• Journal of the Korean Society of Child Welfare
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• no.56
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• pp.133-164
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• 2016

This study investigated the effect of housing poverty in childhood on adolescents' subjective well-being. Specifically, this study examined whether the major factors that have been known to affect adolescents' well-being (i.e., family relationships, peer relationships, school adjustment etc.) mediated the relationship between housing poverty and adolescents' well-being. And then this study aimed to present an empirical evidence for establishing policies against housing poverty in order to enhance adolescent's subjective happiness. Data were derived from the $1^{st}$, $4^{th}$, and $7^{th}$ surveys of the Korea Welfare Panel Study(KOWEPS), and the sample included. 512 high school children in the $7^{th}$ survey. This study utilized structural equation modeling. Housing poverty was measured by the sub-minimum standard housing condition and the household's burden of housing expenditure. Family relationship, as a mediator, was measured by parental involvement in education, parental monitoring, and family conflicts. Another mediator, school adjustment was measured by school environment and school bonding, and the last mediator, peer relationship was measured by friend attachment and peer attachment. The results showed that housing poverty had significant negative effects on the adolescents' subjective well-being. The sub-minimum standard housing condition with inadequate size and facilities negatively affected adolescents' relationships with family directly and subjective well-being indirectly. In addition, the negative family relationships due to the sub-minimum standard housing condition negatively affected adolescents' subjective well-being through school adjustment and peer relationships. The greater the proportion of income a household spends on housing expenditure, the less likely for adolescents to report positive well-being. The sub-minimum standard housing condition had indirect effects through family relationships, whereas the household's housing expenditure directly affected adolescents' subjective well-being. This study suggested the necessity of interventions to alleviate housing poverty for adolescents' families and lays the groundwork for housing poverty policies in Korea.

• Journal of Korean Academy of Nursing
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• v.41 no.5
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• pp.663-672
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• 2011

Purpose: Purpose of this study was to investigate the status of depression in academic high school students and path analysis model for exploring the mediating role of entrapment to depression in relation to academic stress and perceived social support. Methods: Measurements were four reliable questionnaires measuring academic stress, social support, entrapment, and depression. Data were collected from students in 17 high schools in Seoul. Results: Students (n=5,346) completing the questionnaires indicated depression & entrapment from academic stress. Depression was more prevalent in girls, those whose parents' household income was less than two million won, who did not live with father or mother or both due to divorce, separation, or death, and those who smoked or used alcohol. Entrapment was more prevalent in students similar to cases of depression and in seniors. According to the proposed path model, 48.6% of depression was explained by academic stress, social support, and entrapment. The indirect effect of entrapment as a mediator between academic stress and depression was verified and larger than the direct effect of academic stress on depression. Conclusion: Considering levels of depression and entrapment demonstrated by these students, better mental health programs with diverse strategies should be developed for their psychological well-being.

• Toxicological Research
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• v.33 no.3
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• pp.205-209
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• 2017

Transmembrane Protein 39A (TMEM39A) is a member of TMEM family. The understanding about this protein is still limited. The earlier studies indicated that TMEM39A was a key mediator of autoimmune disease. TMEM39A seems to be involved in systemic lupus erythematosus and multiple sclerosis in numerous of populations. All of these works stop at insufficient information by using gene functioning methods such as: Genome-wide association studies (GWASs) and/or follow-up study. It is the fact that the less understood of TMEM39A actually is the attraction to the scientist in near future. In this review the current knowledge about TMEM39A and its possible roles in cell biology, physiology and pathology will be described.

• Journal of Korean Library and Information Science Society
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• v.49 no.2
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• pp.301-326
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• 2018

The study is to find the possibility of cooperation between civil servants as a mediators for changing a society in a region into community of practice. "Community" is the value-oriented concept and exists in a local community, a community of practice and a organization that have the characteristic of "Community." Public libraries as "Community" have both characteristics of local community and community of practice. And public libraries as community gives public services for neighborhood region problem-solving to people. But in Korea, Residents autonomy system in Dong gives the service to people. They all conducts the business for changing a society in a region to community of Practice. Therefore the study conducted a survey about sense of community and necessity of cooperation in the business. The results are following: The group of higher awareness on community feels less needs to corporate the work in community than the group of lower awareness on community; The group of higher awareness on community or the group having more experience on community have lower job satisfaction. Therefore the motivation on working for community is needed for the mediator.

• Journal of Korean Society for Quality Management
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• v.49 no.4
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• pp.505-525
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• 2021

Purpose: The purpose of this study was to investigate factors influencing the intention to use Fintech Digital Sand(D-Testbed), which facilitate digital innovation in the financial sectors and allow fintech startups to simulate the PoC their innovative ideas before starting a business. Methods: This study used the Extended Technology Acceptance Model (TAM2), with independent variables such as social influence, personal innovativeness, service quality, relative advantage, and security concerns used in previous studies, for analysis. For mediator variables, the perceived usefulness and perceived ease of use were used in this study. Results: The results indicated that social influence and perceived usefulness have a positive effect on the intention to use. It was also analyzed that relative advantage has a mediating effect on perceived usefulness whereas service quality nor personal innovativeness are not statistically significant mediation. On the other hand, perceived ease of use on the intention is not statistically significant. By this, it was confirmed that the intention to use Fintech Digital Sand(D-Testbed) was to improve the business performance of fintech companies, but not because it was easy to learn and take less effort. Conclusion: The finding of the study provides valuable implications for invigorating the use of fintech digital sandbox(D-testbed) and identifying the factors that affect the perception and intention to use among employees in fintech companies in advance.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.8-8
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• 2019

The stringent response (SR) is characterized as a bacterial defense mechanism in response to various growth-inhibiting stresses. It is activated by accumulation of a small nucleotide regulator, (p)ppGpp, and induces global changes in bacterial transcription and translation. Recent work from our group has shown that (p)ppGpp plays a critical role in virulence and survival in Vibrio cholerae. The genes, relA and relV, are involved in the production of (p)ppGpp, while the spoT gene encodes an enzyme that hydrolyzes it in V. cholerae. A mutant strain defective in (p)ppGpp production (i.e. ${\Delta}relA{\Delta}relV{\Delta}spoT$ mutant) lost the ability to produce cholera toxin (CT) and lost their viability due to uncontrolled production of organic acids, when grown with extra glucose. In contrast, the ${\Delta}relA{\Delta}spoT$ mutant, a (p)ppGpp overproducer strain, produced enhanced level of CT and exhibited better growth in glucose supplemented media via glucose metabolic switch from organic fermentation to acetoin, a neutral fermentation end product, fermentation. These findings indicates that (p)ppGpp, in addition to its well-known role as a SR mediator, positively regulates CT production and maintenance of growth fitness in V. cholerae. This implicates SR as a promising drug target, inhibition of which may possibly downregulate V. cholerae virulence and survival fitness. Therefore, we screened a chemical library and identified a compound that induces medium acidification (termed iMAC) and thereby loss of wild type V. cholerae viability under glucose-rich conditions. Further, we present a potential mechanism by which the compound inhibits (p)ppGpp accumulation. Together, these results indicate that iMAC treatment causes V. cholerae cells to produce significantly less (p)ppGpp, an important regulator of the bacterial virulence and survival response, and further suggesting that it has a therapeutic potential to be developed as a novel antibacterial agent against cholera.

• English & American cultural studies
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• v.18 no.3
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• pp.1-29
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• 2018

Nadine Gordimer's The Pickup, published in 2001, well shows how the social issues have been changed in a way to reflect the South African society which is more complicated in the post-apartheid era. Examining the two different geographical territories between Johannesburg, South Africa and an unnamed nation in Middle East, putting aside the domestic racism between white and black, she extends her issue of racial other to global one with new rising issue of immigration in South African society. It seems that Gordimer's such issue is well represented by two main characters: Julie Summers who comes from a wealthy family and falls in love with Abdu, an illegal immigrant who was born from a poor country in Middle East and is now working at a garage in a downtown of Johannesburg with hiding his real name Ibrahim ibn Musa. Having an official relationship with Ibrahim and joining the regular meeting at the El-Ay (L.A.) Cafe where all participants can enjoy the freedom of expression/speech except for Abdu, she begins to have interest in his silence and his presence, orientalized as the Arab Prince for her imagination. Arriving at Abdu 's nation later, she also keeps projecting the 'less civilized' images to his nation where there are only desert, uneducated people, and dirty houses and streets. In doing so, Gordimer leads reader to a never-ending issue of Orientalism in the Western literature. Moreover, the writer attempts to create a female-centered community at the male-centered Islam community by marginalizing the presence of Abdu who finally leaves to America alone. As Julie is successfully acculturated to the unknown Abdu's community, she begins to place herself at the center of the community and plays a role as a mediator/communicator who can change/civilize it with her western knowledge of language and culture. By replacing the male-centered with the female-centered through Julie, Gordimer seems to be creating an idealized community with the notion of matriarchy. However, Gordimer places Abdu as an unstable subject who has to endlessly move back and forth for his undetermined national and cultural identity while Julie achieves the determined identity in both nations.

• Journal of Family Relations
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• v.22 no.3
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• pp.29-46
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• 2017

Objectives: The purpose of this study was to investigate a role of self-compassion in conflict resolution strategies among dating couples. Further, we examined conflict resolution strategies as mechanisms to explain in the relationship between self-compassion and relationship satisfaction. Method: Two hundred forty two dating couples were recruited. Actor and Partner Independence Model(APIM) was used to examine actor and partner effects of self-compassion on relationship satisfaction as well as conflict resolution strategies. The total of 4 APIMs, two positive conflict resolution strategies(i.e., positive emotional reactions, active coping) and two negative conflict resolution strategies(i.e., negative emotional reactions and hostility, avoidance) were analyzed. Positive conflict resolution strategies had only actor effect in the link between self-compassion and relationship satisfaction. That is, self-compassionate men and women were more likely to use positive conflict resolution strategies and, in turn, led to their higher relationship satisfaction. Both actor and partner effects were found in the negative conflict resolution strategy models. In terms of actor effect self-compassionate men and women were less likely to use negative conflict resolution strategies and that, in turn, led to their higher relationship satisfaction. In terms of partner effects we found that women's negative emotional reactions and hostility mediated the link between women's self-compassion and their male partners' relationship satisfaction. Men's avoidance mediated the link between men's self-compassion and their female partners' relationship satisfaction.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.700-718
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• 2003

Fructan, a polysaccharide existing in plants or produced by microorganisms, is a sugar polymer of fructose with $\beta$-2,6 linkages. In this study, we investigated some cosmeceutical properties of Fructan such as moisturizing effect, cell proliferation effect, anti-inflammation effect and cell cytotoxicity. Zymomonas mobilis, a microorganism producing Fructan, was cultured in a medium containing 10％ sucrose and 2％ yeast extract as main components for 24 hours at 37$^{\circ}C$ and pH 7. Fructan was obtained by precipitation from the cultured medium by adding alcohol (alcohol ratio of 1:3) after removing the enzyme by centrifuging. Fructan exhibited almost same moisturizing effect as hyaluronic acid and cell proliferation effect on human fibroblast and keratinocyte as well. Moreover, on cell proliferation test on bio-artificial skin constructed by 3-dimensional(3-D) culture after inducing primary skin inflammation with 0.5％ sodium lauryl sulfate (SLS), the 3-D artificial skin treated with 0.01 mg/ml, 0.05mg/ml of Fructan exhibited higher cell proliferation than the 3-D artificial skin treated with SLS only. On anti-inflammation test on 3-D artificial skin evaluated by measuring secreted quantity of interleukin-1$\alpha$ (IL-1$\alpha$) which is a pre-inflammatory mediator induced by SLS, the quantity of IL-1$\alpha$on the 3-D artificial skin treated with 0.01 mg/ml, 0.05mg/ml of Fructan was less than the one on the 3-D artificial skin treated with SLS only. As a result of these studies, Fructan has anti-inflammation effect against inflammatory reaction by a skin irritant as well as cell proliferation effect in bio-artificial skin. Fructan was also evaluated as a safe material without any toxicity in safety tests using fibroblasts and animals.

• Journal of Marine Bioscience and Biotechnology
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• v.15 no.2
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• pp.33-40
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• 2023

This study aimed to investigate the immunomodulatory function of Pyropia yezoensis hydrothermal (water) extract (PYWE) in comparison to the group treated only with lipopolysaccharides (LPS) in RAW264.7 cells. LPS is known to be an inflammatory mediator that activates macrophages, leading to the secretion of nitric oxide (NO), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) as defense responses. Through enzyme-linked immunoassay and western blot analyses, it was observed that PYWE increased the expression levels of NO, iNOS, TNF-α, and IL-6 in RAW264.7 cells in a dose-dependent manner, although to a lesser extent compared with the group treated with LPS alone. In addition, the study examined the mitogen-activated protein kinases (MAPKs) pathway, which regulates various cellular activities, including gene expression, mitosis, cell differentiation, transformation, survival, and death. The western blot analysis confirmed that PYWE also regulated the MAPKs pathway. Furthermore, the expression levels of immunomodulatory-related factors increased in the group treated with PYWE compared with the control group. Even though the effects of PYWE were usually less strong than those of LPS, the effects of PYWE increased with increasing doses compared to the control group. This suggests that PYWE could be used to control the immune system.