• Journal of Yeungnam Medical Science
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• v.41 no.1
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• pp.56-57
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• 2024

• Macromolecular Research
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• v.17 no.2
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• pp.133-136
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• 2009

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8931-8936
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• 2014

Background: Herbal compounds such as curcumin which decrease telomerase and gene expression have been considered as beneficial tools for lung cancer treatment. In this article, we compared the effects of pure curcumin and curcumin-loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in a lung cancer cell line. Materials and Methods: A tetrazolium-based assay was used for determination of cytotoxic effects of curcumin on the Calu-6 lung cancer cell line and telomerase and pinX1 gene expression was measured with real-time PCR. Results: MTT assay showed that Curcumin-loaded NIPAAm-MAA inhibited the growth of the Calu-6 lung cancer cell line in a time and dose-dependent manner. Our q-PCR results showed that the expression of telomerase gene was effectively reduced as the concentration of curcumin-loaded NIPAAm-MAA increased while expression of the PinX1 gene became elevated. Conclusions: The results showed that curcumin-loaded-NIPAAm-MAA exerted cytotoxic effects on the Calu-6 cell line through down-regulation of telomerase and stimulation of pinX1 gene expression. NIPPAm-MAA could be good carrier for such kinds of hydrophobic agent.

• Journal of the Korean Society of Radiology
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• v.12 no.3
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• pp.367-372
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• 2018

The supply of medical services using high-priced medical equipment is increasing due to the medicalization of medical science. The level of medical knowledge of medical consumers and the ability to select medical institutions are required to provide high quality medical services because of the popularization of medical information. As the attitudes of medical consumers toward medical institutions change, medical institutions also need to change their perception to improve customer satisfaction. The purpose of this study is to analyze the difference of medical service satisfaction according to the medical knowledge about the utility of PET / CT in order to change the consciousness structure of medical service. The results of this study showed that both medical satisfaction and environmental satisfaction were high in those who had medical knowledge about their own illness and the usefulness of PET / CT. Therefore, medical institutions will need a practical medical service countermeasures to provide medical information by noticing the changes in perception of the medical knowledge of medical consumers, rather than providing formal medical services.

• Korean journal of medical education
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• v.30 no.4
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• pp.283-294
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• 2018

Since medical education programs in Korea and Japan seem to mutually influence each other, this review article provides a history of Japanese medical education, focusing on the way in which it influenced and was influenced by Korean medical education. In the late 19th century, the University of Tokyo established the core medical school, disseminating its scholarship and system to other medical schools. In the early 20th century, the balance between the quality and quantity of medical education became a new issue; in response, Japan developed different levels of medical school, ranging from imperial universities to medical colleges and medical vocational schools. After World War II, all of Japan's medical schools became part of the university system, which was heavily regulated by the Ministry of Education (MOE) Standard for the Establishment of Universities. In 1991, MOE deregulated the Standard; since 2000, several new systems have been established to regulate medical schools. These new approaches have included the Model Core Curriculum, 2-year mandatory postgraduate training, and a medical education accreditation system. Currently, most medical schools are nervous, as a result of tighter regulatory systems that include an accreditation system for undergraduate education and a specialty training system for postgraduate education.

• The Korean Journal of Emergency Medical Services
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• v.11 no.3
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• pp.111-118
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• 2007

Purpose : It was to present strategies on activation of prehospital medical direction in Korea. Methods : This study was conducted by analysing some papers on prehospital medical direction and statistical data from the National Emergency Management Agency. Results : There was no active application of medical direction methods such as Priority Dispatch System, Pre-Arrival Instructions, System Status Management and no data on prehospital medical direction. To estimate direct medical control on emergency patients who were sorted by EMTs in 2006 was only 2.5%. Conclusion : To improve prehospital medical direction, it needed to applicate data collecting & using system and in-direct & direct medical control by medical doctor.

• The Korean Journal of Emergency Medical Services
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• v.6 no.1
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• pp.129-140
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• 2002

Purpose : To evaluate the emergency medical protocols and assessments through the case reports. Method : We studied retrospectively investigates the emergency calls through the 1339 emergency patients information center in 1997. Results : The emergency calls show an order : abdominal pain(13.5%), unconsciousness(12.0%), traffic accidents(7.4%), bleeding(6.6%), respiration difficulty(5.9%) by emergency medical protocols, and injury and poisoning(22.3%), symptom (51.6%), others (26.1%). Conclusion : The results suggest that a specific training program for emergency medical dispatchers should be established, and emergency medical dispatcher managers must review emergency medical dispatching cases on the basis of emergency medical protocols every year. Emergency medical services, furthermore, will continue to raise the standard for emergency medical dispatching.

• Korean Journal of Radiology
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• v.23 no.11
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• pp.1089-1101
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• 2022

Immunotherapy has revolutionized and opened a new paradigm for cancer treatment. In the era of immunotherapy and molecular targeted therapy, precision medicine has gained emphasis, and an early response assessment is a key element of this approach. Treatment response assessment for immunotherapy is challenging for radiologists because of the rapid development of immunotherapeutic agents, from immune checkpoint inhibitors to chimeric antigen receptor-T cells, with which many radiologists may not be familiar, and the atypical responses to therapy, such as pseudoprogression and hyperprogression. Therefore, new response assessment methods such as immune response assessment, functional/molecular imaging biomarkers, and artificial intelligence (including radiomics and machine learning approaches) have been developed and investigated. Radiologists should be aware of recent trends in immunotherapy development and new response assessment methods.

• The Journal of Korean Medical History
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• v.18 no.2
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• pp.189-195
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• 2005

Medical Records are the clinical chronicles of Korean Medicine. It not only has value as historical documentation, but also has value in clinical use. If studies of medical records that contain specific methods for tackling diseases are accompanied, it will be easier to clearly see the internal development process of Korean Medical History. This paper was written in order to achieve these goals by reporting the thoughts on the necessity and meaning of studying Medical Records.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.553-556
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• 2013

Background: This study was designed to examine changing trends in localization of gastric cancer in Turkey in recent years. Materials and Methods: A total of 796 adult patients with newly diagnosed, histologically proven adenocarcinomas, treated and followed up at our oncology center between 2000-2011, were examined retrospectively. In all cases tumor localization were identified and recorded with clinicopathological features. Results: The median age was 58 with a range between 22-90 for the 552 men and 244 women. Median follow up was 12 months (1-276) and median overall survival was also 12 months (11.5-12.4). There was a trend for a change in tumor localization from distal to proximal. Survival of patients was low with advanced T and N stage tumours. Positive surgical margins, lymphovascular invasion, perineural invasion, cardioesophageal localization were predisposition factors for metastatic disease in gastric cancer. There was no relation between age or sex and histopathological type of gastric cancer. Conclusions: There is a trend in our country for a change in gastric tumour localization from distal to proximal, with clear significance for treatment choices.