• 운동영양학회지
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• 제13권3호
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• pp.179-184
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• 2009

The purpose of this study was to evaluate a exercise combined with nutritional education for improving metabolic risk factor and dietary intakes in obese middle aged women. 35 obese (body mass index of at least ≥ 25 kg/m² or %body fat ≥ 30%) middle aged women were recruited from public health center. For intervention participants, their height, weight, percentage of body fat, waist circumference, blood pressure, lipid profiles, insulin resistance index, and nutrition intakes were measured at before and after post the intervention. And change of the total energy intakes per week was measured during intervention. The subjects underwent a 12 weeks educational program including nutritional education one day per week and, aerobic exercise 3 days per week (walking). After 12 weeks exercise program combined with nutritional education, body weight (p=0.002), percentage of body fat (p<0.001), BMI (p<0.001), waist circumference (p<0.001), WHR (p=0.004), TC (p=0.004), AI (p=0.006), DBP (p=0.010), MAP (p=0.013), glucose (p=0.018), insulin (p=0.003), HOMA-IR (p<0.001) were significantly decreased and cardiorespiratory fitness was significantly (p<0.001) increased. And energy intake was significantly (p<0.001) decreased and nutritional intake and intake-style were improved through 12 weeks exercise program combined with nutritional education.

• 한국동물위생학회지
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• 제24권3호
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• pp.279-285
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• 2001

The change of the body condition score(BCS) and milk production graph as days in milk by lactation number show that the productivity of cow is on the increase as increase the lactation number, but the health condition is much worse because of the inappropriate nutrition intake. Metabolic profiles test(MPT) results indicate that the early-lactation for directly after the parturition to the peak production of milk during the total lactation period is the time of the more likely to be exposed to lack of energy, protein, minerals. To solve this problem, the early-lactation cows should be sufficiently supplied the required nutrients and should maximum intake the supplied nutrients not to be suddenly decline body weight and BCS from postparturition to the peak production of milk. To maximize the dry matter intake of a cow, there is have got to improve the management of body weight for heifer's skeletal development and in the dry period which is carelessly deal by mostly farms. This study presents that the use of measurement of body weight, graph of body condition score, distribution of milk production, metabolic profiles test in the monitoring for dairy herd health management is very valuable.

• Asian-Australasian Journal of Animal Sciences
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• 제31권8호
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• pp.1244-1251
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• 2018

Objective: The objective of the present study was to elucidate the mechanism underlying liver metabolic perturbations in dairy cows exposed to heat stress (HS). Methods: Liquid chromatography massabl spectrometry was used to analyze metabolic differences in livers of 20 dairy cows, with and without exposure to HS. Results: The results revealed 33 potential metabolite candidate biomarkers for the detection of HS in dairy cows. Fifteen of these metabolites (glucose, lactate, pyruvate, acetoacetate, ${\beta}$-hydroxybutyrate, fumaric acid, citric acid, choline, glycine, proline, isoleucine, leucine, urea, creatinine, and orotic acid) were previously found to be potential biomarkers of HS in plasma or milk, discriminating dairy cows with and without HS. Conclusion: All the potential diagnostic biomarkers were involved in glycolysis, amino acid, ketone, tricarboxylic acid, or nucleotide metabolism, indicating that HS mainly affected energy and nucleotide metabolism in lactating dairy cows.

• The Journal of Korean Physical Therapy
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• 제12권1호
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• pp.141-146
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• 2000

Making aged exercise by their age it unreasonable because there an differences of personal strength of their body. The three elements which control the aged's possibility of exercising effectivencess are the level of the physical strength in the present state, potential capacities of physical strength and age. Examined the physical strength of aged, the pliancy of body is considerably marked decline by and large and fast twitch muscle are withered. The reason why aged often do prime exercise like and infant. Aged are not fit for the speedy exercise and they can give full scope to their ability by continuing the long time exercise. The reason why aged should dwindle is mainly the retardation of recovering their fatigue which is related to the decline of oxygen activity. Anaerobic energy supply reduction makes aged be bad for severe physical exercise. Basal metabolic rate of rely on physical cellular quantity and people exercising has a high basal metabolic rate because of muscular amount. There were no decline of basal metabolic rate fellowing the age and physical non activiti influences on the atrophy of muscle.

• Journal of Species Research
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• 제9권4호
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• pp.448-454
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• 2020

Nine free-living heterotrophic flagellates were cultured from marine intertidal sediments and freshwater sediments from Korea. These species are described with uninterpreted records based on light microscopy of living cells and reported taxonomically for the first time from Korea. Diagnostics of these species are as follows; Notosolenus hemicircularis: 9-11.8 ㎛ long with flagellar reservoir, ventrally flattened and dorsally convex with hyaline semicircular collar around short anterior neck, and 8 ridges on cell surface. Thecamonas tranhens: 4.5-7.1 ㎛ long, plastic with proboscis comprising an anterior flagellum surrounded by membranous sleeve. Bodomorpha minima: 4.5-7.0 ㎛ long, rigid with small rostrum in anterior end and active anterior flagellum. Cercomonas hiberna: 5.6-10.9 ㎛ long, very plastic with pseudopodia, cytoplasmic strand and 1 or 2 contractile vacuoles. Cercomonas pellucida: 7.5-13 ㎛ long, plastic with pseudopodia, cytoplasmic strand and single contractile vacuole. With nucleus closely connected to basal bodies. Eocercomonas echina: 4.7-6.5 ㎛ long, plastic with pseudopodia, cytoplasmic strand and 1 or 2 contractile vacuoles. Paracercomonas astra: 5.7-7.3 ㎛ long, moderately metabolic with pseudopodia, cytoplasmic strand and 1 or 2 contractile vacuoles. Paracercomonas minima: 5-9 ㎛ long, metabolic with pseudopodia, cytoplasmic strand and single contractile vacuole. Paracercomonas producta: 6.1-9.9 ㎛ long, very metabolic with pseudopodia, long cytoplasmic strand and single contractile vacuole.

• Molecules and Cells
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• 제41권6호
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• pp.603-611
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• 2018

Triglyceride homeostasis is a key process of normal development and is essential for the maintenance of energy metabolism. Dysregulation of this process leads to metabolic disorders such as obesity and hyperlipidemia. Here, we report a novel function of the Drosophila flightless-I (fliI) gene in lipid metabolism. Drosophila fliI mutants were resistant to starvation and showed increased levels of triglycerides in the fat body and intestine, whereas fliI overexpression decreased triglyceride levels. These flies suffered from metabolic stress indicated by increased levels of trehalose in hemolymph and enhanced phosphorylation of eukaryotic initiation factor 2 alpha ($eIF2{\alpha}$). Moreover, upregulation of triglycerides via a knockdown of fliI was reversed by a knockdown of desat1 in the fat body of flies. These results indicate that fliI suppresses the expression of desat1, thereby inhibiting the development of obesity; fliI may, thus, serve as a novel therapeutic target in obesity and metabolic diseases.

• BMB Reports
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• 제56권9호
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• pp.488-495
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• 2023

Mitochondrial transplantation is a promising therapeutic approach for the treatment of mitochondrial diseases caused by mutations in mitochondrial DNA, as well as several metabolic and neurological disorders. Animal studies have shown that mitochondrial transplantation can improve cellular energy metabolism, restore mitochondrial function, and prevent cell death. However, challenges need to be addressed, such as the delivery of functional mitochondria to the correct cells in the body, and the long-term stability and function of the transplanted mitochondria. Researchers are exploring new methods for mitochondrial transplantation, including the use of nanoparticles or CRISPR gene editing. Mechanisms underlying the integration and function of transplanted mitochondria are complex and not fully understood, but research has revealed some key factors that play a role. While the safety and efficacy of mitochondrial transplantation have been investigated in animal models and human trials, more research is needed to optimize delivery methods and evaluate long-term safety and efficacy. Clinical trials using mitochondrial transplantation have shown mixed results, highlighting the need for further research in this area. In conclusion, although mitochondrial transplantation holds significant potential for the treatment of various diseases, more work is needed to overcome challenges and evaluate its safety and efficacy in human trials.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 1979년도 추계학술대회 심포지움
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• pp.246.1-246
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• 1979

A glucose-limited “pH-stat” continuous culture study of Lactobacillus bulgaricus NLS-4 in an anaerobic condition showed the marked effects of environmental pH on end products, fermentation blances and bioenergetic aspects of the organism. Lactic acid was the major end product of fermentation with minor products, such as acetic acid, formic acid and ethanol throughout the pH range tested. In acidic conditions below pH 6.5, a typi-cal pattern of homofermentation was revealed whereas in alkaline conditions, the metabolic pattern was changed from homofermentation to heterofermentation and led to acquire much energy. This metabolic change was likely due to the pH-dependent lactate dehydrogenase activity. Molar growth yields (Yglc=35.5-44.4) and YATP, $18.5\pm2.5$ in average which was 80％ higher than the value ever postulated seemed to be accounted for less requirement of maintenance energy of the organism in the culture conditions.

• 한국식품영양학회지
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• 제31권1호
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• pp.33-42
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• 2018

The aim of this study was to examine the association between egg consumption and the risk of chronic disease in Korean adult females using the 2013 Korea National Health and Nutrition Examination Survey. A total of 1,230 subjects aged 40~64 were classified into the 4 groups according to the number of egg consumed per week: <1, 1~2.9, 3~5, ${\geq}5.1$ As egg consumption increased, the intake of energy, protein, fiber, cholesterol, calcium, potassium, riboflavin, and vitamin C increased. The percentage of the subjects with lower intake of energy, protein, calcium, iron, vitamin A, riboflavin, niacin, and vitamin C than the estimated average requirement in the <1 group were the highest among the groups. The blood lipid profile including total cholesterol and LDL-cholesterol was not significantly different among the 4 egg groups. The higher egg consumption was inversely related to a lower odds ratio of metabolic syndrome, hypertriglycemia, hyperglycemia, hypoHDL-cholesterolemia, and hypertension. This result indicates that egg consumption does not elevate the plasma cholesterol level and has a beneficial effect of decreasing the risk of chronic disease. (175)