• Molecules and Cells
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• v.46 no.3
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• pp.133-141
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• 2023

Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes. KEAP1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of CULLIN 3 (CUL3)-based E3 ubiquitin ligase. KEAP1 regulates the activity of NRF2 and acts as a sensor for oxidative and electrophilic stresses. NRF2 has been found to be activated in many types of cancers with poor prognosis. Therapeutic strategies to control NRF2-overeactivated cancers have been considered not only by targeting cancer cells with NRF2 inhibitors or NRF2 synthetic lethal chemicals, but also by targeting host defense with NRF2 inducers. Understanding precise molecular mechanisms how the KEAP1-NRF2 system senses and regulates the cellular response is critical to overcome intractable NRF2-activated cancers.

• Journal of Institute of Control, Robotics and Systems
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• v.11 no.6
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• pp.496-501
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• 2005

This paper presents experimental results of the frequency offset locking of He-Ne lasers and the stability analysis. The master laser is free running, and the slave laser is a single-mode operating laser. The frequency difference of two lasers is stabilized to 200 MHz which can be synchronized using PLL servo. The measured beat frequency between two lasers was 200.004 MHz ${\pm}$ 0.15 MHz. The square root of Allan variance as a measure of stability in time domain is also measured. The long-term stability of the beat was worse than sort-term stability. With a gate time $\tau=1000\;s$, the square root of Allan variance was about 1 GHz. The results of the square root of Allan variance of the stabilized beat signal was a gate time of $\tau=1000\;s$, the square root of Allan variance was about 1.5 kHz. The long-term stability was improved by more than several hundred times compared with that without the stabilization.

• Journal of Institute of Control, Robotics and Systems
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• v.22 no.9
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• pp.686-692
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• 2016

A Crimp Force Monitor (CFM) is equipment for detecting crimp errors by analyzing crimp signals obtained from force and strain sensors. The analysis is commonly performed by aligning a measured crimp signal with a reference signal and comparing their difference. Current analysis methods often suffer from wrong alignments that result in false negative detections. This paper presents a new crimp signal analysis method in CFM. First, a falling edge alignment is proposed that matches falling edges of the measured and the reference signals by minimizing the absolute difference summation. Second, a signal parameter error is introduced to evaluate the crimp quality difference between the measured signal and the reference. For calculating the signal parameter error, part of a signal is identified and divided into several regions to maximize the signal parameter errors. Experiments showed that the proposed method can improve the signal alignment and accurately detect bad crimps especially with the strain sensor.

• Journal of Advanced Marine Engineering and Technology
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• v.35 no.6
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• pp.829-834
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• 2011

This paper introduces a new system which measures abrasion quantity of cylinder liners of large-scale marine diesel engines. The proposed system consists of three parts; measurement part where an LVDT, a temperature sensor, a camera and LED for lighting control are installed, monitoring part which accomplishes measurement command transmission and monitoring based on PC or notebook, and master control part which controls the measurement part and transfers measurement data to the monitoring part. The accuracy of the developed system is compared with that of an internal micrometer with 1/100 mm accuracy.

• The Journal of Korea Robotics Society
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• v.7 no.1
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• pp.20-28
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• 2012

In spite of the difficulties and uncertain characteristic of cable driven method, surgical robot instrument has adopted it as driving mechanism for various reasons. To overcome the problem of cable system, previous research applied SMCSPO (sliding mode control with sliding perturbation observer) algorithm as robust controller to control the instrument and found that the value of SPO (sliding perturbation observer) followed force disturbance, reaction force loaded on the tip very similarly. Thus, this paper confirms that the perturbation observer is sufficient estimator which finds out the mount of loaded force on the surgical robot instrument. To prove the proposition, simulation using the similar model with an actual instrument and experimental evaluation are performed. The results show that it is possible to substitute SPO for sensors to measure the reaction force. This estimated reaction force will be used to realize haptic function by sending the reaction force to a master device for a surgeon. The results will contribute to create surgical benefit such as shortening the practice time of a surgeon and giving haptic information to surgeon by using it as haptic signal to protect an organ by making force boundary.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.04a
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• pp.450-454
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• 1997

This system is the automatic boiler tube bending equipment which has four heads for bending the tube and the carriage for moving the tube. The system consists of two frames for transporting each moving parts, high-frequency heating equipment for heating the tube in hot bending, control panel for inputting the job data operating, remote control unit for concetration and distribution of input/output, and the monitoring system which can establish unmanned operationby receiving the bending job data via LAN form a design teamwhich produces the job data and schedule based on master production plan and diagnoses bending data change, input, whole system status, and system malfunctions. By employing this system, 30% of production improvement was achieved was achieved comparing to the existing bending system.

• Journal of Institute of Control, Robotics and Systems
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• v.21 no.3
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• pp.243-249
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• 2015

In direct vehicle teleoperation, a human operator drives a vehicle at a distance through a pair of master and slave device. However, if there is time delay, it is difficult to remotely drive the vehicle due to slow response. In order to address this problem, we introduced a novel methodology of shared vehicle teleoperation using a virtual driving interface. The methodology was developed with four components: 1) virtual driving environment, 2) interface for virtual driving environment, 3) path generator based on virtual driving trajectory, 4) path following controller. Experimental results showed the effectiveness of the proposed approach in simple and cluttered driving environment as well. In the experiments, we compared two sampling methods, fixed sampling time and user defined instant, and finally merged method showed best remote driving performance in term of completion time and number of collision.

• Journal of the Korean Institute of Navigation
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• v.20 no.3
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• pp.43-63
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• 1996

The purpose of this study is to find out what is the functional role of VTS in order to get the people concerned with marine traffic/transportation understand about VTS. VTS could be described as the essential risk management system in both cost effective on cost-benefit analysis and the sea space or time management at port, coastal environment. The important role of the VTS are those functions such as the decision making infrastructure, the passive/active safety measures at sea. VTS could not control/regulate marine traffic as strong as ATC(Air Traffic Control) owing to the marine traffic characters. However, the right and responsibility of VTS finally are belong to the master, pilot and mariners. For the benefit of the electronic technology development, VTS system also cloud be upgraded to communication system from information system. In connection with these system upgrading, the right and responsibility of VTS/staff should be supported by domestic legal system. The followings are presented for VTS to be effective. First, the cooperation and understanding of VTS between the peoples concerned with marine traffic/transportation are essential. Because they are all data supplier and also information consumers. Second, VTS staff/regulator should be selected, educated, trained accordingly as per their career, ability, quality, qualification, certification and etc. Third, the port reliability from VTS users depends on the factors such as economic interests, safety and effectiveness/efficiency of VTS.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.3 no.2
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• pp.1-10
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• 1985

Moire technique is generally divided into shadow Moire Technique and Projection Moire Technique. In this paper, determinating the direction of reference planes for this system, by comparing the results of this system with those of general terrestrial photogrammetry, is an objective of this paper. For the objective, control surveying is done and the results of control surveying are compared with those of moire photograph. In this technique, it is found that though the positions of a projector and a reference grid are not moved, a desired moire contour whose the reference plane is different respectively is easily obtained by changing the pitches of a master grid and a reference grid on an object. Also it is found that when the pitches of the two grids on an object are equal, a moire contour which has the reference plane parallel to the object can be obtained.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.6
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• pp.689-694
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• 2014

An SPLC (Safety Programmable Logic Controller) must be designed to meet the highest safety standards, IEEE 1E, and should guarantee a level of fault-tolerance and high-reliability that ensures complete error-free operation. In order to satisfy these criteria, I/O modules, communication modules, processor modules and bus modules of the SPLC have been configured in triple or dual modular redundancy. The redundant modules receive the same data to determine the final data by the voting logic. Currently, the processor of each rx module performs the voting by deciding on the final data. It is the intent of this paper to prove the improvement on the current system, and develop a voting system for multiple data on a system bus level. The new system bus protocol is implemented based on a TCN-MVB that is a deterministic network consisting of a master-slave structure. The test result shows that the suggested system is better than the present system in view of its high utilization and improved performance of data exchange and voting.