• 한국의사학회지
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• 제33권2호
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• pp.105-127
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• 2020

The three major medical compilations of the Joseon Dynasty, Hyangyak-jipseongbang, Uibang-yuchwi, and Dongui-bogam, directly cited a total of 376 kinds of medical books. Among them, 11 medical books were commonly referred: Gyeongheom-yangbang, Deukyobang, Saminbang, Seonmyeongnon, Seongje-chongnok, Seonghyebang, Eoui-chwaryo, Yeongnyu-geombang, Wisaeng-bogam, Cheongeumbang, and Tangaek-boncho. Most of them were medical classics and formularies representing the period from the Song to the early Ming Dynasties, which most likely influenced the establishment of Joseon's medical tradition throughout the Joseon Dynasty. The reason why the majority of the medical reference books was formularies seems to be that prescription practices and the use of medicinals value knowledge with accumulated experience over a long period, whereas medical ideas and doctrines change with time. Besides, except for Eoui-chwaryo compiled in the Goryeo Dynasty, the three significant compilations referred to Chinese medical books, which indicates that the compilers made efforts to accommodate the newly introduced foreign knowledge. At the same time, the former compilations, Hyangyak-jipseongbang and Uibang-yuchwi, later appeared as primary references in Dongui-bogam's Medical Formularies of Successive Generations. However, in order to avoid overlapping the same contents, the compilers tried to form a differentiated version by extracting only the unique contents.

• Journal of Pharmaceutical Investigation
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• 제8권1호
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• pp.1-5
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• 1978

Drug interaction of a new antibiotic, methampicillin lysinate (MAL) with nine drugs were investigated using four species of gram positive and gram negative bacteria. The experimental results were as follows: 1. MIC of MAL were found to be decreased against E. coil when combined with mefenamic acid, probenecid, aluminium hydroxide gel or corticosteroids. The other drugs did not affect MIC of MAL against the same bacteria. 2. MIC of MAL were found to be increased against Staphylococcus aureus ATCC 6538-P, 9441 when combined with mefenamic acid, aluminum hydroxide gel or dexamethasone acetate. The other drugs did not affect MIC of MAL against the same bacteria. 3. MIC of MAL were found to be increased against Shigella dysenteriae when either of the nine drugs was combined. 4. MIC of MAL were found to be increased approximately 2.5 times when combined with Streptokinase-Streptodornase or hydrocortisone and to be decreased approximately 2 times when combined with probenecid or dexamethasone against Salmonella typhi(type 2). It seems the other drugs do not affect the MIC of MAL against the same bacteria.

• 대한한의학원전학회지
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• 제34권2호
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• pp.63-74
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• 2021

Objectives :This paper analyzes the newly discovered manuscripts of the Sanghanjijangdo(傷寒指掌圖). A bibliographic study was carried out to examine the contents and the background of publication. Methods : First, a bibliographical analysis of the Joseon text was conducted. Next, the contents of the composition were compared with the Yuanand early Ming publications of China. Results : 1. The Joseon publication was published based on the original publication from the Yuan period. The Sanghanjijangdo has been cited in several medical texts from early Joseon such as the Euibangyuchwi and Hyangyakjipseongbang. 3. The background for publication of the Sanghanjijangdo is as following. First, it is an introductory text for beginners of Shanghan[cold damage] studies. Second, its contents do not conflict with the specialized Shanghan text that was used as the textbook for the royal physician examination. Third, it contains many Shanghan formulas that could be composed of domestic drugs only. Conclusions : The Sanghanjijangdo could be described as an introductory text for beginners of Shanghan studies that contributed to the expansion of the base of Shanghan studies in 15c mid-Joseon. Publication of this book clearly shows that Shanghan studies in early Joseon was practiced within the scopes of practicality and localization of medicinals.

• 대한한의학원전학회지
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• 제34권2호
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• pp.169-206
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• 2021

Objectives : Records on medicinal liquor in medical texts and major culinary texts of the Joseon period were examined and compared to identify their relevance. Methods : Liquors that include medicinal ingredients in the Donguibogam, Sangayorok, Suunjapbang, Eumsikdimibang, and the Gyuhapchongseo and Juchan were collected. Similarities and differences of each entry were compared following thorough examination. Results : Direct citing of medical texts or specialized medical descriptions in the culinary texts or descriptions of medical liquor composed of various medicinals close to formula compositions are evidences that medical knowledge influenced culinary texts. Conclusions : Descriptions on medicinal liquor in medical texts and culinary texts could be said to have influenced each other.

• 대한한의학원전학회지
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• 제36권4호
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• pp.109-130
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• 2023

Objectives : The Dong-hwa Yakbang Cheobangcheol, a formulary on proprietary medicines created by Dong-hwa Pharmacy in the early 20th century was analyzed with a focus on characteristics of the formulas that were made and sold at the time. Methods : First, external features such as bibliography, table of contents, and descriptive style were examined. In content, licensure of listed formulas, ingredients, dosage form, manufacturing process, effects, properties were medically and pharmacologically analyzed. In this process, the Japanese Pharmacopeial Convention, legislation related to medicinal pharmacology during Japanese Colonial Period, and the Donguibogam were referenced. Results : In terms of form, the Dong-hwa Yakbang Cheobangcheol faithfully follows medicinal related legislation established in the Japanese Colonial Period. However, in terms of content, we could see that most of the formulas were based on the Korean Medical tradition, while Western pharmaceutical technology and chemicals were selectively integrated when necessary. Conclusions : The Dong-hwa Yakbang Cheobangcheol comprehensively displays the situation and goal of Dong-hwa Pharmacy, one of the most representative pharmaceutical companies in proprietary medicine of the early 20th century, in which it was under pressure to adapt to power for survival, while it strived to help improve the health of the people of the time by adopting strengths of both Eastern and Western medicinals.

• 대한한의학원전학회지
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• 제37권1호
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• pp.25-39
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• 2024

Objectives : This paper focuses on recent research related to the relationship between 'Pizhuweiwei(脾主爲衛)' and intestinal flora, and suggests Korean Medical treatment methods that can treat and prevent diseases related to Spleen Deficiency(脾虛) such as ulcerative colitis, atrophic gastritis, diabetes, and obesity that is prevalent today. Methods : This study summarizes recent research results based on various literature on the relationship between the spleen and intestinal flora. Results : Polysaccharides contained in Jianpi herbs(健脾藥) have the effect of increasing beneficial bacteria and maintaining the diversity of intestinal microorganisms to improve intestinal function, managing intestinal metabolites to improve the body's immune function, and regulating the intestinal immune defense system. Therefore, based on the theory of 'Pizhuweiwei(脾主爲衛)', if the symptoms are treated through the spleen with Spleen-strengthening herbal medicinals, it could provide a substantial starting point for improving immunity. Conclusions : Polysaccharides contained in Jianpi herbs(健脾藥) could be considered as potential probiotics based on research findings which show that polysaccharides can regulate the intestinal flora and strengthen weak spleen, playing an important role.

• 동의생리병리학회지
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• 제29권2호
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• pp.143-151
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• 2015

This study was aimed at investigating the syndrome differentiation and herbal medicine of Thromboangiitis Obliterans by reviewing Chinese traditional medicine's journals. The journal search was carried out using China National Knowledge Infrastructure(CNKI) and PubMed from September 2009 to August 2014. Searching key words were the various combination of "Thromboangiitis Obliterans", "traditional chinese medicine", "syndrome differentiation", "herbal medicine". The final selection of 33 studies were selected and summarized by researchers. The syndrome differentiation was classified as yang deficiency, cold syncope and blood stasis. The most frequently herbs were blood-activating and stasis-resolving medicinals.

• 대한한의학방제학회지
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• 제23권1호
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• pp.1-14
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• 2015

Objectives : In Pharmaceutical Affairs Act, herbal medicinal preparations are defined as medicines made by Korean medicine principles. But in Act, Korean medicine principles are vague. Thus, there is a request to explain what the Korean medicine principles are. The aim of this study is to suggest implications of Korean medicine principles in definition of herbal medicinal preparations. Methods : With regard for definition of Korean medicine principles, we referred to the domestic and foreign regulations and literature about the history of herbal medicinal preparations. As a result, the meaning of Korean medicine principles was historically examined from various angles. Results : Through this study, we studied the Korean medicine principles from the past medical history. Due to the broad definition of Korean medicinal principles, we tried to extract general ideas of medicine principles first. We also found that we had scientific formulations based on korean medicine principles which could be used in modern society. In the end, we found that numerous medicine principles which include ‘Four qi and five flavors theory’, ‘Processing of medicinals’, ‘Yin and yang theory’, ‘Five phases theory’, ‘Meridian entry of viscera and bowels theory’, ‘Herb Couplet Interaction theory’, ‘Sovereign, minister, assistant and courier theory’, etc. Conclusions : Innumerable principles used from the past existed. These principles were broad and could be used as modern scientific principles. Based on these facts, we illustrated details of Korean medicine principles, hope this principles be widely shared and Korean herbal medicinal preparations be further developed.

• 사상체질의학회지
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• 제21권2호
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• pp.48-57
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• 2009

1. Objective : The object of this thesis is to find the basis of Constitution assignment of Nogeun(蘆根, Phragmites communis Trin.) used to the medication for Taeyangin. Also, it is to recognize what kind of Constitution of Mogeun(茅根, Imperata cylindrica var. koenigii) is needed to be assigned to. 2. Methods "Dongyi Soose Bowon", 'SinchukBon', 'ChobonKwun', other related Sasang Constitutional Medicine(SCM) books, herbal medicine books such as "Boncho Kangmok", and etc. were compared and researched. 3. Results & Conclusions : 1) Nogeun(蘆根) lowers Qi and harmonizes the body. Because of the effect of lowering soar-Qi(氣), it used to treat the symptoms of Taeyangin's vomiting(噎膈反胃, Stomach reflux due to dysphagia-occlusion). Also Yuksoo Nogeun(逆水蘆恨, Reed growing near the river in low scream) is the basis of considering inhale-gathering Qi effect as a major indication of Nogeun. 2) The theory of classifying White Mogeun as a Tae-eumin Medicinal is based on the effect of Radiating while classifying White Mogeun as a Taeyangin Medicinal is based on the effect of treating stomach reflux(反胃). But both basis are not conclusive and thus requires further study. 3) In "Sasang Geumge Bibang", the first text ever to write only about separate medicinals and Classified Foods (食物類) of each constitution, there were examples of Nogeun and Mogeun's usage based on other pre-existing medical texts. 4) Because White Mogeun is classified as Tae-yangin medication in "Dongmu Yugo", but classified as a Taeeumin's medication in "Dongyi Soose Bowon" 'ChobonKwun' and "Sasang Geumge Bibang", there remains a controversy.

• 대한본초학회지
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• 제36권1호
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• pp.87-95
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• 2021

Objective : Liquidambaris Storax, the processed resin of Liquidambar orientalis Mill., has been therapeutically used as orifice-opening medicinals in Korean Medicine. However, unauthenticated resinous drugs from various origins were sold as Liquidambaris Storax. This study aimed to establish the quality assessment of genuine Liquidambaris Storax and to provide quantitative differences of Liquidambaris Storax in herbal markets. Methods : Bibliographic research on ancient Liquidambaris Storax was performed using classic books of herbology. The quality assessment was approached by searching modern books of herbal medicines. The marker compounds in Liquidambaris Storax from various origins were quantitatively analyzed using high-performance liquid chromatography. Results : L. orientalis was botanically characterized by palmately 5-lobed shape of leaves. Genuine Liquidambaris Storax was recognized as resinous or semi-solid form (ancient―Song dynasty) to liquid form (Myeong/Cheong dynasty) and two processed forms were available in current markets. Genuine liquid Liquidambaris Storax should be lengthened as a thread when it was lifted by a stick and be sunken under the water. The crystals of cinnamic acid was seen under microscopic observation and the scent of benzaldehyde occurred after the treatment with potassium permanganate. Cinnamyl alcohol, cinnamic acid, and cinnamaldehyde were quantified in two liquid samples of Liquidambaris Storax, while cinnamaldehyde was not quantified in resinous (semi-solid) sample. Conclusion : This study presents the detailed methods of quality assessment for genuine Liquidambaris Storax as well as the status in the herbal markets. Further quantitative study with diverse samples is required to establish the quality standard of Liquidambaris Storax.