• BMB Reports
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• 제45권11호
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• pp.647-652
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• 2012

We previously reported that MSTO-211H cells have a higher capacity to regulate Nrf2 activation in response to changes in the cellular redox environment. To further characterize its biological significance, the response of Nrf2, a transcription factor that regulates ARE-containing genes, on the synergistic cytotoxic effect of clofarabine and resveratrol was investigated in mesothelioma cells. The combination treatment showed a marked growth-inhibitory effect, which was accompanied by suppression of Nrf2 activation and decreased expression of heme oxygenase-1 (HO-1). While transient overexpression of Nrf2 conferred protection against the cytotoxicity caused by their combination, knockdown of Nrf2 expression using siRNA enhanced their cytotoxic effect. Pretreatment with Ly294002, a PI3K inhibitor, augmented the decrease in HO-1 level by their combination, whereas no obvious changes were observed in Nrf2 levels. Altogether, these results suggest that the synergistic cytotoxic effect of clofarabine and resveratrol was mediated, at least in part, through suppression of Nrf2 signaling.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2004년도 제29회 추계학술대회 발표논문집
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• pp.115-118
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• 2004

우리의 연구는 호흡에 의해 움직임의 영향을 받는 장기 및 종양에 대해서 조사된 선량분포를 측정하는 것이다. 이 연구를 수행하기 위해, 사전연구로 이전에 발표된 논문을 토대로 호흡에 의해 장기 및 종양의 움직임 변위를 조사하였다. 그리고 조사된 데이터를 활용하여 호흡에 따른 움직임을 구동 시스템을 적용하여 구현하였다. 내부 움직임에 의한 선량분포의 변화를 측정하기 위해서 이 구동 팬톰 시스템을 사용하였다. 이 결과로부터 호흡에 환자의 조사되는 선량분포의 부정확 정도를 평가할 수 있었다.

• 한국염색가공학회지
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• 제21권5호
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• pp.41-50
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• 2009

Design of experiments (DoE) concept was successfully applied to determine the optimum processing conditions that yield maximum % exhaustion for berberine interaction with synthetic tanning agent pretreated polyamide substrates. The potential of synthetic tanning agent to provide anionic sites on the polyamide for berberine interaction which is cationic in nature was tested to increase the % exhaustion of berberine in this article. Experiments were designed according to Central Composite Rotatable Design (CCRD). The three factors for synthetic tanning agent pretreatment and two factors for berberine interaction each at five different levels, including central and axial points were considered. Experiments were conducted in a laboratory scale infra-red treatment instrument according to CCRD. For each response, second order polynomial models were developed using multiple linear regression analysis incorporating linear, interactions and squared effects of all variables and then optimized. The significance of the mathematical model developed was ascertained using Excel regression (solver) analysis module. Analysis of variance (ANOVA) was performed to check the adequacy and accuracy of the fitted models. The response surfaces and contour maps showing the interaction of process variables were constructed. Applying Monte Carlo simulation, response surface and contour plots, optimum operating conditions were found and at this optimum point, % exhaustion of 81% and 74% respectively for synthetic tanning agent pretreatment and berberine interaction were observed and subsequently the results were experimentally investigated.

• 한국컴퓨터산업학회논문지
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• 제7권4호
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• pp.427-436
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• 2006

운동하는 물체의 동특성 해석을 위한 상태 공간 모델 방식이 컴퓨터에 의한 미분방정식 해석의 수학적인 도구로서 도입되었다. 시스템 표현이 간단한 행렬 연산 형태로 이루어지므로 선형 및 비선형, 시변 및 시불변 시스템과 단변수 및 다변수 시스템 등에 대하여 통일된 방식의 모델이 사용가능하다. 그리고 이러한 상태 공간 모델을 해석하기위해서는 복잡한 벡터 연산을 하여야 하지만 패킷 소프트웨어의 특정함수를 사용하여 쉽게 해석할 수가 있다. 그러나 최근에는 상용 프로그램의 발전에 따라 동특성 해석을 위한 상태 공간 모델을 대화형 도형 처리를 하여 매우 간단하게 동특성을 시뮬레이션 할 수 있는 방법이 제공되고 있다. 본 논문은 운동하는 물체의 동특성 해석을 하는 데 교육용으로 활용할 수 있는 시뮬레이터를 개발하는 목적으로 항공기의 세로 동특성 해석을 위한 시뮬레이션을 수행하고자 하였으며 항공기 세로 안정성에 대한 과도응답 특성을 해석하는 시뮬레이터를 설계하였다.

• Environmental Engineering Research
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• 제15권2호
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• pp.63-70
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• 2010

In this study, the response surface method and experimental design were applied as an alternative to conventional methods for the optimization of coagulation tests. A central composite design, with 4 axial points, 4 factorial points and 5 replicates at the center point were used to build a model for predicting and optimizing the coagulation process. Mathematical model equations were derived by computer simulation programming with a least squares method using the Minitab 15 software. In these equations, the removal efficiencies of turbidity and total organic carbon (TOC) were expressed as second-order functions of two factors, such as alum dose and coagulation pH. Statistical checks (ANOVA table, $R^2$ and $R^2_{adj}$ value, model lack of fit test, and p value) indicated that the model was adequate for representing the experimental data. The p values showed that the quadratic effects of alum dose and coagulation pH were highly significant. In other words, these two factors had an important impact on the turbidity and TOC of treated water. To gain a better understanding of the two variables for optimal coagulation performance, the model was presented as both 3-D response surface and 2-D contour graphs. As a compromise for the simultaneously removal of maximum amounts of 92.5% turbidity and 39.5% TOC, the optimum conditions were found with 44 mg/L alum at pH 7.6. The predicted response from the model showed close agreement with the experimental data ($R^2$ values of 90.63% and 91.43% for turbidity removal and TOC removal, respectively), which demonstrates the effectiveness of this approach in achieving good predictions, while minimizing the number of experiments required.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 D
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• pp.2167-2168
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• 2006

Mobilecomputer of offers more fundamental role than role assistance enemy of modem technology equipment and new Information Technology can reconsider, and reconstruct creatively accuracy of physiological concept. That military register symptoms are developed of disease, before far before rehalibitation, of for possibility that can intervene in process that motive change of military register symptoms after rehalibitation. But, that many parameters become analysis target and mathematical settlement and equalization system of noted data of that is huge, same time collection of all datas can lift difficulty etc.. These main weakness puts in structural relation between elements that compose system. Therefore, dynamics research that time urea of systematic adjustment has selected method code Tuesday nerve dynamics enemy who groping of approach that become analysis point is proper and do with recycling bioelectricity signal. Nature model of do living body signal digital analysis chapter as research result could be developed and scientific foundation groping could apply HSS (Hardware-software system) by rehalibitation purpose. Special quality that isdone radish form Tuesday of bioelectricity signal formation furthermore studied, and by the result, fundamental process of bodysignal in do structure circuit form of analog - digital water supply height modelling do can.

• Journal of Trauma and Injury
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• 제28권4호
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• pp.248-255
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• 2015

Purpose: study of the mutual influence of the individual anatomical regions damage in patients associated with falls from heights. Methods: 561 medical reports of patients associated with falls from heights admitted to Republican Research Center of Emergency Medicine (RRCEM), in period of 2010-2013 yy, were analyzed retrospectively. Patient's age range was from 15 to 89. Treatment of these patients held in three stages: period of acute disorders of vital functions; relative stabilization period; stabilization of vital functions. The scope and content of medical diagnostic procedures performed on pre-hospital and intensive care stages. The severity of each injury was scored according to the AIS scale, the total severity of lesions was scored by points due to ISS. Digital material is treated by methods of mathematical statistics. Results: Falls from heights leads to associated injuries for 4 times more than isolated trauma, and increases according to height of fall and falling surface. Patients with TBI+chest trauma, are most serious contingent that has highest mortality and complications (36.8%). TBI+musculoskeletal system trauma are characterized by high blood loss, traumatic shock and fat embolism, forming a vicious circle. Conclusion: in patients associated with falls from heights clinical manifestations of injuries mutual aggravation syndrome will be seen. TBI leads to complication of chest trauma, delayed diagnostics of abdominal and chest trauma, aggravation of coma condition. Developing of high blood loss and fat embolism in musculoskeletal system trauma leads to shock and pulmonary embolism, which increases probability of death in the presence of abdominal or chest trauma, but abdominal trauma or chest trauma has no significant effect on the severity of the musculoskeletal system trauma.

• 한국의학물리학회지:의학물리
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• 제19권3호
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• pp.172-177
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• 2008

정량적인 방사선치료 선량을 예측하기위한 일환으로 한국표준남성에 기초하여 수학적 모의피폭체를 제작하였다. 이후 전립선을 선원장기로 하여 전립선암 근접치료 시 발생할 것으로 예상되는 전립선 및 주변장기의 흡수선량을 산정하였다. 모의모사를 위하여 방사성핵종은 전립선 근접치료에 유용하게 사용되는 $^{25}I$ 및 $^{103}Pd$선정하였고, 초기 방사능을 1 Ci를 투여하는 것으로 가정하였다. 그 결과 선원장기인 전립선이 $^{125}I$ 및 $^{103}Pd$ 경우 각각 101 Gy/Ci와 7.24 Gy/Ci를 나타냈으며, 전립선을 제외하고 흡수선량이 높은 장기는 비교적 전립선과 인접되어 있는 장기 즉 음경과 음낭, S자결장, 정소, 방광순으로 나타났다.

• 한국환경과학회지
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• 제22권3호
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• pp.331-339
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• 2013

Efforts were made to determine the activation energy and the reaction order by adopting Kissinger and Flynn-Wall-Ozawa analysis methods. All the data were acquired from TGA thermograms for the mixed fuels with different temperature heating rates. It could be known that both the coal and the mixed fuels decomposed thermally at temperature ranges of $300{\sim}700^{\circ}C$. The temperature at the maximum reaction rate, Tp, could be determined by DTG method, which could be obtained by differentiation of TGA thermogram. Kissinger analysis showed the linear relationship with experimental data, showing the activation energy of $319.64{\pm}4$ kJ/mol. From Flynn-Wall-Ozawa analysis, it was shown that the activation energies and the reaction orders did not undergo any significant changes with both the conversions and the heating rates. It was considered from this facts that the combustion mechanism of the mixed fuels could not be affected by the extent of conversion and heating rate. In the present study, the activation energies showed different values according to the different analysis methods. The difference might be originated from the inconsistency of the mathematical data treatment method. In other words, while the activation energies obtained from the Kissinger method indicated the average values for overall reaction, that from Flynn-Wall-Ozawa method showed the average values for the each conversion around Tp.

• 대한전자공학회논문지SP
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• 제48권4호
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• pp.86-97
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• 2011

본 논문에서는 칼라분류 및 방향성 에지정보의 클러스터링과 이들의 통합에 의한 새로운 도로영역 및 차선검출 알고리즘을 제안한다. 도로영역 및 차선을 하나의 인식대상 물체로 취급하고, 통계적 파라미터의 반복 최적화에 의한 칼라정보의 클러스터링을 수행해서 검출과 인식을 위한 초기정보로 사용한다. 다음으로, 칼라정보가 갖는 물체인식 의 한계를 개선하기 위해 에지정보를 검출하고, 관심영역(Region Of Interest for Lane Boundary(ROI-LB))의 추출과 ROI-LB 영역에서 방향성 에지정보의 검출과 클러스터링을 수행한다. 칼라분류 및 에지 클러스터링의 결과를 통합해, 이들 각각의 정보가 갖는 특징을 이용함으로서 도로환경에 적합한 도로영역 및 차선을 검출할 수 있도록 한다. 제안방법은 도로와 차선에 관한 파라미터릭 수학적 모델을 사용하지 않고 칼라 및 에지의 클러스터링 정보에 의한 non-parametric 방법으로 다양한 도로 환경에 유연한 대응이 가능한 장점을 갖는다. 본 제안방법의 유효성을 입증하기 위해 상이한 촬상조건 및 도로환경에서의 영상에 대한 실험결과를 제시한다.