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Usefulness of $^{18}F$-FDG PET/CT in Locoregional Recurrence of Differentiated Thyroid Cancer: Comparison PET/CT to PET and Neck Ultrasonography for Biopsy-proven Lesions (갑상선유두암 재발 진단에서 $^{18}F$-FDG PET/CT와 경부초음파검사 병용의 유용성: PET, 경부초음파검사 그리고 혈청 티로글로불린 (thyroglobulin)의 비교)

  • Kim, Kun-Ho;Shong, Min-Ho;Seo, Young-Duk;Kim, Seong-Min
    • Nuclear Medicine and Molecular Imaging
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    • v.43 no.5
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    • pp.411-420
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    • 2009
  • Purpose: The aim of this study was to investigate the usefulness of $^{18}F$-FDG PET/CT with neck ultrasonography (neck US) in patients with recurrent, papillary thyroid cancer. Material and methods: This retrospective study (December 2006 to April 2008) enrolled sixty-one patients (ninety-one lesions) who underwent high-dose $^{131}I$-ablation therapy after total thyroidectomy, and evaluated recurred papillary thyroid cancer. All lesions were confirmed by histopathology and compared histopathologic findings to PET, PET/CT, and neck US findings. Results: In sixty-one patients (57 women, 4 men; age range, 24-81 years, mean 49 years; 61 papillary carcinomas), the sensitivity, specificity, accuracy of $^{18}F$-FDG PET/CT was 87.2%, 64.0%, 78.1% on a patient basis and 92.3%, 66.7%, 80.9% on a lesion basis, respectively. The sensitivity, specificity, accuracy of $^{18}F$-FDG PET was 71.8% (p=0.03), 59.0% (p=1.00), 67.2% (p=0.03) on a patient basis and 78.8% (p<0.01), 64.1% (p=1.00), 72.5% (p=0.02) on a lesion basis, respectively. The sensitivity, specificity, accuracy of neck US was 71.1% (p=0.07), 52.2% (p=0.75), 63.9% (p=0.05) on a patient basis and 71.2% (p<0.01), 61.5% (p=1.00), 67.0% (p=0.06) on a lesion basis, respectively. Combined $^{18}F$-FDG PET/CT with neck US improved the sensitivity, specificity, accuracy to 94.7% (p=0.50), 82.6% (p=0.13), 90.2% (p=0.03) on a patient basis and 96.2% (p=0.50), 89.7% (p<0.01), 93.4% (p<0.01) on a lesion basis, respectively. Conclusion: $^{18}F$-FDG PET/CT demonstrated significantly higher sensitivity than neck US for the detection of recurred papillary thyroid cancer lesions. Furthermore, combined $^{18}F$-FDG PET/CT with neck US showed more improved sensitivity, specificity, accuracy for diagnosis of recurrent papillary thyroid cancer.

Effect of F$e_2$P Addition on Microstructures of Sintered 4600 Steel (4600계 소결강의 조직에 미치는 F$e_2$P첨가의 영향)

  • Kim, Dong-Uk;Lee, Wan-Jae
    • Korean Journal of Materials Research
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    • v.2 no.6
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    • pp.428-435
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    • 1992
  • AISI 4600 Iron powder was mixed with 0~1.0% phosphor as F$e_2$P powder and/or 0~0.8% carbon as graphite powder in rotating mixer. Mixed powder was pressed 800MPa in double-punch mould. Compacts were sintered at 115$0^{\circ}C$for 30 min. in vacuum or mixed hydrogen and nitrogen gas. Sintered compacts were ground and polished, and etched by 2% nital etchant. The microstructure was observed by image analyzer and optical microscope. Density and microhardness were tested by ASTM B3l2 and Microvickers hardness tester. The results obtained were as follows : (1) As the amount of F$e_2$P powder increased, sintered microstructure showed more densified effect and the grain size was larger. (2) The shape of pore was rounded and the number of pore was decreased by F$e_2$P addition. But mean pore size was larger with F$e_2$P content. (3) Simultaneous alloying addition of F$e_2$P and graphite brought about larger grain growth than respective addition. (4) Sintering atmosphere did not affect the microstructure. (5) Hardness of sintered compact increased with phosphrous and carbon content.

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The relationship between fluency levels and suprasegmentals according to the sentence types in the English read speech by Korean middle school English learners (한국 중학생의 영어 읽기 발화에서 문장유형에 따른 유창성 등급과 초분절 요소의 관계)

  • Kim, Hwa-Young
    • Phonetics and Speech Sciences
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    • v.14 no.3
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    • pp.51-66
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    • 2022
  • This study aims to help Korean English learners to learn English pronunciation by revealing which suprasegmentals affect the implementation of English sentences closer to native English speakers when they read English sentences. To this end, Korean middle school English learners were selected as subjects and research data were gathered through sentence types (declarative, interrogative, imperative, and exclamative), as well as syllables. Speech rate, pause frequency, pause duration, F0 range, and rhythm among suprasegmentals were used for analysis of these English sentence utterances. Mean analysis, correlation analysis, and regression analysis were performed. The results showed that speech rate, pause frequency, pause duration, and F0 range affected the evaluation of fluency levels. In the regression analysis between all suprasegmentals and fluency levels, the suprasegmentals that most affected fluency levels were speech rate and F0 range. Rhythm had no meaningful relation with fluency levels. Therefore, when teaching English pronunciation, it is necessary to teach students to increase their speech rate and F0 range. In addition, students should be trained to reduce both the number and the duration of pauses during utterance to improve their fluency. It is noteworthy that of the four sentence types, exclamative sentences were produced with faster speech rate, fewer pauses, shorter pause duration, and higher rhythm values.

Effect of Culture Medium on Results of Maerobroth Dilution Antifungal Susceptibility Testing of Candida albicans (Candida albicans의 시험관 희석법에 의한 항균력 검사시 배지가 항균력에 미치는 영향)

  • Koh, Choon-Myung;Kim, Soo-Ki
    • The Journal of the Korean Society for Microbiology
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    • v.22 no.3
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    • pp.301-307
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    • 1987
  • A total of 42 strains of Candida albicans were examined for susceptibility to three antifungal agents, amphotericin B(AMB), 5-fluorocytosine(5-FC), and ketoconazole(KTZ), using defined medium, synthetic amino acid medium-fungal(SAAM-F), supplemented yeast nitrogen base(SYNB) and undefined medium Sabouraud's dextrose broth(SDB) and Kimmig broth media. A tube dilution method was used with minimum inhibitory concentrations(MICs) determined after incubation for 24 hour and 48 hours. All testes were performed in duplicate. In general, MICs were more reproducible after 48 hour of incubation. Forthermore, MICs determined after incubation for 48 hours were significantly higher than those determined after 24 hours. The actural MICs obtained with the different antifungal agents were clearly influenced by the test medium used. The rank order of AMB MICs according to the test medium was as follows: SAAM-F>SYNB>SDB>Kimmig broth. With 5-FC, the following pattern was observed: SYNB>SAAM-F>SDB>Kimmig borth. For ketoconazole, the MICs according to the test medium was SAAM-F>SDB>SYNB> Kimmig broth. In amphotericin B, the MICs mean value with the test medium was as follows: SDB, 0.24 mcg/ml; Kimmig broth, 0.29 mcg/ml; SYNB, 0.21 mcg/ml and SAAM-F, 0.15mcg/ml. The actural value of 5-FC was; SDB, 37.20 mcg/ml; Kimmig broth, 67.41mcg/ml; SYNB, 21.29 mcg/ml and SAAM-F, 24.61 mcg/ml and in ketoconazole, the MICs value was; SDB, 1.83 mcg/ml; Kimmig broth, 4.08 mcg/ml; SYNB, 1.95 mcg/ml and SAAM-F, 1.41 mcg/ml. The results of this investigation suggested that broth dilution susceptibility testing of yeast and yeast-like fungi are best performed with an incubation period of 48 hours. Furthermore, medium composition can significantly influence the results of such testing.

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A Study on the Factors of the school health Teachers' Self-confidence Affecting the School Nursing Activities in Jeonbuk Province (전북지역 양호교사의 업무수행과 자신감과 그에 영향하는 요인에 관한 연구)

  • Yang, Koung-Hee
    • Research in Community and Public Health Nursing
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    • v.1 no.1
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    • pp.582-594
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    • 1989
  • The purpose of this study is to analyze the factors affecting the school health teachers' self-confidence. This study was conducted with 87 school health teachers working in Jeonbuk province, from September to December, 1986, The results are follows; 1. Demographic characteristics of school health teachers 1) Age mean ; 34, range; 23-54 2) School Nursing experience mean; 11 years, range; 0-24 3) Clinical experience mean; 1.5 years, range: 0-13 2. Status of school health resources & nursing activities 1) Personnel resource school health teacher: pupils : 1 : 1,436 'classes=1:31 'general teacher=1:39 2) Budget Total school operating budget: School health budget : 100 : 4.2 (52.2 thousand Won) Half of the school health budget expend on medicine. 3) Clinic 80% of all schools have health clinic seperately. 71.32 of all schools have less than $35m^2$, 23.9%, $36-66m^2$. 4) Only 20% of all schools have organization for health 5) Average of clinic visitor for 1 year; 2,084 Major problem is on digestive system. And other problem: respiratory, skin, musculo - skeletal system, dental problem, etc... 6) Literal message for 1 year; 12 times. For health education (4), vaccination (3), examination of parasites (2), etc... 3. The degrees of the school health teachers' self-confidence 1) Program planning & evaluation; 2.9. 2) Clinic management; 2.8 3) Health education; 2.8 4) Management of school environment; 2.7 5) Health care services; 2.5. 6) Operating of school health organization; 2.3 4. Significances to self-confidence on school health nursing activities 1) Program planning & evaluation: home message (r=.228, p<.05) No. of clinic visitor (r=.220, p<.05) expending time for clinic management (r=.229, p<.05) religion (t: 2.5, p<.05) level of school (F=6.3, p<.005) 2) Clinic management: age of school health teacher (r=-.202, p<.05) school health experience (r=-.211, p<.05) salary step (r=.187, p<.05) expending time for clinic management (r=.315, p<0.1) marital status (t=3.97, p<.005) level of school (F=3,139, p<0.5) 3) Management of school environment: level of school (F=3.899, p<.05) expending time for clinic management (r=-,216, p<0.5) 4) Health care service: age of school health teacher (r=-.186, p<.05) marital status (t= 3.67, pH.005) 5) Health education: expending times for clinic management (r=-.252, p<05) level of school (F=5.343, p<.01) 6) Operating of health organization; age of school health teacher (r=-.258, p<.01)salary step (r=.188, p<.05) Based on the above results, the suggestions are as follows; 1. Need to raise ,appointment rate school health teacher. 2. Need to raise self-confidence on school health nursing activities through the inservice education or re-inforcement. 3. Need to secure adequate budget for school health. 4. Participation of school health teacher and support of school master for school health services are required. 5. Need for use the health clinic seperately, adequate facilities and free utilization by visitors.

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A Study of the Relationship Among Health Promoting Behaviors, Climacteric Symptoms and Depression of Middle-Aged Women (중년여성의 건강증진행위와 갱년기 증상, 우울과의 관계 연구)

  • 유은광;김명희;김태경
    • Journal of Korean Academy of Nursing
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    • v.29 no.2
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    • pp.225-237
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    • 1999
  • The purpose of this study was to analyze the relationship among the health promoting behaviors, self-reported climacteric symptoms and depression on a cross-sectional survey desist The subjects were 108 middle-aged women who were nonhystrectomized and ranged in age from 40 to 60. They were selected in Seoul and Kyoung-ki province. Korea. Data were collected from Oct. 25 to Nov. 10, 1997 by a structured Questionnaire. The instrument used for this study was the revised Health Promotion Lifestyle Profile(HPLP) developed by Walker, Sechrist and Pender, revised Climacteric Symptoms Scale developed by Chi, Sung Ai, and the Beck's Depression Inventory(BID). The data were analyzed by the SPSS /PC$^{+}$ program using t-test, ANOVA and Scheffe test as a post hoc and Pearson Correlation Coefficient. The results of the study were as follows ; 1. The mean score of health promoting behaviors was low(2.42$\pm$0.35). There were statistically significant difference in the score of health promoting behaviors according to the educational background. family income, marital satisfaction, and whether or not taking a restoraitve food(t =-2.07, F=2.60~7.57, p<0.05). 2. The mean score of self-reported climacteric symptoms was 1.69 ; 99% of middle-aged women had symptoms. There were statistically significant difference in the score of middle-aged women's self-reported climacteric symptoms according to the age, number of children, educational background, occupation, family income, marital satisfaction, whether or not receiving hormone replacement therapy(HRT) or consultation experience with a professional, and perceived health status(t=-2.04~3.69. F=2.87~11.63, p<0.05). 3. The mean score of depression was 10.84. There were statistically significant differences in the score of the depression according to the age, number of children, educational background, occupation, marital satisfaction, whether or not receiving menopausal treatment or consultation by a professional, and perceived health status(t =-2.25~3.00, F=3.50~9.24, p<0.05). 4. Women's degree of health promoting behaviors was a negative correlation with the degree of climacteric symptoms(r=-0.19, p=0.03) and the degree of depression(r=-0.23, p=0.01). The degree of climacteric stmptoms was a positive correlation with the degree of depression(r=0.64 p=0.01). In conclusion. health promoting behavior should be considered when developing nursing strategies for middle-aged women. especially when dealing with climacteric symptoms and depression.

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Correlation of Cord Serum Adiponectin and IGF-I with Fetal Growth in Healthy Term Neonates (제대혈 Adiponectin과 IGF-I이 태아성장에 미치는 영향)

  • Kim, Ji-Young;Cho, Su-Jin;Kim, Hae-Soon;Park, Hye-Sook;Park, Eun-Ae
    • Neonatal Medicine
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    • v.15 no.1
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    • pp.38-43
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    • 2008
  • Purpose : The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth. Methods : Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI). Results : The mean cord serum APN was 29.2${\pm}$10.46 $\mu$g/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26${\pm}$21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI. Conclusion : APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.

Effectiveness of nutrition education intervention focusing on fruits and vegetables in children aged six years and under: a systematic review and meta-analysis (유아 대상 과일·채소 영양교육 효과분석: 체계적 문헌고찰 및 메타분석)

  • An, Sumin;Ahn, Hyejin;Woo, Jeonghyeon;Yun, Young;Park, Yoo Kyoung
    • Journal of Nutrition and Health
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    • v.54 no.5
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    • pp.515-533
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    • 2021
  • Purpose: A systematic review and meta-analysis of nutrition educational intervention studies was performed to assess the association between nutrition education intervention and fruit & vegetable (F&V) preferences and nutrition knowledge in preschool children. Methods: The relevant studies of nutrition education intervention and F&V preferences and nutrition knowledge published from January 2000 to June 2020 were located using PubMed, Web of Science, Cochrane Library, Research Information Sharing Service, Korean Studies Information Service System databases, and lists of references. A random-effects meta-analysis was conducted to estimate the standardized mean difference with a 95% confidence interval (CI). Subgroup analyses were performed to identify the association between nutrition education and F&V preferences and nutrition knowledge. Results: The results show that the effect sizes (ES) of F&V preferences and nutrition knowledge of preschool children were 0.31(95% CI, 0.23, 0.39), and 1.69(95% CI, 1.27, 2.12), respectively. The result of subgroup analysis, nutrition education focused on F&V (F&V preferences, ES: 0.32; nutrition knowledge, ES: 2.09) presented a slightly larger effect than general nutrition education (F&V preferences, ES: 0.26; nutrition knowledge, ES: 1.62). As for the type of exposure to F&V, direct exposure education (F&V preferences, ES: 0.40) had a greater effect than indirect exposure (F&V preferences, ES: 0.26). This meta-analysis showed that nutrition education intervention had positive effects on the F&V preferences and nutrition knowledge in preschool children. Conclusion: In conclusion, from the meta-analysis and subsequent subgroup analysis, we found that varied types of nutrition education intervention had varying effects on F&V preferences and nutrition knowledge in preschool children.

A Study on Exposure to Asbestos a Shipbuilding Repair Business (수리조선 작업장에서의 공기중 석면 노출에 관한 연구)

  • Sim, Sang-Hyo;Chung, Hee-Tae;Song, Ki-Min;Kim, Yoon-Shin;Kang, Yong-Seon
    • Journal of Environmental Health Sciences
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    • v.34 no.4
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    • pp.279-284
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    • 2008
  • This paper aims to provide basic data for work environment control, prevention of worker exposure to asbestos and improvement of air quality to protect workers ‘health after measuring the level of airborne asbestos and workers' exposure in a shipbuilding repair businesses. For this study, a total of 27 samples were collected from 27 workers who had been exposed to asbestos during engine, piping, boiler and other manufacturing processes in 'A' Shipbuilding Repair Company in Gyeongnam. This research was conducted from Oct. 1 to 30, 2007 and had the following results: The target group (27 workers) consisted of all men with an average age of 35.9 years and 6.6 years of work on average. Among them, fifteen 15 (55.6%) were smokers. In terms of their duties at work, there were 12 plumbing repair engineers (44.4%), 8 boiler repair engineers (29.6%) and 7 engine engineers (25.9%). The geometric mean concentration of airborne asbestos was 0.004 f/cc. A total of 4 samples exceeded the exposure limit. In particular, three exceeded the legal limit by more than double, which means that some workers have been highly exposed to asbestos. In terms of the concentration of asbestos fibres by work process, plumbing repair was the highest (0.0071 f/cc($0.001{\sim}0.57\;f/cc$)) while boiler was the lowest (0.0015 f/cc($0.001{\sim}0.007\;f/cc$)). Based on this study, proper action needs to be taken as soon as possible to protect workers from the threat of asbestos.