weeks of age. Birds were fed two wheat middlings-based diets comprising of a control treatment which contained SBM (78.3 g/kg) and a test diet containing dehulled-micronized faba bean (130 g/kg) as the main protein source. Substituting SBM with faba bean had no adverse effect on growth traits, dressing percentage, or breast and thigh muscles relative weight of the guinea fowls. Conversely, a decrease (p<0.05) of abdominal fat was found in guinea fowls fed the faba bean-diet. Breast muscle of birds fed faba bean had higher $L^*$ score (p<0.05) and water-holding capacity (p<0.05) than the SBM control diet. Meat from guinea fowls fed faba bean had less total lipids (p<0.05) and cholesterol (p<0.01), and higher concentrations of phospholipids (p<0.01). Feeding faba bean increased polyunsaturated fatty acid concentrations in breast meat and decreased the saturated fatty acid levels. Moreover, dietary faba bean improved the atherogenic and thrombogenic indexes in guinea fowl breast meat. Results indicated that substitution of SBM with faba bean meal in guinea fowl diet can improve carcass qualitative traits, enhancing also meat lipid profile without negatively affecting growth performance.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2007년도 제32회 펄프종이기술 국제세미나
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• pp.33-55
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• 2007

This article portrays special cellulose fibers, which are designed to be a functional additive and a carrier for papermaking chemicals. The first part of the presentation deals with the micronized $ARBOCEL^{(R)}$ cellulose fibers, which are used as a functional paper/paperboard additive. In particular as a bulk and speed aid. The detailed description of the micronized $ARBOCEL^{(R)}$ fibers, their function and effects on papermaking process and paper products are given. The second part of the study describes the concept of fiber-based papermaking chemicals. A new generation of fiber-based papermaking chemicals were presented for the first time at the PTS Pulp Technology Symposium 2005, and then several articles were published in various magazine in Asia ("Paper Asia"), the US ("Pulp & Paper"). and Europe ("Wochenblatt fuel Papierfabrikation"). The information generated quite an interest in the paper industry. Extensive studies of these papermaking additives have been made recently, new information obtained, and the compounds have gained more recognition in the industry. The company J. Rettenmaier und Soehne developed a group of fiber-based papermaking additives. They include combination of fibers with sizing agents, starch, fluorochemicals, minerals, biocides and some others. This article presents in-depth study of the AKD modified micronized cellulose as an example of the fiber-based papermaking chemicals concept. The material of the present paper is based mostly on the results of the pilot paper machine study at the Paper Research Institute PTS (Heidenau, Germany), and includes case studies from the mills, which used $ARBOCELPLUS^{(R)}-AKD$ compounds. It should be noted that the $ARBOCELPLUS^{(R)}$ compounds were not designed to replace traditional additives in paper industry. They should rather be used in those areas, where application of "normal" chemicals is especially problematic

• 한국식품영양과학회지
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• 제32권1호
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• pp.75-81
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• 2003

전지활성 생대두미세분말(micronized full-fat soyflour, MFS)로부터 제조된 두유는 의가소성 의 비뉴턴성 유체로서, 고형분 증가와 응고제의 첨가 및 가열에 따라 점도가 증가하였다. MFS용액은 열처리에 따른 점도가 급격하게 증가되는 시점의 온도는 응고제의 첨가 및 단백질의 함량이 증가함에따라 낮아졌다 충진형 전두부제조에 적합한 응고제는 가열된 MFS용액에 응고제 첨가 후 MFS용액의 점도를 완만하게 변화시키는 GDL, MgSO$_4$가 적 합한 것으로 나타났으며 전두부용 응고제는 0.1% salt, 0.1% GDL, 0.2% MgSO$_4$ㆍ7$H_2O$로 조제되었다. 고형분과 물의 비율이 1 : 6.0인 MFS60용액을 121$^{\circ}C$에서 3분간 가열하여 응고제를 첨가하여 제조된 전두부는 견고성과 깨짐성이 양호한 조직감을 나타내었으며, 여기에 SPI를 첨가하여 총단백질이 7.1%인 MFSS60용액으로 제조된 전두부의 경도와 깨짐성(brittleness)은 각각 120 g, 176 g으로 조직감이 개선되었다.

• Journal of the Korean Wood Science and Technology
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• 제40권3호
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• pp.212-227
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• 2012

본 연구에서는 CCA일몰 후, 내구성 향상을 위한 목재보존제의 최근 국제적 연구 동향에 대해 조사 연구하였다. 가압용 약제로 많이 사용되고 있는 최근의 구리 기반 약제의 형태는 수용성으로 ACQ나 CuAz 등의 구리 정착 개선 및 유효성분의 용탈 방지 등이 이슈화 되어 있으며, 미분화(micronized copper) 또는 나노 크기 입자를 이용한 유제형 약제 출현으로 이들의 목재 내 침투 및 정착 특성 연구 등에 대한 논란이 많은 상황이다. 또한 CCA와 달리 현재의 alkyl ammonium quat. 또는 azol 약제 등의 경우에는 구리 내성균에 대해 항균성 감소가 많아 이에 대비한 co-biocide 개발이 심각하게 요구되고 있다.